A Hydrogel-based First-Aid Tissue Adhesive with Effective Hemostasis and Anti-bacteria for Trauma Emergency Management

Dongjie Zhang,Li Mei,Yuanping Hao,Bingcheng Yi,Jilin Hu,Danyang Wang,Yaodong Zhao,Zhe Wang,Hailin Huang,Yongzhi Xu,Xuyang Deng,Cong Li,Xuewei Li,Qihui Zhou,Yun Lu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Clinical tissue adhesives remain some critical drawbacks for managing emergency injuries, such as inadequate adhesive strength and insufficient anti-infection ability. Herein, a novel, self-healing, and antibacterial carboxymethyl chitosan/polyaldehyde dextran (CMCS/PD) hydrogel is designed as the first-aid tissue adhesive for effective trauma emergency management. Methods We examined the gel-forming time, porosity, self-healing, antibacterial properties, cytotoxicity, adhesive strength, and hemocompatibility. Liver hemorrhage, tail severance, and skin wound infection models of rats are constructed in vivo, respectively. Results Results demonstrate that the CMCS/PD hydrogel has the rapid gel-forming (~ 5 s), good self-healing, and effective antibacterial abilities, and could adhere to tissue firmly (adhesive strength of ~ 10 kPa and burst pressure of 327.5 mmHg) with excellent hemocompatibility and cytocompatibility. This suggests the great prospect of CMCS/ PD hydrogel in acting as a first-aid tissue adhesive for trauma emergency management. The CMCS/PD hydrogel is observed to not only achieve rapid hemostasis for curing liver hemorrhage and tail severance in comparison to commercial hemostatic gel (Surgiflo ®) but also exhibit superior anti-infection for treating acute skin trauma compared with clinical disinfectant gel (Prontosan ®). Conclusions Overall, the CMCS/PD hydrogel offers a promising candidate for first-aid tissue adhesives to manage the trauma emergency. Because of the rapid gel-forming time, it could also be applied as a liquid first-aid bandage for mini-invasive surgical treatment.

Research on the Inquiry Teaching Model of Men's Basketball Teaching in College Physical Education based on Network Information Technology

Li Aimin,Long Jianjun,Tao Ganchen,Chen Yuanping,Wan Shaoyong 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.10

Network education is a new concept of modern information technology applied to education, which is the education of the use of network technology, according to a series of outstanding problems in the traditional basketball teaching, we discussed the application value and effect of inquiry teaching in college basketball education. The data was collected from Jiangxi Normal University; experiment object is 36 students, and we put them in the experimental group (18) and the control group (18).By using interview method and empirical analysis, the result shows that in 50 meters (F=4.227, P=0.048<0.05); standing long jump (F=5.495, P=0.025<0.05); 1000 meters (F=4.702, P=0.037<0.05); Run-up to touch high( F=6.398 P=0.016<0.05); 1 minute shot (F=9.396 P=0.004<0.01); basketball technology F=9.116 P=0.005<0.01; basketball interest (F=16.279, P=0.000<0.01); basketball theory results (F=12.066 P=0.001<0.01). Inquiry teaching method can effectively improve the normal teaching, not only promote students to actively take the basketball class, but also strengthen comprehensive physical education, as the effect is significant, so this education model is worth to promote.

Spreading behaviors of high-viscous nanofluid droplets impact on solid surfaces

Hai Long Liu,Xuefeng Shen,RUI WANG,Yuanping Huo,Changfeng Li,Junfeng Wang 한국유변학회 2019 Korea-Australia rheology journal Vol.31 No.3

In this work, the impact dynamics of high-viscous nanofluid droplets onto a solid surface has been investigated experimentally by means of high-speed camera visualization technique. We dispersed various nanoparticles (multiwall carbon nanotube (MWCNT), nano-graphene, and nano-graphite powder) into highviscous base fluid (epoxy resin) to obtain the stable and homogenous nanofluids without surfactant additives. The well dispersed nanofluids show different degree of shear-thinning behaviors, and the shear-thinning properties of those fluids have been characterized by the power-law rheology model. The dynamic contact angle (DCA), transient dimensionless height, and transient contacting factor along with the spreading time under different Weber numbers (We) have been investigated. The results show that the nanofluid with a lower shear viscosity over the entire range of the shear rates results in larger variations of the contacting factor and the dimensionless height. The effect of surface wettability on droplet impact behaviors is more significant for the fluid with higher shear viscosity and less shear-thinning degree during the receding phase. The latter spreading and receding motions of the droplet with higher shear viscosity and shearthinning degree are suppressed significantly, regardless of the Weber numbers in current study. Finally, a model based on experimental data has been proposed to predict the maximum spreading factor of high-viscous droplet impact on solid surface.

