Hygrothermoelasticity in a porous cylinder under nonlinear coupling between heat and moisture

Masayuki Ishihara,Taku Yoshida,Yoshihiro Ootao,Yoshitaka Kameo 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.75 No.1

The purpose of this study is to develop practical tools for the mechanical design of cylindrical porous media subjected to a broad gap in a hygrothermal environment. The planar axisymmetrical and transient hygrothermoelastic field in a porous hollow cylinder that is exposed to a broad gap of temperature and dissolved moisture content and is free from mechanical constraint on all surfaces is investigated considering the nonlinear coupling between heat and binary moisture and the diffusive properties of both phases of moisture. The system of hygrothermal governing equations is derived for the cylindrical case and solved to illustrate the distributions of hygrothermal-field quantities and the effect of diffusive properties on the distributions. The distribution of the resulting stress is theoretically analyzed based on the fundamental equations for hygrothermoelasticity. The safety hazard because of the analysis disregarding the nonlinear coupling underestimating the stress is illustrated. By comparing the cylinder with an infinitesimal curvature with the straight strip, the significance to consider the existence of curvature, even if it is infinitesimally small, is demonstrated qualitatively and quantitatively. Moreover, by investigating the bending moment, the necessities to consider an actual finite curvature and to perform the transient analysis are illustrated.

Asymmetric transient thermal stress of a functionally graded hollow cylinder with piecewise power law

Ootao, Yoshihiro,Ishihara, Masayuki Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.47 No.3

This paper is concerned with the theoretical treatment of transient thermoelastic problems involving a functionally graded hollow cylinder with piecewise power law due to asymmetrical heating from its surfaces. The thermal and thermoelastic constants of each layer are expressed as power functions of the radial coordinate, and their values continue on the interfaces. The exact solution for the two-dimensional temperature change in a transient state, and thermoelastic response of a hollow cylinder under the state of plane strain is obtained herein. Some numerical results for the temperature change and the stress distributions are shown in figures. Furthermore, the influence of the functional grading on the thermal stresses is investigated.

Asymmetric transient thermal stress of a functionally graded hollow cylinder with piecewise power law

Yoshihiro Ootao,Masayuki Ishihara 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.47 No.3

This paper is concerned with the theoretical treatment of transient thermoelastic problems involving a functionally graded hollow cylinder with piecewise power law due to asymmetrical heating from its surfaces. The thermal and thermoelastic constants of each layer are expressed as power functions of the radial coordinate, and their values continue on the interfaces. The exact solution for the two-dimensional temperature change in a transient state, and thermoelastic response of a hollow cylinder under the state of plane strain is obtained herein. Some numerical results for the temperature change and the stress distributions are shown in figures. Furthermore, the influence of the functional grading on the thermal stresses is investigated.

Static model simulation for routine mumps vaccination in Japan: with a result of mumps-related complications in a Japanese community hospital

Taito Kitano,Masayuki Onaka,Mariko Ishihara,Atsuko Nishiyama,Naoki Hashimoto,Sayaka Yoshida 대한백신학회 2017 Clinical and Experimental Vaccine Research Vol.6 No.2

Purpose: Mumps vaccine has not been included in the routine national immunization program in Japan, leading to low vaccine coverage rates and periodic epidemics approximately every 5 years. Our hospital (a secondary community hospital in Japan) experienced an increased number of mumps-related complications with a nationwide epidemic in 2016. Using previously reported data and mumps-related cases in our hospital, we estimated the cost-effectiveness of routine mumps vaccination in Japan with a static model using current epidemiologic data. Materials and Methods: With a decision tree flowchart of mumps infection and adverse events, we estimated the burden of mumps-related complications in our hospital for 5 years, and calculated the current annual national burden. Finally, we compared the current burden and assumptive burden of the stable state after routine vaccination in Japan using a static model. Results: The cost-benefit ratios with sensitivity analysis were 3.69 (1.08-9.52) and 6.84 (1.51-23.73) in independent inoculation and simultaneous inoculation, respectively, from a social perspective in addition to an annual gain of 9,487 (3,227-14,659) quality adjusted life years. Conclusion: We contributed additional evidence in terms of cost-effectiveness that routine mumps vaccination should be introduced in Japan with simultaneous inoculation.

