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Mukwaya Anthony,Jensen Lasse,Lagali Neil 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Blinding eye diseases such as corneal neovascularization, proliferative diabetic retinopathy, and age-related macular degeneration are driven by pathological angiogenesis. In cancer, angiogenesis is key for tumor growth and metastasis. Current antiangiogenic treatments applied clinically interfere with the VEGF signaling pathway—the main angiogenic pathway—to inhibit angiogenesis. These treatments are, however, only partially effective in regressing new pathologic vessels, and the disease relapses following cessation of treatment. Moreover, the relapse of pathological angiogenesis can be rapid, aggressive and more difficult to treat than angiogenesis in the initial phase. The manner in which relapse occurs is poorly understood; however, recent studies have begun to shed light on the mechanisms underlying the revascularization process. Hypotheses have been generated to explain the rapid angiogenic relapse and increased resistance of relapsed disease to treatment. In this context, the present review summarizes knowledge of the various mechanisms of disease relapse gained from different experimental models of pathological angiogenesis. In addition, the basement membrane—a remnant of regressed vessels—is examined in detail to discuss its potential role in disease relapse. Finally, approaches for gaining a better understanding of the relapse process are discussed, including prospects for the management of relapse in the context of disease.
Creating Conditions for Reflective Practice in Early Childhood Education
Tuulikki Venninen,Jonna Leinonen,Mikko Ojala,Lasse Lipponen 육아정책연구소 2012 International Journal of Child Care and Education Vol.6 No.1
In this study, we describe the development of working practices in Finnish day care centers within the Helsinki metropolitan area, which has 500 day care centers. Every two years, 21 of them are selected for a study to be included in a development network. The Development Unit of Early Childhood Education (VKK-Metro), which includes the University of Helsinki and four municipalities in the metropolitan area, coordinates the development of working practices. The objective is to collaborate on the development of day care pedagogy. The objectives and operating structure of VKK-Metro and the principles of developing practices included within it are described and the operation itself is illustrated in the context of the research results. The leading idea is the development of working practices and pedagogy through a reflective and open dialogue. Research results will be utilized in the development of the day care network studied and in workshops arranged for educators in the region.
Bright single photon sources in lateral silicon carbide light emitting diodes
Widmann, Matthias,Niethammer, Matthias,Makino, Takahiro,Rendler, Torsten,Lasse, Stefan,Ohshima, Takeshi,Ul Hassan, Jawad,Tien Son, Nguyen,Lee, Sang-Yun,Wrachtrup, Jö,rg American Institute of Physics 2018 Applied Physics Letters Vol.112 No.23