Synthesis of full concentration gradient cathode studied by high energy X-ray diffraction

Li, Yan,Xu, Rui,Ren, Yang,Lu, Jun,Wu, Huiming,Wang, Lifen,Miller, Dean J.,Sun, Yang-Kook,Amine, Khalil,Chen, Zonghai Elsevier 2016 Nano energy Vol.19 No.-

<P><B>Abstract</B></P> <P>Nickel-rich metal oxides have been widely pursued as promising cathode materials for high energy-density lithium-ion batteries. Nickel-rich lithium transition metal oxides can deliver a high specific capacity during cycling, but can react with non-aqueous electrolytes. In this work, we have employed a full concentration gradient (FCG) design to provide a nickel-rich core to deliver high capacity and a manganese-rich outer layer to provide enhanced stability and cycle life. <I>In situ</I> high-energy X-ray diffraction was utilized to study the structural evolution of oxides during the solid-state synthesis of FCG lithium transition metal oxide with a nominal composition of LiNi<SUB>0.6</SUB>Mn<SUB>0.2</SUB>Co<SUB>0.2</SUB>O<SUB>2</SUB>. We found that both the pre-heating step and the sintering temperature were critical in controlling phase separation of the transition metal oxides and minimizing the content of Li<SUB>2</SUB>CO<SUB>3</SUB> and NiO, both of which deteriorate the electrochemical performance of the final material. The insights revealed in this work can also be utilized for the design of other nickel-rich high energy-density cathode materials.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Solid-state synthesis of FCG cathode is investigated by <I>in situ</I> XRD. </LI> <LI> Covariance analysis and Rietveld refinement are used to analyze the HEXRD data. </LI> <LI> Synthetic optimization of FCG cathode with excellent electrochemical performance. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Benefit from the covariance analysis and Rietveld refinement of <I>in situ</I> HEXRD data during the solid state synthesis, we can optimized the solid state synthesis conditions in a short time. And the full concentration gradient cathode composites (nickel-rich core and manganese-rich outer layer) with excellent electrochemical performance are obtained.</P> <P>[DISPLAY OMISSION]</P>

A Novel Molecular Grading Model: Combination of Ki67 and VEGF in Predicting Tumor Recurrence and Progression in Non-invasive Urothelial Bladder Cancer

Chen, Jun-Xing,Deng, Nan,Chen, Xu,Chen, Ling-Wu,Qiu, Shao-Peng,Li, Xiao-Fei,Li, Jia-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Purpose: To assess efficacy of Ki67 combined with VEGF as a molecular grading model to predict outcomes with non-muscle invasive bladder cancer (NMIBC). Materials: 72 NMIBC patients who underwent transurethral resection (TUR) followed by routine intravesical instillations were retrospectively analyzed in this study. Univariate and multivariate analyses were performed to confirm the prognostic values of the Ki67 labeling index (LI) and VEGF scoring for tumor recurrence and progression. Results: The novel molecular grading model for NMIBC contained three molecular grades including mG1 (Ki67 $LI{\leq}25%$, VEGF $scoring{\leq}8$), mG2 (Ki67 LI>25%, VEGF $scoring{\leq}8$; or Ki67 $LI{\leq}25%$, VEGF scoring > 8), and mG3 (Ki67 LI > 25%, VEGF scoring > 8), which can indicate favorable, intermediate and poor prognosis, respectively. Conclusions: The described novel molecular grading model utilizing Ki67 LI and VEGF scoring is helpful to effectively and accurately predict outcomes and optimize personal therapy.

Aprotic and Aqueous Li–O₂ Batteries

Lu, Jun,Li, Li,Park, Jin-Bum,Sun, Yang-Kook,Wu, Feng,Amine, Khalil American Chemical Society 2014 Chemical reviews Vol.114 No.11

<P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/chreay/2014/chreay.2014.114.issue-11/cr400573b/production/images/medium/cr-2013-00573b_0033.gif'></P>

Manganese-based spinel adsorbents for lithium recovery from aqueous solutions by electrochemical technique

Honglong Zhan,Yingjun Qiao,Zhiqiang Qian,Jun Li,Zhijian Wu,Xiaogang Hao,Zhong Liu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-

The manganese-based spinel adsorbent (HMO) refers to lithium-ion adsorbents derived from the spinellithium manganese oxide (LMO). Two types of lithium ions extraction composite films composed of HMO(HMn2O4 and H1.6Mn1.6O4) are successfully prepared by the blade coating method. Based on the excellentLi+ selectivity of HMO and the outstanding conductivity of conductive carbon black (C), HMO/C films arecarried out to extract lithium by electrochemically switched ion exchange (ESIX) technique. HMO has acertain adsorption capacity for Li+ when the Li+ concentration is close to the actual brine, and the adsorptioncapacity of HMn2O4 and H1.6Mn1.6O4 is 24.56 mg/g and 34.40 mg/g, respectively. HMO showed goodselectivity for Li+ in multiple metal ions solution. The capacity of HMn2O4 and H1.6Mn1.6O4 keep 80% and86% of the initial values after 5 cycles, respectively. The inherent different lithium occupied leads to thedifference of electrical-adsorption abilities between HMn2O4 and H1.6Mn1.6O4. H1.6Mn1.6O4 has a broadapplication prospect in lithium extraction from salt lake brine due to its lower application voltage, largeadsorption capacity and superior stability.

