Clinical outcome of high-dose-rate interstitial brachytherapy in patients with oral cavity cancer

Sung Uk Lee,MD,Kwan Ho Cho,MD,Sung Ho Moon,MD,Sung Weon Choi,MD,Sung Uk Lee,MD,Kwan Ho Cho,MD,Sung Ho Moon,MD,Sung Weon Choi,MD 대한방사선종양학회 2014 Radiation Oncology Journal Vol.32 No.4

Purpose: To evaluate the clinical outcome of high-dose-rate (HDR) interstitial brachytherapy (IBT) in patients with oral cavity cancer. Materials and Methods: Sixteen patients with oral cavity cancer treated with HDR remote-control afterloading brachytherapy using 192Ir between 2001 and 2013 were analyzed retrospectively. Brachytherapy was administered in 11 patients as the primary treatment and in five patients as salvage treatment for recurrence after the initial surgery. In 12 patients, external beam radiotherapy (50–55 Gy/25 fractions) was combined with IBT of 21 Gy/7 fractions. In addition, IBT was administered as the sole treatment in three patients with a total dose of 50 Gy/10 fractions and as postoperative adjuvant treatment in one patient with a total of 35 Gy/7 fractions. Results: The 5-year overall survival of the entire group was 70%. The actuarial local control rate after 3 years was 84%. All five recurrent cases after initial surgery were successfully salvaged using IBT ± external beam radiotherapy. Two patients developed local recurrence at 3 and 5 months, respectively, after IBT. The acute complications were acceptable (≤grade 2). Three patients developed major late complications, such as radio-osteonecrosis, in which one patient was treated by conservative therapy and two required surgical intervention. Conclusion: HDR IBT for oral cavity cancer was effective and acceptable in diverse clinical settings, such as in the cases of primary or salvage treatment.

Comparison in Disease Development and Gas Exchange Rate of Pinus densiflora Seedlings Artificially Inoculated with Bursaphelenchus xylophilus and B. mucronatus

( Kwan Soo Woo ),( Jun Hyuck Yoon ),( Su Young Woo ),( Seong Han Lee ),( Sang Urk Han ),( Hye Rim Han ),( Saeng Geul Baek ),( Chang Soo Kim ) 한국산림과학회 2010 Forest Science And Technology Vol.6 No.2

Four-year-old seedlings of Pinus densiflora were inoculated with a suspension of B. xylophilus, or B. mucronatus adjusted to 3,000 nematodes per 50 μL sterilized distilled water in a greenhouse on July 21, 2008 to evaluate initial symptom development and the changes of gas exchange rate. B. xylophilus and B. mucronatus were distinguished by four restriction enzymes except Rsa I, and the result of ITSRFLP of B. xylophilus used in this experiment was completely matched to that of pine wood nematode reported previously. Needle dehydration and subsequent yellowing were observed in all seedlings inoculated with B. xylophilus isolate while the appearance of the seedlings was normal in all seedlings inoculated with B. mucronatus and control. Needle dehydration was observed in most seedlings inoculated with B. xylophilus between 2 and 3 weeks after inoculation. In seedlings inoculated with B. xylophilus, continuous decrease in photosynthetic rate was observed after 6 days of inoculation. Photosynthetic rate decreased more markedly after 12 days of inoculation when external symptoms appeared in most seedlings, and ceased almost completely 19 days after inoculation. Photosynthetic decline in seedlings inoculated with B. mucronatus was only observed at 19 days after inoculation but recovered above control level after 25 days of inoculation. We found that disease development and the changes of gas exchange rate in the seedlings of Pinus densiflora inoculated with B. xylophilus were not observed on those inoculated with B. mucronatus.

A Study on Maternity Aids Utilization in the Maternal and Child Health and Family Planning

Lee, Sung-Kwan,Kim, Doo-Hie,Jung, Jong-Hak,Chae, Hie-Kap,Kim, Hie-Kyo,Yeh, Min-Hae,Hong, Soon-Ho 慶北大學校 醫科大學 1972 慶北醫大誌 Vol.13 No.2