Chemokine expression in human 3-dimensional cultured epidermis exposed to PM2.5 collected by cyclonic separation

Kono Maori,Okuda Tomoaki,Ishihara Nami,Hagino Hiroyuki,Tani Yuto,Okochi Hiroshi,Tokoro Chiharu,Takaishi Masayuki,Ikeda Hidefumi,Ishihara Yasuhiro 한국독성학회 2023 Toxicological Research Vol.39 No.1

Fine particulate matter (PM2.5) exposure has a risk of inducing several health problems, especially in the respiratory tract. The skin is the largest organ of the human body and is therefore the primary target of PM2.5. In this study, we examined the effects of PM2.5 on the skin using a human 3-dimensional cultured epidermis model. PM2.5 was collected by cyclonic separation in Yokohama, Japan. Global analysis of 34 proteins released from the epidermis revealed that the chemokines, chemokine C-X-C motif ligand 1 (CXCL1) and interleukin 8 (IL-8), were significantly increased in response to PM2.5 exposure. These chemokines stimulated neutrophil chemotaxis in a C-X-C motif chemokine receptor 2-dependent manner. The oxidative stress and signal transducer and activator of transcription 3 pathways may be involved in the increased expression of CXCL1 and IL-8 in the human epidermis model. Interestingly, in the HaCaT human keratinocyte cell line, PM2.5 did not affect chemokine expression but did induce IL-6 expression, suggesting a different effect of PM2.5 between the epidermis model and HaCaT cells. Overall, PM2.5 could induce the epidermis to release chemokines, followed by neutrophil activation, which might cause an unregulated inflammatory reaction in the skin.

Acute Effect of Whole-Body Periodic Acceleration on Brachial Flow-Mediated Vasodilatation Assessed by a Novel Semi-Automatic Vessel Chasing UNEXEF18G System

Bonpei Takase,Hidemi Hattori,Yoshihiro Tanaka,Akimi Uehata,Masayoshi Nagata,Masayuki Ishihara,Masatoshi Fujita 한국심초음파학회 2013 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.21 No.3

Background: Repeated application of whole-body periodic acceleration (WBPA) upregulates endothelial nitric oxide synthase and improves brachial artery endothelial function (BAEF) as assessed by measurement of flow-mediated vasodilatation (FMD). However, the acute effect of a single application of WBPA on BAEF has not been fully characterized. In addition, although a novel semi-automatic vessel chasing system (UNEXEF18G) has now been developed in Japan, the direct comparison of UNEXEF18G with a conventional method for FMD measures has not been conducted even if UNEXEF18G has already been utilized in a relatively large scale study. Methods: We have developed a novel semi-automatic vessel chasing system (UNEXEF18G) that can measure FMD on-line,identify time to peak vasodilatation (TPV), and determine the area under the vasodilatation curve (AUC). Thus, 45 min of WBPA was applied in 20 healthy volunteers (age, 34 ± 13 years), and BAEF was measured by UNEXEF18G before and after WBPA. Also, UNEXEF18G measured FMD was compared with those of a conventional FMD measurement method at rest in order to validate a novel UNEXEF18G measured FMD. Results: Single WBPA resulted in a significant increase in FMD (from 6.4 ± 3.4 to 10.7 ± 4.3%, p < 0.01), a significant decrease in TPV and a significant increase in AUC. In the validation study for UNEXEF18G, Bland and Altman analysis showed that UNEXEF18G measured FMD was almost identical to those of the conventional method at rest. Conclusion: These data suggest the usefulness of a new UNEXEF18G and that single application of WBPA results in acute improvement in BAEF in humans.