漢語蘇州方言和合肥方言入聲字的比較研究

吳舒雅(Wu, Shu-Ya),李偉(Li, Wei),吳世畯(Oh, Se-Jun) 대한중국학회 2019 중국학 Vol.67 No.-

中國地域廣袤,方言種類繁多,但是,信息科技飛速發展的今天,方言正在悄然流逝,人們 對地方方言和傳統文化漸漸漠視和遺忘,方言的喪失必將導致傳統文化的失根,所以對方言的重視 和保護很重要。作為一名語言文化研究愛好者,希望通過研究比較更多的方言來讓人們更了解自己 的語言。方言作為母語,在我們學習第二語言的時候會直接影響到第二語言的習得,不僅存在積極 的促進作用,也存在消極的阻礙作用,這就需要我們對兩種語言進行深刻的了解和多方面的比較研究。蘇州和合肥分別歸屬於吳語區和江淮官話區,雖然是兩種方言,但是從地理位置上看,相互接連,可見兩種方言之間一定存在一些共同特點和差別。筆者就蘇州和合肥的語言上進行比較研究,選擇展現入聲字的中古音在兩地的今讀,分別從方言的聲母和韻母的對比進行分析和解說,以此來 找出兩種方言之間的差異。 However, with the rapid development of information technology, dialects are slipping away. People are gradually ignoring and forgetting local dialects and traditional culture. The loss of dialects will surely lead to the loss of traditional culture. As a language and culture research enthusiast, I hope to make people know more about their own language by studying and comparing more dialects. As the mother tongue, dialect will directly affect the acquisition of the second language when we learn the second language, which not only has a positive role in promoting, but also has a negative role in hindering, which requires us to have a deep understanding of the two languages and a comprehensive comparative study. Suzhou and Hefei belong to the wu-speaking area and the jianghuai guanhua area respectively. Although they are two dialects, they are connected with each other from the geographical position. It can be seen that there must be some common characteristics and differences between the two dialects. Based on a comparative study of the languages of Suzhou and Hefei, the author chooses to present the modern pronunciation of the Chinese ancient pronunciation of rusheng characters in the two places, and analyzes and explains the differences between the initial and final vowels of the dialects respectively, so as to find out the differences between the two dialects.

Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth

Lyu, Junfang,Yang, Eun Ju,Head, Sarah A.,Ai, Nana,Zhang, Baoyuan,Wu, Changjie,Li, Ruo-Jing,Liu, Yifan,Yang, Chen,Dang, Yongjun,Kwon, Ho Jeong,Ge, Wei,Liu, Jun O.,Shim, Joong Sup Elsevier 2017 Cancer letters Vol.409 No.-

<P><B>Abstract</B></P> <P>Cholesterol is an important modulator of membrane protein function and signaling in endothelial cells, thus making it an emerging target for anti-angiogenic agents. In this study, we employed a phenotypic screen that detects intracellular cholesterol distribution in endothelial cells (HUVEC) and identified 13 existing drugs as cholesterol trafficking inhibitors. Cepharanthine, an approved drug for anti-inflammatory and cancer management use, was amongst the candidates, which was selected for in-depth mechanistic studies to link cholesterol trafficking and angiogenesis. Cepharanthine inhibited the endolysosomal trafficking of free-cholesterol and low-density lipoprotein in HUVEC by binding to Niemann-Pick disease, type C1 (NPC1) protein and increasing the lysosomal pH. The blockade of cholesterol trafficking led to a cholesterol-dependent dissociation of mTOR from the lysosomes and inhibition of its downstream signaling. Cepharanthine inhibited angiogenesis in HUVEC and in zebrafish in a cholesterol-dependent manner. Furthermore, cepharanthine suppressed tumor growth in vivo by inhibiting angiogenesis and it enhanced the antitumor activity of the standard chemotherapy cisplatin in lung and breast cancer xenografts in mice. Altogether, these results strongly support the idea that cholesterol trafficking is a viable drug target for anti-angiogenesis and that the inhibitors identified among existing drugs, such as cepharanthine, could be potential anti-angiogenic and antitumor agents.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A phenotypic screen identified 13 existing drugs, including cepharanthine, as cholesterol trafficking inhibitors. </LI> <LI> Cepharanthine inhibited lysosomal cholesterol trafficking by binding to NPC1 protein and increasing the lysosomal pH. </LI> <LI> The blockade of cholesterol trafficking led to a cholesterol-dependent dissociation of mTOR from the lysosomes. </LI> <LI> Cepharanthine inhibited angiogenesis in HUVEC and in zebrafish in a cholesterol-dependent manner. </LI> <LI> Cepharanthine treatment enhanced the antitumor activity of cisplatin in lung and breast cancer xenografts in mice. </LI> </UL> </P>