1. 硏究內容의 槪要 近間 地域社會醫學의 一環으로 開發途上國家에 있어서도 分娩을 醫療施設에서 수행하거나 혹은 有資格 醫療人에 의해서 介助하는 傾向이 增加하고 있다. 그러나 우리나라에 있어서 여러 保健分野가 向上되고 있으나 唯獨 母子保健 分野에서는 舊態依然하게 古來의 風習 그대로 分娩의 95%가 家庭에서 施行되고 있으며 分娩介助者로서 90%以上이 家族이나 이웃등 醫療와는 門外漠에 의해서 施行되고 있어 何等의 發展을 볼 수 없다. 이런 狀態下에서는 母性死亡이나 幼兒死亡이 高率인 것은 不問可和로서 우리나라 保健에 있어서 가장 留意하여야 할 問題라고 生覺된다. 따라서 今般 本敎室에서는 이러한 農村에서의 母子保健 分野를 改善코저 部落民中 指導的인 立場에 있고 母子保健事業에 興味를 가질 수 있는 婦人을 敎育시켜 各 部落에 配置시켜서 姙娠中 合倂症이 있는 사람에 對하여는 公醫나 保健所에 의뢰코자 每月 家庭訪問을 實施하고 分娩前에 消毒된 分娩介助器를 配付하여 分娩時에 可能한 限 直接介助를 하고 産前, 産後 姙娠婦와의 여러번 接觸을 通하여 子女數에 關한 議論과 피임법에 對한 相談을 遂行하여 出生, 死亡申告의 勸誘등으로 生政統計의 改善을 企圖하였다. 따라서 本硏究의 主目的은 이들 分娩介助要員의 奉仕로서 1) 農村婦人들의 分娩 및 母子保健 態度에 어느 程度 變化를 갖어 올 것인가? 2) 이러한 奉仕를 通하여 幼兒死亡이 어느 程度 減少할 것인가? 3) 빈번한 妊婦와의 接觸으로 어느 程度 避姙率이 增加할 것인가? 4) 申告에 대한 권유와 助力으로 屆出事業이 얼마나 改善될 것인가를 試圖함을 目的으로 하였다. 2. 結果의 槪要 1970年 4月부터 1971年 12月까지 21個月間의 事業을 通하여 다음과 같은 成績을 얻을 수 있었다. 1) 農村婦人들의 分娩에 關한 態度에 있어서 分娩場所나 유아의 死亡場所는 硏究前後나 硏究地域이나 對照地域間에 何等의 差異를 볼 수 없었으나 消毒된 介助器使用率은 硏究地域에서 顯箸하게 高率이었고 分娩介助에 있어서 本 硏究를 통하여 配置된 分娩介助要員에 依한 介助가 硏究地域에서 10%로 되어있는 以下는 거의 同一하였다. 2) 家族計劃에 있어서 避姙率은 硏究地域이 28%에 比하여 對照地域은 24%로서 硏究地域에서 多少 높았으며 分娩後 피임까지의 其間이 6個月 以內에서도 9%內外의 實施者가 있어 從前에 比하여 多少 일찍 實施하는 傾向이 있었다. 産前, 産後를 通하여 연구지역 對象者의 약 70-75%가 피임을 實施함을 願하고 있었다. 피임실시율에 있어서 産前에 임신을 願, 不願에 따라 그 結果에 현저한 差異가 있어 産前 姙娠을 不願한 경우에는 約 30%가 人工流産으로 끝나고 出産한 것이 67%이며 그중 20%는 이미 피임을 실시하였고 5%만이 피임을 不願하였다. 한편 産前에 다음 分娩되는 子女의 性에 따라 分娩後 곧 피임하겠다고 한 사람중 남아 男兒分娩을 願하는 대상자에서 男兒出生때 80%, 女兒出生때는 30%였고, 女兒를 希望하는 사람 中 女兒를 分娩했을때 86%, 男兒분만 때 66%로서 여기서도 男兒에게 好選的인 傾向을 볼 수 있었다. 그리고 大體的으로 연구지역 婦人에서는 대조지역에 比하여 피임實施에 있어서 年齡的으로 젊은 사람에서 男兒數나 子女數가 적은 婦人에서 高率로 實施함을 볼 수 있었다. 3) 幼兒死亡은 현저한 低下를 볼 수 있었는데 그간 出生 2,235名中 68名에서 死亡을 볼 수 있었으며 이것은 出生 1,000名堂 30으로서 동일 대상자에서 전번 幼兒死亡이 42에 比하여 有意的인 差異를 볼 수 있었다. 特記할 것은 이번 幼兒死亡은 各介助要員이 自己들이 登錄한 婦人들에서 出生을 確認하고 1年間 觀察해서 死亡을 확인한 만큼 이때까지의 질문식으로 얻은 成績과는 다른 點이며 質問에 의한 성적에서는 農村 사람의 性格으로 보아 出生後 數日以內 死亡은 말하기를 꺼리는 點을 生覺할 때 死亡率 42는 그 보다 훨씬 高率일것이 추측된다. 死因에 있어서도 傳染性疾에 의한 死亡이 줄어들었으며 特히 파상풍에 의한 死亡은 현저하게 減少하였다. 4) 申告에 있어서 연구지역에서 대조지역에 比하여 若干의 증가를 볼수 있었으나 아직더 改善을 要한다고 生覺된다. 5) 人工流産은 全地域에 있어서 점차적으로 增加가 현저 한데 1969年에 14%가 1972年에는 19%로 增加하고 있으나 本對象者 中에서는 過去가 8% 이번 임신자에서는 不過 2,4%이며 이는 大部分의 대상자가 아직 子女를 願하고 있는 사실에 기인 한다고 生覺된다.

