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Jun Lu,Jia Na Li,Bo Lei,San Gen Wang,You Rong Chai 한국유전학회 2009 Genes & Genomics Vol.31 No.2
Encoding a WD40 protein, Arabidopsis thaliana TRANSPARENT TESTA GLABRA1 (AtTTG1) regulates trichome and root hair differentiation as well as flavonoids and seed mucilage deposition in plants. Here, two Brassica napus TTG1 (BnTTG1) genes were isolated, and Southern hybridization also generated only two bands. The 1511-bp BnTTG1-1 and the 1555-bp BnTTG1-2 both have one intron, and show alternative sites for transcription start, polyadenylation and intron right border splicing. EST and GSS tags suggested that BnTTG1-1 was derived from B. rapa, while BnTTG1-2 from B. oleracea. Evidence implies that TTG1 was possibly triplicated in Brassiceae, but some triplicated members were lost soon, which might involve fragmental rearrangements. BnTTG1-1 shares 88.7% genomic and 95.7% mRNA identities with BnTTG1-2. Deduced BnTTG1-1 and BnTTG1-2 proteins both are 337 aa, differed only by substitution of a similar residue. They resemble AtTTG1 in WD40 domain and all conserved motifs. TTG1/AN11-type WD40 proteins are extremely conserved even across kingdoms. Homological and structural characterizations identified BnTTG1-1 and BnTTG1-2 to be orthologs of AtTTG1. Several non-coding motifs are conserved between AtTTG1 and BnTTG1. BnTTG1 coding regions tend to evolve high GC contents through T/A→C/G substitutions especially T→C transition, but AtTTG1 shows opposite base preference. BnTTG1 genes also evolve a GA-stretch in the leader sequence. RT-PCR detected complementation in organ-specificity between BnTTG1-1 and BnTTG1-2. BnTTG1-2 is more like AtTTG1 and is expressed in all major organs. BnTTG1-1 is more organ-specific with lower expression in seed and root, possibly withdrawing from regulating seed coat pigment/mucilage deposition and root hair formation.
Lu, Jian-Jun,Li, Heng-Ai,Xiong, Ying Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11
Background: To explore the hospitalizations of breast cancer patients undergoing mastectomy, and to provide a basis for management, clinical prevention and treatment. Materials and Methods: We conducted an investigation by means of the retrospective survey and the medical records retrieval system, and made out the data of patients suffered from breast cancer in a hospital in Guangzhou from 2004 to 2013, including age, medical payment methods, pathological type, treatment, treatment results, complications, hospitalization days, cost and so on. Results: The average age of the inpatients was 50.14 years old. The main histologic types were infiltrating duct carcinoma (88.06%). The main surgery was modified radical mastectomy (80.41%). The cure rate was 90.80% during the 10 years. The main medical payment method was self-paying (57.28%). The average hospital stay was 13.51 days, and average hospitalization cost was RMB 23,083.66 yuan, proportion of drug fees up to 39.70%. Postoperative complication rate was 0.79%. The self-paying group was with the highest proportion of drug fees (P<0.05), while the free medical service group was with the longest hospitalization days (P<0.05). Conclusions: The payment methods significantly affected the proportion of drug fees and hospitalization days. The therapeutic effect was satisfactory with less complications and reasonable proportion of drug fees in our hospital.
Stabilization of a Coupled ODE-wave System with Disturbances
Lu Lu,Yu-Long Zhang,Jun-Min Wang,Dong-Xia Zhao 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.3
This paper is devoted to stabilizing an ODE-PDE coupled system with boundary disturbance, where the PDE is chosen to be a wave equation with viscous damping. Applying the active disturbance rejection control (ADRC) technic, the unknown disturbance is estimated by the extended state observer (ESO). Assuming the absence of disturbance, the dynamic boundary connection is designed. The methods of spectral analysis and separation of operator are applied, which ensures the Riesz basis property as well as the spectrum determined growth condition. The exponential stability of the coupled system without disturbance is then concluded. Finally, combining the disturbance estimation and the dynamic boundary connection, a feedback controller designed to stabilize the coupled system, and the closed-loop system is proved to be asymptotically stable.
