Mixture copulas with discrete margins and their application to imbalanced data

Liu Yujian,Xie Dejun,Edwards David A.,Yu Siyi 한국통계학회 2023 Journal of the Korean Statistical Society Vol.52 No.4

This article introduces the approach of using Bayesian sampling to estimate the mixture copula with discrete margins, we further apply our models to solve the class imbalanced problems in data science by oversampling. The methodology makes it possible to learn and sample from the data set with the discrete and continuous features exists simultaneously. On the other hand, the discreetness of factors in a data set are not naturally considered for the classic SMOTE algorithm and classic random oversampling is simply performed by generating the already existing points, which do not give any new information to the classifiers and is easy to overfit. Copula methods enable us to generate new points with the correlation structure memorized by learning from the training set. Hence, the overfitting problems are reduced. Experiments with synthetic and real data are done in the article following the introduction of the methodology. The outcomes shows the validity of the approach when compared with the benchmark methods.

Ganoderic acid A attenuates high‑fat‑diet‑induced liver injury in rats by regulating the lipid oxidation and liver inflammation

Fuli Liu,Kejian Shi,Jiaojiao Dong,Zhousheng Jin,Yiquan Wu,Yaoyao Cai,Tingting Lin,Qianqian Cai,Le Liu,Yujian Zhang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.7

Ganoderic Acid A (GA) has many pharmacologicaleffects such as anti-tumor, antibacterial, anti-inflammatory,and immunosuppressive effects. However, the protectiveeffect of GA on liver injury has not been reported. Thisstudy aimed to investigate the action of GA on insufficientmethionine and choline combined with high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in rats. NAFLD model was established by insufficient methionineand choline combined with high fat feeding to rats. The levelsof Acetyl-CoA carboxylase, fatty acid synthase, sterolregulatory element binding protein, liver X receptors, AMPactivatedprotein kinase, peroxisome proliferator-activatedreceptor α, PPARg coactivator 1α and NF-κB pathway inthe liver were detected by western blot. The results of thisstudy demonstrated that the expression of GA can not onlysignificantly decrease the live weight and liver weight perbody weight of HFD mice, but also restore the alanine aminotransferase,aspartate aminotransferase, total bilirubinlevels, triglyceride and cholesterol in serum. In addition,the expression of GA increased the levels of high-densitylipoprotein cholesterol in serum, ameliorated pathologicalchanges and decreased NAS score of mice’s liver. In conclusion,the treatment with GA could improve NAFLD in ratsby regulating the levels of signaling events involved in freefatty acid production, lipid oxidation and liver inflammation.

Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN

Tonglei Liu,Shuang Liu,Yu Xu,Ruo Shu,Feng Wang,Cheng Chen,Yujian Zeng,Huayou Luo 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4

Purpose This study aimed to probe into the associations among circular RNA ZFR (circ-ZFR), miR- 130a/miR-107, and PTEN, and to investigate the regulatory mechanism of circ-ZFRmiR- 130a/miR-107PTEN axis in gastric cancer (GC). Materials and Methods GSE89143 microarray data used in the study were acquired from publicly available Gene Expression Omnibus database to identify differentially expressed circular RNAs in GC tissues. The expressions of circ-ZFR, miR-130a, miR-107, and PTEN were examined by real-time reverse transcription polymerase chain reaction, while PTEN protein expression was measured by western blot. The variation of GC cell proliferation and apoptosis was confirmed by cell counting kit-8 assay and flow cytometry analysis. The targeted relationships among circ- ZFR, miR-130a/miR-107, and PTEN were predicted via bioinformatics analysis and demonstrated by dual-luciferase reporter assay and RNA immunoprecipitation assay. The impact of ZFR on gastric tumor was further verified in xenograft mice model experiment. Results Circ-ZFR and PTEN were low-expressed whereas miR-107 and miR-130a were highexpressed in GC tissues and cells. There existed targeted relationships and interactions between miR-130a/miR-107 and ZFR/PTEN. Circ-ZFR inhibited GC cell propagation, cell cycle and promoted apoptosis by sponging miR-107/miR-130a, while miR-107/miR-130a promoted GC cell propagation and impeded apoptosis through targeting PTEN. Circ-ZFR inhibited cell proliferation and facilitated apoptosis in GC by sponging miR-130a/miR-107 and modulating PTEN. Circ-ZFR curbed GC tumor growth and affected p53 protein expression in vivo. Conclusion Circ-ZFR restrained GC cell proliferation, induced cell cycle arrest and promoted apoptosis by sponging miR-130a/miR-107 and regulating PTEN.

