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- 저자 : Lu Zhou (검색결과 391 건)
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Cao, Chunyan,Xie, Along,Zhou, Tianliang,Zhong, Haichang,Lu, Xiangjun,Xie, An,Noh, Hyeon Mi,Jeong, Jung Hyun Elsevier 2020 Journal of luminescence Vol.217 No.-
<P><B>Abstract</B></P> <P>Some lutetium molybdenum oxides were synthesized through a solid-state reaction method. By adjusting the molar ratios of raw materials of Lu<SUB>2</SUB>O<SUB>3</SUB> (Eu<SUB>2</SUB>O<SUB>3</SUB>) to MoO<SUB>3</SUB>, Eu<SUP>3+</SUP> doped lutetium molybdenum oxides Lu<SUB>2</SUB>MoO<SUB>6</SUB>, Lu<SUB>2</SUB>Mo<SUB>2</SUB>O<SUB>9</SUB>, Lu<SUB>2</SUB>(MoO<SUB>4</SUB>)<SUB>3</SUB>, and Lu<SUB>6</SUB>MoO<SUB>12</SUB> were obtained. The materials were characterized by X-ray diffraction (XRD) patterns, scanning electron microscope (SEM) images, energy-dispersive spectra (EDS), diffuse reflection (DR) spectra, photoluminescence (PL) excitation and emission spectra, luminescence decay curves, and temperature dependent integrated emission spectra. Enhanced excitation and emission spectra were recorded at high temperatures. Possible energy transfer processes were proposed to explain the excitation and emission spectra. By combining some phosphors with near ultraviolet (NUV) chips, the obtained light emitting diodes (LEDs) gave red light under forward bias current. The results suggest that the obtained Eu<SUP>3+</SUP> doped lutetium molybdenum oxides have potential applications in phosphor converted based NUV LEDs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Eu<SUP>3+</SUP> doped Lu<SUB>2</SUB>MoO<SUB>6</SUB>, Lu<SUB>2</SUB>Mo<SUB>2</SUB>O<SUB>9</SUB>, Lu<SUB>2</SUB>(MoO<SUB>4</SUB>)<SUB>3</SUB>, and Lu<SUB>6</SUB>MoO<SUB>12</SUB> were obtained. </LI> <LI> The materials present different structures, morphologies, optical properties, and luminescece decay behaviors. </LI> <LI> Eu<SUP>3+</SUP> concentration dependent optical properties in Lu<SUB>2</SUB>MoO<SUB>6</SUB> were researched. </LI> <LI> Enhanced excitation and emission spectra were recorded under high temperatures in some materials. </LI> <LI> Red LEDs were obtained by packaging phosphors to NUV LED chips. </LI> </UL> </P>
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Robotics in Cervical Spine Surgery: Feasibility and Safety of Posterior Screw Placement
Lu-Ping Zhou,Zhi-Gang Zhang,Dui Li,Shu Fang,Rui Sheng,Ren-Jie Zhang,Cai-Liang Shen 대한척추신경외과학회 2023 Neurospine Vol.20 No.1
Objective: Robot-assisted (RA) techniques have been widely investigated in thoracolumbar spine surgery. However, the application of RA methods on cervical spine surgery is rare due to the complex morphology of cervical vertebrae and catastrophic complications. Thus, the feasibility and safety of RA cervical screw placement remain controversial. This study aims to evaluate the feasibility and safety of RA screw placement on cervical spine surgery. Methods: A comprehensive search on PubMed, Cochrane Library, Embase Database, Web of Science, Chinese National Knowledge Databases, and Wanfang Database was performed to select potential eligible studies. Randomized controlled trials (RCTs), comparative cohort studies, and case series reporting the accuracy of cervical screw placement were included. The Cochrane risk of bias criteria and Newcastle-Ottawa Scale criteria were utilized to rate the risk of bias of the included literatures. The primary outcome was the rate of cervical screw placement accuracy with robotic guidance; subgroup analyses based on the screw type and insertion segments were also performed. Results: One RCT, 3 comparative cohort studies, and 3 case series consisting of 160 patients and 719 cervical screws were included in this meta-analysis. The combined outcomes indicated that the rates of optimal and clinically acceptable cervical screw placement accuracy under robotic guidance were 88.0% (95% confidence interval [CI], 84.1%–91.4%; p = 0.073; I 2 = 47.941%) and 98.4% (95% CI, 96.8%–99.5%; p = 0.167; I2 = 35.954%). The subgroup analyses showed that the rate of optimal pedicle screw placement accuracy was 88.2% (95% CI, 83.1%–92.6%; p = 0.057; I2 = 53.305%); the rates of optimal screw placement accuracy on C1, C2, and subaxial segments were 96.2% (95% CI, 80.5%–100.0%; p = 0.167; I2 = 44.134X%), 89.7% (95% CI, 80.6%–96.6%; p = 0.370; I2 = 0.000X%), and 82.6% (95% CI, 70.9%–91.9%; p = 0.057; I2 = 65.127X%;), respectively. Conclusion: RA techniques were associated with high rates of optimal and clinically acceptable screw positions. RA cervical screw placement is accurate, safe, and feasible in cervical spine surgery with promising clinical potential.
