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Lee, Sang-Eok,Lee, Jun-Ho,Ryu, Keun-Won,Nam, Byung-Ho,Cho, Soo-Jeong,Lee, Jong-Yeul,Kim, Chan-Gyoo,Choi, Il-Ju,Kook, Myeong-Cherl,Park, Sook-Ryun,Kim, Young-Woo The Korean Gastric Cancer Association 2012 Journal of gastric cancer Vol.12 No.2
Purpose: The aim of the present study was to assess the association between the pre-operative plasma fibrinogen level and the adjacent organ involvement in advanced gastric cancer. Materials and Methods: A total of 923 pre-operative plasma samples were obtained from 923 patients diagnosed clinically as having advanced gastric cancer, and fibrinogen levels were measured by immunoassay. Associations between fibrinogen levels and clinicopathologic findings (depth of tumor, adjacent organ involvement, and lymph node metastasis), along with survival were examined by univariate and multivariate analyses. Results: Tumor size, tumor depth, and the presence of lymph node metastasis were found to be positively correlated with the preoperative plasma fibrinogen levels (P<0.001). Fifty (5.4%) patients had adjacent organ involvement. Lymphatic invasion (P<0.001), tumor size (P<0.001), clinical T (depth of invasion) stage (P<0.001), and clinical nodal stage (P=0.018) were found to be associated with adjacent organ involvement. Univariate and multivariate regression analyses showed that a preoperatively elevated plasma fibrinogen level was associated with adjacent organ involvement (P<0.001, 0.028), and Kaplan-Meier analysis showed that it was associated with poorer survival (P<0.001). Conclusions: Plasma fibrinogen was found to be a clinically useful marker of adjacent organ involvement and overall survival. When a high fibrinogen level is encountered, preoperatively, adjacent organ involvement should be suspected in clinically advanced gastric cancer.
Sentinel Node Mapping and Skip Metastases in Patients with Early Gastric Cancer
Lee, Sang Eok,Lee, Jun Ho,Ryu, Keun Won,Cho, Soo Jeong,Lee, Jong Yeul,Kim, Chan Gyoo,Choi, Il Ju,Kook, Myung Cherl,Nam, Byung-Ho,Park, Sook Ryun,Lee, Jong Seok,Kim, Young-Woo Springer - Society of Surgical Oncology 2009 Annals of surgical oncology Vol.16 No.3
Lee, Jun Ho,Ryu, Keun Won,Lee, Jong Seok,Lee, Jong Ryeol,Kim, Chan Gyoo,Choi, Il Ju,Park, Sook Ryun,Kook, Myeong-Cherl,Kim, Young-Woo,Bae, Jae-Moon A. R. Liss, inc., etc 2007 Journal of surgical oncology Vol.95 No.6
<B>Background and Objectives</B><P>There is a prevailing belief that young patients with gastric adenocarcinomas have a more aggressive disease.</P><B>Methods</B><P>We reviewed the prospectively collected database of 753 gastric adenocarcinomas patients who had undergone curative gastrectomy. Clinicopathological factors and the survival rates for each pathological TNM stage were compared between patients younger than 40 years of age and the others.</P><B>Results</B><P>Fifty-four (9.8%) patients were younger than 40 years of age. The overall accuracy of the intra-operative stage was 62.5%; 54.0% in the young patients and 63.5% in older patients (P = 0.006). Intraoperative under-staging was more commonly seen in the younger patients when compared to the older patients. These trends were more prominent in patients with surgical stage I disease. Age proved to be an independent risk factor influencing the accuracy of intraoperative staging using a logistic regression analysis. There was no difference in overall 3-year survival rate between the two age groups for each pathological TNM stage.</P><B>Conclusions</B><P>The present study showed that intra-operative under-staging was more common in young patients with gastric cancer, especially with stage I disease. This finding raises the concern for inaccurate diagnosis and surgical under treatment in younger patients with stage I gastric cancer. J. Surg. Oncol. 2007; 95: 485–490. © 2006 Wiley-Liss, Inc.</P>
