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Chen Liangliang,Zhao Lin,Han Ju,Xiao Ping,Zhao Mingzhe,Zhang Sen,Duan Jinao 한국미생물학회 2024 The journal of microbiology Vol.62 No.2
Glycyrrhizic acid, glycyrrhetinic acid, and their oxo, ester, lactone, and other derivatives, are known for their anti-inflammatory, anti-oxidant, and hypoglycemic pharmacological activities. In this study, chryseno[2,1-c]oxepin-12-carboxylic acid (MG) was first biosynthesized from glycyrrhizic acid through sequential hydrolysis, oxidation, and esterification using Aspergillus terreus TMZ05-2, providing a novel in vitro biosynthetic pathway for glycyrrhizic acid derivatives. Assessing the influence of fermentation conditions and variation of strains during culture under stress-induction strategies enhanced the final molar yield to 88.3% (5 g/L glycyrrhizic acid). CCK8 assays showed no cytotoxicity and good cell proliferation, and anti-inflammatory experiments demonstrated strong inhibition of NO release (36.3%, low-dose MG vs. model), transcriptional downregulation of classical effective cellular factors tumor necrosis factor-α (TNF-α; 72.2%, low-dose MG vs. model), interleukin-6 (IL-6; 58.3%, low-dose MG vs. model) and interleukin-1β (IL-1β; 76.4%, low-dose MG vs. model), and decreased abundance of P-IKK-α, P-IKB-α, and P-P65 proteins, thereby alleviating inflammatory responses through the NF-κB pathway in LPS-induced RAW264.7 cells. The findings provide a reference for the biosynthesis of lactone compounds from medicinal plants.
Is the mobile touch device a good tool to learn Chinese?
Zhe Chen,Yatzu Tsao,Bumsuk Kim,Philipp Osterwald,Da Sun,Xuhui Liu,Yalong Chen,Constantin Siemons,Jean Elie Guillaume,Shuiping Chen,Liangliang Zhang,Karl Jesper Ornerud 대한인간공학회 2014 대한인간공학회 학술대회논문집 Vol.2014 No.5
Learning Chinese language becomes increasingly important and popular worldwide. It is a challenge for native alphabetic language speaker to learn Chinese as Chinese is a symbolic language. Various learning methods are used to help foreign students to improve their learning performance. Interactive applications in the mobile touch devices make it possible to learn Chinese anytime anywhere. It is interesting to discover the role of mobile touch devices in Chinese learning. Thus, this study investigated the usability of mobile touch devices, including mobile phones and tablet personal computer, in Chinese learning for foreign students. This study included two phases. In the first phase, an online survey and an after-interview were used to investigate the users’ attitude to using mobile touch devices in Chinese learning. Thirty international students were invited to the survey (19 males and 11 females) with 10 Germany, 4 French, 3 Italians, 2 Iranian, 2 Russians, 2 English, 2 American, 1 Indonesian, 1 Pakistani, 1 Thai, 1 Swedish and 1 Kazakhstan. In the second phase, an experiment was conducted to evaluate the effect of mobile touch devices in Chinese learning. Fourteen participants were invited to experiment with 8 international students and 6 Chinese students. International students were considered as beginner learner students compared to Chinese students who were considered as advanced learner. Both Android and iOS developing systems for smart devices are considered in the experiment. The results of the survey showed users have a positive attitude towards using mobile touch devices in Chinese learning. The interview results indicated that most participants were willing to pay for it if the usability of learning tool in mobile devices improves. The experiment results indicated the advantage and disadvantage of using mobile phones and tablets in Chinese learning. It was suggested that beginning leaner regarded motivation and organization of Chinese learning tool in the mobile devices. Advanced learner focused on visual design, touch performance, cognitive process. As an exploration of usability of mobile touch device in Chinese learning, this study found that user held a positive attitude to learning Chinese in mobile touch devices. Mobile touch device is a good tool to learn Chinese as it provides interactive learning tools. However, it needs much effort for the mobile application designer to improve the usability. This study had suggestions on how to develop a user-friendly Chinese learning tool in touch mobile devices.
Is the Mobile Touch Device a Good Tool to Learn Chinese?
( Zhe Chen ),( Bumsuk Kim ),( Philipp Osterwald ),( Da Sun ),( Xuhui Liu ),( Yalong Chen ),( Constantin Siemons ),( Jean Elie Guillaume ),( Shuiping Chen ),( Liangliang Zhang ),( Karl Jesper Ornerud ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-
Learning Chinese language becomes increasingly important and popular worldwide. It is a challenge for native alphabetic language speaker to learn Chinese as Chinese is a symbolic language. Various learning methods are used to help foreign students to improve their learning performance. Interactive applications in the mobile touch devices make it possible to learn Chinese anytime anywhere. It is interesting to discover the role of mobile touch devices in Chinese learning. Thus, this study investigated the usability of mobile touch devices, including mobile phones and tablet personal computer, in Chinese learning for foreign students. This study included two phases. In the first phase, an online survey and an after-interview were used to investigate the users`attitude to using mobile touch devices in Chinese learning. Thirty international students were invited to the survey (19 males and 11 females) with 10Germany, 4 French, 3 Italians, 2 Iranian, 2 Russians, 2 English, 2 American, 1 Indonesian, 1 Pakistani, 1 Thai, 1 Swedish and 1 Kazakhstan. In the second phase, an experiment was conducted to evaluate the effect of mobile touch devices in Chinese learning.