기획주제(企劃主題) : 동아시아 각국의 한자, 한문 교육 연구의 새로운 과제; 漢字使用現狀及對策硏究

( Li Jun Wu ),( Xiao Huan Wang ),( Yan Fang Ma ) 한국한자한문교육학회 2013 漢字 漢文敎育 Vol.31 No.-

Chinese character with a history of thousands of years is the important carrier of Chinese culture. Just like the living fossil of Chinese historic culture, it`s also the significant part of Chinese culture. With the increasingly frequent cultural exchanges between the East and the West, the influence of Chinese character is wider and wider. And the advantages of it are more and more obvious. However, under the influence of various complex factors, it appeared some bad phenomenon in the process of using Chinese character. Plenty of nonstandard and wrong characters could be seen everywhere, which severely damaged standardization and purity of language, and which also destroyed the harmonious and healthy environment of language culture. Currently, the society has paid extensive and highly attention on how to correctly learn and use Chinese character, and how to give full play to traditional advantages of it.

Dynamic stiffness analysis of steel-concrete composite beams

Jun Li,Qiji Huo,Xiaobin Li,Xiangshao Kong,Weiguo Wu 국제구조공학회 2014 Steel and Composite Structures, An International J Vol.16 No.6

An exact dynamic stiffness method is introduced for investigating the free vibration characteristics of the steel-concrete composite beams consisting of a reinforced concrete slab and a steel beam which are connected by using the stud connectors. The elementary beam theory is used to define the dynamic behaviors of the two beams and the relative transverse deformation of the connectors is included in the formulation. The dynamic stiffness matrix is formulated from the exact analytical solutions of the governing differential equations of the composite beams in undamped free vibration. The application of the derived dynamic stiffness matrix is illustrated to predict the natural frequencies and mode shapes of the steel-concrete composite beams with seven boundary conditions. The present results are compared to the available solutions in the literature whenever possible.

Novel method for equivalent stiffness and Coulomb’s damping ratio analyses of leaf spring

Wu Wen-jun,Zhu Le-mei,Xiang Yu,He Li-jun 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.11

The leaf spring is a representative type of laminated structure. Based on the linear theories of curve beams, the first derivatives of the leave’s status-vector of the leaf spring are provided. The first derivatives of the combination status-vector are obtained by properly dealing with the nonlinear interacted forces between adjacent leaves. Moreover, the precise integration technology and the transform matrix method are introduced to solve the equations. The force-displacement curve of a leaf spring is then calculated separately by using the present method and the finite element software ANSYS. From the results, the precision and advantages of the present methods for analyzing the leaf spring are revealed. The Coulomb’s damping ratio of the leaf spring is studied by using the present method.

Cloning, Heterologous Expression, and Characterization of Novel Protease- Resistant α-Galactosidase from New Sphingomonas Strain

( Jun Pei Zhou ),( Yan Yan Dong ),( Jun Jun Li ),( Rui Zhang ),( Xianghua Tang ),( Yuelin Mu ),( Bo Xu ),( Qian Wu ),( Zun Xi Huang ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.11

The α-galactosidase-coding gene agaAJB13 was cloned from Sphingomonas sp. JB13 showing 16S rDNA (1,343 bp) identities of ≤97.2% with other identified Sphingomonas strains. agaAJB13 (2,217 bp; 64.9% GC content) encodes a 738-residue polypeptide (AgaAJB13) with a calculated mass of 82.3 kDa. AgaAJB13 showed the highest identity of 61.4% with the putative glycosyl hydrolase family 36 α-galactosidase from Granulicella mallensis MP5ACTX8 (EFI56085). AgaAJB13 also showed <37% identities with reported protease-resistant or Sphingomonas α-galactosidases. A sequence analysis revealed different catalytic motifs between reported Sphingomonas α-galactosidases (KXD and RXXXD) and AgaAJB13 (KWD and SDXXDXXXR). Recombinant AgaAJB13 (rAgaAJB13) was expressed in Escherichia coli BL21 (DE3). The purified rAgaAJB13 was characterized using p-nitrophenyl-α-D-galactopyranoside as the substrate and showed an apparent optimum at pH 5.0 and 60oC and strong resistance to trypsin and proteinase K digestion. Compared with reported proteaseresistant α-galactosidases showing thermolability at 50oC or 60oC and specific activities of <71 U/mg with or without protease treatments, rAgaAJB13 exhibited a better thermal stability (half-life of >60 min at 60oC) and higher specific activities (225.0-256.5 U/mg). These sequence and enzymatic properties suggest AgaAJB13 is the first identified and characterized Sphingomonas α-galactosidase, and shows novel protease resistance with a potential value for basic research and industrial applications.