EAI U.S.-China Relations Statement Factsheet February 2013

Kyle Cassily,Yang Gyu Kim 재단법인 동아시아연구원 2013 EAI 미중관계 시리즈 Vol.- No.-

An Overview of Cancer Prevention: Chemoprevention and Immunoprevention

Kyle J. Gu,Guojun Li 대한암예방학회 2020 Journal of cancer prevention Vol.25 No.3

Cancer prevention encompasses a broad spectrum of strategies designed to lower the chance of developing cancer and reduce the morbidity of established cancer. There are three levels of cancer prevention. Eliminating or mitigating cancer risk factors by adopting healthy behaviors and lifestyles, such as avoiding tobacco and alcohol use, exercising, eating a healthy diet, and applying sunscreen to protect against UV exposure, belongs to primary prevention and is the easiest and most effective way of preventing cancer for the general public. Secondary prevention includes screening to identify precancerous lesions and taking intervention measures to prevent disease progression to malignancy. Tertiary prevention refers to reducing or controlling the symptoms and morbidity of established cancer or the morbidity caused by cancer therapy. For high-risk populations, chemopreventive agents, such as selective estrogen receptor modulators (including tamoxifan and raloxifene) in breast cancer prevention and non-steroidal anti-inflammatory drugs (aspirin) in colorectal cancer prevention, and immunoprevention using human papillomavirus and hepatitis B virus vaccines in infection-related cancers have shown clear clinical benefits of reducing cancer incidences. In this review, we will summarize the current status of cancer prevention, focusing on the major agents that are clinically used for chemoprevention and immunoprevention.

Impact of molybdenum cross sections on FHR analysis

Kyle M. Ramey,Marat Margulis,Nathaniel Read,Eugene Shwageraus,Bojan Petrovic 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.3

A recent benchmarking effort, under the auspices of the Organization for Economic Cooperation andDevelopment (OECD) Nuclear Energy Agency (NEA), has been made to evaluate the current state ofmodeling and simulation tools available to model fluoride salt-cooled high temperature reactors (FHRs). The FHR benchmarking effort considered in this work consists of several cases evaluating the neutronicparameters of a 2D prismatic FHR fuel assembly model using the participants’ choice of simulation tools. Benchmark participants blindly submitted results for comparison with overall good agreement, exceptfor some which significantly differed on cases utilizing a molybdenum-bearing control rod. Participantsutilizing more recently updated explicit isotopic cross sections had consistent results, whereas thoseusing elemental molybdenum cross sections observed reactivity differences on the order of thousands ofpcm relative to their peers. Through a series of supporting tests, the authors attribute the differences asbeing nuclear data driven from using older legacy elemental molybdenum cross sections. Quantitativeanalysis is conducted on the control rod to identify spectral, reaction rate, and cross section phenomenaresponsible for the observed differences. Results confirm the observed differences are attributable to theuse of elemental cross sections which overestimate the reaction rates in strong resonance channels.

EAI U.S.-China Relations Statement Factsheet October 2013

Kyle Cassily 재단법인 동아시아연구원 2013 EAI 기타간행물 Vol.- No.-

Combined orthogeriatric and fracture liaison service for improved postfracture patient care

Kyle M. Schweser,Brett D. Crist,Vu H. Nguyen 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.3

The article by Yeap et al. [1] brings necessary attention to the subject of managing osteoporotic fractures, as nearly threequarters of patients in their study who suffered from fractures were not placed on treatment regimens, and the few who were received it for only around a month. We agree with the authors that this is a missed opportunity to prevent future fractures, and that their study shows the need to establish a fracture liaison service (FLS) to increase the treatment rate after the occurrence of an osteoporotic fracture. In addition, we believe that the FLS combined with other services can further improve care and outcomes for patients suffering from osteoporotic fractures. A current review of recent studies on osteoporosis management found that the FLS model of care is effective in initiating and adhering to osteoporosis treatment, and it is cost-saving in decreasing secondary fracture risk, but a combination of the FLS with the orthogeriatric (OG) service models of care may be an even more effective approach towards long-term bone health, as it can be a cost-effective method of further decreasing secondary fracture risk and mortality [2]. An OG service is generally a collaboration between an orthopaedic surgeon and a geriatrician, and usually centers on an osteoporotic fracture. While results have been inconclusive in the past regarding the effectiveness of involving a geriatrician in postfracture care, recent data has shown that the OG model likely has an impact on mortality, and patients were “more likely to receive preoperative medical assessments, have greater recognition of postoperative medical problems, and have implementation of long-term osteoporosis management” [3e5]. Both FLS and OG models have proven costeffectiveness [6]. The 2 models appear to be effective on their own, and while the exact model eludes us, some inference can be made that a dual approach may offer the best medical care for the patient while in the hospital, as well as coordinating care effectively upon discharge. The collaboration and communication between primary care and subspecialties has traditionally been poor [7]. Perhaps combining an OG service with an FLS would help mitigate these communication problems by placing the physicians in direct contact with each other over the ongoing care of patients. Post osteoporotic fracture care has improved recently, but there is significant room for advancement, and while implementation of an FLS is a step in the right direction, consideration should be made towards the inclusion of an OG service as well.

