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Chen Liangliang,Zhao Lin,Han Ju,Xiao Ping,Zhao Mingzhe,Zhang Sen,Duan Jinao 한국미생물학회 2024 The journal of microbiology Vol.62 No.2
Glycyrrhizic acid, glycyrrhetinic acid, and their oxo, ester, lactone, and other derivatives, are known for their anti-inflammatory, anti-oxidant, and hypoglycemic pharmacological activities. In this study, chryseno[2,1-c]oxepin-12-carboxylic acid (MG) was first biosynthesized from glycyrrhizic acid through sequential hydrolysis, oxidation, and esterification using Aspergillus terreus TMZ05-2, providing a novel in vitro biosynthetic pathway for glycyrrhizic acid derivatives. Assessing the influence of fermentation conditions and variation of strains during culture under stress-induction strategies enhanced the final molar yield to 88.3% (5 g/L glycyrrhizic acid). CCK8 assays showed no cytotoxicity and good cell proliferation, and anti-inflammatory experiments demonstrated strong inhibition of NO release (36.3%, low-dose MG vs. model), transcriptional downregulation of classical effective cellular factors tumor necrosis factor-α (TNF-α; 72.2%, low-dose MG vs. model), interleukin-6 (IL-6; 58.3%, low-dose MG vs. model) and interleukin-1β (IL-1β; 76.4%, low-dose MG vs. model), and decreased abundance of P-IKK-α, P-IKB-α, and P-P65 proteins, thereby alleviating inflammatory responses through the NF-κB pathway in LPS-induced RAW264.7 cells. The findings provide a reference for the biosynthesis of lactone compounds from medicinal plants.
Investigation of the 2D Aerodynamic Admittances of a Closed-Box Girder in Sinusoidal Flow Field
Haohong Li,Liangliang Zhang,Bo Wu,Yang Yang,Zhao Xiao 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.3
This study investigates the aerodynamic admittances of a closed-box girder in both streamwise (u-) and vertical (w-) sinusoidal flow fields. A series of sinusoidal flows with discrete oscillation frequencies (fu = 0.2 − 1.2 Hz) and different oscillation amplitudes (Δu = 0.5 − 2.0 m/s) are experimentally generated, which are fully coherent in the span-wise direction. Meanwhile, the Computational Fluid Dynamics (CFD) method is utilized to simulate streamwise sinusoidal flows with higher frequencies (fu = 0.2 − 14 Hz). The u-turbulence-related two-dimensional aerodynamic admittance functions (2D AAFs) of the closed-box girder are identified frequency by frequency. On the other hand, the vertical sinusoidal flows are numerically simulated (fw = 0.2 − 14 Hz, Δw = 1.2 m/s), and the w-turbulence-related 2D AAFs are identified. Finally, the differences between u-, w- admittances and the equivalent ones are compared. The results indicate that u- and w-turbulence-related AAFs have different trends with the reduced frequency, and thus it is inaccurate to treat the contributions of u- and w-turbulence to admittances as equivalent in previous studies.
Yu Yue,Shen Liangliang,Xie Xiaoyun,Zhao Jingjun,Jiang Miao 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.1
BACKGROUND: Scleroderma is a multisystem disease in which tissue fibrosis is caused by inflammation and vascular damage. The mortality of scleroderma has remained high due to a lack of effective treatments. However, exosomes derived from human umbilical cord mesenchymal stem cells (HUMSCs)-Ex have been regarded as potential treatments for various autoimmune diseases, and may also act as candidates for treating scleroderma. METHODS: Mice with scleroderma received a single 50 lg HUMSCs-Ex. HUMSCs-Ex was characterized using transmission electron microscopy, nanoparticle tracking analysis and nanoflow cytometry. The therapeutic efficacy was assessed using histopathology, immunohistochemistry, immunofluorescence, quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay and western blot. RESULTS: HUMSCs-Ex ameliorated the deposition of extracellular matrix and suppressed the epithelial-mesenchymal transition process, and the effects lasted at least three weeks. In addition, HUMSCs-Ex promoted M1 macrophage polarization and inhibited M2 macrophage polarization, leading to the restoration of the balance of M1/M2 macrophages. CONCLUSION: We investigated the potential antifibrotic and anti-inflammatory effects of HUMSCs-Ex in a bleomycininduced mouse model of scleroderma. So HUMSCs-Ex could be considered as a candidate therapy for scleroderma.
Research on PSA-MFAC for a novel bionic elbow joint system actuated by pneumatic artificial muscles
Hui Yang,Chaoqun Xiang,Lina Hao,Liangliang Zhao,Bangcan Xue 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.7
A 3-DOF bionic elbow joint actuated by Pneumatic artificial muscle (PAM) was designed in this paper, and its inverse kinematics model was also established. Then, based on the Model-free adaptive control (MFAC) theory and the effects of control parameters to the control system, a Parameter self-adjust Model-free adaptive control (PSA-MFAC) strategy was proposed, and its adaptability for different control objects was also tested in simulation environment. Combined with the inverse kinematics model, motion control experiments of the bionic elbow joint were conducted in semi-physical platform. Compared with conventional MFAC and PID control algorithm, the experiment results strongly verified the improvement of PSA-MFAC control accuracy. The tracking accuracy of conventional MFAC and PID controller were 9.5 % and 15 %, respectively, in contrast, the PSA-MFAC controller was only 3.8 %. Moreover, complex dynamics modelling of the elbow joint and adjusting process of control parameters were neglected in PSA-MFAC control system.