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Increased serum thymic stromal lymphopoietin in children with atopic dermatitis
Lee, Eun Byoul,Kim, Kyung Won,Hong, Jung Yeon,Jee, Hye Mi,Sohn, Myung Hyun,Kim, Kyu-Earn Blackwell Publishing Ltd 2010 Pediatric allergy and immunology Vol.21 No.2
<P>Lee EB, Kim KW, Hong JY, Jee HM, Sohn MH, Kim K-E. Increased serum thymic stromal lymphopoietin in children with atopic dermatitis.Pediatr Allergy Immunol 2010: 21: e457–e460.© 2010 John Wiley & Sons A/S</P><P>The present study investigated the relationship between serum thymic stromal lymphopoietin (TSLP) levels and the presence and severity of atopic dermatitis (AD). Serum TSLP levels, blood eosinophil counts, and serum total and specific immunoglobulin E (IgE) levels were measured in 232 children. Subjects were characterized as having atopic eczema (AE; n = 75), non-atopic eczema (NAE; n = 70), or normal controls (n = 87). Serum TSLP levels in children with AD were significantly higher than normal controls but there were no differences in children with atopic and non-atopic eczema. However, serum TSLP levels in children with AD were not significantly correlated with disease severity, blood eosinophil counts and serum total IgE levels. Our findings show an association between TSLP and AD including both AE and NAE. It is suggested that TSLP may play a contributory role in the pathogenesis of AD regardless of the presence of atopy.</P>
이은별(Eun Byoul Lee),허윤정(Yun Jung Hur),김세훈(Se Hoon Kim),김동석(Dong Seok Kim),이승구(Seung Koo Lee),김흥동(Heung Dong Kim),이준수(Joon Soo Lee) 대한소아신경학회 2007 대한소아신경학회지 Vol.15 No.1
목 적: 난치성 간질로 뇌엽 절제술을 받은 환자의 조직병리 소견상 피질 이형성증과 미세발생이상으로 분류되는 환자들의 임상양상과 뇌파, 영상학적 검사결과를 비교 고찰하여 진단에 도움이 되고자 하였다. 방 법: 2003년 10월부터 2006년 9월까지 난치성 간질로 연세대학교 세브란스병원에 입원하여 뇌엽절제술 시행 후 병리학적으로 피질 이형성증으로 확인된 11명과 미세발생이상으로 확인된 16명의 소아을 대상으로 후향적 의무기록 고찰과 분석을 시행하여 임상양상, 병변 위치, 뇌파, 뇌 자기공명영상, 수술 예후에 대하여 조사하였다. 결 과: 1) 임상 양상 : 피질 이형성증 환자와 미세발생이상 환자 모두 남아의 비율이 높았으며 난치성 간질을 보이는 연령이나 경련 양상, 경련의 빈도 등의 차이는 없었다. 수술 시 피질이형성증 환자의 83.3%(5/6), 미세발생이상 환자의 69.2%(9/13)에서 역연령 수준에 대하여 70% 미만의 발달 지연을 보였다. 2) 뇌파 소견 : 대뇌피질 발달 기형 부위에서 보이는 뇌파 소견은 피질 이형성증과 미세발생 이상에서 공통적으로 국소적 서파, 예파, 국소적인 속파순으로 나타났으며 각 군에서만 보이는 특징적인 소견은 없었다. 3) 영상학적 검사 결과 : 자기공명영상에서 국소적인 피질 두께 증가, 백질과 회질의 경계가 불분명한 소견, 기저 백질 부위에 신호 강도 변화, T2 강조영상에서 신호 강도 증가는 피질 이형성증을 시사하는 소견으로, 피질 이형성증 환자의 81.8%(9/11), 미세발생이상 환자의 43.8%(7/16)에서 병변 부위에 이러한 소견이 나타났으나, 피질 이형성증 환자의 18.2%(2/11), 미세발생이상 환자의 37.5%(6/16)는 정상 소견을 보였다. PET 검사가 병변을 국소화하는데 있어 자기공명영상보다 높은 진단양성율을 보였다. 4) 대뇌피질 발달기형 부위 : 대뇌피질 발달기형의 부위는 피질 이형성증과 미세발생이상 모두 전두엽에 가장 높은 빈도를 보였으며 관자엽이 그 다음이었다. 5. 수술 후 결과 : 수술 후 예후는 피질 이형성증 환자의 81.8%(9/11), 미세발생이상 환자의 68.7%(11/16)에서 발작 소실 상태를 유지하였고, MCD의 부위가 수술 후 예후에 영향을 주지 않음을 확인하였으며, 수술 후 발달 지연에 대한 평가가 이루어진 환자 모두에서 발달 지연의 호전을 보였다. 결 론: 본 연구에서 피질 이형성증과 미세발생이상은 대뇌피질 발달 기형의 정도에 따른 조직병리학적 분류로, 임상양상, 특징적인 뇌파소견, 병변 부위, 뇌파, 뇌 자기공명영상 소견에서 두 군간의 유의한 차이는 없었다. 