Transient Thermal Response of a Multilayered Geomaterial Subjected to a Heat Source
Lu Jun Wang,Zhi Yong Ai 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.9
The analysis of layered geomaterials thermo-mechanical coupling response is important in design and analysis of a nuclear waste repository. Conventional analytical approaches usually have some intrinsic faults of ill-conditioned matrices for thick layers or accumulative numerical errors for a great quantity of layers for containing positive exponential functions. This paper presents a stable computational approach with no positive exponential functions to study the transient thermal responses of a layered geomaterial subjected to a heat source. Based on the governing equations of thermo-mechanical coupling problems, the analytical layer elements for a finite layer and a half–space are derived by utilizing Laplace and Hankel transforms. The analytical layer elements are then assembled into the total stiffness matrix and solved in the transformed domain. Finally, the Laplace–Hankel transform inversion is employed to obtain an actual solution in the physical domain. Numerical computations indicate that the difference of geomaterial mass properties between layers shows obvious effects on thermal response of the layered system, and these results can be served as a benchmark solution for future analyses of stratified material.
Lu Yang,Xiaoxiang Chen,Zirong Bi,Jun Liao,Weian Zhao,Wenqi Huang 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.5
Apoptosis is proved responsible for renal damage during ischemia/reperfusion. The regulation for renal apoptosis induced by ischemia/reperfusion injury (IRI) has still been unclearly characterized to date. In the present study, we investigated the regulation of histone acetylation on IRI-induced renal apoptosis and the molecular mechanisms in rats with the application of curcumin possessing a variety of biological activities involving inhibition of apoptosis. Sprague–Dawley rats were randomized into four experimental groups (SHAM, IRI, curcumin, SP600125). Results showed that curcumin significantly decreased renal apoptosis and caspase-3/-9 expression and enhanced renal function in IRI rats. Treatment with curcumin in IRI rats also led to the decrease in expression of p300/cyclic AMP response element-binding protein (CBP) and activity of histone acetyltransferases (HATs). Reduced histone H3 lysine 9 (H3K9) acetylation was found near the promoter region of caspase-3/-9 after curcumin treatment. In a similar way, SP600125, an inhibitor of c-Jun N-terminal kinase (JNK), also attenuated renal apoptosis and enhanced renal function in IRI rats. In addition, SP600125 suppressed the binding level of p300/CBP and H3K9 acetylation near the promoter region of caspase-3/-9, and curcumin could inhibit JNK phosphorylation like SP600125. These results indicate that curcumin could attenuate renal IRI via JNK/p300/CBP-mediated anti-apoptosis signaling.
Fabrication and actuation of electro-active polymer actuator based on PSMI-incorporated PVDF
Lu, Jun,Kim, Sang-Gyun,Lee, Sunwoo,Oh, Il-Kwon Institute of Physics Publishing 2008 Smart materials & structures Vol.17 No.4
<P>In this study, an ionic networking membrane (INM) of poly(styrene-<I>alt</I>-maleimide) (PSMI)-incorporated poly(vinylidene fluoride) (PVDF) was applied to fabricate electro-active polymer. Based on the same original membrane of PSMI-incorporated PVDF, various samples of INM actuator were prepared for different reduction times with the electroless-plating technique. The as-prepared INM actuators were tested in terms of surface resistance, platinum morphology, resonance frequency, tip displacement, current and blocked force, and their performances were compared to those of the widely used traditional Nafion actuator. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed that much smaller and more uniform platinum particles were formed on the surfaces of the INM actuators as well as within their polymer matrix. Although excellent harmonic responses were observed for the newly developed INM actuators, they were found to be sensitive to the applied reduction times during the fabrication. The mechanical displacement of the INM actuator fabricated after the optimum reduction times was much larger than that of its Nafion counterpart of comparable thickness under the stimulus of constant and alternating current voltage. The PSMI-incorporated PVDF actuator can become a promising smart material to be used in the fields of biomimetic robots, biomedical devices, sensors and actuator, haptic interfaces, energy harvesting and so on. </P>
Lu, Jun,Lau, Kah Chun,Sun, Yang-Kook,Curtiss, Larry A,Amine, Khalil The Electrochemical Society 2015 Journal of the Electrochemical Society Vol.162 No.14
<P>In this article, we have reviewed our work on understanding and mitigating some of the key factors that limit non-aqueous Li-air battery performance. Advances in Li-air battery technology require fundamental understanding of the discharge and charge processes. We first summarize an investigation of Li-air batteries based on a well-defined cathode surfaces having size-selected silver clusters. This work provided key insight into the nucleation and growth mechanism of the discharge product and its relationship to lowering charge potentials. We then describe the development of new cathode materials including ones based on Pd and Mo<SUB>2</SUB>C nanoparticles that give very low charge potentials. This work has shown that it is possible to achieve very good round-trip efficiencies as well as up to 100 cycles in a Li-air cell. Finally, we discuss investigations of likely sources of electrolyte decomposition at the cathode and anode, which need to be resolved in order to achieve the long cycle life that is necessary to enable Li-air batteries.</P>