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Mir, Manzoor R.,Shabir, Nadeem,Wani, Khursheed A.,Shaffi, Sheikh,Hussain, Ishraq,Banday, Manzoor A.,Chikan, Naveed A.,Bilal, S.,Aejaz, Sheikh Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
The aim of this study was to evaluate the methylation status of three important cancer related genes viz. p16, E-cadherin and hMLH1 promoters and to associate the findings with specific dietary habits in Kashmiris, a culturally distinct population in India, with gastric cancer. The study subjects were divided into three age groups viz. 0-30yrs ($1^{st}$), 31-60yrs ($2^{nd}$) and 61-90yrs ($3^{rd}$). A highly significant association between the intake of local hot salted tea in $2^{nd}$ (p=0.001) and $3^{rd}$ (p=0.009) age groups was observed with the promoter hypermethylation of E cadherin. Again a highly significant association between the aberrant methylation of hMLH1 (p=0.000) and p16 (p=0.000) promoters and the intake of local hot salted tea was observed in the $2^{nd}$ age group of gastric cancer patients. The intake of sun-dried food was also significantly associated with the promoter hypermethylation of E cadherin (p=0.003) and p16 (p=0.015) genes in $3^{rd}$ age group. The results of the present study suggest a close association between the aberrant methylation of p16, E-cadherin and hMLH1 promoters and the intake of local hot salted tea and sun-dried foods in Kashmiri population.
NLRP6 as a Negative Regulator of Innate Immunity
Manzoor, Zahid,Koh, Young-Sang The Korean Society for Microbiology 2013 Journal of Bacteriology and Virology Vol.43 No.1
Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) play important role in immune responses by regulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-${\kappa}B$), type I interferon and inflammasomes. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) is vital for protection of mice from colitis and colorectal tumorigenesis. However, the role of NLRP6 in microbial infection remains unclear. NLRP6 was recently reported as negative regulator of inflammatory signaling and demonstrated that how it hinders clearance of bacterial pathogens.
Bacterial 23S Ribosomal RNA, a Ligand for Toll-like Receptor 13
Manzoor, Zahid,Koh, Young-Sang The Korean Society for Microbiology 2012 Journal of Bacteriology and Virology Vol.42 No.4
Toll-like receptors are required for detection of pathogen-associated molecular patterns and play critical roles in protection of host from infection. Murine TLR13 was recently reported to be involved in recognition of bacterial 23S ribosomal RNA sequence that is the binding site of different antibiotics.
협업 사이버물리시스템의 결함 치명도 분석을 통한 안전성 확보
( Manzoor Hussain ),( Nazakat Ali ),홍장의 ( Jang-eui Hong ) 한국정보처리학회 2021 정보처리학회논문지. 소프트웨어 및 데이터 공학 Vol.10 No.8
Collaborative Cyber-Physical Systems (CCPS) are those systems that contain tightly coupled physical and cyber components, massively interconnected subsystems, and collaborate to achieve a common goal. The safety of a single Cyber-Physical System (CPS) can be achieved by following the safety standards such as ISO 26262 and IEC 61508 or by applying hazard analysis techniques. However, due to the complex, highly interconnected, heterogeneous, and collaborative nature of CCPS, a fault in one CPS's components can trigger many other faults in other collaborating CPSs. Therefore, a safety assurance technique based on fault criticality analysis would require to ensure safety in CCPS. This paper presents a Fault Criticality Matrix (FCM) implemented in our tool called CPSTracer, which contains several data such as identified fault, fault criticality, safety guard, etc. The proposed FCM is based on composite hazard analysis and content-based relationships among the hazard analysis artifacts, and ensures that the safety guard controls the identified faults at design time; thus, we can effectively manage and control the fault at the design phase to ensure the safe development of CPSs. To justify our approach, we introduce a case study on the Platooning system (a collaborative CPS). We perform the criticality analysis of the Platooning system using FCM in our developed tool. After the detailed fault criticality analysis, we investigate the results to check the appropriateness and effectiveness with two research questions. Also, by performing simulation for the Platooning, we showed that the rate of collision of the Platooning system without using FCM was quite high as compared to the rate of collisions of the system after analyzing the fault criticality using FCM.
Mitogen-activated Protein Kinases in Inflammation
Manzoor, Zahid,Koh, Young-Sang The Korean Society for Microbiology 2012 Journal of Bacteriology and Virology Vol.42 No.3
Mitogen-activated protein kinases (MAPKs) play critical regulatory roles in the production of the pro-inflammatory cytokines and downstream signaling events which lead to inflammation. Inflammation is a primarily localized and protective response of host against microbial infection. Controlled inflammation is beneficial and necessary for host defense while uncontrolled inflammatory response results in inflammatory diseases such as septic shock, rheumatoid arthritis and cancer. The MAPK family consists of three subfamilies; the extracellular signal-regulated kinases (ERKs), the c-Jun N-terminal kinases (JNKs), and the p38 MAPKs. MAPKs are involved in transmitting extracellular signals to nucleus which leads to gene regulation. In this review, we summarize the current knowledge of ERK1/2, JNKs, and p38 MAPK members and their roles in inflammation.
