http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Matthew Sloan,Hui Li,Hernan A. Lescay,Clark Judge,Li Lan,Parviz Hajiyev,Maryellen L. Giger,Mohan S. Gundeti 대한비뇨의학회 2023 Investigative and Clinical Urology Vol.64 No.6
Purpose: Hydronephrosis is a common pediatric urological condition, characterized by dilation of the renal collecting system. Accurate identification of the severity of hydronephrosis is crucial in clinical management, as high-grade hydronephrosis can cause significant damage to the kidney. In this pilot study, we demonstrate the feasibility of machine learning in differentiating between high and low-grade hydronephrosis in pediatric patients. Materials and Methods: We retrospectively reviewed 592 images from 90 unique patients ages 0–8 years diagnosed with hydronephrosis at the University of Chicago’s Pediatric Urology Clinic. The study included 74 high-grade hydronephrosis (145 images) and 227 low-grade hydronephrosis (447 images). Patients were excluded if they had less than 2 studies prior to surgical intervention or had structural abnormalities. We developed a radiomic-based artificial intelligence algorithm incorporating computerized texture analysis and machine learning (support-vector machine) to yield a predictor of hydronephrosis grade. Results: Receiver operating characteristic analysis of the classifier output yielded an area under the curve value of 0.86 (95% CI 0.81–0.92) in the task of distinguishing between low and high-grade hydronephrosis using a five-fold cross-validation by kidney. In addition, a Mann–Kendall trend test between computer output and clinical hydronephrosis grade yielded a statistically significant upward trend (p<0.001). Conclusions: Our findings demonstrate the potential of machine learning in the differentiation between low and high-grade hydronephrosis. Further studies are warranted to validate our findings and their generalizability for use in clinical practice as a means to predict clinical outcomes and the resolution of hydronephrosis.
SIRT2 directs the replication stress response through CDK9 deacetylation
Zhang, Hui,Park, Seong-Hoon,Pantazides, Brooke G.,Karpiuk, Oleksandra,Warren, Matthew D.,Hardy, Claire W.,Duong, Duc M.,Park, So-Jeong,Kim, Hyun-Seok,Vassilopoulos, Athanassios,Seyfried, Nicholas T.,J National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.33
<P>Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that SIRT2 directs replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for recovery from replication arrest. SIRT2 deficiency results in replication stress sensitivity, impairment in recovery from replication arrest, spontaneous accumulation of replication protein A to foci and chromatin, and a G2/M checkpoint deficit. SIRT2 interacts with and deacetylates CDK9 at lysine 48 in response to replication stress in a manner that is partially dependent on ataxia telangiectasia and Rad3 related (ATR) but not cyclin T or K, thereby stimulating CDK9 kinase activity and promoting recovery from replication arrest. Moreover, wild-type, but not acetylated CDK9, alleviates the replication stress response impairment of SIRT2 deficiency. Collectively, our results define a function for SIRT2 in regulating checkpoint pathways that respond to replication stress through deacetylation of CDK9, providing insight into how SIRT2 maintains genome integrity and a unique mechanism by which SIRT2 may function, at least in part, as a tumor suppressor protein.</P>
Novel size and surface oxide effects in silicon nanowires as lithium battery anodes.
McDowell, Matthew T,Lee, Seok Woo,Ryu, Ill,Wu, Hui,Nix, William D,Choi, Jang Wook,Cui, Yi American Chemical Society 2011 NANO LETTERS Vol.11 No.9
<P>With its high specific capacity, silicon is a promising anode material for high-energy lithium-ion batteries, but volume expansion and fracture during lithium reaction have prevented implementation. Si nanostructures have shown resistance to fracture during cycling, but the critical effects of nanostructure size and native surface oxide on volume expansion and cycling performance are not understood. Here, we use an ex situ transmission electron microscopy technique to observe the same Si nanowires before and after lithiation and have discovered the impacts of size and surface oxide on volume expansion. For nanowires with native SiO(2), the surface oxide can suppress the volume expansion during lithiation for nanowires with diameters <???50 nm. Finite element modeling shows that the oxide layer can induce compressive hydrostatic stress that could act to limit the extent of lithiation. The understanding developed herein of how volume expansion and extent of lithiation can depend on nanomaterial structure is important for the improvement of Si-based anodes.</P>
Strength in Numbers and Voice: An Assessment of the Networking Capacity of Chinese ENGOs
Shapiro, Matthew A.,Brunner, Elizabeth,Li, Hui World Association for Triple Helix and Future Stra 2018 Journal of Contemporary Eastern Asia Vol.17 No.2
Under authoritarian regimes, citizen-led NGOs such as environmental NGOs (ENGOs) often operate under close scrutiny of the government. While this presents a challenge to a single ENGO, we propose here - in line with existing research on network effects - that there are opportunities for multiple ENGOs to coordinate and thus work in ways that supersede government controls, affect public opinion, and contribute to policy revision and/or creation. In this paper, we specifically examine the possibility that the gamut of citizen-based ENGOs in China are coordinating. Based on network analysis of ENGOs web pages as well as interviews with more than a dozen ENGO leaders between 2014 and 2016, we find that ENGOs have few direct and public connections to each other, but social media sites and personal connections offline provide a crucial function in creating bridges. A closer examination of these bridges reveals, however, that they can be substantive to the environmental discussion or functional to the dissemination of web page information but typically not both. In short, ENGOs in China are not directly connected but rather are connected in a way that responds to the available social media and the government's censorship practices.
Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia
Varga, Matthew G.,Cai, Hui,Waterboer, Tim,Murphy, Gwen,Shimazu, Taichi,Taylor, Phil R.,Qiao, You-Lin,Park, Sue K.,Yoo, Keun-Young,Jee, Sun Ha,Cho, Eo Rin,Kim, Jeongseon,Abnet, Christian C.,Tsugane, Sh Springer-Verlag 2018 Digestive diseases and sciences Vol.63 No.10
( Zi Qiang Glen Liau ),( Matthew Song Peng Ng ),( Shawn Shao En Low ),( Brian Zhaojie Chin ),( James Hoi Po Hui ),( Fareed Husain Yusuf Kagda ) 대한슬관절학회 2024 대한슬관절학회지 Vol.36 No.-
Background Predicting hamstring graft size preoperatively for anterior cruciate ligament (ACL) reconstruction is important for preempting an insufficient diameter in graft size intraoperatively, possibly leading to graft failure. While there are multiple published methods using magnetic resonance imaging (MRI) picture archiving and communication systems (PACS), most are not feasible and practical. Our study aims to (1) practically predict the ACL hamstring graft size in a numerically continuous manner using the preoperative MRI from any native MRI PACS system, (2) determine the degree of correlation between the predicted and actual graft size, and (3) determine the performance of our prediction method if we define an adequate actual graft size as ≥ 8 mm. Methods A retrospective review of 112 patients who underwent primary ACL reconstruction with quadrupled hamstring semitendinosus-gracilis grafts at a tertiary institution was conducted between January 2018 and December 2018. Graft diameter can be predicted in a numerically continuous manner as √[2*(AB + CD)], where A and B are the semitendinosus cross-sectional length and breath, respectively, and C and D are the gracilis cross-sectional length and breath, respectively. Results A moderately positive correlation exists between the predicted and actual graft diameter (r = 0.661 and p < .001). Our method yields a high specificity of 92.6% and a moderate sensitivity of 67.2% if we define an adequate actual graft size as ≥ 8 mm. An area under receiver-operating characteristic curve shows good discrimination (AUC = 0.856). Conclusions We present a practical method to predict the ACL hamstring graft size with high specificity using preoperative MRI measurements.
Haider Al-Hamadani,Taylan An,Matthew King,Hui Long 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.11
Wind turbine (WT) drivetrain design configurations affect dynamic loads experienced by the drivetrain components under different operational conditions. This paper presents system modelling of dynamic loads experienced by key mechanical components within WT gearbox under different operational conditions by using MATLAB/Simulink. Two operational conditions of WTs are considered; normal operation and shutdown, using torque spectrums measured from a field operating wind turbine. The torsional dynamic loads under these conditions differ significantly; during normal operation, the maximum torque ratio is below the recommend value however it exceeds the recommended level during shutdown. It has been found that the shutdown event has a considerable effect on gear loading; it causes occurrences of loading reversal of gear meshing forces. Moreover, the variation range of meshing forces between planetary and sun gears is five to six times higher than that during normal operation. During shutdown, the most dominated vibration frequency of the WT drivetrains is the lowest one which is very close to the estimated natural frequency of the low speed shaft and that may cause the resonance of the drivetrain system.
Haifeng Hang,Yuanxin Guo,Jian Liu,Li Bai,Jianye Xia,Meijin Guo,Matthew Hui 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.3
We previously developed an inverted frustoconical shaking bioreactor (IFSB) which had high mammalian cell culture performance when compared with a mechanically stirred tank reactor (STR) or a flat-bottom shaking bioreactor (FBSB). Here, we determined the mixing time (t) and volumetric oxygen transfer coefficient (kLa) of this IFSB at various speeds, and simulated the fluid hydrodynamics, including the shear stress and specific surface area, by computational fluid dynamics. The shortest mixing time was observed in a STR. The maximum kLa value of 12/h was achieved in the IFSB at an aeration rate of 4 L/h, demonstrating that our IFSB has enhanced oxygen transfer capabilities needed to meet the demands of mammalian cells. Simulation studies revealed a 3% greater specific surface area and a 21% lower shear strain in the IFSB compared to an FBSB under the same conditions. Additionally, the conical angle of the vessel, which significantly affected cell growth and recombinant protein production,was tested here. We conclude that, compared to the STR and FBSB, the IFSB has an increased liquid surface area for oxygen uptake and exhaust CO_2 stripping,an enhanced k_La for cell robust growth to a high cell density, and a lower shear stress to alleviate cell damage.