Developing an Institutional Protocol Guideline for Laparoscopy-Assisted Distal Gastrectomy
Lee, Sang Eok,Kim, Young-Woo,Lee, Jun Ho,Ryu, Keun Won,Cho, Soo Jeong,Lee, Jong Yeul,Kim, Chan Gyoo,Choi, Il Ju,Kook, Myeong-Cherl,Nam, Byung-Ho,Park, Sook Ryun,Kim, Min Ju,Lee, Jong Seok Springer - Society of Surgical Oncology 2009 Annals of surgical oncology Vol.16 No.8
Feasibility of laparoscopic sentinel basin dissection for limited resection in early gastric cancer
Lee, Jun Ho,Ryu, Keun Won,Kook, Myeong-Cherl,Lee, Jong Yeul,Kim, Chan Gyoo,Choi, Il Ju,Kim, Seok-Ki,Jang, Seyoun,Park, Sook Ryun,Kim, Young Woo,Nam, Byung-Ho,Bae, Jae-Moon Wiley Subscription Services, Inc., A Wiley Company 2008 Journal of surgical oncology Vol.98 No.5
<B>Background</B><P>The clinical applications of sentinel node (SN) biopsies in early gastric cancer are limited because of low sensitivity. Sentinel basin (SB) dissection has been suggested as alternative to SN biopsy to improve sensitivity. The aim of this study was to examine the feasibility of laparoscopic SB dissection.</P><B>Methods</B><P>Twenty-one gastric adenocarcinoma patients of cT1N0 were enrolled. Technetium 99 m human serum albumin and indocyanine green were injected into the submucosal layer around tumor using an intraoperative endoscope. Green-stained or radioactive lymphatic basins were detected and defined as SBs. After laparoscopic SB dissection, laparoscopy-assisted gastrectomy with D2 lymphadenectomy was performed. Dissected SB nodes and non-SB nodes were evaluated for metastasis pathologically.</P><B>Results</B><P>The SB detection rate was 95.2%. Numbers of SBs were one in 6, two in 10, and three in 4 patients. The mean number of SB nodes was 7.0. Two patients with lymph node metastasis were diagnosed by SB dissection. Mean time of laparoscopic SB dissection procedure was 15.2 min.</P><B>Conclusions</B><P>Above findings suggest that laparoscopic SB dissection is technically feasible, and it might have better sensitivity than SN biopsy. However, the validity of this procedure should be evaluated in a larger series before being clinically applied. J. Surg. Oncol. 2008;98:331–335. © 2008 Wiley-Liss, Inc.</P>
Lee, Sang Eok,Ryu, Keun Won,Nam, Byung Ho,Lee, Jun Ho,Kim, Young-Woo,Yu, Jun Sik,Cho, Soo Jeong,Lee, Jong Yeul,Kim, Chan Gyoo,Choi, Il Ju,Kook, Myeong Cherl,Park, Sook Ryun,Kim, Min Ju,Lee, Jong Seok Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of surgical oncology Vol.100 No.5
<B>Background and Objective</B><P>Only a few surgeons with much experience of laparoscopic surgery perform laparoscopy-assisted total gastrectomy (LATG), because of its technical difficulty and concern about subsequent complications. The aim of this study was to evaluate the technical feasibility and safety of LATG as compared with laparoscopy-assisted distal gastrectomy (LADG) in gastric cancer.</P><B>Methods</B><P>From January 2002 to December 2007, LADG was performed in 473 patients and LATG in 67 patients at the Korean National Cancer Center. Surgical procedures and short-term surgical outcomes of LATG were analyzed.