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Kosuke Shimizu 한국국제정치학회 2018 The Korean Journal of International Studies Vol.16 No.1
The Kyoto School of philosophy has recently come to be seen as one of the sources that gave rise to non-Western international relations (IR). Despite the high regard with which this philosophy is held, there is a dark side to the School’s history; this is especially important in terms of critically engaging in IR as an academic discipline because it supposedly provides a cautionary tale to the contemporary literature of alternative IR theories, and non-Western IRT in particular. This paper strives to clarify Nishida Kitaro’s involvement in the wartime regime with a particular focus on the inherent and contradictory relationship between being and language. I will do so by critically investigating Nishida’s experience of involvement in the wartime regime by utilising his very concept of the eternal present. In other words, I will criticise Nishida’s politics by employing his philosophy.
A Proposal of Wheel/Rail Contact Model for Friction Control
Kosuke Matsumoto,Yoshihiro Suda,Hisanao Komine,Takuji Nakai,Masao Tomeoka,Kunihito Shimizu,Masuhisa Tanimoto,Yasushi Kishimoto,Takashi Fujii 대한기계학회 2005 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.19 No.1S
Controlling the friction between wheel and rail is direct and very effective measures to Improve the curving performances of railway trucks, because the curving performances depend much on friction characteristics Authors have proposed a method, "fllction control", which utilizes friction modifier (KELTRACKTM HPF) with onboard spraying system With the method, not only friction coefficient, but also fuction characteristics can be controlled as expected In this study, MBD simulation is very valuable tool to foresee the effect of the contiol In advance of experiment With real car And the creep characteristics of wheel/rail contact With the friction modifier takes very Important role In the simulation In this paper, authors propose a theoretical model of wheel/rat I contact condition considering the creep characteristics of friction modifier, Which is derived the application of principle tribological theories<br/>
Novel mutations of CDKN1C in Japanese patients with Beckwith-Wiedemann syndrome
Hitomi Yatsuki,Ken Higashimoto,Kosuke Jozaki,Kayoko Koide,Junichiro Okada,Yoriko Watanabe,Nobuhiko Okamoto,Yoshinobu Tsuno,Yoko Yoshida,Kazutoshi Ueda,Kenji Shimizu,Hirofumi Ohashi,Tsunehiro Mukai,Hid 한국유전학회 2013 Genes & Genomics Vol.35 No.2
Beckwith-Wiedemann syndrome (BWS) is an imprinting-related human disease that is characterized by macrosomia, macroglossia, abdominal wall defects, and variable minor features. BWS is caused by several genetic/epigenetic alterations, such as loss of methylation at KvDMR1,gain of methylation at H19-DMR, paternal uniparental disomy of chromosome 11, CDKN1C mutations, and structural abnormalities of chromosome 11. CDKN1C is an imprinted gene with maternal preferential expression, encoding for a cyclin-dependent kinase (CDK) inhibitor. Mutations in CDKN1C are found in 40 % of familial BWS cases with dominant maternal transmission and in *5 % of sporadic cases. In this study, we searched for CDKN1C mutations in 37BWS cases that had no evidence for other alterations. We found five mutations—four novel and one known—from a total of six patients. Four were maternally inherited and one was a de novo mutation. Two frame-shift mutations and one nonsense mutation abolished the QT domain, containing a PCNA-binding domain and a nuclear localization signal. Two missense mutations occurred in the CDK inhibitory domain,diminishing its inhibitory function. The above-mentioned mutations were predicted by in silico analysis to lead to loss of function; therefore, we strongly suspect that such anomalies are causative in the etiology of BWS.
Masaaki Usami,Ichiro Takeuchi,Reiko Kyodo,Yuri Hirano,Kosuke Kashiwagi,Hiroki Fujikawa,Hirotaka Shimizu,Toshinao Kawai,Katsuhiro Arai 대한장연구학회 2022 Intestinal Research Vol.20 No.4
Background/Aims: Very early-onset inflammatory bowel disease (VEO-IBD), defined as IBD diagnosed in patients younger than 6 years, is a challenge for pediatric gastroenterologists. Although there have been reports regarding VEO-IBD in Western countries, those in Asia are still lacking. This study aimed to investigate the clinical features of Japanese VEO-IBD patients.Methods: Patients with VEO-IBD diagnosed between 2006 and 2019 were evaluated retrospectively. The disease phenotypes were classified into ulcerative colitis type (UC-type) and Crohn’s disease type (CD-type), and the clinical features and courses were compared between the phenotypes.Results: Overall, 54 VEO-IBD patients (19 patients with UC-type and 35 patients with CD-type) were evaluated. The median age at onset was 18 months. One patient had severe combined immunodeficiency (SCID), and 9 patients had monogenic IBD. Monogenic IBD was more prevalent in the CD-type patients with perianal disease (CD-type (PD)). The age at onset was significantly lower in the CD-type group (P<0.05). The most common initial symptom was bloody stools (70%), followed by diarrhea (63%), weight loss (24%), fever (20%), and perianal disease (20%). Excluding patients with SCID and monogenic IBD, 23 out of 44 patients (52%) required biologics. The biologics were switched in 11 out of 44 patients (25%), and the majority of these patients (82%) were in the CD-type group. Overall, 9 patients (20%) required intestinal resection or ostomy placement.Conclusions: CD-type tends to occur at an earlier age, and monogenic IBD occurs significantly more frequently in CD-type (PD). Disease severity and treatment should be individualized, owing to the disease heterogeneity.