Pretreatment Thrombocytosis as a Prognostic Factor in Women with Gynecologic Malignancies: a Meta-analysis

Yu, Min,Liu, Lei,Zhang, Bing-Lan,Chen, Qi,Ma, Xue-Lei,Wu, Yu-Ke,Liang, Chun-Shui,Niu, Zhi-Min,Qin, Xin,Niu, Ting Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Background: This study was performed to analyze the prognostic implications of pretreatment or preoperative thrombocytosis in women with gynecologic malignancies. Material and Methods: We surveyed 2 medical databases, PubMed and EMBASE, to identified all relevant studies. A total of 14 (n=3,490) that evaluated the link between thrombocytosis and 5-year survival were included. REVMAN version 5.1 was used for our analysis and publication bias was evaluated using the Begg's funnel plot and tested by STATA 11.0. Risk ratios (RRs) with 95% confidence intervals (CIs) generated by the random effect model were used to assess the strength of any association. Results: 709(20.3%) of the 3,490 patients exhibited thrombocytosis (platelet counts > $400{\times}10^9/L$) at primary diagnosis, and their mortality was 1.62-fold higher compared with the others (RR=1.62, 95%CI=[1.28-2.05], p<0.0001). Thrombocytosis failed to have a stronger effect on the survival of advanced patients of stages III to IV in our study (n=478, RR=1.29, 95% CI=[1.13-1.48], p=0.0003), nor in women with cervical cancer in stage IB (n=1371, RR=1.73, 95% CI=[1.71-2.58], p=0.007). In addition, when adjusted for different carcinoma, it was associated with worse prognosis for all except the ones with vulvar cancer (n=201, RR=0.43, 95% CI=[0.14-1.29], p=0.13). Conclusions: This meta-analysis indicated that thrombocytosis might be associated with a worse prognosis for patients with gynecologic malignancies but without specificity or sensitivity for the ones in advanced stage. When adjusted for different gynecologic malignancies, it showed a significant effect on survival of all except vulvar cancers.

Structural Stability and Electronic and Optical Properties of Coinage-Metal (4; 2) Alloy Nanotubes: A First-Principles Study

Xi-Zhi Wang,Liang-Cai Ma,Ling Ma,Xue-Ling Lin,Jian-Min Zhang 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.74 No.6

Using rst-principles calculations, we have systematically investigated the structural stability and the electronic and optical properties of bimetallic AgAu, CuAu, and CuAg (4; 2) alloy nanotubes (NTs). We found that the tip-suspended AgAu and CuAu alloy NTs were stable structures due to the existence of local minima in both the binding energies and the string tensions variation with their unit-cell lengths and that the stability was enhanced when the content of Au was increased. However, a tip-suspended CuAg alloy NT would be difficult to form in future experiments. We also found that both the relativistic effect of elemental gold and the string tension applied by the tip contacts play important roles in suppressing effectively the self-purication effect, leading to the formation of these coinage alloy NTs. The quantum conductance of the stable alloy NTs is increased by 1G0 as compared with that of the corresponding pure coinage-metal NTs.

Protective Effects of Scutellaria barbata Against Rat Liver Tumorigenesis

Dai, Zhi-Jun,Wu, Wen-Ying,Kang, Hua-Feng,Ma, Xiao-Bin,Zhang, Shu-Qun,Min, Wei-Li,Lu, Wang-Feng,Lin, Shuai,Wang, Xi-Jing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Scutellaria barbata D. Don (S. barbata), a traditional Chinese medicine, is used to treat cancers, inflammation, and urinary diseases. This study aimed to determine any protective effects of S. barbata crude extract (CE-SB) against rat liver tumorigenesis induced by diethylnitrosamine (DENA). Liver malfunction indices in serum were measured by biochemical examination. Hematoxylin and eosin staining was performed to examine liver pathology. Contents of malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in liver homogenates to evaluate oxidative stress. The levels of liver malfunction indices in the CE-SB groups, especially in the CE-SB high dose group, were lower than that of the model group (P<0.05). The results from histological examination indicated that the number of liver nodules in the CE-SB groups decreased compared with the model group (P<0.05). Content of MDA determined in liver was significantly decreased, and level of SOD elevated by CE-SB. CE-SB can inhibit experimental liver tumorigenesis and relieve hepatic injury in rats.

