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Dielectric and Optical Study of Polymer Nematic Liquid Crystal Composite
Manohar, S.,Shukla, S.N.,Chandel, V.S.,Shukla, J.P.,Manohar, R. The Korean Institute of Electrical and Electronic 2013 Transactions on Electrical and Electronic Material Vol.14 No.3
The dielectric anisotropy and dispersion of the real and imaginary part of the permittivity of commercially important nematic mixture E-24 and its polymer composite were investigated in the frequency range from 1 kHz to 10 MHz, and temperature range $14^{\circ}C$ to $55^{\circ}C$. The percentage optical transmittance and density have also been measured for both the systems. The results have been explained by assuming molecular rotation about the long molecular axis, under a hindering nematic potential. The dielectric anisotropy ${\Delta}{\varepsilon}$ is positive, and the mean dielectric permittivity falls with rising temperature. ${\Delta}{\varepsilon}$ is also used to determine the order parameter with varying temperature.
Dielectric and Optical Study of Polymer Nematic Liquid Crystal Composite
S. MANOHAR,V. S. CHANDEL,S. N. SHUKLA,J. P. SHUKLA,R. MANOHAR 한국전기전자재료학회 2013 Transactions on Electrical and Electronic Material Vol.14 No.3
The dielectric anisotropy and dispersion of the real and imaginary part of the permittivity of commercially important nematic mixture E-24 and its polymer composite were investigated in the frequency range from 1 kHz to 10 MHz, and temperature range 14℃ to 55℃. The percentage optical transmittance and density have also been measured for both the systems. The results have been explained by assuming molecular rotation about the long molecular axis, under a hindering nematic potential. The dielectric anisotropy Δε is positive, and the mean dielectric permittivity falls with rising temperature. Δε is also used to determine the order parameter with varying temperature.
Manohar, Kuruva,Mittal, Bhagwant Rai,Bhattacharya, Anish,Gupta, Amod The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.1
Metastases to orbit occur rarely but are the most common form of malignant orbital tumors. Usually the orbital metastases occur in disseminated disease. Very rarely orbital metastases can be the presenting feature of systemic malignancy. We report here a case with orbital metastases as the presenting feature of lung malignancy and describe the utility of FDG PET/CT as one-stop-shop imaging modality in this setting.
Amyloglucosidase Catalyzed Syntheses of Bakuchiol Glycosides in Supercritical Carbon Dioxide
Manohar, Balaraman,Divakar, Soundar,Sankar, Kadimi Udaya Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.8
Enzymatic syntheses of water soluble Bakuchiol glycosides were carried out in di-isopropyl ether organic media using amyloglucosidase from Rhizopus mold. The reactions were carried out under conventional reflux conditions and in supercritical $CO_2$ atmospheric conditions. Out of the eleven carbohydrate molecules employed for the reaction, D-glucose, D-ribose and D-arabinose gave glycosides in yields of 9.0% to 51.4% under conventional reflux conditions. Under supercritical $CO_2$ atmosphere (100 bar pressure at 50 ${^{\circ}C}$), bakuchiol formed glycosides with Dglucose, D-galactose, D-mannose, D-fructose, D-ribose, D-arabinose, D-sorbitol and D-mannitol in yields ranging from 9% to 46.6%. Out of the bakuchiol glycosides prepared, 6-O-(6-D-fructofruranosyl)bakuchiol showed the best antioxidant (1.4 mM) and ACE inhibitory activities (0.64 mM).
