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      • SCIESCOPUSKCI등재

        Effects of Different Fatty Acids and Levels on the Lipogenesis Capacity and Lipolysis Rate of Broilers In Vitro

        Lien, T.F.,Wu, C.P.,Chen, K.L.,Yang, K.H. Asian Australasian Association of Animal Productio 2000 Animal Bioscience Vol.13 No.9

        This study investigated the lipogenesis capacity of hepatocytes and lipolysis rate of adipocytes of broilers as affected by different fatty acids (trial one) and different linoleic acid (C18:2) levels (trial two). Twenty 6-wk old broilers were used; their hepatocytes and adipocytes were isolated for the in vitro study. In trial one, four treatments were tested. The control group in which no fatty acid was added, and the test groups to which were added $300{\mu}M$ of C16:0, C18:1 and C18:2, respectively. For trial two, different levels (0, $300{\mu}M$ and 1 mM) of C18:2 combined to fatty acid-free bovine serum albumin (BSA) were added to the medium. According to results of trial one, added fatty acids significantly reduced the incorporation by hepatocytes of [U,$^{14}C$]glucose into total lipid (p<0.05); the lipogenesis capacity in C18:2 group was the lowest. Although a similar pattern was found with [l,$^{14}C$]acetate, the groups only slightly differed in terms of lipogenesis capacity (p=0.11). In addition, the C18:2 group had a significantly (p<0.05) greater lipolysis rate than the C16:0 and control groups. Results of trial two indicated that C18:2 significantly (p<0.05) reduced lipogenesis capacity both for [U,$^{14}C$]glucose and [l,$^{14}C$]acetate, and markedly stimulated the lipolysis rate (p<0.05), displaying a dose response. Results presented herein demonstrate that C18:2 can reduce lipogenesis capacity and stimulate the lipolysis rate in broilers.

      • SCIESCOPUSKCI등재

        Effects of Supplemental Levels of Bazhen on Growth Performances, Serum Traits, Immunity, Meat Quality and Antioxidant Activity of Taiwan Country Chickens

        Lien, Tu-Fa,Lin, Kou-Joong,Yang, Ling-Ling,Chen, Lih-Geeng Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.5

        One hundred and sixty Taiwan country chickens (d-old chicks) were randomly assigned into four groups with four replicates and equal sex. Basal diets were supplemented with 0, 0.5, 1 and 2% of Bazhen powder, a traditional Chinese herbal medicine complex. The study was conducted for 14 wks. Experimental results indicated that Bazhen supplement did not influence feed intake, body weight gain and feed:gain ratio. Compared with control group, the percentage of serum HDL (high-density lipoprotein) linearly increased (p<0.03) and that of VLDL+LDL (very low-density+low-density lipoprotein) linearly decreased (p<0.03) in Bazhen supplemented groups, that 2% Bazhen was significantly different with control group (p<0.05). Chickens fed diets containing 2% Bazhen displayed reduced (p<0.05) serum GOT (glutamic-oxaloacetic transaminase) levels. The IgG, ${\gamma}$-globulin levels and PHA (phytohemagglutinin) skin challenge results in 1% Bazhan supplemented group were higher (p<0.05) than in the control group, the SRBC (sheep red blood cell) and ND (newcastle disease) titers in Bazhen supplemented groups were linear higher (p<0.05) than in the control group. The liver catalase activity and the capacity of scavenging DPPH (${\alpha}$-${\alpha}$-diphenyl-${\beta}$-picrylhydrazyl) radical were linearly increased (p<0.03) in Bazhen supplemented groups, and the 1 and 2% groups were different from the control group (p<0.05). Liver TBARS (thiobarbituric acid-reactive substances) levels in all Bazhen supplemented groups and total glutathione level in the 2% group were reduced (p<0.05) compared to the control group and displayed a linear response (p<0.05). The TBA (thiobarbituric acid) and pH value of the breast muscle after 24 h post-mortem in the Bazhen supplemented groups was linear lower (p<0.05) than in the control group. Results from this study demonstrated that Bazhen supplement in chicken had several beneficial effects, including increased SRBC and ND titers, HDL and IgG, ${\gamma}$-globulin levels, PHA skin challenge result, decreased VLDL+LDL and GOT levels, and displayed antioxidation effects in serum and carcass meat parameters.