DISPERSION OF CARBON NANOFIBERS IN AQUEOUS SOLUTION

BAO-MIN WANG,YUAN ZHANG,ZHI-QIANG GUO,YU HAN,HAI-NAN MA 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.6

Carbon nano¯bers (CNFs) were puri¯ed by the method of heat treating, and stable homogeneous suspensions of heat-treated CNFs were prepared by using methylcellulose (MC) as a surfactant. The heat-treated CNFs were characterized by di®erential thermal analysis (DTA) and thermogravimetry analysis (TGA), and the sonication-driven dispersion of CNFs in aqueous solution was investigated by measuring ultraviolet absorbency (UV absorbency), zeta potential, adsorption isotherm of MC on CNFs and surface tension of CNF suspensions. In these CNF suspensions, the zeta potentials of CNFs progressively increase with increasing MC concentration, and change from ?15.4?0 mV. The surface tension of CNF suspensions decrease from 38.87mN/m to 36.54mN/m. The adsorption isotherm of MC on CNFs shows an adsorption platform (namely \L" style), and the adsorption isotherm reaches the saturation plateau at MC concentration of about 0.4 g/L. All results show that the optimum concentration ratio of MC to CNFs is 2:1 for dispersion.

A novel catalyst of Ni–Mn complex oxides supported on cordierite for catalytic oxidation of toluene at low temperature

Qiong Huang,Zhi-Yuan Zhang,Wen-Jiao Ma,Ying-Wen Chen,She-Min Zhu,Shu-Bao Shen 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.2

The catalytic combustion of toluene over Ni–Mn mixed complex supported on industrial cordierite was investigated. The catalysts were prepared by the wet impregnation method and characterized by using the Brunauer Emmett Teller (BET), Scanning Electron Microscopy (SEM), X-ray diffraction (XRD),Transmission Electron Microscope (TEM) and X-ray fluorescence (XRF). The catalytic activity toward the complete oxidation of toluene to CO2 and H2O strongly depended on the molar ratio of Ni/Mn, loading amount of Ni–Mn oxides, and calcination temperature. All the results above indicated that the Ni–Mn complex oxide catalyst calcined at 400 8C with 0.5 mol ratio of Ni/Mn, 10 wt.% loading amounts, and showed the highest activity as complete oxidation of toluene.

Efficacy of Pap Test in Combination with ThinPrep Cytological Test in Screening for Cervical Cancer

Chen, Hua,Shu, Hui-Min,Chang, Zhou-Lin,Wang, Zhi-Feng,Yao, Hai-Hong,Zhu, Hong-Mei,Lu, Tian-Mei,Ma, Qiang-Yan,Yang, Bin-Lie Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Background: Our aim was to investigate the efficacy of the Pap test in combination with the ThinPrep cytological test (TCT) in screening for cervical cancer in China. Design: From March 2006 to October 2008, 988 women with the mean age $46.4{\pm}10.5$ years (range, 23-80 years) were recruited to receive cervical cancer screening. Pap test results ${\geq}$ grade III and TCT findings ${\geq}$ ASCUS/AGUS were considered abnormal. Subjects with a Pap test result ${\geq}$ grade IIb received TCT. Colposcopy and biopsies were performed in all participants, and final diagnosis was based on pathological findings. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and Youden index for predicting CIN I or above were determined. Results: The sensitivity, specificity, PPV, NPV and Youden index of the Pap test were 43.1%, 97.2%, 70.0%, 91.9%, and 40.3%, respectively. The same values for TCT in predicting CIN were 80.0%, 63.2%, 16.0%, 97.3%, and 43.2%, respectively. The two tests in combination gave values for predicting CIN of 64.8%, 87.6%, 43.6%, 94.4%, and 53.5%, respectively. Combined testing exhibited the highest Youden index (53.4%). Conclusion: The Pap test with a reduced threshold in combination with the TCT has high sensitivity and high specificity in screening for cervical cancer.

Genetic Variants of NBS1 Predict Clinical Outcome of Platinum-based Chemotherapy in Advanced Non-small Cell Lung Cancer in Chinese

Xu, Jia-Li,Hu, Ling-Min,Huang, Ming-De,Zhao, Wan,Yin, Yong-Mei,Hu, Zhi-Bin,Ma, Hong-Xia,Shen, Hong-Bing,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

