http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Alteration of Lung and Gut Microbiota in IL-13-Transgenic Mice Simulating Chronic Asthma
( Kyoung-hee Sohn ),( Min-gyung Baek ),( Sung-mi Choi ),( Boram Bae ),( Ruth Yuldam Kim ),( Young-chan Kim ),( Hye-young Kim ),( Hana Yi ),( Hye-ryun Kang ) 한국미생물생명공학회(구 한국산업미생물학회) 2020 Journal of microbiology and biotechnology Vol.30 No.12
Increasing evidence suggests a potential role of microbial colonization in the inception of chronic airway diseases. However, it is not clear whether the lung and gut microbiome dysbiosis is coincidental or a result of mutual interaction. In this study, we investigated the airway microbiome in interleukin 13 (IL-13)-rich lung environment and related alterations of the gut microbiome. IL-13- overexpressing transgenic (TG) mice presented enhanced eosinophilic inflammatory responses and mucus production, together with airway hyperresponsiveness and subepithelial fibrosis. While bronchoalveolar lavage fluid and cecum samples obtained from 10-week-old IL-13 TG mice and their C57BL/6 wild-type (WT) littermates showed no significant differences in alpha diversity of lung and gut microbiome, they presented altered beta diversity in both lung and gut microbiota in the IL-13 TG mice compared to the WT mice. Lung-specific IL-13 overexpression also altered the composition of the gut as well as the lung microbiome. In particular, IL-13 TG mice showed an increased proportion of Proteobacteria and Cyanobacteria and a decreased amount of Bacteroidetes in the lungs, and depletion of Firmicutes and Proteobacteria in the gut. The patterns of polymicrobial interaction within the lung microbiota were different between WT and IL-13 TG mice. For instance, in IL-13 TG mice, lung Mesorhizobium significantly affected the alpha diversity of both lung and gut microbiomes. In summary, chronic asthma-like pathologic changes can alter the lung microbiota and affect the gut microbiome. These findings suggest that the lung-gut microbial axis might actually work in asthma.
Kyoung-Hee Sohn,Woo-Jung Song,Jong-Sook Park,박흥우,Tae Bum Kim,Choon-Sik Park,조상헌,Elderly Asthma Cohort in Korea Group 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.3
Purpose: Asthma in the elderly (EA; ≥ 65 years of age) is increasing, adding a heavy socioeconomic burden to the healthcare system. However, little is known about risk factors associated with acute exacerbations in EA patients. The objective of this study was to investigate risk factors for acute exacerbation in EA compared to non-elderly asthma (NEA). Methods: We combined data from 3 adult asthma cohorts under a unified protocol and database. Asthmatic patients with regular follow-up during a 1-year period were selected from the cohorts to identify the risk factors predicting acute exacerbations in EA compared to NEA. Results: We selected a total of 1,086 patients from the merged cohort. During the observation period, 503 and 583 patients were assigned to the EA and NEA groups, respectively. The exacerbation rate was 31.0% in the EA and 33.2% in the NEA group. Multivariate logistic regression analysis revealed fixed airway obstruction, chronic rhinosinusitis (CRS), and male sex as independent risk factors for exacerbation in the EA group. In the NEA group, exacerbation increased along with an increase in eosinophil count. Bayesian analysis of the interactions among clinical factors revealed that forced expiratory volume in 1 second/forced vital capacity was directly related to exacerbation in the EA group, and eosinophil count was related to exacerbation in the NEA group. Conclusions: We suggest that fixed airway obstruction and CRS as the important clinical factors predicting acute exacerbations in EA, whereas in NEA, eosinophil count was the strong predictor of exacerbation.