수술 후 예후는 피질 이형성증 환자가 더 좋았으나 통계적으로 유의하지는 않았고, 수술 후 피질 이형성증과 미세발생이상 모두에서 발달 지연의 호전을 보였다. Purpose : The diagnosis of cortical dysplasia(CD) and microdysgenesis(MD) is valuable because they often cause childhood intractable epilepsy. This study is to analyze clinical manifestations, EEG findings, and imaging features based on the pathologic diagnosis(cortical dysplasia and microdysgenesis) in childhood intractable epilepsy with surgical treatment. Methods : We performed retrospective studies and analyzed 27 patients with MCD diagnosed by pathologic findings after brain lobectomy for intractable epilepsy from October 2003 to September 2006 in our hospital. We compared their clinical characteristics, EEGs, neuroimaging studies including MRI, and FDG-PET. We analyzed the locations of malformations of cortical development(MCD). The surgical outcomes were reviewed. Results : There were no pathognomonic seizure types or EEG findings for microdysgenesis. The clinical and EEG features of microdysgenesis were similar to those of cortical dysplasia. Only 6(37 percent) out of 16 microdysgenesis patients showed normal MRI findings and also 2(18 percent) out of 10 cortical dysplasia patients showed normal MRI findings. The most common location of MCD was frontal lobe in both of the groups, followed by temporal lobe. 10(63%) out of 16 microdysgenesis patients and 9 (90%) out of 10 cortical dysplasia patients became seizure free. The locations of MCD was not related to the prognosis of the outcomes. All the patients who had had developmental delay showed improvement in development after the surgery. Conclusion : There were no significant differences in gender, seizure onset age, duration of seizures, seizure types, EEG findings, and MCD locations between CD and MD. The seizure outcomes were better in CD than in MD. All the patients whose pre- and post-oprative developmental status were compared showed developmental improvement.
Cancer Chemopreventive Effects of Korean Seaweed Extracts
Saet Byoul Lee,Joo Young Lee,Dae-Geun Song,Cheol-Ho Pan,Chu Won Nho,Min Cheol Kim,Eun Ha Lee,Sang Hoon Jung,Hyung-Seop Kim,Yeong Shik Kim,Byung Hun Um 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.3
Cancer chemopreventive effects can be exerted through the induction of phase II detoxification enzymes and the inhibition of inflammatory responses. In this study, the cancer chemopreventive effects and anti-inflammatory responses of 30 seaweed extracts were examined. The extracts of Dictyota coriacea and Cutleria cylindrica exhibited the high chemoprevention index, having 4.36 and 4.66, respectively. They also activated antioxidant response element at 100 μg/mL by about 3-fold while did not activate xenobiotic response element. Seven seaweed extracts, Ishige okamurae, Desmarestia ligulata, Desmarestia viridis, Dictyopteris divaricata, D. coriacea, Sargassum horneri, and Sargassum yezoense, showed significant inhibition on nitric oxide (NO) and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) production in a dose-dependant manner in 5-20 μg/mL. These seaweed extracts could be used as food materials for cancer chemoprevention. D. coriacea could contain potential chemopreventive agents not only that regulate genes via an ARE-dependent mechanism but also prevent the inflammation through inhibition of NO and PGE<sub>2</sub> production.