Vijaya Manohar,Bobby Echard,Nicholas Perricone,Cass Ingram,Mary Enig,Debasis Bagchi,Harry G. Preuss 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.6
Since monolaurin, a monoglyceride formed in the human body in small quantities, has proven effective both in vitro and in vivo against certain strains of Staphylococcus aureus, an important question arises whether consuming a substance high in lauric acid content, such as coconut oil could increase intrinsic monolaurin production to levels that would be successful in overcoming staphylococcal and other microbial invaders. Both a cup plate method and a microdilution broth culture system were employed to test bacteriostatic and bactericidal effects of the test agents in vitro. To test effectiveness in vivo, female C3H/he mice (10–12 per group) were orally administered sterile saline (regular control), vancomycin (positive control), aqueous monolaurin, or two varieties of coconut oil (refined, bleached, deodorized coconut oil and virgin coconut oil) for 1 week before bacterial challenge and 30 days after. A final group received both monolaurin and vancomycin. In contrast to monolaurin, the coconut oils did not show bactericidal activity in vitro. In vivo, the groups receiving vancomycin, monolaurin, or the combination showed some protection—50–70% survival, whereas the protection from the coconut oils were virtually the same as control—0–16% survival. Although we did not find that the two coconut oils are helpful to overcome S. aureus infections, we corroborated earlier studies showing the ability of monolaurin to do such.
Immunotherapeutic Approach for Better Management of Cancer - Role of IL-18
Kuppala, Manohar Babu,Syed, Sunayana Begum,Bandaru, Srinivas,Varre, Sreedevi,Akka, Jyothy,Mundulru, Hema Prasad Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
Interleukin-18 (IL-18) is an immune-stimulatory cytokine with antitumor activity in preclinical models. It plays pivotal roles in linking inflammatory immune responses and tumor progression and is a useful candidate in gene therapy of lymphoma or lymphoid leukemia. A phase I study of recombinant human IL-18 (rhIL-18) in patients with advanced cancer concluded that rhIL-18 can be safely given in biologically active doses to patients with advanced cancer. Some viruses can induce the secretion of IL-18 for immune evasion. The individual cytokine activity might be potentiated or inhibited by combinations of cytokines. Here we focus on combinational effects of cytokines with IL-18 in cancer progression. IL-18 is an important non-invasive marker suspected of contributing to metastasis. Serum IL-18 may a useful biological marker as independent prognostic factor of survival. In this review we cover roles of IL-18 in immune evasion, metastasis and angiogenesis, applications for chemotherapy and prognostic or diagnostic significance.
Rashmi Manohar Mahalle,Barry R. Pittendrigh,Keon Mook Seong 한국응용곤충학회 2024 한국응용곤충학회 학술대회논문집 Vol.2024 No.04
Spodoptera frugiperda, commonly known as the fall armyworm (FAW), is a major pest across the globe due to its broad host range and distribution worldwide. We investigated the function of microRNAs (miRNAs) in the detoxification of insecticides, with a specific focus on its susceptibility to chlorantraniliprole which is widely utilized insecticide for its management. miRNAs are small non-coding RNA molecules, crucial for post-transcriptional regulation of gene expression. This study aims to elucidate the impact of these miRNAs on the expression of cytochrome P450 genes, which play a significant role in conferring insecticide resistance. We identified notable changes in the abundance of two specific miRNAs, sfr-miR-10465-5p and sfr-miR- 10476-5p through RNA sequencing, after chlorantraniliprole exposure. These miRNAs exhibited significantly high expression in the fat body tissue, while showing relatively lower expression in the head, midgut, and malpighian tubules. Further analysis suggested that these miRNAs might target specific cytochrome P450 genes, like CYP4C1 and CYP4C21, which are known to play a role in insecticide resistance development. Experimentation with miRNA mimics through microinjection revealed a notable increase in the survival rates of S. frugiperda larvae when subjected to chlorantraniliprole exposure, with a significant reduction in CYP4C1 and CYP4C21 gene expression levels. This suggests a direct connection between the miRNAs and the increased tolerance of Spodoptera larvae to the insecticide. Our research presents the complex function of miRNAs in gene expression regulation related to insecticide resistance, offering valuable insights into the molecular mechanisms of chlorantraniliprole resistance in S. frugiperda. These findings pave the way for further investigations into miRNA roles and their potential in managing pesticide resistance in agricultural pests.