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- 저자 : Li Mingying (검색결과 5 건)
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Gait Programming of Quadruped Bionic Robot
Mingying Li,Chengbiao Jia,이응주,Yiran Feng 한국멀티미디어학회 2021 The journal of multimedia information system Vol.8 No.2
Foot bionic robot could be supported and towed through a series of discrete footholds and be adapted to rugged terrain through attitude adjustment. The vibration isolation of the robot could decouple the fuselage from foot-end trajectories, thus, the robot walked smoothly even if in a significant terrain. The gait programming and foot end trajectory algorithm were simulated. The quadruped robot of parallel five linkages with eight degrees of freedom were tested. The kinematics model of the robot was established by setting the corresponding coordinate system. The forward and inverse kinematics of both supporting and swinging legs were analyzed, and the angle function of single leg driving joint was obtained. The trajectory planning of both supporting and swinging phases was carried out, based on the control strategy of compound cycloid foot-end trajectory planning algorithm with zero impact. The single leg was simulated in Matlab with the established kinematic model. Finally, the walking mode of the robot was studied according to bionics principles. The diagonal gait was simulated and verified through the foot-end trajectory and the kinematics.
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Platelet-derived exosomes promote the epithelial–mesenchymal transition in MCF7 cells
Li Mingying,Xin Ying,Liu Miao,Yu Kun 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.1
Background Breast cancer is a common female malignancy. In recent years, the incidence of breast cancer has increased and has become much younger. Studies have shown that platelet-derived exosomes play an important role in the progression of cancer . Objective In this study, we investigated the effect of platelet-derived exosomes on the epithelial–mesenchymal transition (EMT), migration, and invasion of breast cancer cells. Activated and unactivated platelet-derived exosomes were extracted by ultracentrifugation. The morphology of platelet exosomes was observed and identifi ed by transmission electron microscopy and western blotting. After MCF7 cells are treated with platelet or exosomes, the mRNA and protein levels of EMT-related genes were detected by RT-PCR and western blotting, respectively, and the migration and invasion abilities of MCF7 cells were also observed by transwell. Results We observed some exosomes-like structures derived from activated platelets by transmission electron microscopy. The level of transforming growth factor-β in activated platelet-derived exosomes was higher than that in unactivated plateletderived exosomes. After activated platelet or activated platelet-derived exosomes were co-cultured with MCF7 cells, the expression of Snai1, N-cadherin, Vimentin and Fibronectin in activated platelets and breast cancer cells was significantly increased, while the expression of E-cadherin was significantly decreased. Activated platelets and activated platelet-derived exosomes significantly promoted the migration and invasiveness of MCF7 cells. These findings revealed that activated platelet or activated platelet-derived exosome enhances migration and invasion by promoting EMT in MCF cells. Conclusion In conclusion, platelet-derived exosomes initiate EMT and promote the migration and invasiveness of MCF7 cells.
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Haonan Li,Baojia Sun,Mingying Wang,Xu Hu,Xiang Gao,Sheng-tao Xu,Yongnan Xu,Jin-yi Xu,Hui-Ming Hua,Da-Hong Li 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.11
Diterpenoids are important and widely distributed natural compounds with various biological effects, including antitumor, anti-inflammatory and so on. Great efforts have been put in phytochemistry research on diterpenoids. A number of structural modified derivatives and pharmacophore incorporated hybrids were also designed and synthesized with promising therapeutic effects. Among the hopefuls, enmein-type 6,7-seco-ent-kaurane diterpenoids with unique ring system and stereogenic centers exhibit attractive activities. Based on their lead-like properties, enmein-type diterpenoids are suitable for further medicinal study. The derivatives were biologically evaluated and showed promising activities, which warranted in-depth research for further understanding. In this review, the natural bioactive enmein-type diterpenoids and the synthetic derivatives were comprehensively summarized.
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Challenges and Real-world Validation of Autonomous Surface Vehicle Decision-making System
Mingi Jeong,Arihant Chadda,Alberto Quattrini Li 한국항해항만학회 2022 한국항해항만학회 학술대회논문집 Vol.2022 No.2
Autonomous decision-making is key to safe and efficient marine autonomy, as global marine industry comprises over 90 percent of the world’s cargo transportation. Challenges of the real-world validation in the aquatic domain limits the wide-spread of ASVs despite their promising societal impacts. We propose and demonstrate the real-world validation platform and comprehensive algorithm steps. Such a framework will serve as a more explainable and reliable decision-making system of ASVs as well as autonomous vehicles in other domains.
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Municipal Solid Waste Degradation and Compaction
( Jae Hac Ko ),( Mingying Li ),( Fan Yang ),( Qiyong Xu ) 한국폐기물자원순환학회(구 한국폐기물학회) 2015 한국폐기물자원순환학회 3RINCs초록집 Vol.2015 No.-
This study investigated the impact of compaction on anaerobic degradation of municipal solid waste (MSW) during the phase of methane formation. Two stainless steel lysimeters were constructed with equipped a hydraulic cylinder to apply pressure load on the MSW. When methane production rates decreased from the peak rate of each column, pressure load was applied at different degrees of decomposition (DOD). When pressure load was applied, chemical oxygen demand (COD) showed temporary increases, Methane production rate also increased by the compaction. However, the impact of compaction on methane production rate varied with different degrees of decomposition. MSW compaction reduced pore space of MSW resulting in increasing the contact surface area of among MSW particles. It was thought that the mass transfer of volatile fatty acids could be enhanced by increased contact surface area and degree of saturation as the consequence of the compaction.
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