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Hygrothermoelasticity in a porous cylinder under nonlinear coupling between heat and moisture
Masayuki Ishihara,Taku Yoshida,Yoshihiro Ootao,Yoshitaka Kameo 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.75 No.1
The purpose of this study is to develop practical tools for the mechanical design of cylindrical porous media subjected to a broad gap in a hygrothermal environment. The planar axisymmetrical and transient hygrothermoelastic field in a porous hollow cylinder that is exposed to a broad gap of temperature and dissolved moisture content and is free from mechanical constraint on all surfaces is investigated considering the nonlinear coupling between heat and binary moisture and the diffusive properties of both phases of moisture. The system of hygrothermal governing equations is derived for the cylindrical case and solved to illustrate the distributions of hygrothermal-field quantities and the effect of diffusive properties on the distributions. The distribution of the resulting stress is theoretically analyzed based on the fundamental equations for hygrothermoelasticity. The safety hazard because of the analysis disregarding the nonlinear coupling underestimating the stress is illustrated. By comparing the cylinder with an infinitesimal curvature with the straight strip, the significance to consider the existence of curvature, even if it is infinitesimally small, is demonstrated qualitatively and quantitatively. Moreover, by investigating the bending moment, the necessities to consider an actual finite curvature and to perform the transient analysis are illustrated.
Yuta Yoshino,Takaaki Mori,Taku Yoshida,Yasutaka Toyota,Hideaki Shimizu,Jun-ichi Iga,Shusaku Nishitani,Shu-ichi Ueno 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.3
Objective: Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used to assess both visual perception and reasoning ability in DLB subjects treated with donepezil. Methods: Twenty-one DLB patients (mean age, 78.7±4.5 years) were enrolled. RCPM assessment was performed at the time of starting donepezil and within one year after starting donepezil. Results: There were significant improvements of RCPM in the total scores between one year donepezil treatment (p=0.013), in both Set A score (p=0.002) and Set AB score (p=0.015), but trend in the Set B score (p=0.083). Conclusion: Donepezil is useful for improving visuo-spatial impairment in DLB, but not for problem-solving impairment
Kiyohiro Yamazaki,Yuta Yoshino,Yoko Mori,Shinichiro Ochi,Taku Yoshida,Takashi Ishimaru,Shu-ichi Ueno 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.3
Nasu-Hakola disease (NHD) is a rare autosomal recessive neuropsychiatric disorder characterized by bone cysts, fractures, and cognitive impairment. Two genes are responsible for the development of NHD; TYROBP and TREM2. Although it presents with typical signs and symptoms, diagnosing this disease remains difficult. This case report describes a male with NHD with no family or past history of bone fractures who was diagnosed using exome sequencing. His frontal lobe psychiatric symptoms recovered partially following treatment with sodium valproate, but not with an antipsychotic.