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Mehmet Sinan Yildirim,Ümit Gokkus 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.5
Port storage area optimization is resulted from the space allocation requirements of a seaport. Inventory analysis, covered in the scope of operation research topics, is frequently used in the port management such as determining the capacity of the storage areas. In the scope of port planning, the feasible storage area will yield an economic configuration with minimal investment. To achieve this, there must be none or minimum idle container slots in the storage area. In this study, a model based on the inventory analysis considering the minimization of the port expenses was implemented for the İzmir port in Turkey and the optimum future storage area of İzmir port was estimated for the coming years by forecasting the container traffic using Artificial Neural Networks considering the Turkey’s economic growth. The study indicated that there is a requirement of a storage area capacity for the coming years. It was found that, the capacity requirement for an optimal storage area management for the seaport was around 10000 containers for 2014, 11000 for 2018 and 12000 for 2023.
Lack of Any Role of Systemic Inflammatory Responses in Predicting Muscle Invasion by Bladder Cancer
Solakhan, Mehmet,Demirpence, Ozlem,Orhan, Nuri,Yildirim, Omer Aydin,Guzel, Ebru,Yildirim, Mustafa Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Background: The purpose of this study is to evaluate if there is a relation between platelet: lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) values and tumour histology and spread in bladder cancer cases. Materials and Methods: Bladder cancer patients undergoing TUR-M operation, with histopathologically verified diagnosis, followed-up and treated at the Private Medical Park Gaziantep Hospital between 2010 and 2015, have were included in the study. NLR and PLR values were calculated using complete blood count data obtained at the first presentation. Results: A total of 99 patients were included in the study, 7 (7.1%) women and 92 men (92.9%). When NLR was used as the indicator of systemic inflammatory response (SIR), it was determined that, 52 (52.5%) of the patients were SIR negative and 47 (47.5%) SIR positive. No significant relation could be detected between NLR and tumour grade and muscle invasion (p=0.948, p=0.480). When PLR was used as SIR indicator, it was determined that 71 (71.7%) of the patients were found as negative and 28 (28.3%) as positive. No significant relation could be detected between PLR and tumour grade and muscle invasion (p=0.651, p=0.494). Conclusions: In our study we did not detected a relation between tumour histological behavior and PLR and NLR in bladder cancer. However, NLR and PLR are easily calculated, accessible, inexpensive and simple-to-use laboratory data from whole blood counts.
Aldemir, Mehmet Naci,Turkeli, Mehmet,Simsek, Melih,Yildirim, Nilgun,Bilen, Yusuf,Yetimoglu, Harun,Bilici, Mehmet,Tekin, Salim Basol Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Background: We aimed to investigate the prognostic value of baseline neutrophil, lymphocyte, and platelet counts along with the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in local and advanced gastric cancer patients. Materials and Methods: In this retrospective cross-sectional study, a total of 103 patients with gastric cancer were included. For all, patient characteristics and overall survival (OS) times were evaluated. Data from a complete blood count test including neutrophil, lymphocyte, monocyte, white blood cell (WBC) and platelet (Plt) count, hemoglobin level (Hb) were recorded, and the NLR and PLR were obtained for every patient prior to pathological diagnosis before any treatment was applied. Results: Of the patients, 53 had local disease, underwent surgery and were administered adjuvant chemoradiotherapy where indicated. The remaining 50 had advanced disease and only received chemotherapy. OS time was $71.6{\pm}6$ months in local gastric cancer patients group and $15{\pm}2$ months in the advanced gastric cancer group. Univariate analysis demonstrated that only high platelet count (p=0.013) was associated with better OS in the local gastric cancer patients. In contrast, both low NLR (p=0.029) and low PLR (p=0.012) were associated with better OS in advanced gastric cancer patients. Conclusions: This study demonstrated that NLR and PLR had no effect on prognosis in patients with local gastric cancer who underwent surgery and received adjuvant chemoradiotherapy. In advanced gastric cancer patients, both NLR and PLR had significant effects on prognosis, so they may find application as easily measured prognostic factors for such patients.
Turkeli, Mehmet,Aldemir, Mehmet Naci,Cayir, Kerim,Simsek, Melih,Bilici, Mehmet,Tekin, Salim Basol,Yildirim, Nilgun,Bilen, Nurhan,Makas, Ibrahim Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3
Background: Docetaxel, cisplatin, 5-fluorouracil (DCF) given every three weeks is an effective, but palliative regimen and significantly toxic especially in patients who have a low performance score. Here, we aimed to evaluate the efficacy and tolerability of a weekly formulation of DCF in locally advanced and metastatic gastric cancer patients. Materials and Methods: 64 gastric cancer patients (13 locally advanced and 51 metastatic) whose ECOG (Eastern Cooperative Oncology Group) performance status (PS) was 1-2 and who were treated with at least two cycles of weekly DCF protocol as first-line treatment were included retrospectively. The weekly DCF protocol included $25mg/m^2$ docetaxel, $25mg/m^2$ cisplatin, and 24 hours infusion of $750mg/m^2$ 5-fluorouracil, repeated every week. Disease and patient characteristics, prognostic factors, treatment response, grade 3-4 toxicity related to treatment, progression free survival (PFS) and overall survival (OS) were evaluated. Results: Of the patients, 41 were male and 23 were female; the median age was 63 (29-82) years. Forty-one patients were ECOG-1 and 23 were ECOG-2. Of the total, 81.2% received at least three cycles of chemotherapy. Partial response was observed in 28.1% and stabilization in 29.7%. Overall, the disease was controlled in 57.8% whereas progression was noted in 42.2%. The median time to progression was 4 months (95%CI, 2.8-5.2 months) and median overall survival was 12 months (95%CI, 9.2-14.8 months). The evaluation of patients for grade 3-4 toxicity revealed that 10.9% had anemia, 7.8% had thrombocytopenia and 10.9% had neutropenia. Non-hematologic toxicity included renal toxicity (7.8%) and thrombosis (1.6%). Conclusions: In patients with locally advanced or metastatic gastric cancer who were not candidates for DCF administered every-3-weeks, a weekly formulation of DCF demonstrated modest activity with minimal hematologic toxicity, suggesting that weekly DCF is a reasonable treatment option for such patients.
