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GO-62 : Lower extremity edema in patients with endometrial cancer
( Myong Cheol Lim ),( Jeong Seon Lee ),( Jung Nam Joo ),( Sang Soo Seo ),( Sok Bom Kang ),( Sang Yoon Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
The objective of this study was to investigate clinical manifestations of lower extremity edema (LEE) in endometrial cancer Medical records for LEE and/or responses to the Gynecologic Cancer Lymphedema Questionnaire (GCLQ) were evaluated in 177 patients with endometrial cancer Patients had a median age of 53 years. Sixty-seven patients (37.9%) had past (9 patients, 13.4%) and/or current patient-reported LEE (58 patients, 86.6%). Symptoms reported on the GCLQ in over 20% of respondents were swelling, numbness, aching , and heaviness. GCLQ total symptoms score was significantly higher in patients with current LEE. Most of the LEE (43/67, 64.2%) developed within 12 months after surgery and LEE lasted more than 6 months in most patients (56/59, 94.9%) Prospective clinical trials are needed to know the clinical significance, impact on quality of life, and preventive strategy of LEE in patients with endometrial cancer
Immobilization with Ketamine HCI and Tiletamine-Zolazepam in Cynomolgus Monkeys
Myung-cheol Kim,Sung-hyeok Hong,Soo-jin Lee,Young-suk Kim,Jae-il Lee 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2
with Ketamine HCl and Tiletamine-Zolazepam in Cynomolgus MonkeysJae-il Lee, Sung-hyeok Hong, Soo-jin Lee, Young-suk Kim and Myung-cheol Kim*Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, KoreaReceived March 4, 2003 / Accepted July 2, 2003J. Vet. Sci. (2003), 4(2), 187-191JOURNAL OFVeterinaryScience*Corresponding author: Myung-cheol Kim Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea Tel: +82-42-821-6757, Fax: +82-42-822-4216 E-mail: mckim@cnu.ac.kr
한국형발사체 3단 과산화수소 추력기시스템 제어장치 아날로그 데이터 취득 스케줄링 변경을 통한 노이즈 측정오류 개선
이상현(Sang-Hyun Lee),송우근(Woo-Keun Song),오현명(Hyun-Myung Oh),이정운(Jung-Un Lee),이종철(Jong-Cheol Lee),박상준(Sang-Joon Park),이상빈(Sang-Bin Lee),이희중(Hee-Joong Lee),오상관(Sang-Gwan Oh),민병주(Byeong-Joo Min) 한국항공우주학회 2020 한국항공우주학회 학술발표회 논문집 Vol.2020 No.11
Lee, Young Ho,Bae, Sang-Cheol,Song, Gwan Gyu Acta Medica Belgica ; Springer London 2015 CLINICAL RHEUMATOLOGY Vol.34 No.4
<P>The aim of this study was to determine whether the prolactin -1149 G/T polymorphism confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted for examining the associations between prolactin -1149 G/T polymorphism and susceptibility to SLE or RA using allele contrast, recessive and dominant models, and homozygote contrast. A total of 10 comparative studies, consisting of 4 SLE and 6 RA studies, involving 4252 patients and 4949 controls, were included in the meta-analysis. No association between the prolactin -1149 G allele and SLE was found when all study subjects were considered together (OR?=?1.019, 95 % CI?=?1.841-1.236, p?=?0.845). Stratification by ethnicity also indicated no association between the prolactin G allele and SLE in either Caucasian or Latin American populations. In contrast, a significant association was observed between the prolactin G allele and RA in all subjects (OR?=?1.123, 95 % CI?=?1.052-1.198, p?=?4.6??10(-5)). After stratification by ethnicity, the G allele was found to be significantly associated with RA in Caucasians (OR?=?1.112, 95 % CI?=?1.041-1.189, p?=?0.002). Furthermore, the prolactin -1149 G/T polymorphism was found to be associated with RA in Caucasians under the dominant model and under homozygote contrast. This meta-analysis demonstrates that the prolactin -1149 G/T polymorphism is associated with susceptibility to RA, but not SLE, in Caucasians.</P>
Lee Seung Won,Kim Hayeon,Byun Youngjoo,Baek Yoo Sang,Choi Cheol Ung,Kim Jae Hyun,Kim Kyungim 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.2
Purpose: Despite increasing evidence for the potential association between atopic dermatitis (AD) and cardiovascular diseases (CVDs), results have still remained controversial. Therefore, this study investigated the association between AD and subsequent CVDs in adults newly diagnosed with AD. Methods: Datasets from the National Health Insurance Service-National Sample Cohort in South Korea from 2002 to 2015 were analyzed. The primary outcome was new-onset CVD, which included angina pectoris, myocardial infarction, stroke, or any revascularization procedure. The crude and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated in the AD group compared with the matched control group using the Cox proportional hazards regression models. Results: A total of 40,512 individuals with AD were matched with 40,512 control subjects without AD. The overall incidence of CVDs was 2,235 (5.5%) and 1,640 (4.1%) in the AD and matched control groups, respectively. In the adjusted model, AD was associated with an increased risk of CVDs (HR, 1.42; 95% CI, 1.33–1.52), angina pectoris (adjusted HR, 1.49; 95% CI, 1.36–1.63), myocardial infarction (adjusted HR, 1.40; 95% CI, 1.15–1.70), ischemic stroke (adjusted HR, 1.34; 95% CI, 1.20–1.49), and hemorrhagic stroke (adjusted HR, 1.26; 95% CI, 1.05–1.52). Most of the subgroup and sensitivity analysis results were consistent with those of the main analysis. Conclusions: The current study found that adult patients newly diagnosed with AD were at significantly increased risk for subsequent CVDs, suggesting the need to consider early prevention strategies for CVDs targeting patients with AD.
