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Polygoum Tinctoria와 합성 인디고 염료의 물리화학적 특성 비교
최창용,장미경,공병기,최혜영,나상권,이동병,양숙향,나재운 한국공업화학회 2002 응용화학 Vol.6 No.2
The natural dye substances appear to have a lot of benefits that enable the dyed materials to exhibit their natural colors. It may have a bit of a harmful influence on the human body itself, in comparison with the synthetic substances. It also causes hardly any environmental pollution because of the natural chemicals and costs much less to disposal. In this study was investigated physicochemical characterization of polygoum tinctoria dye substance and synthetic indigo. Calcium hydroxide was added into polygoum tinctoria leaves to precipitate dye substances and it was freezing dried into powder form. Characterizations of dye substances were investigated by UV/VIS spectrophotometer, TLC, DSC, TGA, HPLC, and MALDI-TOF Mass. Resultantly, polygoum tinctoria was confirmed that is consisted of two ingredients from these results.
Jang, Mi-Kyeong,Ryu, Su-Hyun,Kim, Dong-Gon,Kim, Tae-Hyoung,Nah, Jae-Woon 한국공업화학회 2004 응용화학 Vol.8 No.2
Water soluble chitosan (WSC) removed salts in amine group of glucosamine unit has a strong positive charge and high reactivity. Therefore, WSC can be a superior gene carrier and easily modifying with functional group. In this study, we prepared various WSC derivatives with MPEG and cholesterol and performed the electrophoresis, transfection efficiency and cytotoxicity. First, WSC was formed compex with DNA above 1:8 weight ratio, but WSC derivatives was formed higher weight ratio than itself, above 1:16. It was considered that the positice charge of WSC derivatives were declined due to substitute with MPEG or cholesterol in amine group of glucosamine unit. In the transfection test, WSC 10K was showed higher transfection efficiency than WSC 18K, but its derivatives was a contrast to this result. In cytotoxicity test, all WSC and its derivatives complexes showed negligible cytotoxicity for 293T cells. Therefore, WSCs having free amine group will be useful in the development of safe gene carriers.
Jang, Mi-Kyeong,Nah, Jae-Woon Korean Chemical Society 2003 Bulletin of the Korean Chemical Society Vol.24 No.9
The low molecular water-soluble chitosan nanoparticles (LMWSC-NPs) were prepared, which was modified with hydrophilic and hydrophobic moieties to evaluate the potential for pharmaceutics application. The synthesis of LMWSC-NPs was identified by FT-IR and $^1H$-NMR spectra. Also, we measured the photon correlation spectroscopy (PCS), transmission electron microscope (TEM) and atomic force microscope (AFM) to investigate the characteristics and morphology of the LMWSC-NPs. At the PCS measurement, the more increase the number of substitutive group, the more decrease the positive charge of LMWSC-NP surface. From the results of TEM and AFM, spherical morphologies were observed, and their sizes were 30-150 nm. Resultantly, LMWSC-NPs prepared in this experiment will be expected as a suitable device for the drug targeting system.
Drug and Gene Delivery System Based on Study of Polymeric Carrier for Disease Therapy
Mi-Kyeong Jang 한국당과학회 2017 한국당과학회 학술대회 Vol.2017 No.01
In the present study, a targeted gene carrier for αvβ3 integrin-overexpressed tumor cells was designed with widely applied materials containing water soluble chitosan(WSC), RGD peptide, and polyethyleneimine(PEI). A study of the endocytic mechanism resulted in the microtubule-dependent macropinocytosis and clathrin-mediated endocytosis. In addition, the PEI/WSC copolymer with dendrimer RGD peptide (four-branched RGD moiety) as a targeting moiety suppressed the growth of a solid tumor mass in an in vivo mouse xenograft model with PC3 cells, prostate tumor cells, by silencing BCL-2 mRNA. This result provides a good candidate with a simple and biocompatible gene carrier. On the other hand, the development of drug delivery system (DDS) for antibiotic therapy may be essential to reduce cytotoxicity and side effects of drug, and to overcome drug-resistant fungal strains. Until now, many researches have been reported to improve the therapeutic index of AmB in PEG-based, lipid-based, and polymer-based AmB formulations. However, their high cost and side effects is mainly limiting factor in public use. The aim of this study was to prove another function of the antifungal peptide as a novel ligand which targets fungal pathogens specifically in infected animal model and to investigate a synergistic action between antifungal peptide and agent. In addition, we proposed a minimum dose of antifungal agent in clinical application via pH-responsive and redox-sensitive drug carrier.