쌀 아밀로그램 特性의 品種 變異와 食味關聯 特性과의 相關

Sang Jong Lim(林尙鍾),Dal Ung Kim(金達雄),Jae Keun Sohn(孫再根),Soo Kwan Lee(李壽寬) 한국육종학회 1995 한국육종학회지 Vol.27 No.3

This study was carried out to understand the varietal variation in amylogram properties of rice grain evaluated by Rapid visco analyzer and the interrelationship among these and other characteristics related with palatability of cooked rice. All amylogram estimates showed highly significient of variation, while consistency viscosity exhibited the lowest varietal variation. Gelatinization initiation temperature of glutinous rices were similar to that of nonglutinous rices, but the peak viscosity of the former was progressed more rapidly than the latter. Peak and cool viscosity of nonglutinous rices were markedly higher than those of glutinous rices. The turning point of rapidly changing viscosity followed soon after the initiation of gelatinization in nonglutinous rices coincided with the peak viscosity of glutinous rices. Peak viscosity of brown rice was lower than that of milled rice, but hot and cool viscosity of brown rice were similiar to those of milled rice in nonglutinous rices. However, peak, hot and cool viscosity of brown rice was lower than those of milled rice in glutinous rice. There was highly positive correlation between amylogram properties of brown and milled rice. Peak and breakdown viscosity was positively correlated with the taste and total panel score of cooked rice, while the setback viscosity was negatively correlated with the taste of cooked rice. The panel scoring components of cooked rice such as taste, stickiness, texture and total score could be estimated by multiple linear regression formula derived from amylogram properties with the range 0.58~0.72 of determination coefficients.

Weibull parameter calculation and estimation of wind speeds for the return period: A case study in the Kori and Wolsong NPP areas

Lee, Jong Kuk,Lee, Kwan-Hee,Kim, Sung Il,Yook, Daesik,Ahn, Sangmyeon Elsevier 2017 Annals of nuclear energy Vol.108 No.-

<P><B>Abstract</B></P> <P>This paper presents the results of a case study on a wind characteristic analysis performed using a probabilistic distribution function to evaluate the meteorology of the Kori and Wolsong nuclear power plants (NPPs) in the Republic of Korea. The return period for daily extreme wind speed considering the wind direction was estimated using a Weibull distribution for the Kori and Wolsong NPP sites. From the directional wind calculation, the Weibull scale parameter <I>c</I> ranged from 5.83 to 9.06 at the Kori site and from 4.53 to 6.79 at the Wolsong site. The shape parameter <I>k</I> ranged from 1.97 to 3.59 at the Kori site and from 2.56 to 4.77 at the Wolsong site. The minimum and maximum directional wind speeds for the return period were 10.29 and 21.00m/s in the WSW and WNW directions, respectively, at the Kori site and 6.54 and 12.07m/s, respectively, at the Wolsong site. The results of this research offer a useful reference to evaluate the site safety assessment for the construction of Shin-Kori units 5 and 6 near the Kori site and a 2nd-stage low-intermediate level radioactive waste depository site near the Wolsong site. The study results can also be utilized to plan an evacuation pathway during unexpected radiation emergency conditions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A case study was performed using the probabilistic distribution function for Kori and Wolsong nuclear power plant area. </LI> <LI> Weibull shape and scale parameter was calculated using the daily extreme wind data for Kori and Wolsong NPP area. </LI> <LI> Wind speed for the return period was estimated for Kori and Wolsong NPP area. </LI> <LI> The results of this study offer a reference to evaluate the site safety assessment for the construction of newly NPP. </LI> <LI> The results of this study can be utilized to plan an evacuation pathway during unexpected radiation emergency conditions. </LI> </UL> </P>