( Kyoung-hee Sohn ),( Woo-jung Song ),( Sae-hoon Kim ),( Hak-chul Jang ),( Ki Woong Kim ),( Yoon-seok Chang ) 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.6
Background/Aims: Depression and allergic diseases, including asthma, are frequently reported as comorbid conditions. However, their associations have been rarely examined in community-based elderly populations. Methods: The analyses were performed using the baseline data set of the Korean Longitudinal Study of Health and Aging, which consists of 1,000 elderly participants (aged > 65 years) randomly recruited from an urban community. Depression was assessed using the Geriatric Depression Scale, Center for Epidemiologic Studies Depression Scale, and Hamilton Rating Scale for Depression. Major and minor depressive disorders were diagnosed by psychiatrists. Allergic conditions were assessed using structured questionnaires, lung function, and skin prick test. Quality of life and comorbidities were assessed using structured questionnaires. Results: Prevalence of asthma and major depressive disorder were 5.4% and 5.3%, respectively. The rate of depression was not significantly different between the non-asthmatic and asthmatic groups. No correlation was observed between the scores obtained using the depression scales and self-reported asthma. However, chronic, frequent, and nocturnal cough were significantly associated with depression and scores obtained using the depression scales, which remained significant in multivariate logistic regression analyses (chronic cough: odds ratio [OR], 3.23; 95% confidence interval [CI], 2.57 to 12.74; p = 0.04). Rhinitis was independently associated with high Mini-Mental State Examination scores (OR, 1.11; 95% CI, 1.05 to 1.17; p < 0.001) and low 36-item short-form (OR, 0.96; 95% CI, 0.80 to 0.98; p = 0.002). Conclusions: Depression may not be significantly associated with asthma and allergic diseases in elderly populations, but cough is a significant factor affecting depression.
손경희 ( Kyoung Hee Sohn ),김주영 ( Ju Young Kim ),이서영 ( Suh Young Lee ),이승은 ( Seung Eun Lee ),강혜련 ( Hye Ryun Kang ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.4
Background: Vitamin K1 (phytonadione), a fat-soluble vitamin, has widely been used to correct bleeding tendency. Although delayed hypersensitivity to vitamin K in new borns is relatively well known, it has rarely been reported in adults. Case History: A 39-year-old woman with thyroid cancer presented with eczematous erythema and severe itching sense with local heat on her right buttock that occurred after intramuscular injection of vitamin K1 7 days ago. She had received intramuscular injections of vitamin K1 to correct bleeding tendency before total thyroidectomy. Results: The pathologic findings of a skin biopsy specimen revealed vacuolar dermatitis with perivascular inflammatory cell infiltration. The skin lesion rapidly improved after administration of oral prednisolone (30 mg/day), a topical steroid, and an oral antihistamine for 5 days. After resolution of the primary lesion, a patch test with vitamin K1 was performed. The patient showed a positive reaction to vitamin K1 with an erythematous plaque with blistering at vitamin K1 injection site. Conclusion: We report here in a case of vitamin K1-induced delayed hypersensitivity reaction confirmed by a patch test.
Kim, Hee-Jin,Ahn, Hee Kyung,Jung, Chul Won,Moon, Joon Ho,Park, Chang-Hun,Lee, Ki-O,Kim, Sun-Hee,Kim, Yeo-Kyeoung,Kim, Hyeoung-Joon,Sohn, Sang Kyun,Kim, Sung Hyun,Lee, Won Sik,Kim, Kyoung Ha,Mun, Yeung Springer International 2013 Annals of hematology Vol.92 No.2
<P>Core binding factor (CBF)-positive acute myeloid leukemia (AML) presents a favorable prognosis, except for patients with KIT mutation, especially D816 mutation. The current retrospective study attempted to validate a prognostic role of KIT mutation in 121 Korean patients with CBF AML. The study patients consisted of 121 patients with CBF AML (82 patients with RUNX1/RUNX1T1 [67.8?%] and 39 patients with CBFB/MYH11 [32.2?%]) recruited from eight institutions in Korea. All patients received idarubicin plus cytarabine or behenoyl cytosine arabinoside 3?+?7 induction chemotherapy. The KIT gene mutation status was determined by direct sequencing analyses. A KIT mutation was detected in 32 cases (26.4?%) in our series of patients. The KIT mutation was most frequent in exon 17 (n?=?18, 14.9?%; n?=?16 with D816 mutation), followed by exon 8 (n?=?10, 8.3?%). The presence of KIT D816 mutation was associated with adverse outcomes for the event-free survival (p?=?0.03) and for the overall survival (p?=?0.02). The unfavorable impact of D816 mutation was more prominent when the analysis was confined to the RUNX1/RUNX1T1 subtype. The KIT mutation was detected in 26.4?% of Korean patients with CBF AML. The KIT D816 mutation demonstrated an unfavorable prognostic implication, particularly in the RUNX1/RUNX1T1 subtype.</P>