      • SCIESCOPUSKCI등재

        The Lipogenic Capacity of Hepatocytes and Lipolytic Rate of Adipocytes in Tsaiya Ducks during Growing and Laying Periods

        Lien, T.F.,Jan, D.F. Asian Australasian Association of Animal Productio 1999 Animal Bioscience Vol.12 No.8

        With an attempt to elucidating the lipid metabolism of Tsaiya ducks, thirty ducks at growing (8 weeks of age) and laying periods (10 weeks after the onset of laying) were examined, respectively. The ducks were randomly allocated into ad libitum feeding and 3-day fasting groups, to investigate their in vitro hepatocytes lipogenesis capacity and adipocytes lipolysis rate. Results indicate that (1) the capacity of hepatocytes incorporation of glucose and acetate into total lipid and metabolite of $^{14}CO_2$ production during the laying period was greater than during the growing period. Approximately 50% of the glucose or acetate converted into triacylglycerol (TG) by the hepatocytes were recovered as fatty acid during the growing period, while it was 65-70% during the laying period. (2) Acetate used for lipogenesis ability was superior to glucose in both periods. (3) The adipocytes lipolysis rate was increased significantly (p<0.05) by fasting. In contrast, the capacity of incorporated glucose or acetate into total lipid, triacylglycerol, fatty acid and glycerol by hepatocytes was reduced significantly (p<0.05) by fasting.

      • SCOPUS

        The Effect of Trade Openness on Foreign Direct Investment in Vietnam

        LIEN, Nguyen Thi Kim Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.3

        The purpose of this paper is to study the impact of trade openness on foreign direct investment (FDI) inflows into Vietnam, an emerging country with relatively high trade openness in recent years. The study used the vector autoregression (VAR) model to examine the impact of trade openness on FDI in Vietnam, in the period from 2005 to 2019. The research data are time-series data, with quarterly frequency, from 2005:Q4 to 2019:Q3. The FDI data were collected by International Financial Statistics. The data of trade openness were calculated based on Vietnam's export, import, and GDP data collected by the General Statistics Office of Vietnam. The estimated result shows that the trade openness has a positive effect on FDI. The current FDI is heavily influenced by FDI in the past with an average explanation of 74%. The main findings indicate that trade openness has a positive effect on FDI inflows into Vietnam. The findings also show that FDI in Vietnam is significantly affected by the shocks of the FDI itself in the past. The findings of the study suggest the Vietnamese Government improves the quality of trade openness and FDI, continues and maintains economic relations with other countries to increase trade openness.

      • SCIESCOPUSKCI등재

        Enzyme Activities Related to Lipid Metabolism in the Liver and Adipose Tissue of Tsaiya Ducks under Fasting and Ad libitum Feeding Conditions

        Lien, Tu-Fa,Jan, Der-Fang Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.3

        The study investigated the lipid metabolism of Tsaiya ducks under fasting and ad libitum feeding conditions. Sixty Tsaiya ducks in their growing period (8-12 wk-old) and sixty Tsaiya ducks in their laying period (26-30 wk-old, 10-14 weeks after the onset of laying) were randomly divided into ad libitum feeding and 3-day fasting groups. The activities of lipid metabolism related enzymes were determined. Experimental results indicated that fasting depressed the activities of lipogenesis related enzymes such as fatty acid synthetase and NADP-malic dehydrogenase in both periods (p<0.05). Fasting also increased the activities of liver fatty acid $\beta$-oxidation enzymes (p<0.05). However, the activities of lipoprotein lipase in adipose tissue, heart and ovarian follicle in both periods and the hormone-sensitive lipase of adipose tissue in the growing period were decreased by fasting (p<0.01).

      • KCI등재

        Factors Impacting Tourism Demand: An Analysis of 10 ASEAN Countries

        Lien Phuong NGUYEN,Ha Thu NGUYEN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.1

        This study investigates the effect of infrastructure, economic sectors and its status, foreign direct investment and private investment, as well as the role of political stability in enhancing the tourism demand in the ASEAN region. The research collected the secondary data from the World Bank database and the UNWTO website of 10 ASEAN countries over 17 years from 2000 to 2016. Applying the generalized method of moments, this research found that, “private investment”, “economic sectors”, “exchange rate and infrastructure measured by “using of the internet” can increase the tourism demand of a country in the ASEAN region. This research provided evidence indicating that the “foreign direct investment” and “inflation” are two detrimental factors for tourist attraction. The major finding confirmed the positive role of “political stability” in increasing tourist arrivals. First, attracting tourists to a country always poses many challenges to its government. It has been observed in the past decades that though there were many documents, which confirmed that industry can help in promoting tourism, very few studies investigated the role of both agriculture and manufacturing sectors in tourism promotion. Secondly, there are only a few studies which verifies the stability of the political system to the tourism demand in the ASEAN region and that this variable (political stability) has the strongest impact.