Does body mass index influence improvement in patient reported outcomes following total knee arthroplasty? A retrospective analysis of 3918 cases

( Kyle W. Lawrence ),( Walter Sobba ),( Vinaya Rajahraman ),( Ran Schwarzkopf ),( Joshua C. Rozell ) 대한슬관절학회 2023 대한슬관절학회지 Vol.35 No.-

Purpose The study aimed to determine whether body mass index (BMI) classification for patients undergoing total knee arthroplasty (TKA) is associated with differences in mean patient reported outcome measure (PROM) score improvements across multiple domains―including pain, functional status, mental health, and global physical health. We hypothesized that patients with larger BMIs would have worse preoperative and postoperative PROM scores, though improvements in scores would be comparable between groups. Materials and methods Patients undergoing primary TKA from 2018 to 2021 were retrospectively reviewed and stratified into four groups: Normal Weight; 18.5-25 kg/m², Overweight; 25.01-30 kg/m², Obese; 30.01-40 kg/ m², and Morbidly Obese > 40 kg/m². Preoperative, postoperative, and pre/post-changes (Δ) in knee injury and osteoarthritis, joint replacement (KOOS, JR) and Patient-Reported Outcome Measurement Information System (PROMIS) measures of pain intensity, pain interference, physical function, mobility, mental health, and physical health were compared. Multivariate linear regression was used to assess for confounding comorbid conditions. Results In univariate analysis, patients with larger BMIs had worse scores for KOOS, JR and all PROMIS metrics preoperatively. Postoperatively, scores for KOOS, JR and PROMIS pain interference, mobility, and physical health were statistically worse in higher BMI groups, though differences were not clinically significant. Morbidly obese patients achieved greater pre/post-Δ improvements in KOOS, JR and global physical health scores. Multivariate regression analysis showed high BMI was independently associated with greater pre/post-Δ improvements in KOOS, JR and global health scores. Conclusion Obese patients report worse preoperative scores for function and health, but greater pre/post-Δ improvements in KOOS, JR and physical health scores following TKA. Quality of life benefits of TKA in obese patients should be a factor when assessing surgical candidacy.

Hyponatremia of 100 mEq./1tr. Associated with Pituitary Adenoma : A Case Report

Kyle, Robert H.,Lee, Hwa Dong,Jeon, Byung Chan 고신대학교 의학부 1985 高神大學校 醫學部 論文集 Vol.1 No.1

본 44세 남자환자로 내원 12개월 전부터 성욕감퇴, 20일 전부터 식욕 감퇴, 오심, 구토를 주소로 입원했다. 내원 당시 탈수현상을 보였으며 2일후 의식이 변화(혼미)와 한차례의 대발작증세를 보였다. 뇨와 혈청 소견상 혈중 나트륨치가 100mEq/L, 혈중 Cortisol치가 1.1mEq/24hrs, 요비중은 변동이 있었으나 1.004까지 보였고, 그 외는 정상범위였다. 단순두개골 방사선학적 소견으로는 터키 안장부위가 커져있고 부분결손을 보였으며 뇌 전산화 단층 촬영 소견으로는 터어키 안장상부 및 왼쪽에 팽대된 뇌하수체종양을 보였다. 수술요법과 방사선요법을 받았으며, 현재 투약없이 비교적 안정된 일상생활을 영위하고 있다.

Pore Structure of Calcium Sulfoaluminate Paste and Durability of Concrete in Freeze–Thaw Environment

Kyle de Bruyn,Eric Bescher,Chris Ramseyer,홍성원,강현구 한국콘크리트학회 2017 International Journal of Concrete Structures and M Vol.11 No.1

Mercury intrusion and nitrogen sorption porosimetry were employed to investigate the pore structure of calcium sulfoaluminate (CSA) and portland cement pastes with cement-to-water ratio (w/c) of 0.40, 0.50, and 0.60. A unimodal distribution of pore size was drawn for CSA cement pastes, whereas a bimodal distribution was established for the portland cement pastes through analysis of mercury intrusion porosimetry. For the experimental results generated by nitrogen sorption porosimetry, the CSA cement pastes have a smaller and coarser pore volume than cement paste samples under the same w/c condition. The relative dynamic modulus and percentage weight loss were used for investigation of the concrete durability in freeze–thaw condition. When coarse aggregate with good freeze–thaw durability was mixed, air entrained portland cement concrete has the same durability in terms of relative dynamic modulus as CSA cement concrete in a freeze–thaw environment. The CSA cement concrete with poor performance of durability in a freeze–thaw environment demonstrates the improved durability by 300 % over portland cement concrete. The CSA concrete with good performance aggregate also exhibits less surface scaling in a freeze–thaw environment, losing 11 % less mass after 297 cycles.

Landscape Changes: Assessing Pennsylvania State Park Viewsheds Across the Marcellus Shale Region

Kyle Nicholas 한국국토정보공사 2016 지적과 국토정보 Vol.46 No.2

The Marcellus Shale industry has impacted Pennsylvania since 2005 and has been a major driver of land use change ever since. The Pennsylvania state park system has been facing encroachment from this industry ever since the first Pennsylvania wellpad was drilled in 2008. Previous research conducted overviews the impacts associated with this industry in regards to environmental quality, but there is limited research associated with the social impacts. The conducted research overviews the Marcellus Shale industry in regards to encroachment on Pennsylvania state parks through a GIS analysis. The purpose of the research is to evaluate how the viewsheds (areas of vision from a given point) of Pennsylvania state park land has been impaired by the Marcellus Shale industry. The results of the research show how the landscape of state parks have change due to the Marcellus Shale industry, and also a focus will be placed on scenic vistas (areas that highlight spectacular views within state parks) of selected parks to see to what extent that pristine landscape has been altered. The results of the research will help provide an idea of landscape change utilizing a GIS analysis and hopefully help to guide future growth.

EAI U.S.-China Relations Statement Factsheet February 2013

Kyle Cassily,Yang Gyu Kim 재단법인 동아시아연구원 2013 EAI 기타간행물 Vol.- No.-