Low-cycle Fatigue Performances of P/M Ti-Fe-Mo-Al-Nd Alloy

Haiyan Liu,Huiping Tang,Cheng Li,Yuanping Huang,Boyun Huang,Yong Liu 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1

The low-cycle fatigue performance and fracture of the P/M Ti-Fe-Mo-Al-Nd Alloys after sintering and forging have been studied. The linear regression equation of low-cycle fatigue lifetime has been obtained; the fatigue performances are objected under two different conditions. The fatigue fracture surface is analyzed by SEM. The low-cycle fatigue behavior of the P/M titanium alloy has been discussed.

Compressive force regulates ephrinB2 and EphB4 in osteoblasts and osteoclasts contributing to alveolar bone resorption during experimental tooth movement

Jianhua Hou,Yanze Chen,Xiuping Meng,Ce Shi,Chen Li,Yuanping Chen,Hongchen Sun 대한치과교정학회 2014 대한치과교정학회지 Vol.44 No.6

Objective: To investigate the involvement of ephrinB2 in periodontal tissue remodeling in compression areas during orthodontic tooth movement and the effects of compressive force on EphB4 and ephrinB2 expression in osteoblasts and osteoclasts. Methods: A rat model of experimental tooth movement was established to examine the histological changes and the localization of ephrinB2 in compressed periodontal tissues during experimental tooth movement. RAW264.7 cells and ST2 cells, used as precursor cells of osteoclasts and osteoblasts, respectively, were subjected to compressive force in vitro. The gene expression of EphB4 and ephrinB2, as well as bone-associated factors including Runx2, Sp7, NFATc1, and calcitonin receptor, were examined by quantitative real-time polymerase chain reaction (PCR). Results: Histological examination of the compression areas of alveolar bone from experimental rats showed that osteoclastogenic activities were promoted while osteogenic activities were inhibited. Immunohistochemistry revealed that ephrinB2 was strongly expressed in osteoclasts in these areas. Quantitative real-time PCR showed that mRNA levels of NFATc1, calcitonin receptor, and ephrinB2 were increased significantly in compressed RAW264.7 cells, and the expression of ephrinB2, EphB4, Sp7, and Runx2 was decreased significantly in compressed ST2 cells. Conclusions: Our results indicate that compressive force can regulate EphB4 and ephrinB2 expression in osteoblasts and osteoclasts, which might contribute to alveolar bone resorption in compression areas during orthodontic tooth movement.

Monitoring and Evaluation of Artificial Ground Freezing in Metro Tunnel Construction-A Case Study

Qixiang Yan,Wang Wu,Chuan Zhang,Shuqi Ma,Yuanping Li 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.5

The turn-back tunnel of Guangzhou Metro Line 3 Tianhe Station with a large span was excavated in sandy clay which may easily break and disintegrate. The artificial ground freezing (AGF) technique was used to stabilize the soil and to prevent its collapse during excavations. Most of the existing theoretical analysis and numerical simulation on the AGF technique are purely based on a couple of assumptions, which are not able to produce accurate predictions. It would be more accurate for the AGF analysis to include the field monitoring. In this study, the coupled method of the field monitoring, the analytical formula, and the numerical method is used to evaluate the thickness and average temperature of the frozen zone. Field monitoring was conducted to measure the temperature of the brine and the ground. Analytical formula was used to compute the thickness and the average temperature of the frozen zone. Numerical simulation is also carried out to predict the thickness and the temperature field of the frozen zone. According to the analytical and numerical analysis, the computed thickness and average temperature of the frozen zone meet the designed requirements of the project, which are further confirmed by the successful excavation of the tunnel. This indicates that the coupled method used in this paper is reliable and would be helpful for the AGF application in practical engineering.

Dirac semimetal-enabled multi-bit coding metasurface for dynamic manipulation of terahertz beams

Zhang Yonggang,Yin Kehao,Liang Lanju,Yao Haiyun,Yan Xin,Hu Xiaofei,Huang Chengcheng,Qiu Fu,Zhang Rui,Li Yuanping,Wang Yaru,Li Zhenhua,Wang Ziqun 한국물리학회 2024 Current Applied Physics Vol.58 No.-

In this study, a switchable multi-bit coding metasurface that is applied under a terahertz (THz) frequency by adjusting the Fermi level (EF) of Dirac semimetals (DSMs) is proposed. At a EF of 0.2 eV, a 1-bit coding metasurface can be applied in the 2.58–2.62 THz. At 0.3 eV, a 3-bit coding metasurface is realized at 1.88 THz, and at 0.05 eV, the phase of the coding units coincides in the 1.5–3 THz. So, different functions of the metasurface can be realized. The proposed coding metasurfaces has promising applications in terahertz communication.