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Komariah Komariah,Wasmen Manalu,Bambang Kiranadi,Adi Winarto,Ekowati Handharyani,M. Orliando Roeslan 한국독성학회 2018 Toxicological Research Vol.34 No.2
Valproic acid (VPA) plays a role in histone modifications that eventually inhibit the activity of histone deacetylase (HDAC), and will affect the expressions of genes Pdx1, Nkx6.1, and Ngn3 during pancreatic organogenesis. This experiment was designed to study the effect of VPA exposure in pregnant rats on the activity of HDAC that controls the expression of genes regulating the development of beta cells in the pancreas to synthesize and secrete insulin. This study used 30 pregnant Sprague-Dawley rats, divided into 4 groups, as follows: (1) a control group of pregnant rats without VPA administration, (2) pregnant rats administered with 250 mg VPA on day 10 of pregnancy, (3) pregnant rats administered with 250 mg VPA on day 13 of pregnancy, and (4) pregnant rats administered with 250 mg VPA on day 16 of pregnancy. Eighty-four newborn rats born to control rats and rats administered with VPA on days 10, 13, and 16 of pregnancy were used to measure serum glucose, insulin, DNA, RNA, and ratio of RNA/DNA concentrations in the pancreas and to observe the microscopical condition of the pancreas at the ages of 4 to 32 weeks postpartum with 4-week intervals. The results showed that at the age of 32 weeks, the offspring of pregnant rats administered with 250 mg VPA on days 10, 13, and 16 of pregnancy had higher serum glucose concentrations and lower serum insulin concentrations, followed by decreased concentrations of RNA, and the ratio of RNA/DNA in the pancreas. Microscopical observations showed that the pancreas of the rats born to pregnant rats administered with VPA during pregnancy had low immunoreaction to insulin. The exposure of pregnant rats to VPA during pregnancy disturbs organogenesis of the pancreas of the embryos that eventually disturb the insulin production in the beta cells indicated by the decreased insulin secretion during postnatal life.
Komariah, Kokoy Siti,Machbub, Carmadi,Prihatmanto, Ary S.,Sin, Bong-Kee Korea Multimedia Society 2016 멀티미디어학회논문지 Vol.19 No.7
Efficient Market Hypothesis (EMH), states that at any point in time in a liquid market security prices fully reflect all available information. This paper presents a study of proving the hypothesis through daily Twitter sentiments using the hybrid approach of the lexicon-based approach and the naïve Bayes classifier. In this research we analyze the currency exchange rate movement of Indonesia Rupiah vs US dollar as a way of testing the Efficient Market Hypothesis. In order to find a correlation between the prediction sentiments from Twitter data and the actual currency exchange rate trends we collect Twitter data every day and compute the overall sentiment to label them as positive or negative. Experimental results have shown 69% correct prediction of sentiment analysis and 65.7% correlation with positive sentiments. This implies that EMH is semi-strong Efficient Market Hypothesis, and that public information provide by Twitter sentiment correlate with changes in the exchange market trends.
Rahma Nur Komariah,Yusuf Sudo Hadi,Muh Yusram Massijaya,Jajang Suryana 한국목재공학회 2015 목재공학 Vol.43 No.2
The aim of this study was to determine the physical and mechanical properties of glued laminated timber (glulam) manufactured from small-diameter logs of three wood species, Acacia mangium (mangium), Maesopsis eminii (manii), and Falcataria moluccana (sengon), with densities of 533, 392, and 271 kg/m 3 , respectively. Glulam measuring 5 cm by 7 cm by 160 cm in thickness, width, and length, respectively, was made with three to five lamina, or layers, and isocyanate adhesive. The glulams contained either the same wood species for all layers or a combination of mangium face and back layers with a core layer of manii or sengon. Solid wood samples of the same size for all three species were included as a basis for comparison. Physical-mechanical properties and delamination tests of glulam referred to JAS 234:2003. The results showed that the properties of same species glulam did not differ from those of solid wood, with the exception of the shear strength of glulam being lower than that of solid wood. Wood species affected glulam properties, but three- and five-layer glulams were not different except for the modulus of elasticity. All glulams were resistant to delamination by immersion in both cold and boiling water. The glulams that successfully met the JAS standard were three- and five-layer mangium, five-layer manii, and five-layer mangium-manii glulams.
Multi-objective Mathematical Modeling for Scheduling Machines in Parallel with Batch Processors
Evy Segarawati Ampry,Aan Komariah,Dedy Achmad Kurniady,Muhammad Rafiq,Asep Priatna,Muneam Hussein Ali,Haydar Abdulameer Marhoon,Lakshmi Thangavelu,Purnima Chaudhary 대한산업공학회 2022 Industrial Engineeering & Management Systems Vol.21 No.2
In this paper, the problem of scheduling the production of unrelated parallel machines to simultaneously minimize the goals of production time span, early and late fines, and the cost of purchasing machines is investigated, and a two-objective mathematical model is considered considering clearance and preparation times and limit capacity. Due to faster and cheaper operations with batch processors and increasing the efficiency of operating systems, all machines are batch processors. Initially, the model is coded and executed using the exact method in GAMS software. Due to the hard-NP nature and complex nature of the problem, a multi-objective meta-heuristic algorithm based on the coordination search method is proposed and designed. Then Taguchi method is used to find the best level for the algorithm parameters, and two examples of problems in different dimensions of tasks and machines are presented and solved by this proposed algorithm. The results of the calculations show the efficiency of this algorithm to generate more solutions at a much lower solution time.
Design of a Two-tier Supply Chain Based on Integration, Pricing, Routing, and Inventory Control
Aruzhan Jussibaliyeva,Ius Rusnati,Aan Komariah,Aigul Kurmanalina,Nikolay N. Reutov,Gulnar Temirgaliyevna Kunurkulzhaeva,Alim Al Ayub Ahmed,Ravil Akhmadeev,Supat Chupradit 대한산업공학회 2021 Industrial Engineeering & Management Systems Vol.20 No.4
This paper integrates decisions about the three key components of the supply chain including pricing, routing and inventory control, and multi-product multi-cycle in a two-tier supply chain; includes a manufacturer and a collection of dedicated retailers. In addition to pricing, inventory management and distribution planning, production planning is also considered in the study. The goal is to maximize profits in the supply chain, where products are delivered to retailers by a fleet of limited-capacity identical vehicles under a multiple-delivery strategy. Also, limited production and storage capacity and unauthorized shortages are assumed. The proposed model will then be solved using CPLEX software package in GAMS environment and genetic algorithm in Matlab software to determine the optimal supply chain policy.