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Zhou, Wen-xiu,Hou, Wen-bo,Zhou, Chao,Yin, Yu-xia,Lu, Shou-tao,Liu, Guang,Fang, Yi,Li, Jian-wen,Wang, Yan,Liu, Ai-hua,Zhang, Hai-jun The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.2
Objective : Shunt infection is a common complication while treating hydrocephalus. The antibiotic-impregnated shunt catheter (AISC) was designed to reduce shunt infection rate. A meta-analysis was conducted to study the effectiveness of AISCs in reduction of shunt infection in terms of age, follow-up time and high-risk patient population. Methods : This study reviewed literature from three databases including PubMed, EMBASE, and Cochrane Library (from 2000 to March 2019). Clinical studies from controlled trials for shunt operation were included in this analysis. A subgroup analysis was performed based on the patient's age, follow-up time and high-risk population. The fixed effect in RevMan 5.3 software (Cochrane Collaboration) was used for this meta-analysis. Results : This study included 19 controlled clinical trials including 10105 operations. The analysis demonstrated that AISC could reduce the infection rate in shunt surgery compared to standard shunt catheter (non-AISC) from 8.13% to 4.09% (odds ratio [OR], 0.48; 95% confidence interval [CI], 0.40-0.58; p=0.01; I2=46%). Subgroup analysis of different age groups showed that AISC had significant antimicrobial effects in all three groups (adult, infant, and adolescent). Follow-up time analysis showed that AISC was effective in preventing early shunt infections (within 6 months after implant). AISC is more effective in high-risk population (OR, 0.24;95% CI, 0.14-0.40; p=0.60; I2=0%) than in general patient population. Conclusion : The results of meta-analysis indicated that AISC is an effective method for reducing shunt infection. We recommend that AISC should be considered for use in infants and high-risk groups. For adult patients, the choice for AISC could be determined based on the treatment cost.
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Lu-Lu Zhang,Yi-Yang Li,Jiang Hu,Guan-Qun Zhou,Lei Chen,Wen-Fei Li,Ai-Hua Lin,Jun Ma,Zhen-Yu Qi,Ying Sun 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4
Purpose Local relapse-free survival (LRFS) differs widely among patients with T4 category nasopharyngeal carcinoma (NPC). We aimed to build a nomogram incorporating clinicopathological information to predict LRFS in T4 NPC after definitive intensity-modulated radiation therapy (IMRT). Materials and Methods Retrospective study of 415 Chinese patients with non-metastatic T4 NPC treated with definitive IMRT with or without chemotherapy at our cancer center between October 2009 and September 2013. The nomogram for LRFS at 3 and 5 years was generated based on multivariate Cox proportional hazards regression, and validated using bootstrap resampling, assessing discriminative performance using the concordance index (C-index) and determining calibration ability via calibration curves. Results Five-year LRFS was 88.8%. We identified and incorporated four independent prognostic factors for LRFS: ethmoid sinus invasion, primary gross tumor volume, age, and pretreatment body mass index. The C-index of the nomogram for local recurrence was 0.732 (95% confidence interval, 0.726 to 0.738), indicating excellent predictive accuracy. The calibration curve revealed excellent agreement between nomogram-predicted and observed LRFS probabilities. Risk subgroups based on total point score cutoff values enabled effective discrimination of LRFS. Conclusion This pretreatment nomogram enables clinicians to accurately predict LRFS in T4 NPC after definitive IMRT, and could help to facilitate personalized patient counselling and treatment strategies.
