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- 저자 : Li-Xiong Gu (검색결과 4 건)
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Bo Li,Xiaojuan Gu,Hanbing Zhang,Hao Xiong 한국통합생물학회 2022 Animal cells and systems Vol.26 No.3
Background: High expression levels of the TTK gene are closely related to tumor occurrence and poor prognosis, as confirmed by some studies. Our study explored the prognosis of lung adenocarcinoma (LUAD) patients with different TTK levels and the possible pathological mechanism of TTK in LUAD. Methods: We extensively searched literature databases and high-throughput sequencing databases and included relevant literature or datasets in the meta-analysis according to the inclusion and exclusion criteria. Hazard ratios (HRs) and 95% confidence intervals (CIs) related to TTK expression were calculated, publication bias was assessed, and sensitivity tests were performed. We also compared the relationship between cancer immune infiltrating cells and tumor mutation burden (TMB) in patients with different TTK expression levels via bioinformatics analysis. The half maximal inhibitory concentration (IC50) of some chemotherapeutic and targeted therapy drugs were calculated. The potential biological functions or pathways associated with different TTK expression levels were determined by gene set enrichment analysis (GSEA). Results: The meta-analysis revealed that higher TTK expression level was significantly associated with poor prognosis in LUAD patients, both in overall survival (OS) and progression-free survival (PFS). The expression level of TTK was significantly correlated with presence of some immune cells and TMB. Tumors with higher TTK expression levels were mostly enriched for the cell cycle, DNA replication and homologous recombination pathways. In addition, patients with different TTK expression levels were differently sensitive to some antitumor drugs. Conclusion: TTK may be a promising prognostic biomarker for LUAD and is worthy of further investigation.
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Tao Gu,Li‑Min Wang,Qiang Hu,Xiu‑Bing Liang,Dong‑Xing Fu,Yong‑Xiong Chen,Xin‑Ming Zhao,Yan‑Wei Sheng 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.11
An equiatomic refractory high-entropy alloy (RHEA) NbMoTaWRe is prepared by mechanical alloying (MA) and sparkplasma sintering (SPS). The effects of mechanical alloying and sintering behaviors on the microstructure and propertiesof the RHEA are investigated. After ball-milling for 30 h, the metastable and supersaturated MA powders with the bodycenteredcubic (BCC) structure are obtained. Then, the MA powders are sintered using the SPS method under the sinteringtemperature range of 1700–1900 °C, and the C atoms and WC introduced by the MA process reacts with the metastable andsupersaturated Ta/Nb phase of the MA powers to form the face-centered cubic (FCC) structure (Nb, Ta)C particles alongthe BCC matrix boundaries during the SPS process. The NbMoTaWRe alloy sintered at 1800 °C consisted of BCC matrixand FCC-type (Nb, Ta)C particles has high compactness (porosity fraction is 0.32%), fracture strength (2630 MPa), plasticstrain (6.82%), and hardness (992 ± 20 HV). These excellent properties of this RHEA are mainly attributed to the combinationof multi-effects, including sintering densification, grain refinement strengthening from the refined sizes (3.80 μm) BCCmatrix, precipitation strengthening from the (Nb, Ta)C particles, solid solution strengthening from multi-principal elementsand interstitial solid solution strengthening from C atoms dissolving into BCC matrix.
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Mathematical Model Relating Dynamic Dewatering Process of Fresh Mortar and Its Composition
Tao Ji,Xiaoying Zhang,Xiong Zhang,Yong-juan Zhang,Caiyong Gu,Weihua Li 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.2
The composition and properties of raw materials have significant influences on water retention capacity of mortar, but the basic origin remains unclear. To clarify the movement of water inside mortar and the mechanism of water retention, the dynamic dewatering experiment was designed and the mathematical model describing the dewatering process of mortar was set up in this work. The model proved to be effective according to the results from dynamic dewatering experiment. The study demonstrated that capillary gradual contraction model is suitable for describing early dewatering process of fresh mortar and the parameters in the dewatering equation are relevant to the properties of raw materials, which certify that the model is of physical significance. Moreover, influencing factors such as water properties and binding materials properties were obtained and their relationship with water retention of mortar were discussed theoretically based on capillary gradual contraction model.
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Niu-Jing Ma,Li-Xiong Gu,Chang-Li Peng 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.5
To make sure the tension adjustment in the cables of concrete cable-stayed bridges is conducted successfully, a new adjustment technique for the tension adjustment is presented, with the cable-girder temperature difference taken into account. The tensions are measured via frequency method. Prior to the tension adjustment, tensions and temperatures of all cables and girders are measured when the ambient temperature is stable, and this set of tensions is taken as reference tensions. During the tension adjustment, the relative variable quantities of the tensions are regarded as the control values, while the vertical displacement in the mid-span section of the main span is regarded as the verification value. After each pair of cables is adjusted, it is required to measure the temperatures of cables and girders as well as the vertical displacement variation in the mid-span section of the main span. To guarantee the structural behavior of entire bridge is controlled, at one-third cable points, two-third cable points and the farthest cable points, the frequencies of each pair of cables as well as the temperatures of each pair of cables and girders should be measured so as to recalculate the cable tensions. After that, these cable tensions are compared with the theoretical ones to ensure the structural behavior of entire bridge in control. Finally, Furong bridge, a concrete cable-stayed bridge with double inclined pylons, is taken as a sample application of this proposed technique. The results of cable tensions in this bridge illustrate the new adjustment technique is both accurate and efficient.
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