</P><B>Results</B><P>D2 lymph node dissection was performed in 35 LATG (52.2%) cases and in 274 LADG (57.9%) cases (P = 0.378). Mean blood losses during operation were 156.8 ± 158.0 ml and 190.7 ± 176.2 ml, respectively (P = 0.114). The open conversion rate for LATG was higher than LADG without significance (4.3% vs. 1.7%, P = 0.153). Complications occurred in 18 LATG cases (26.9%) and 38 LADG cases (8.0%) (P < 0.001). The most common postoperative complication of LATG was anastomotic stricture after esophagojejunostomy.</P><B>Conclusions</B><P>LATG is a technically feasible procedure as compared with LADG. However, its postoperative complication rate is higher than that of LADG, especially that of anastomotic stricture. A more effective anastomotic method during LATG is required to prevent stricture. J. Surg. Oncol. 2009;100:392–395. © 2009 Wiley-Liss, Inc.</P>
Comparative analysis of human facial skin microbiome between topical sites compared to entire face
Lee Haeun,Jeong Jinuk,Oh Yunseok,Lee Cherl-Jun,Mun Seyoung,Lee Dong-Geol,Jo HyungWoo,Heo Young Mok,Baek Chaeyun,Heo Chan Yeong,Kang So Min,한규동 한국유전학회 2021 Genes & Genomics Vol.43 No.12
Background Skin is an essential outer barrier and supports the growth of commensal microorganisms that protects a host from the ofense of foreign toxic organisms. With the rapid development of next-generation sequencing (NGS)-based applications, skin microbiome research for facial health care has reached industry growth, such as therapy and cosmetic product development. Despite the acceleration of skin microbiome research, experimental standardization protocol has not yet been established in the facial site and method of sampling. Objective Thus, we aimed to investigate the diferences in microbial composition at each facial site (cheek, mouth, forehead, and entire face) using comprehensive microbiome analysis. Methods Twelve specimens from three men (four specimens per one person) were collected. The hypervariable regions (V3–V4) of the bacterial 16S rRNA gene were targeted for 16S amplicon library construction and classifcation of bacterial taxonomy. Skin microbial composition for all specimens was investigated, and the diferences site-by-site in skin microbial composition were analyzed and evaluated by the various statistical tests. Results We were able to validate the independent correlation between the skin microbiome composition and the facial sites. The cheek site showed the highest alpha-diversity in richness and evenness scores compared to the forehead and mouth. The cheek and mouth sites showed a positive correlation (R2 value>0.93) with the entire face, while the forehead sites were negatively correlated (R2 value<0.2). Given the relative abundance based on statistical correlation analysis, we estimated that the cheek site could be considered an optimal topical site to replace the entire face. Conclusion Our study suggests that skin microbiome profling of four facial sites confrms that the cheek shows the most similar skin fora with the entire face. This study would be informative for preventing bias caused by sampling methods before researching and understanding skin cosmetics development or skin diseases.
이병선,김인준,이수전,황유라,정원찬,김재훈,김해연,이훈희,이상철,조영민,김방엽,Lee, Byoung-Sun,Kim, In-Jun,Lee, Soo-Jeon,Hwang, Yoo-La,Jung, Won-Chan,Kim, Jae-Hoon,Kim, Hae-Yeon,Lee, Hoon-Hee,Lee, Sang-Cherl,Cho, Young-Min,Kim, Bang-Ye Korea Society of Satellite Technology 2011 한국위성정보통신학회논문지 Vol.9 No.1
