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Hyunseok Lee(Hyunseok Lee),Dongryul Oh(Dongryul Oh),Yong Chan Ahn(Yong Chan Ahn),Hongryull Pyo(Hongryull Pyo),Kyungmi Yang(Kyungmi Yang),Jae Myoung Noh(Jae Myoung Noh) 대한방사선종양학회 2024 Radiation Oncology Journal Vol.42 No.1
Purpose: This retrospective study aimed to compare clinical outcomes and dosimetric parameters between radiation therapy (RT) techniques in patients with thymic epithelial tumor (TET). Materials and Methods: From January 2016 to December 2020, 101 patients with TET received adjuvant RT (median, 52.8 Gy; range, 48.4 to 66.0). Three different RT techniques were compared: three-dimensional conformal RT (3D-CRT; n = 59, 58.4%), intensity-modulated RT (IMRT; n = 23, 22.8%), and proton beam therapy (PBT; n = 19, 18.8%). Results: The median age of the patients and the follow-up period were 55 years (range, 28 to 79) and 43.4 months (range, 7.7 to 77.2). Patients in the PBT group were of the youngest age (mean age, 45.4 years), while those in IMRT group had the largest clinical target volume (mean volume, 149.6 mL). Patients in the PBT group had a lower mean lung dose (4.4 Gy vs. 7.6 Gy vs. 10.9 Gy, respectively; p < 0.001), lower mean heart dose (5.4 Gy vs. 10.0 Gy vs. 13.1 Gy, respectively; p = 0.003), and lower mean esophageal dose than patients in the 3D-CRT and IMRT groups (6.3 Gy vs. 9.8 Gy vs. 13.5 Gy, respectively; p = 0.011). Twenty patients (19.8%) showed disease recurrence, and seven patients (6.9%) died. The differences in the survival rates between RT groups were not statistically significant. Conclusion: In patients with TET who underwent adjuvant RT, PBT resulted in a lower dose of exposure to adjacent organs at risk. Survival outcomes for patients in PBT group were not significantly different from those in other groups.
Kyungmi Lee,이현석,강준원 강원대학교 산림과학연구소 2021 Journal of Forest Science Vol.37 No.4
This study aimed to enhance seed productivity and secure genetic resources for Pinus densiflora for. multicaulis. We analyzed the characteristics of cone and seed generated by control pollination between Pinus densiflora (PD) and Pinus densiflora for. multicaulis (PDM). The highest number of cone scales (63.0) was obtained from the self-pollinated (sp) PDM clone B (PDM-sp-B), whereas the lowest number of cone scales (44.7) was obtained from two combinations designated as PDM-A×PD-075 and PDM-A×PD-0111. Both female parents of the hybrids were PDM-A. The highest seed production capacity (80.8) was obtained from the open-pollinated (op) PDM clone B (PDM-op-B). The seed potentials of PDM-B×PD-0111, PDM-op-A, and PDM-sp-B were 67.4, 66.5, and 63.1, respectively. The highest number of fertile scales (41.5) was obtained from PDM-op-B, and the lowest number of fertile scales (28.8) was obtained from PDM-A×PD-075. The total number of aborted ovules and 1st aborted ovules was not statistically significant in the mating design. The cross combination of PDM-B×PD-0111 had the highest number (34.8) of filled seeds and the lowest number of 2nd aborted ovules (5.2) and empty seeds (9). PDM-op-B had the highest number of developed seeds (47.6), although the number of empty seeds was the highest (41.2). Therefore, we conclude that the mating design of PDM-B×PD-0111 is useful for future breeding programs to improve seed yield of PDM. Our results showed that there was a strong correlation between the following two parameter pairs: number of scales and number of fertile scales, and the number of fertility scales and seeds potential (r=0.89 and r=0.84, respectively; both p<0.01).
Lee, Heeyoung,Kim, Kyungmi,Lee, Soomin,Yoon, Yohan Cambridge University press 2015 The Journal of dairy research Vol.82 No.1
<P>This study developed mathematical models in order to evaluate the effect of Aw (Water activity) and growth temperature on Staphylococcus aureus kinetic behaviour. The Aw levels (0·970, 0·975, 0·983, and 0·991) of cheese were adjusted by NaCl; then, Staph. aureus was inoculated on the cheese, followed by storage at 7-30 °C for 72-720 h. Total bacterial and Staph. aureus cell counts were enumerated on tryptic soy agar and mannitol salt agar, respectively. The Baranyi model was fitted to the Staph. aureus growth data in order to calculate the maximum specific growth rate (관max; log CFU/g/h), lag phase duration (관; h), lower asymptote (N0; log CFU/g) and upper asymptote (Nmax; log CFU/g). The effects of storage temperature and Aw on the kinetic parameters (관max and 관) were then further analysed with the Ratkowsky-type model and a polynomial equation, respectively. The root mean square error (RMSE) and relative error (RE) were calculated in order to estimate the model performance. No significant effect of Aw on Staph. aureus growth was observed at 7 °C; thus, the Baranyi model was fitted to the growth data from 15, 25 and 30 °C. The 관max values (0·011-0·303 log CFU/g/h) increased (P<0·05) as the storage temperature and Aw increased. In addition, 관 values (2·42-63·48 h) decreased (P<0·05) as storage temperature and Aw increased; yet, the effect of Aw on 관 was observed only at 15 °C. The theoretical minimum storage temperature and Aw were 10·15 °C and 0·882, respectively. RMSE (0·010-1·544) and RE values (-0·131 to 0·187) from validation indicated that model performance was appropriate. Hence, these results suggest that the developed models in this study should be useful in describing the effect of temperature and Aw on the growth kinetic behaviour of Staph. aureus in cheese along with the exposure assessment of Staph. aureus in cheese as well.</P>
S-655 A rare case of spondylodiscitis with epidural abscess caused by Cardiobacterium valvarum
( Kyungmi Lee ),( Wonsuk Choi ),( Daewon Park ),( Chihyun Cho ),( Sehoon Kim ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Cardiobacterium valvarum is Gram-negative bacteria of the HACEK group (Haemophilus parainfluenzae, Aggregatibacter spp., Cardiobacterium spp., Eikenella corrodens, and Kingella spp.). C. valvarum was first described in patient with endocarditis complicated by ruptured mycotic aneurysm in 2004. Since then, all the reported cases caused by C. valvarum were endocarditis-related ones. We report here the isolation of a C. valvarum from a patient who suffered from spondylodiscitis with epidural abscess. A 83-year-old man presented to the emergency department with complaints of low back pain and numbness of both legs that started 2 months ago. Neurological exam showed L5 dermatome numbness with pain and magnetic resonance imaging study of the spine showed spondylodiscitis at L5-S1-2. Empirical therapy with Ceftriaxone was initiated, but later we put him on meropenem due to constant fever along with no improvement on pain. In blood culture, C. valvarum was identified. After which, two more blood cultures that were done also show C.valvarum. An echocardiogram was done and found no infective endocarditis in this case unlike the previously reported C. valvarum infection. Followed-up MRI of spine done after two months of antibiotic treatment still showed epidural abscess, which made us put him on Cefepime for another month. Both his symptoms and MRI of spine showed improvement, which led him to be discharged from our institution. We report the first case of spondylodiscitis caused by Cardiobacterium valvarum, a well-known endocarditis-causing rare species.