      • KCI등재

        Synthesis and Conformation of Novel 4'-Fluorinated 5'-Deoxythreosyl Phosphonic Acid Nucleosides as Antiviral Agents

        Lien Kang,김은애,최은주,유진철,이원재,홍준희 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.12

        Efficient synthetic route to novel 4'-fluorinated 5'-deoxythreosyl phosphonic acid nucleosides was described from glyceraldehyde using Horner-Emmons reaction in the presence of triethyl α-fluorophosphonoacetate. Glycosylation reaction of nucleosidic bases with glycosly donor 14 gave the nucleosides which were further phosphonated and hydrolyzed to reach desired nucleoside analogues. Synthesized nucleoside analogues 18, 21, 25 and 28 were tested for anti-HIV activity as well as cytotoxicity. Adenine derivatives 18 and 21 showed significant anti-HIV activity up to 100 μM.

      • KCI등재

        Linking an Anxiety-Related Personality Trait to Cardiac Autonomic Regulation in Well-Defined Healthy Adults: Harm Avoidance and Resting Heart Rate Variability

        Lien-Cheng Kao,Yu-Wen Liu,Nian-Sheng Tzeng,Terry B. J. Kuo,San-Yuan Huang,Chuan-Chia Chang,Hsin-An Chang 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.4

        ObjectiveaaAnxiety trait, anxiety and depression states have all been reported to increase risks for cardiovascular disease (CVD), possibly through altering cardiac autonomic regulation. Our aim was to investigate whether the relationship between harm avoidance (HA, an anxiety-related personality trait) and cardiac autonomic regulation is independent of anxiety and depression states in healthy adults. MethodsaaWe recruited 535 physically and mentally healthy volunteers. Participants completed the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI) and Tri-dimensional Personality Questionnaire. Participants were divided into high or low HA groups as discriminated by the quartile value. Cardiac autonomic function was evaluated by measuring heart rate variability (HRV). We obtained the time and frequency-domain indices of HRV including variance (total HRV), the low-frequency power (LF; 0.05–0.15 Hz), which may reflect baroreflex function, the high-frequency power (HF; 0.15–0.40 Hz), which reflects cardiac parasympathetic activity, as well as the LF/HF ratio. ResultsaaThe BDI and HA scores showed associations with HRV parameters. After adjustment for the BDI scores and other control variables, HA is still associated with reduced variance, LF and HF power. Compared with the participants with low HA, those with high HA displayed significant reductions in variance, LF and HF power and a significant increase in their LF/HF ratio. ConclusionaaThis study highlights the independent role of HA in contributing to decreased autonomic cardiac regulation in healthy adults and provides a potential underlying mechanism for anxiety trait to confer increased risk for CVD.

      • SCISCIESCOPUS

        Configurable 3GPP Licensed Assisted Access to Unlicensed Spectrum

        Lien, Shao-Yu,Chien, Chun-Che,Tsai, Hua-Lung,Liang, Ying-Chang,Kim, Dong In Institute of Electrical and Electronics Engineers 2016 IEEE wireless communications Vol.23 No.6

        <P>An emerging issue in the development of next generation mobile networks originates in the shortage of available licensed spectrum. This increasing demand for a large amount of bandwidth has recently driven the development of new technologies to utilize unlicensed spectrum. In 2015, 3GPP launched the standardization activity to deploy LTE-A networks on the 5 GHz unlicensed bands using licensed assisted access. To fully understand this crucial technology, in this article, we provide a comprehensive overview on the standardization of licensed assisted access, and raise specific open issues. Configurable radio operations to eliminate the transmission inefficiency and radio access inefficiency in licensed assisted access and a game-theoretic pricing strategy on the licensed and unlicensed bands are further proposed. The provided insights consequently strengthen knowledge of the practice of licensed assisted access.</P>

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