메타콜린 기관지유발검사 시행방법: 대한천식알레르기학회 의견서
손경희 ( Kyoung-hee Sohn ),김환수 ( Hwan Soo Kim ),김병근 ( Byung-keun Kim ),김주희 ( Joo-hee Kim ),이상민 ( Sang Min Lee ),이재현 ( Jae-hyun Lee ),우성일 ( Sung-il Woo ),김철홍 ( Cheol Hong Kim ),정재원 ( Jae Won Jung ),김세훈 ( 대한천식알레르기학회 2023 Allergy Asthma & Respiratory Disease Vol.11 No.2
The Korean Academy of Asthma, Allergy, and Clinical Immunology task force report aims to provide new protocols for methacholine challenge test (MCT). Although new devices have different delivery system compared to old ones, previous protocols are still used, which cannot guarantee adequate diagnoses of asthma. Another important issue is the recent recommendation in European Respiratory Society (ERS) technical standard guideline to use a delivered methacholine dose that causes a 20% decrease in forced expiratory volume in 1 second (FEV<sub>1</sub>) (PD<sub>20</sub>). Although the previous protocol based on the methacholine concentration causing a 20% decrease in FEV<sub>1</sub> (PC<sub>20</sub>) has been used globally, several studies have reported that PD<sub>20</sub> is more reliable and applicable for new protocols of MCT. Indeed, a tidal breathing inhalation protocol using a breath-actuated or continuous nebulizer is recommended. Herein, we recommend 3 protocols for the MCT using new devices and provide a brief summary of the change in strategy based on the updated ERS guideline. (Allergy Asthma Respir Dis 2023;11:56-62)
Metabolic Engineering of Corynebacterium glutamicum for the Production of 5-Hydroxyvaleric Acid
Yu Jung SOHN,Minsoo KANG,Kei-Anne BARITUGO,Jina SON,Kyoung Hee KANG,Mi Hee RYU,Siseon LEE,Mingi SOHN,Ye Jean JUNG,Kyungmoon PARK,Si Jae PARK,Jeong Chan JOO,Hee Taek KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.4
A hemothorax secondary to pulmonary embolism: an unusual complication of infective endocarditis
( Kyoung Jin Kim ),( Young Kyung Yoon ),( Seung Hee Baek ),( Jang Wook Sohn ),( Min Ja Kim ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1
Infective endocarditis involving the tricuspid valve (TV) is an uncommon condition. It is rarer to see a hemothorax associated with pulmonary embolism. There are no even definite guidelines to aid the management for this complication. Here we describe arare case of a hemothorax complicated by pulmonary embolism caused by infective endocarditis. A 25-year old man with a congenital perimembranous VSD presented with fever for about 30 days. On physical examination, his body temperature was 38.8℃ and grade III holo-systolic murmur was heard. Laboratory results revealed leukocytes 11,600 cells/μL, and C-reactive protein 111.72 mg/l. A chest radiograph did not demonstrate any specific findings. Transesophageal echocardiogram showed echogenic material attached on ventricular side of TV and its chordae, which suggested infective endocarditis. Because, all blood culture bottles drawn from three different sites yielded growth of a Gram-positive coccus, penicillin and gentamycin were prescribed empirically. Finally,pan-susceptible Streptococcus sanguinis was identified as the causative microorganism in the blood cultures using a VITEK II system. On the 12th day of hospitalization, he complained of a pleuritic chest pain without fever. Physical examination revealed reduced breathing sounds and dullness in the lower left thorax. On his computerized tomography of the chest revealed pleural effusion with focal infarction with pulmonary embolism on left lower lung. A thoracentesis was performed and yielded the hemothorax.A chest tube was inserted to drain the pleural effusion and removed after nine days. However, he did not receive anticoagulation therapy. He responded well to this treatment with penicillin for 6 weeks and gentamycin for 2 weeks. After that, ceftriaxone for the outpatient antimicrobial therapy was prescribed for 3 weeks. During a 10-month post-discharge follow-up, he showed no evidence of recurrent infective endocarditis or pulmonary embolism. Our case suggests an extremely rare complication of hemothorax resulted from pulmonary embolism caused by infective endocarditis. Particularly he was successfully treated by intravenous antibiotics with effective drainage, except anticoagulation therapy.