http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Koyasu Hiroki,Horie Shigeo,Matsushita Kazuhito,Ashizawa Takeshi,Muto Satoru,Isotani Shuji,Tanaka Tohru,Nakajima Motowo,Tsujimura Akira 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.3
Purpose: As the concept of late-onset hypogonadism (LOH) has gained increased attention, the treatment of eugonadal patients with LOH symptom has become a clinical problem. Previous studies have shown the possible benefits of 5-aminolevulinic acid (5-ALA) on the somatic, psychological and sexual functions. We therefore conducted this randomized, double‑blind, placebo‑controlled study to confirm the efficacy and safety of 5-ALA for LOH symptoms. Materials and Methods: Thirty-two eugonadal subjects with LOH symptoms were randomly divided into a 5-ALA group (n=15) and a placebo group (n=17). Treatment was continued for 8 weeks. The change of the Aging Males’ Symptoms (AMS) scale score and several biochemical and endocrinological variables during treatment were compared between the groups. Results: After treatment, the change in the total AMS in the 5-ALA group was significantly greater than that in the placebo group (-7.4±4.7 vs. -4.9±4.9, p=0.029). However, the differences between the groups in the change of the somatic, psychological, and sexual sub-scores of the AMS did not reach the statistical significance, although these changes in the 5-ALA group were greater than those in the placebo group. Furthermore, the change in the biochemical and endocrinological variables in the two groups did not differ to a statistically significant extent. During the 8-week treatment period, no patients discontinued 5-ALA due to treatment-emergent adverse events (TEAEs). Conclusions: The intake of 5-ALA for 8 weeks was beneficial for eugonadal patients with symptoms of LOH and no severe TEAEs was experienced. 5-ALA should be considered as an option for those patients.
Flavonoids and Stilbenes as Repellents against the Blue Mussel, Mytilus edulis galloprovincialis
Singh, Inder Pal,Etoh, Hideo,Asai, Eiko,Kikuchi, Kojiro,Ina, Kazuo,Koyasu, Katsuya,Terada, Yukimasa The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.1
We studied the attachment-repelling activity of flavonoids, stilbenes, and their glycosides against the blue mussel Mytilus edulis galloprouincialis. Molecular mechanics calculations have shown that the most stable conformations of potent repellents 29 and 32 were the same. On the basis of these results, structure-activity relationships of these compounds are discussed.