A Comparison Between Stroke Patients Admitted to Oriental Hospital in the Years 1987 and 1994

Lee Kyung-sup,Cho, Ki-ho,Kim, Young-suk,Ko, Chang-nam,Moon Sang-kwan,Bae Hyung-sup INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 1998 JOURNAL OF ORIENTAL MEDICINE Vol.3 No.1

The characteristics of stroke slightly vary as time changes. To compare the characteristics of stroke between the 1980s and 1990s we investigated the clinical records of stroke patients in 1987 and 1994. The subjects of this study consisted of the 1971 patients who were admitted as stroke patients to the Kyunghee University Oriental Medicine Hospital during these two years. There were 1092 stroke patients admitted from May, 1987 to April, 1988 and 879 stroke patients admitted between May, 1994 and April, 1995. The results were as follows. The frequency of cerebral infarction was 77.9% in 1987 and 79.9% in 1994. The male to female ratio of stroke patients was 1.4:1 in 1987 and 1.6:1 in 1994. The occurrence rate of stroke in both 1987 and 1994 were highest in patients in their 60s, followed by those in their 50s, 70s and older, in their 40s, and finally their 30s and below. We especially found that the rate of patients in their 70s and over increased from 17.8% in 1987 to 25.3% in 1994, which was remarkable in cerebral infarction patients. The most common disease preceding a stroke was hypertension, followed by heart disease and diabetes in 1987, and in 1994 hypertension was the most common, followed by diabetes and heart disease. The rate of recurrence among cerebral hemorrhage, that was 12% in 1987 and 24.7% in 1994. The most frequent complications of stroke in 1987 and 1994 were pneumonia and urinary tract infection, respectively. The prescriptions used most frequently during admission were Chungpaesagan-tang followed by Sunghyangjungki-san, Yangyeksanhwa-tang etc. in both 1987 and 1994. When patients were getting better, prescriptions for invigorating Qi and enriching the blood(補氣血) were used more frequently. In conclusion, the most remarkable change of stroke patients from 1987 to 1994 was an increase in occupancy rate of aged patients, especially those in their 70s and older. So we suggest that more research are needed on the stroke of aged man, along with many other subjects on stroke.

The Effect of Antisense Oligodeoxynucleotides for CTGF in Unilateral Ureteral Obstruction in Rats

( Sang Mi Han ),( Kwan Kyu Park ),( Jin Gu Lee ),( Hey Jeong Noh ),( Sung Bae Park ),( Hyunl Chul Kim ) 대한신장학회 2003 춘계학술대회 초록집 Vol.22 No.1

Memristor-based programmable logic array (PLA) and analysis as Memristive networks.

Lee, Kwan-Hee,Lee, Sang-Jin,Kim, Seok-Man,Cho, Kyoungrok American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.5

<P>A Memristor theorized by Chua in 1971 has the potential to dramatically influence the way electronic circuits are designed. It is a two terminal device whose resistance state is based on the history of charge flow brought about as the result of the voltage being applied across its terminals and hence can be thought of as a special case of a reconfigurable resistor. Nanoscale devices using dense and regular fabrics such as Memristor cross-bar is promising new architecture for System-on-Chip (SoC) implementations in terms of not only the integration density that the technology can offer but also both improved performance and reduced power dissipation. Memristor has the capacity to switch between high and low resistance states in a cross-bar circuit configuration. The cross-bars are formed from an array of vertical conductive nano-wires cross a second array of horizontal conductive wires. Memristors are realized at the intersection of the two wires in the array through appropriate processing technology such that any particular wire in the vertical array can be connected to a wire in the horizontal array by switching the resistance of a particular intersection to a low state while other cross-points remain in a high resistance state. However the approach introduces a number of challenges. The lack of voltage gain prevents logic being cascaded and voltage level degradation affects robustness of the operation. Moreover the cross-bars introduce sneak current paths when two or more cross points are connected through the switched Memristor. In this paper, we propose Memristor-based programmable logic array (PLA) architecture and develop an analytical model to analyze the logic level on the memristive networks. The proposed PLA architecture has 12 inputs maximum and can be cascaded for more input variables with R(off)/R(on) ratio in the range from 55 to 160 of Memristors.</P>