Alpay Aribas,Mehmet Kayrak,Mehmet Tekinalp,Hakan Akilli,Hayrudin Alibasic,Serkan Yildirim,Mehmet Gunduz,Alpaslan Taner 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.3
Background/Aims: Poor sleep quality (SQ) is associated with increased cardiovascular mortality and morbidity. Additionally, asymmetric dimethylarginine (ADMA) is an independent predictor of cardiovascular mortality and morbidity. However, no sufficient data regarding the relationship between ADMA levels and SQ have been reported. The goal of the current study was to evaluate the association between SQ and ADMA levels in normotensive patients with type 2 diabetes mellitus. Methods: The study participants consisted of 78 normotensive type 2 diabetics. The SQ of all participants was assessed using the Pittsburgh Sleep Quality Index (PSQI). Patients with a global PSQI score > 5 were defined as "poor sleepers." Factors associated with poor SQ were analyzed using a multiple regression model. Serum ADMA levels were measured using high performance liquid chromatography. Results: The median ADMA levels of the poor sleepers were increased compared with patients defined as good sleepers (5.5 [4.2 to 6.6] vs. 4.4 [2.9 to 5.4], p < 0.01, respectively). However, the L-arginine/ADMA ratio was decreased in poor sleepers (p < 0.01). Global PSQI scores were positively correlated with ADMA levels (p < 0.01) and negatively correlated with the L-arginine/ADMA ratio (p = 0.02). ADMA levels were correlated with sleep latency (p < 0.01) and sleep efficiency (p = 0.01). Logistic regression analysis showed that ADMA levels (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.16 to 2.44; p = 0.01) and body mass index (OR, 1.15; 95% CI, 1.01 to 1.31; p = 0.04) were associated with poor SQ independently of glomerular filtration rate, sex, age, duration of diabetes, hemoglobin A1c, total cholesterol, and systolic blood pressure. Conclusions: Self-reported SQ was independently associated with ADMA levels in normotensive patients with diabetes mellitus.
Erratum- How will surface treatments affect the translucency of porcelain laminate veneers?
Sedanur Turgut,Bora Bagis,Elif Aydogan Ayaz,Fatih Mehmet Korkmaz,KıvançUtku Ulusoy,Yildirim Hakan Bagis 대한치과보철학회 2014 The Journal of Advanced Prosthodontics Vol.6 No.2
The article 'How will surface treatments affect the translucency of porcelain laminate veneers?' authored by Sedanur Turgut, Bora Bagis, Elif Aydogan Ayaz, Fatih Mehmet Korkmaz, KıvançUtku Ulusoy, and Yildirim Hakan Bagis published in February issue [Vol 6, No 1] of The Journal of Advanced Prosthodontics (2014), has an erratum.
Identification of the optimal faculty behaviors for performance improvement in distance education
Mehmet Kara,Zahide Yildirim 서울대학교 교육연구소 2020 Asia Pacific Education Review Vol.21 No.1
The current study reports the findings of the first step of a comprehensive performance improvement study, identification of the optimal behaviors. In this sense, this study aims to determine the optimal faculty behaviors in distance education based on the perspectives of the stakeholders based on the framework of transactional distance (TD) theory. The data were obtained from the stakeholders of distance education practices; distance education experts from eight universities, and faculty members, administrators, and students from two universities as well as observations on online courses and available relevant documents. The data from the multiple sources were analyzed through constant comparison method. The emerged codes created the themes based on the TD theory. The findings indicated that the identified behaviors, which are student-centered and interrelated in producing the outcomes, are expected from all faculty at varying degrees in any context to manage TD outcomes. The identified behaviors might be used as the performance objectives in faculty professional development studies and practices in distance education.
On the Hilbert Type Integral Inequalities with Some Parameters and Its Reverse
Yildirim, Huseyin,Ozkan, Umut Mutlu,Sarikaya, Mehmet Zeki Department of Mathematics 2009 Kyungpook mathematical journal Vol.49 No.4
This paper deals with some new generalizations of the Hardy-Hilbert type integral inequalities with some parameters. We also consider the equivalent inequalities and the reverse forms.
Pseudoparallel invariant submanifolds of $(LCS)_n$-manifolds
MEHMET ATCEKEN,UMIT YILDIRIM,Suleyman Dirik 강원경기수학회 2020 한국수학논문집 Vol.28 No.2
The aim of this paper is to study the invariant submanifolds of $(LCS)_n$-manifolds. We study pseudo parallel, generalized Ricci-pseudo parallel and 2-pseudo parallel invariant submanifolds of a $(LCS)_n$-manifold and get the necessary and sufficient conditions for an invariant submanifold to be totally geodesic and give some new results contribute to differential geometry.
Mehmet Mutlu Catli,Umut Ozsoy,Yasemin Kaya,Arzu Hizay,Fatos Belgin Yildirim,Levent Sarikcioglu 대한해부학회 2012 Anatomy & Cell Biology Vol.45 No.2
A four-headed biceps brachii muscle and three-headed coracobrachialis muscle, high-originated radial artery and communication between the median and musculocutaneous nerves have been well documented in the available literature. However co-existence of these variations is rare. In this study we aimed to describe multiple variations in the upper limb and discuss their co-existence from clinical and embryological points of view.