Objective: NBS1 plays a key role in the repair of DNA double-strand break (DSB). We conducted this study to investigate the effect of two critical polymorphisms (rs1805794 and rs13312840) in NBS1 on treatment response and prognosis of advanced non-small cell lung cancer (NSCLC) patients with platinum-based chemotherapy. Methods: Using TaqMan methods, we genotyped the two polymorphisms in 147 NSCLC patients. Odds ratios (ORs) and their 95% confidential intervals (CIs) were calculated as a measure of difference in the response rate of platinum-based chemotherapy using logistic regression analysis. The Kaplan-Meier and log-rank tests were used to assess the differences in progression-free survival (PFS) and overall survival (OS). Cox proportional hazards model was applied to assess the hazard ratios (HRs) for PFS and OS. Results: Neither of the two polymorphisms was significantly associated with treatment response of platinum-based chemotherapy. However, patients carrying the rs1805794 CC variant genotype had a significantly improved PFS compared to those with GG genotype (16.0 vs. 8.0 months, P = 0.040). Multivariable cox regression analysis further showed that rs1805974 was a significantly favorable prognostic factor for PFS [CC/CG vs. GG: Adjusted HR = 0.62, 95% CI: 0.39-0.99; CC vs. CG/GG: Adjusted HR = 0.56, 95% CI: 0.32-0.97). Similarly, rs13312840 with a small sample size also showed a significant association with PFS (CC vs. CT/TT: Adjusted HR = 25.62, 95% CI: 1.53-428.39). Conclusions: Our findings suggest that NBS1 polymorphisms may be genetic biomarkers for NSCLC prognosis especially PFS with platinum-based chemotherapy in the Chinese population.

Extramedullary Plasmacytoma Involving the Bilateral Adrenal Glands on MR Imaging

Yuan Li,Ying-kun Guo,Zhi-gang Yang,En-sen Ma,Peng-qiu Min 대한영상의학회 2007 Korean Journal of Radiology Vol.8 No.3

We report here on a 64-year-old woman with extramedullary plasmacytoma involving the bilateral adrenal glands. Primary adrenal extramedullary plasmacytoma is extremely rare and only three cases of extramedullary plasmacytoma in the unilateral adrenal gland have currently been reported on. This case is of interest in that the bilateral adrenals were involved. In this article, we present the MRI findings and we briefly review the relevant literature.

Clinical Profles and Short-Term Outcomes of Acute Disseminated Encephalomyelitis in Adult Chinese Patients

Hong-Qi Yang,Wen-Cong Zhao,Wei-Min Yang,Yong-Li Li,Zhi-Kun Sun,Shuai Chen,Wei Li,Jian-Jun Ma 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.3

Background and PurposezzAcute disseminated encephalomyelitis (ADEM) is an infammatory demyelinating disorder that predominantly afects children. Previous studies have mostly involved children in Western developed countries. MethodszzTis study retrospectively reviewed the clinical profles of ADEM in adult Chinese patients. ResultszzADEM occurred during summer and autumn in about two-thirds of the 42 included patients. Prior infection was found in fve patients and no preimmunization was recorded. Te most frequent clinical presentations were alterations in consciousness (79%) and behavior changes (69%), followed by motor defcits (64%) and fever (50%). About one-quarter (26%) of the patients showed positive results for oligoclonal bands, and about half of them exhibited increases in the IgG index and 24-hour IgG synthesis rate. Magnetic resonance imaging showed white- and gray-matter lesions in 83% and 23% of the patients, respectively. Steroids were the main treatment, and full recovery occurred in 62% of the patients, with residual focal neurological defcits recorded in a few patients. Afer a mean follow-up period of 3.4 years, two patients exhibited recurrence and one patient exhibited a multiphasic course. One patient was diagnosed with multiple sclerosis (MS). ConclusionszzWith the exception of the seasonal distribution pattern and prior vaccine rate, the clinical profles of ADEM in adult Chinese patients are similar to those in pediatric populations. No specifc markers are available for distinguishing ADEM from MS at the initial presentation. Careful clinical evaluations, cerebrospinal fuid measurements, and neuroradiological examinations with long-term follow-up will aid the correct diagnosis of ADEM.

Multi Objective Optimization of Outer Rotor Wheel-Hub Permanent Magnet Synchronous Motor Based on Exact Analytical Method

Jing Yi-Yang,He Biao,Yang Xiang-Yu,Ma Zhi-Min 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.1

Based on the exact analytical method, this paper calculates the no-load back electromotive force, air gap fux density, cogging torque, and electromagnetic torque of outer rotor wheel-hub permanent magnet synchronous motor (PMSM); the calculation results are in good agreement with those of the fnite element method, which verifes the accuracy of the exact analytical method for solving the outer rotor PMSM. On this basis, the second-generation non-dominated sorting genetic algorithm (NSGA-II) is applied to optimize the multiple structural parameters and performance of the motor more quickly. Compared with the initial scheme of the motor, the torque ripple and permanent magnet mass of the optimized scheme is decreased by a quarter; the average electromagnetic torque, efciency is also improved. Finally, the simulation and experimental results show that the proposed method is reasonable and efective.