Cyanoacrylate Injection versus Band Ligation for the Treatment of Bleeding from Cardiac Varices on Lesser Curvature Side of the Stomach

( Sang Jung Park ),( Yeon Seok Seo ),( Seung Woon Park ),( Han Ah Lee ),( Tae Hyung Kim ),( Sang Jun Suh ),( Young Kul Jung ),( Ji Hoon Kim ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ),( S 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: Practice guidelines recommend endoscopic band ligation (EBL) for the treatment of bleeding from cardiac varices on lesser curvature side of the stomach (CVs). However, endoscopic variceal obturation (EVO) using cyanoacrylate has been reported more effective than EBL for fundal variceal bleeding and considering that the mucosa covering cardiac varices is more thickened than esophageal varices and being exposed to gastric acids or food materials continuously, EVO could be more effective than EBL for the treatment of bleeding from CVs. This study was performed to compare the efficacy between EVO and EBL for the treatment of bleeding from CVs. Methods: All patients who were treated EBL or EVO for bleeding from CVs were enrolled. The patients diagnosed with hepatocellular carcinoma or treated with endoscopic injection therapy were excluded. Results: A total of 77 patients treated with bleeding from CVs were enrolled. Age was 56.4±10.6 years and 67 patients (87.0%) were men. Fifty-one and 26 patients were treated with EBL and EVO, respectively. Hemostasis were achieved in 73 patients (94.8%). Hemostasis rates did not differ between EBL (47 patients, 92.2%) and EVO (26 patients, 100%) groups. Varices rebled in 13 patients during follow-up. Rebleeding rate was significantly higher in EBL group compared to EVO group (P=0.044). During follow-up, 12 patients died (10 in EBL group, 2 in EVO group). Mean survival time was 310.4±13.5 days, which did not differ between two groups (P=0.142). Conclusions: Hemostasis success rate and survival did not differ between the EBL and EVO groups. However, rebleeding rate was significantly lower in EVO group compared to EBL group. EVO could be better option for the treatment of bleeding from CVs on lesser curvature side of the stomach.

A Phase 3 Study of TAF Compared with TDF in Patients with HBeAg-Negative CHB: Week48 Efficacy Results of Korea Patients

( Sang Hoon Ahn ),( Young-Suk Lim ),( Si-Hyun Bae ),( Hyung Joon Kim ),( Kwan Sik Lee ),( Won Young Tak ),( Byoung Kuk Jang ),( Ki Tae Yoon ),( Seung Woon Paik ),( Kwan Soo Byun ),( Sunjin Hwang ),( B 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: In this Phase-3 randomized, double-blind, active-controlled study in 425 HBeAg-negative patients, the efficacy of TAF was demonstrated to be non-inferior to that of TDF at Week48 in the proportion with HBV DNA<29 IU/mL with improved bone and renal effects. Here we present the subgroup efficacy analysis of Korea patients in the study. Methods: Patients with HBeAg-negative CHB were randomized 2:1 to TAF 25mg or TDF 300mg, and treated for 96weeks. The primary efficacy analysis was the proportion with HBV DNA<29 IU/mL at Week48. The results for the subgroup of Korean patients were compared to non-Koreans. Results: Of the 425 patients who were randomized and treated, 45 subjects (11%; TAF 30; TDF 15 subjects) were enrolled in Korea. In contrast to the non-Korea population, the Korea population for the TAF and TDF groups included a higher proportion of females (60% and 47%) a lower mean baseline HBV DNA level, and more treatment experienced subjects. Nearly all were genotype C. Key efficacy end points are summarized in the Table. The percentages of Korean subjects with HBV DNA levels<29 IU/mL at Week48 were 100.0% with TAF and 80.0% with TDF. The results were consistent with the non-Korean and overall populations. A greater percentage of patients treated with TAF also achieved normalization of serum ALT values. The rates of treatment discontinuations and serious AEs were low and similar in the two arms. No viral resistance was observed overall. Similar to non-Korean subjects, those from Korea who were treated with TAF also showed smaller declines in BMD at hip and spine and in CrCl at Week48 compared with TDF subjects in Korea. Conclusions: Compared to TDF 300mg, the efficacy and safety of TAF 25mg in patients with HBeAg-negative CHB from Korea were consistent with those of the nonKorea and overall populations at Week48.