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Lu, Zhi-Hao,Yang, Li,Yu, Jing-Wei,Lu, Ming,Li, Jian,Zhou, Jun,Wang, Xi-Cheng,Gong, Ji-Fang,Gao, Jing,Zhang, Xiao-Tian,Li, Jie,Li, Yan,Shen, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Background: Weight loss during chemotherapy has not been exclusively investigated. Macrophage inhibitory cytokine-1 (MIC-1) might play a role in its etiology. Here, we investigated the prognostic value of weight loss before chemotherapy and its relationship with MIC-1 concentration and its occurrence during chemotherapy in patients with advanced esophageal squamous cell carcinoma (ESCC). Materials and Methods: We analyzed 157 inoperable locally advanced or metastatic ESCC patients receiving first-line chemotherapy. Serum MIC-1 concentrations were assessed before chemotherapy. Patients were assigned into two groups according to their weight loss before or during chemotherapy:>5% weight loss group and ${\leq}5%$ weight loss group. Results: Patients with weight loss>5% before chemotherapy had shorter progression-free survival period (5.8 months vs. 8.7 months; p=0.027) and overall survival (10.8 months vs. 20.0 months; p=0.010). Patients with weight loss >5% during chemotherapy tended to have shorter progression-free survival (6.0 months vs. 8.1 months; p=0.062) and overall survival (8.6 months vs. 18.0 months; p=0.022), and if weight loss was reversed during chemotherapy, survival rates improved. Furthermore, serum MIC-1 concentration was closely related to weight loss before chemotherapy (p=0.001) Conclusions: Weight loss both before and during chemotherapy predicted poor outcome in advanced ESCC patients, and MIC-1 might be involved in the development of weight loss in such patients.
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Establishing a Nomogram for Stage IA-IIB Cervical Cancer Patients after Complete Resection
Zhou, Hang,Li, Xiong,Zhang, Yuan,Jia, Yao,Hu, Ting,Yang, Ru,Huang, Ke-Cheng,Chen, Zhi-Lan,Wang, Shao-Shuai,Tang, Fang-Xu,Zhou, Jin,Chen, Yi-Le,Wu, Li,Han, Xiao-Bing,Lin, Zhong-Qiu,Lu, Xiao-Mei,Xing, H Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: This study aimed to establish a nomogram by combining clinicopathologic factors with overall survival of stage IA-IIB cervical cancer patients after complete resection with pelvic lymphadenectomy. Materials and Methods: This nomogram was based on a retrospective study on 1,563 stage IA-IIB cervical cancer patients who underwent complete resection and lymphadenectomy from 2002 to 2008. The nomogram was constructed based on multivariate analysis using Cox proportional hazard regression. The accuracy and discriminative ability of the nomogram were measured by concordance index (C-index) and calibration curve. Results: Multivariate analysis identified lymph node metastasis (LNM), lymph-vascular space invasion (LVSI), stromal invasion, parametrial invasion, tumor diameter and histology as independent prognostic factors associated with cervical cancer survival. These factors were selected for construction of the nomogram. The C-index of the nomogram was 0.71 (95% CI, 0.65 to 0.77), and calibration of the nomogram showed good agreement between the 5-year predicted survival and the actual observation. Conclusions: We developed a nomogram predicting 5-year overall survival of surgically treated stage IA-IIB cervical cancer patients. More comprehensive information that is provided by this nomogram could provide further insight into personalized therapy selection.