2022 Clinical practice guidelines for central precocious puberty of Korean children and adolescents
Kim Su Jin,Kim Ji Hyun,Hong Yong Hee,Chung In Hyuk,Lee Eun Byoul,Kang Eungu,Kim Jinsup,Yang Aram,Rhie Young-Jun,Yoo Eun-Gyong,Shin Young-Lim,Choi Jin Ho,Kim Soo Young,Lee Ji Eun 대한소아내분비학회 2023 Annals of Pediatirc Endocrinology & Metabolism Vol.28 No.3
The Committee of Central Precocious Puberty of Korean Pediatrics and Adolescents of the Korean Society of Pediatric Endocrinology has newly developed evidence-based 2022 clinical practice guidelines for central precocious puberty in Korean children and adolescents. These guidelines provide the grade of recommendations, which includes both the strength of recommendations and the level of evidence. In the absence of sufficient evidence, recommendations are based on expert opinion. These guidelines have been revised and supplement the previous guidelines "Clinical Guidelines for Precocious Puberty 2011," and are drawn from a comprehensive review of the latest domestic and international research and the grade of recommendation appropriate to the domestic situation. This review summarizes the newly revised guidelines into 8 key questions and 27 recommendations and consists of 4 sections: screening, diagnosis, treatment, and long-term outcome of central precocious puberty.
Do we have to test hemoglobin level routinely after total laparoscopic hysterectomy?
( Yunjin Park ),( In Ok Lee ),( Jung-yun Lee ),( Eun Ji Nam ),( Han Byoul Cho ),( Sang Wun Kim ),( Jae-hoon Kim ),( Young Tae Kim ),( Sunghoon Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: Routine checking of hemoglobin (Hb) level after total laparoscopic hysterectomy (TLH) has been questioned by researchers. Postoperative Hb might help to find out patients who need intervention to correct postoperative anemia. The aim of this study is to investigate perioperative factors affecting to postoperative intervention and cut-off values of the factors for predicting the patients' probability of receiving postoperative intervention. 방법: Medical records of patients who underwent elective TLH in our institution from January 2012 to December 2014 were reviewed. Patients who had intraoperative complications including vaginal laceration, bladder rupture or received transfusion during the operations were excluded. Women who received transfusion or took iron agent before the operations were also excluded. Patients with or without postoperative intervention were classified. Postoperative intervention included intravenous or oral iron agent, transfusion, abdomino-pelvic computer tomography scan, and reoperation. 결과: A total of 966 women underwent TLH during study period. 265 patients (27.4%) were received postoperative intervention. Patients with postoperative intervention had lower preoperative and postoperative Hb level, longer operation time, heavy uterine weight and blood loss during operation compared with patients without postoperative intervention. (p<0.001) Analysis by subgroup divided by preoperative Hb level revealed that lower preoperative Hb level was related with smaller decrease of Hb level after operation and greater opportunity to receive postoperative intervention. (p<0.001) Cutoff value of preoperative Hb level for predicting the patients' probability of receiving postoperative intervention was 10.1 g/dL with an area under curve (AUC) of 0.837. (sensitivity: 0.343, specificity: 0.967) 결론: Possibility of having postoperative intervention after TLH is affected by not decreasing amount of Hb levels but absolute value of Hb level. Patients, whose preoperative Hb level was below 10.1g/dL, had strong possibility to take postoperative intervention to correct postoperative anemia.
Tip-Enhanced Raman Scattering with a Nanoparticle-Functionalized Probe
Park, Chan-Gyu,Kim, Ju-Young,Lee, Eun-Byoul,Choi, Han-Kyu,Park, Won-Hwa,Kim, Jin-Wook,Kim, Zee-Hwan Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.5
We carried out the tip-enhanced Raman scattering (TERS) with a tip that is functionalized with a Aunanoparticle (AuNP, with a diameter of 250 nm). The AuNP tip is fabricated by a direct mechanical pickup of a AuNP from a flat substrate, and the TERS signal from the AuNP tip - organic monolayer - Au thin film (thickness of 10 nm) is recorded. We find that such a AuNP-tip interacting with a thin film routinely yields signal enhancement larger than ${\sim}10^4$, which is sufficient not only for local (with detection area of ~200 $nm^2$) Raman spectroscopy, but also the nanometric imaging of organic monolayers within a reasonable acquisition time (~20 minutes/image).