Sung-Cheol Koh(고성철),Sung-Woo Shin(신성우),Hyun-Duk Cho(조현덕),Tae-Soo Chon(전태수),Jong-Sang Kim(김정상),Sung-Kyu Lee(이성규) 환경독성보건학회 2009 환경독성보건학회지 Vol.24 No.4
본 연구의 목적은 다이아지논(Diazinon; O, O-diethyl O-[6-methyl-2 (1-methylethyl)-4-pyrimidinyl] phosphorothioate)에 노출된 모델 생물체(송사리)의 행동변화와 관련된 분자생물학적 기전 규명을 통하여 비정상적 행동의 모니터링을 위한 생물지표(biomarker)를 개발하는데 있다. 이를 위해 우선 suppression subtractive hybridization (SSH) 및 DNA microarray 기법을 활용하여 다양한 유전자를 스크리닝하였다. 다이아지논에 노출시킨 송사리에서 발현의 차이가 나는 상향 조절된 유전자 97개 (알려지지 않은 유전자 27개 포함)와 하향 조절된 유전자 99개 (알려지지 않은 유전자 60개 포함)를 동정 하였고 이들 중 이상행동과 관련되는 것으로 보이는 유전자 10개 (상향조절 5개, 하향조절 5개)를 선발하였다. 이들 중에서 primer 제작이 잘된 beta-1, Orla C3-1, parvalbumin 및 apolipoprotein E을 선발하여 그 유전자 발현을 real-time PCR 기법을 사용하여 정량적으로 모니터링 하였다. Orla C3-1, parvalbumin 및 apolipoprotein E는 고농도의 다이아지논 처리(1000 ppb; 24 h)에서 그 발현이 억제됨이 관찰되었다. 다이아지논 처리 시 신경질환 (알츠하이머 병 및 다운신드롬)에 관련된 apolipoprotein E와 근육세포의 유연화에 작용하는 parvalbumin 등의 발현억제는 송사리의 인지능력 교란 및 근육세포의 경직 등을 각각 유도하여 송사리의 비정상적 행동을 야기하는 것으로 판단되었다. 따라서 이들 생물지표는 신경독성물질에 의한 송사리 및 기타 어류의 이상행동의 변화의 감지에 활용될 수 있을 것으로 사료된다.
Lee, Sung-Hyun,Park, Junbeom,Kim, Hye-Rim,Lee, Taeseon,Lee, Jaegeun,Im, Yong-O.,Lee, Cheol-Hun,Cho, Hyunjung,Lee, Hyeseon,Jun, Chi-Hyuck,Ahn, Yu-Chan,Lee, In-Beum,Lee, Kun-Hong Elsevier 2016 Carbon Vol.100 No.-
<P>The optimum synthesis conditions for carbon nanotube (CNT) fibers were investigated using the Design of Experiment (DOE) technique. Direct spinning processes are governed by a variety of experimental factors: the methane flow rate, ferrocene flow rate, sulfur flow rate, hydrogen flow rate, water flow rate, and reaction temperature. The process was optimized in two stages that addressed first the Fractional Factorial Design (FFD) and then the Response Surface Methodology (RSM). Results from each experiment were classified according to a 6-step rating system: nothing(1), black gas(2), dust(3), ribbon or film(4), fiber(5), or continuous fiber(6). In the first step, three major factors (methane, sulfur, temperature) were identified as important among the six experimental factors tested using FFD. The effects of the major factors and the interactions were analyzed through the main effect plot and the interaction plot. In the second step, the experimental conditions were optimized using a model equation derived from Box-Behnken design experiments. Finally, the CNT fibers were continuously synthesized under the optimum conditions. The synthesized CNT fibers mainly consisted of single-walled CNTs (SWCNTs) 1.2 -3.8 nm in diameter. The I-G/I-D ratio of the CNT fibers was 48. This work provides a useful methodology for synthesizing the CNT fibers. (C) 2016 Elsevier Ltd. All rights reserved.</P>