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ZHOU, LU,PARK, JIN,JANG, KYU YUN,PARK, HO SUNG,WAGLE, SAJEEV,YANG, KYU HYUN,LEE, KWANG-BOK,PARK, BYUNG-HYUN,KIM, JUNG RYUL Spandidos Publications 2013 Oncology reports Vol.30 No.3
<P>The pseudoreceptor BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor), formerly known as NMA, is an inhibitor of the TGF-β signaling pathway. BAMBI exhibits structural homology to TGF-βRI but lacks an intracellular kinase domain. In most of the high-grade carcinomas, the degree of BAMBI expression is abnormally increased, which leads to the proliferation and metastasis of tumor cells. Recent studies have reported that BAMBI is involved in the Wnt-β-catenin pathway that regulates the proliferation and metastasis of tumor cells. However, little is known about the role of BAMBI and β-catenin in human osteosarcoma. Given the above background, we examined the role of BAMBI in the pathophysiology of osteosarcoma. Using immunohistochemical staining and western blot analysis, the degree of the expression of BAMBI and β-catenin was significantly higher in osteosarcoma specimens compared with normal tissues. With the overexpression of BAMBI, mediated by adenovirus, the degree of invasion and migration was significantly increased and the proliferation of U2-OS osteosarcoma cells was stimulated. Transwell analysis showed that BAMBI increased the invasion of osteosarcoma cells and upregulated the secretion of matrix metalloproteinases (MMPs), which was demonstrated by gelatin zymography. Fluorescence-activated cell sorting (FACS) analysis showed a significant arrest in cell cycle progression at G0/G1 in osteosarcoma cells transfected with siRNA targeting BAMBI. With the overexpression of BAMBI, mediated by the adenovirus, however, there was a decrease in the number of cells at G0/G1. Consistent with the findings that cell growth was increased, BAMBI promoted the transition from G0/G1 to G2/M in the osteosarcoma cells. Our results suggest that BAMBI plays a key role in the pathogenesis and progression of osteosarcoma by regulating the expression of β-catenin and other signaling molecules via the pathways involved in the regulation of the cell cycle. This relationship between BAMBI and its involvement in the regulation of the cell cycle would provide a possibility that the BAMBI may be a new target for gene therapy.</P>
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Overexpression of the prolyl isomerase PIN1 promotes cell growth in osteosarcoma cells
ZHOU, LU,PARK, BYUNG-HYUN,PARK, JONG HYUK,JANG, KYU YUN,PARK, HO SUNG,WAGLE, SAJEEV,LEE, KWANG-BOK,KIM, JUNG RYUL Spandidos Publications 2013 Oncology reports Vol.29 No.1
<P>PIN1 was recently identified as a peptidyl-prolyl cis-trans isomerase (PPIase). It binds to and isomerizes specific pSer/Thr-Pro motifs and catalytically induces conformational changes after phosphorylation. PIN1 plays an important role in several cellular events, such as cell cycle progression, transcriptional regulation, RNA processing, cell proliferation and differentiation. The relationship between PIN1 and osteosarcoma has not been previously studied. In the present study, we investigated the expression pattern of PIN1 in human osteosarcoma tissues and the role of PIN1 in osteosarcoma generation and development. The expression levels of PIN1 were detected by immunohistochemistry and western blotting. Results demonstrated that the expression of PIN1, cyclin?D1 and β-catenin were significantly higher in human osteosarcoma tissues compared to normal tissues. The in?vitro effects of PIN1 overexpression were studied in human osteosarcoma cell lines. Adenovirus-mediated PIN1 overexpression significantly stimulated the proliferation of MG-63 and U2-OS osteosarcoma cells by 14810.5?and?18721.5%, respectively. In FACS analysis, U2-OS cells displayed significant levels of arrest in cell cycle progression at the G0/G1 phase. Consistent with increased cell growth, levels of cyclin?D1 and cyclin?E and their associated cyclin-dependent kinases, CDK4 and CDK6, were enhanced in PIN1-overexpressed cells compared with the control virus-transfected cells. When the PIN1 inhibitor juglone was added to the cells, the proliferative effects of PIN1 were abolished. These results suggest that PIN1 may play an important role in tumorigenesis and tumor progression of osteosarcoma and therefore, provide a new target for gene therapy.</P>
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