2010년 6월 26일에 발사된 통신해양기상위성(천리안)은 Ka-대역 위성통신, 정지궤도 해양관측, 그리고 기상관측을 위한 탑재체를 가지고 있다. 정지궤도상의 위성을 효과적으로 운용하기 위해서 위성 임무운영 개념을 정립하여 이를 위성관제시스템의 개발 초기 단계부터 적용하였다. 천리안 위성의 임무운영은 일별, 주별, 월별 그리고 계절별 운영으로 구분된다. 위성의 일별운영은 임무계획, 명령계획 및 전송, 원격측정 데이터 처리 및 분석, 위성 거리측정 및 궤도결정, 위성의 궤도 및 이벤트 예측, 그리고 휠 오프로딩 파라미터 계산으로 구분된다. 위성의 주별 운영으로는 화요일에 남북방향 위치유지조정, 목요일에 동서방향 위치유지조정으로 구분된다. 월별운영으로는 위성의 온보드 오실레이터를 갱신하기 위한 비행역학 파라미터 계산과 위성으로의 전송이 수행되며 계절별 운영으로 봄과 가을에는 지구가 태양을 가리는 식에 관련된 위성운영을 수행한다. 이 논문에서는 통신해양기상위성이 발사된 후 약 3개월에 걸친 궤도 내 시험 기간 중에 이루어진 위성관제시스템의 주요 기능들에 대한 운영검증을 기술한다. 이 기간 중에 위성관제시스템의 대부분 기능이 성공적으로 검증되었으며 천리안 위성관제시스템은 위성의 설계 수명기간인 7년 또는 위성이 수명을 다하는 그 이후까지 계속 사용될 예정이다. COMS(Chollian) satellite which was launched on June 26, 2010 has three payloads for Ka-band communications, geostationary ocean color imaging and meteorological imaging. In order to make efficient use of the geostationary satellite, a concept of mission operations has been considered from the beginning of the satellite ground control system development. COMS satellite mission operations are classified by daily, weekly, monthly, and seasonal operations. Daily satellite operations include mission planning, command planning and transmission, telemetry processing and analysis, ranging and orbit determination, ephemeris and event prediction, and wheel off-loading set point parameter calculation. As a weekly operation, North-South station keeping maneuver and East-West station keeping maneuver should be performed on Tuesday and Thursday, respectively. Spacecraft oscillator updating parameter should be calculated and uploaded once a month. Eclipse operations should be performed during a vernal equinox and autumnal equinox season. In this paper, operational validations of the major functions in COMS SGCS are presented for the first three month of in-orbit test operations. All of the major functions have been successfully verified and the COMS SGCS will be used for the mission operations of the COMS satellite for 7 years of mission life time and even more.
Lee, Jong-Yeul,Choi, Il-Ju,Cho, Soo-Jeong,Kim, Chan-Gyoo,Kook, Myeong-Cherl,Lee, Jun-Ho,Ryu, Keun-Won,Kim, Young-Woo The Korean Gastric Cancer Association 2012 Journal of gastric cancer Vol.12 No.2
Purpose: Local recurrence, due to residual tumor, may occur after endoscopic resection for early gastric cancer. The aims of this study are to evaluate the predictive factors for local recurrence, and suggest an appropriate follow-up biopsy strategy. Materials and Methods: We retrospectively reviewed 396 early gastric cancers from 372 consecutive patients, who underwent endoscopic resection between January 2002 and April 2008. Cumulative recurrence rates were determined by the Kaplan-Meier method, and Cox proportional hazard analysis was used to determine the risk factors for local recurrence. Results: Local recurrence at the endoscopic resection site was found in 17 cases, among the total 396 lesions, during a median follow-up period of 48 months. The 5-year cumulative local recurrence rate was 4.8%. Multivariate analyses determined that tumor involvement at the lateral resection margin [hazard ratio: 35.9; P<0.001], uncheckable lateral resection margin [hazard ratio: 16.8; P<0.001], uncheckable or involved deep resection margin [hazard ratio: 3.76; P=0.047], and piecemeal resection [hazard ratio: 3.95; P=0.007] were associated with local recurrence. If a lesion was positive for any of these risk factors, the 5-year cumulative recurrence rate was 27.0%, while local recurrence was not found in any lesion that lacked these risk factors. Most episodes of recurrence were found during the first or second follow-up endoscopic biopsy at the ulcer scar. Conclusions: Routine follow-up biopsies at the endoscopic resection site might be unnecessary in cases where an early gastric cancer lesion was endoscopically resected en bloc with tumor-free lateral and deep margins.