Zhang, Liangliang,Xiao, Zuyao,Chen, Xi,Chen, Jingyuan,Wang, Wei American Chemical Society 2019 ACS NANO Vol.13 No.8
<P>There is mounting interest in synthetic microswimmers (“micromotors”) as microrobots as well as a model system for the study of active matters, and spatial navigation is critical for their success. Current navigational technologies mostly rely on magnetic steering or guiding with physical boundaries, yet limitations with these strategies are plenty. Inspired by an earlier work with magnetic domains on a garnet film as predefined tracks, we present an interdigitated microelectrodes (IDE) system where, upon the application of AC electric fields, metallodielectric (e.g., SiO<SUB>2</SUB>-Ti) Janus particles are hydrodynamically confined and electrokinetically propelled in one dimension along the electrode center lines with tunable speeds. In addition, comoving micromotors moved in single files, while those moving in opposite directions primarily reoriented and moved past each other. At high particle densities, turbulence-like aggregates formed as many-body interactions became complicated. Furthermore, a micromotor made U-turns when approaching an electrode closure, while it gradually slowed down at the electrode opening and was collected in large piles. Labyrinth patterns made of serpentine chains of Janus particles emerged by modifying the electrode configuration. Most of these observations can be qualitatively understood by a combination of electroosmotic flows pointing inward to the electrodes, and asymmetric electrical polarization of the Janus particles under an AC electric field. Emerging from these observations is a strategy that not only powers and confines micromotors on prefabricated tracks in a contactless, on-demand manner, but is also capable of concentrating active particles at predefined locations. These features could prove useful for designing tunable tracks that steer synthetic microrobots, as well as to enable the study of single file diffusion, active turbulence, and other collective behaviors of active matters.</P> [FIG OMISSION]</BR>
Analysis of running depth and study of combined tubing of drill-grinding string in horizontal wells
Wenkang Chen,Chuanjun Han,Liangliang Ding 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.12
To solve the difficulty of running drill-grinding string in oilfields, the joining pattern of two-line weight tubing combination is used to increase the running depth of drill-grinding string. There are currently few theoretical bases and systematic researches on the combined tubing. Thus, a calculation model of the combined tubing was established. Meanwhile, an experimental study of running drill-grinding string was conducted. The accuracy of the calculation model was discussed based on the experimental results. The field application of the calculation model was discussed. Finally, the combined characteristics and sensitivity analysis were studied. The results indicate that the critical condition for the optimal combination proportion of twoline weight tubing is a well depth of 1.236 rad deviated angle. The parameters affect running drill-grinding string, including frictional coefficient, running velocity, liquid density, and inner diameter. The work presented provides an effective solution and theoretical evidence for solving this difficulty.
Zhangjing Chen,Liangliang Li,Gang Cheng 한국탄소학회 2023 Carbon Letters Vol.33 No.5
Photocatalytic CO2 reduction is a promising approach for reducing CO2 emissions and achieving the goal of carbon neutrality. In this work, selectively coupling Cu(OH)2 and CuO with amine-modified brookite TiO2 ( NH2–B–TiO2) has been achieved by a simple precipitation method. The results show that CuO is better than Cu(OH)2 as a co-catalyst to enhance the CO2 photoreduction capability of NH2– B–TiO2. The highest rates of CO2 conversion to CH4 and CO of NH2– B–TiO2–CuO composite reach 6.05 and 3.25 μmol h? 1 g? 1, respectively, which is higher than 8 times the yield of CH4 of NH2– B–TiO2. It is proposed that the NH2– B–TiO2–CuO composite offers an effective charge transfer through the formation of a p–n junction between NH2– B–TiO2 and CuO interfaces, while in the NH2– B–TiO2–Cu(OH)2 composite, the Cu(OH)2 dominantly serves as an electron sink to capture photo-induced electrons, promoting photo-induced carrier separation. This work provides an ingenious synthetic method for selectively anchoring Cu(OH)2 and CuO on semiconductors with different charge transfer routes for an efficient CO2 photoreduction.
Click Reaction을 통한 Nanocellulose-lignin 공중합체 제조 및 항산화 특성
안량량 ( Liangliang An ),허지원 ( Ji Won Heo ),배진호 ( Jin Ho Bae ),진건송 ( Jiansong Chen ),김용식 ( Yong Sik Kim ) 한국목재공학회 2021 한국목재공학회 학술발표논문집 Vol.2021 No.2
Cellulose and lignin are the main components in lignocellulosic biomass. They are the most abundant, biodegradable, and renewable natural polymers. In this work, a novel and environmentally friendly copolymer was prepared using cellulose nanocrystals (CNCs) and lignin via Diels-Alder reaction. Firstly, CNC furoate (diene) was synthesized by acylation reaction using furoyl chloride. Lignin maleimide (dienophile) was prepared by a two-step reaction. Then, a novel copolymer was obtained by a Diels-Alder covalent adduct between CNC furoate and lignin maleimide. Three products (CNC/L-1, CNC/L-2, and CNC/L-3) were prepared by different weight ratios of CNCs and lignin (1:0.5, 1:1, and 1:2, respectively). The chemical structural analyses from Fourier-transform infrared (FT-IR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, and element analysis confirmed the successful Diels-Alder reaction of CNCs and lignin. Owing to the introduction of lignin onto CNCs, the CNC-lignin copolymers with phenolic hydroxyl groups exhibited good antioxidant activity with an IC50 value of 1.49 mg/mL. The cellulose nanocrystals-lignin copolymer with excellent antioxidant activity shows a promising application in biomaterials.