Manzoor Ahmad Wani,Showkat Ali Zargar,Ghulam Nabi Yatoo,Inaamul Haq,Altaf Shah,Jaswinder Singh Sodhi,Ghulam Mohammad Gulzar,Mushtaq Khan 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.4
Background/Aims: This study aimed to study the endoscopic yield, appropriateness, and complications of pediatric endoscopyperformed by adult gastroenterologists in an adult endoscopic suite. Methods: This a retrospective study in which records of all the patients less than 18 years of age who underwent endoscopy in the last5 years were studied. The indications of endoscopy in children were categorized as appropriate or inappropriate per the latest guidelinesby American Society for Gastrointestinal Endoscopy and North American Society for Pediatric Gastroenterology, Hepatology andNutrition. Positive endoscopic yield was defined as the presence of any abnormality on endoscopy. Results: Among the total of 822 children (age <18 years), the most common indications were variceal surveillance/eradication in 157(19.1%), followed by dyspepsia in 143 (17.4%), upper gastrointestinal (UGI) bleeding in 136 (16.5%), recurrent abdominal pain in 94(11.4%), unexplained anemia in 74 (9%), recurrent vomiting in 50 (6.08%), chronic refractory gastroesophageal reflux disease in 34 (4.1%)and others; 780 out of 822 endoscopic procedures (94.9%) done in children were appropriate as per the guidelines. The endoscopicyield was 45.8%, highest in patients with UGI bleeding (71.3%), followed by variceal surveillance (54.8%), recurrent vomiting (38%),dyspepsia (37.8%), and recurrent abdominal pain (36%). Minor adverse events occurred in 7.3% of children. Conclusions: Pediatric endoscopy performed by an experienced adult gastroenterologist may be acceptable if done in cooperation witha pediatrician.
Hyperostotic Esthesioneuroblastoma: Rare Variant and Fibrous Dysplasia Mimicker
Manzoor Ahmed,Phillip Daniel Knott 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.1
A 65-year-old male presented with a 3-year history of orbital symptoms. An imaging-based diagnosis of fibrous dysplasia involving the skull base was made at another institution. CT showed a diffuse sinonasal mass and ground-glass appearance of the bones of the anterior skull base with bony defects and mucocele formation. MRI demonstrated an accompanying intracranial and orbital rind of soft tissue mass along the hyperostotic bones. FDG-PET showed corresponding intense hypermetabolism. Small cysts were observed at the tumor-brain interface. Biopsy revealed esthesioneuroblastoma with boneinfiltration that is compatible with the hyperostotic variant of esthesioneuroblastoma. There are a few cases of hyperostotic esthesioneuroblastoma reported in the literature.
Manzoor, U.,Kim, D.K. North-Holland 2009 Physica E, Low-dimensional systems & nanostructure Vol.41 No.3
ZnO nanostructures were synthesized by the vapor transport method. ZnO nanocombs, nanowires and nanorods were formed in a single experiment, in high-, intermediate- and low-temperature zones, respectively. A systematic increase in diameters is observed for all the nanostructures when Ar flow is gradually increased. The diameters of these nanostructures were controlled from few 10's of nanometers to few micrometers. Photoluminescence (PL) properties of as-synthesized nanostructures and effect of heat treatment on optical properties and morphology were investigated.
Manzoor, Zahid,Ali, Irshad,Chae, Doobyeong,Koh, Young-Sang The Korean Society for Microbiology 2016 Journal of Bacteriology and Virology Vol.46 No.4
Marine algae exhibit broad spectrum anti-bacterial and anti-inflammatory activities. Acrosorium polyneurum (A. polyneurum) is a marine red alga and belongs to the family Delesseriaceae. The present research evaluates the anti-inflammatory effects of A. polyneurum extract (APE) on pro-inflammatory cytokine production. APE demonstrated substantial inhibitory effects on production of pro-inflammatory cytokine in bone marrow-derived macrophages (BMDMs). APE pre-treatment in the lipopolysaccharide (LPS)-stimulated BMDMs exhibited a robust inhibitory effect on production of interleukin (IL)-12, IL-6 and tumor necrosis factor $(TNF)-{\alpha}$. It revealed a robust inhibitory effect on phosphorylation of ERK1/2, JNK1/2 and p38. APE also showed remarkable inhibitory effect on phosphorylation and degradation of $I{\kappa}B{\alpha}$. Furthermore, APE pre-treatment demonstrated substantial inhibition of LPS-induced production of nitric oxide and inducible nitric oxide synthase. Collectively, these data suggest that APE has a noteworthy anti-inflammatory property and deserve further studies concerning its potential use as a medicinal agent for inflammation-related disorders.