ONE-POT SYNTHESIS OF INTERESTING 3D γ-MnOOH NETWORKS

HAIQIU LIU,MINDONG CHEN,FEI TENG,YUJIAN JIN,Na Li,Lili Wang,SUNQI LOU,XIA HUA,KAI WANG,Peng Sun 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.7

Three-dimensional (3D) γ-MnOOH networks are successfully prepared by one-pot solvothermalmethod without using any catalyst. The samples are characterized by X-ray diffraction (XRD),scanning electron microscopy (SEM) and high-resolution transmission electron microscopy(HRTEM). It is found that the amounts of urea and H2O2 added, reaction temperature and timehave important infuences on the samples. It is interesting that the 3D networks are formed fromthe oriented attachment (OA) of Mn3O4 octahedrons; and that the phase transformation from Mn3O4 to γ-MnOOH occurs via the protonation of Mn3O4. This study is expected to offer a facileapproach to the syntheses of new, intricate nanostructures.

Exhaust Gas Recirculation Control in a Spark-Ignition LPG Engine Using Neural Networks

Hongwei Cui,Yifang Liu,Yujian Zhai 제어로봇시스템학회 2002 제어로봇시스템학회 국제학술대회 논문집 Vol.2002 No.10

The role of CTNNB1 and LEF1 in feather follicles development of Anser cygnoides and Anser anser

Yue Sun,Yuxuan Zhou,Petunia Msuthwana,Jing Liu,Chang Liu,Cornelius Tlotliso Sello,Yupu Song,Ziqiang Feng,Shengyi Li,Wei Yang,Yunpeng Xu,Xiaomin Yan,Chuanghang Li,Yujian Sui,Jingtao Hu,Yongfeng Sun 한국유전학회 2020 Genes & Genomics Vol.42 No.7

Background Wingless-types/beta-catenin (Wnt/β-catenin) signaling pathway is one of the most extensively studied transcriptional cascades involved in various types of organogenesis including embryonic and postnatal development. Downy feather quantity is primarily affected by follicular development and gene regulations. Objective This research was aimed to investigate the role of catenin beta-1(CTNNB1) and lymphoid enhancerbinding factor-1 (LEF1) on feather follicles development at different developmental stages. Methods Fluorescence quantitative PCR, Western-blot and immunohistochemical methods were used in Anser cygnoides and Anser anser embryos (E12, E13 E18, and E28) and after birth gosling stages (G18, G48, G88) for gene expression analysis. Results CTNNB1 and LEF1 genes were expressed in Anser cygnoides and Anser anser at different embryonic and after-birth gosling developmental stages and the expression levels were significantly different in different stages (p < 0.05). The mRNA expression of CTNNB1 and LEF1 genes reached the highest level at D88 in Anser cygnoides, while the highest expression levels were at D18 and D88 in Anser anser, and the expression levels of CTNNB1 genes at D88 in all embryonic stages were significantly lower than after-birth stages. CTNNB1 and LEF1 protein expression were the highest at E12 and E28 for Anser cygnoides feather follicles development. While at a similar stage for Anser anser, the expression of CTNNB1 and LEF1 protein was the highest at D48 and D18. Protein expression at embryonic stages was in the epidermis (E) and the hair basal plate (P), the expression site for after-birth stages was in the dermal papilla (DP). Conclusion Our study illustrated that CTNNB1 and LEF1 has an impact on Anser cygnoides and Anser anser feather follicles growth and development.