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Minhyung Jung,Po-Hyun Park,Young-Ran Joo,Lee-Hyeon Sin,Uk-Gyo Lee,Doo-Hyung Lee 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04
Seasonal abundance and distribution of mosquitoes and chigger mites are important for human populations. However, factors affecting the abundance and distribution of vector species are not well - understood. Furthermore, global climate change makes it difficult to predict the population dynamics of vector species. Therefore, it is important to monitor this vector species over a long period of time. In 2015, mosquitoes were collected from three potential mosquito habitats using black light trap and BG-Sentinel trap in Gyeongi-do in April through October. Also, we collected chigger mite using sherman live traps in Cheorwon, Gangwon-do in April, September and October. From the survey, we collected a total of 11,649 mosquitoes in three potential mosquito habitats, and a total of 3,656 chigger mites from 54 wild rodents. In the samples, dominant mosquito species were Aedes vexans nipponii (Species Ratio 70%), Culex pipens pallens (SR 9.8%) in Gyeonggi area and dominant chigger mite species was Leptotrombidium pallidium (SR 59%) in Cheorwon. The results of this study can serve as provide fundamental basis to develop effective management strategy under the global climate change environment.
Seasonal abundance of mosquito species in diverse habitat types in Gyeonggi-do, South Korea
Minhyung Jung,Po-Hyun Park,Young-Ran Joo,Lee-Hyeon Sin,Uk-Gyo LeeUk-Gyo Lee,Doo-Hyung Lee 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10
Mosquitoes are vectors of many human diseases such as Japanese encephalitis, vivax malaria, west nile fever, dengue fever and yellow fever. However, factors affecting the abundance and distribution of mosquitoes are not well-understood. Moreover, the global climate change makes it even more difficult to address and predict the population dynamics of mosquitoes. Therefore, it is important to monitor this medically-important pest throughout landscapes over a long period of time. This study was conducted as a part of the nation-wide surveillance program to monitor insect vectors. In 2015, mosquitoes were collected using black light traps and BG-Sentinel traps in Gyeonggi-do at every two weeks from April to September. Three types of potential mosquito habitats were selected for surveillance: urban area (Suwon), cattle shed (Yongin) and wild bird refuge (Gwangju). Among the three habitats, female mosquitoes were first caught on April 4 by BG-Sentinel trap in the urban area. The highest density of female mosquitoes in the traps was recorded in July in the urban area (134 ± 84 per trap); the highest density was observed in June in the cattle shed (2473 ± 1319) and wild bird refuge (21 ± 15) (mean ± SE). The dominant mosquito species were Culex pipens pallens (91%), Aedes vexans nipponii (79%) and Anopheles sinensis (33%) in the urban area, cattle shed and wild bird refuge, respectively. The results of this study indicate that female mosquitoes were most abundant in the cattle shed habitat type. It is also noteworthy that the dominant mosquito species varied among the habitat types surveyed. This nation-wide monitoring program for medical pests will provide fundamental basis to develop effective management strategy under the global climate change environment.
Lee, Dahee,Choi, Eunji,Lee, Jaewon,Oh, Jungju,Lee, Seonyeong,Lee, Minhyung THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2018 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.67 No.-
<P><B>Abstract</B></P> <P>Receptor for advanced glycation end-products (RAGE) is overexpressed in various cancer cells. In this study, a RAGE-binding peptide (RBP) was conjugated to polyethylenimine (25kDa, PEI). RBP-conjugated PEI (PEI-RBP) was characterized as a dual-functional reagent, a RAGE-mediated gene carrier and an anti-angiogenic reagent. As a gene carrier, PEI-RBP had higher transfection efficiency to the C6 glioblastoma cells than PEI. As an anti-angiogenic reagent, the pEmpty/PEI-RBP complex reduced RAGE expression on the surface of the C6 glioblastoma cells. Also, the complex reduced the VEGF expression and tube formation of endothelial cells. Therefore, PEI-RBP may be useful for development of glioblastoma therapy.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
BES를 이용한 연동형 온실의 냉 · 난방 부하 산정 및 PV 시스템 발전 성능 분석
이민형(Minhyung Lee),이인복(In-Bok Lee),하태환(Tae-Hwan Ha),김락우(Rack-Woo Kim),여욱현(Uk-Hyeon Yeo),이상연(Sang-Yeon Lee),박관용(Gwanyong Park),김준규(Jun-Gyu Kim) (사)한국생물환경조절학회 2017 생물환경조절학회지 Vol.26 No.4
The price competitiveness of photovoltaic system (PV system) has risen recently due to the growth of industries, however, it is rarely applied to the greenhouse compared to other renewable energy. In order to evaluate the application of PV system in the greenhouse, power generation and optimal installation area of PV panels should be analyzed. For this purpose, the prediction of the heating and cooling loads of the greenhouse is necessary at first. Therefore, periodic and maximum energy loads of a multi-span greenhouse were estimated using Building Energy Simulation(BES) and optimal installation area of PV panels was derived in this study. 5 parameter equivalent circuit model was applied to analyzed power generation of PV system under different installation angle and the optimal installation condition of the PV system was derived. As a result of the energy simulation, the average cooling load and heating load of the greenhouse were 627,516MJ and 1,652,050MJ respectively when the ventilation rate was 60AE·hr<SUP>-1</SUP>. The highest electric power production of the PV system was generated when the installation angle was set to 30°. Also, adjustable PV system produced about 6% more electric power than the fixed PV system. Optimal installation area of the PV panels was derived with consideration of the estimated energy loads. As a result, optimal installation area of PV panels for fixed PV system and adjustable PV system were 521m² and 494m² respectively.
Lee, Minhyung,Choi, Joon Sig,Choi, Min Ji,Pak, Youngmi Kim,Rhee, Byoung Doo,Ko, Kyung Soo Informa Healthcare 2007 JOURNAL OF DRUG TARGETING Vol.15 No.2
<P> Some genetic diseases are associated with the defects of the mitochondrial genome. Direct DNA delivery to the mitochondrial matrix has been suggested as an approach for mitochondrial gene therapy for these diseases. We hypothesized that a mitochondrial leader peptide (LP) conjugated polyethylenimine (PEI) could deliver DNA to the mitochondrial sites. PEI-LP was synthesized by the conjugation of LP to PEI using disulfide bond. The complex formation of PEI-LP with DNA was confirmed by a gel retardation assay. In this study, DNA was completely retarded at a 0.4/1 PEI-LP/DNA weight ratio. In vitro delivery tests into isolated mitochondria or living cells were performed with rhodamin-labeled DNA and PEI-LP. In vitro cell-free delivery assay with isolated mitochondria showed that PEI-LP/DNA complexes were localized at mitochondria sites. Furthermore, the PEL-LP/DNA complexes were localized at the mitochondrial sites in living cells. However, a control carrier, PEI, did not show this effect. In addition, MTT assay showed that PEI-LP showed lower cytotoxicity than PEI. These results suggest that PEI-LP can deliver DNA to the mitochondrial sites and may be useful for the development of mitochondrial gene therapy.</P>
Lee, Minhyung,Ryu, Ji-Kan,Piao, Shuguang,Choi, Min Ji,Kim, Hyun Ah,Zhang, Lu-Wei,Shin, Hwa-Yean,Jung, Haeng In,Kim, In-Hoo,Kim, Sung Wan,Suh, Jun-Kyu Blackwell Pub 2008 JOURNAL OF SEXUAL MEDICINE Vol.5 No.6
<P>The application of gene therapy for a nonlife-threatening disease, such as erectile dysfunction (ED), requires a higher safety level and more efficacious systems for gene transfer.</P>
Vortex-Induced Vibrations of a Circular Cylinder at Low Reynolds Numbers
Lee, Minhyung,Lee, Sung-Yeoul The Korean Society of Mechanical Engineers 2003 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.17 No.11
The vortex-induced vibrations of a circular cylinder at low Reynolds (Re) numbers are simulated by applying a method of the two-dimensional computational fluid dynamics coupled with the structural dynamics based on the multi-physics. The fluid solver is first tested on the case of a fixed cylinder at Re$\leq$160, and shows a good agreement with the previous high-resolution numerical results. The present study then reports on the detailed findings concerning the vibrations of an elastic cylinder with two degrees of translational freedom for a number of cases in which Re is fixed at 200, a reduced damping parameter Sg=0.01, 0.1, 1.0, 10.0 and the mass ratio M$\^$*/ = 1, 10.
Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
Lee, Jason S.,Kim, Yunho,Kim, Ik Soo,Kim, Bogyou,Choi, Hee June,Lee, Ji Min,Shin, Hi-Jai R.,Kim, Jung Hwa,Kim, Ji-Young,Seo, Sang-Beom,Lee, Ho,Binda, Olivier,Gozani, Or,Semenza, Gregg L.,Kim, Minhyung Elsevier 2010 Molecular cell Vol.39 No.1
<P><B>Summary</B></P><P>Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia.</P> <P><B>Highlights</B></P><P>► Reptin is a target of G9a methyltransferase ► Reptin K67 methylation is induced by hypoxia ► Genome-wide identification of hypoxia target genes negatively regulated by Reptin ► Hypoxia-driven Reptin methylation negatively regulates tumorigenic behavior in vivo</P>