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Using genetically engineered mouse models to study cancer and radiation biology
David Kirsch 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Genetically engineered mouse models are powerful systems to study cancer and radiation biology. We have employed several genetic tools to model cancer and dissect mechanisms of tumor and normal tissue response to radiation therapy. For example, we have used Cre-loxP technology to delete genes in a cell-type specific manner to study the cell types and molecular pathways that regulate the response of the intestine to radiation damage. We have also utilized in vivo shRNA to reversibly block p53 during total body irradiation to make the surprising discovery that during total body irradiation the tumor suppressor p53 promotes radiation-induced thymic lymphoma via a non-cell autonomous mechanism. We have also generated p53FRT mice in which FRT sites flank p53, so that it can be deleted by FLP recombinase. We combined the FLP/FRT system with the Cre/loxP system to enable dual recombinase technology where FLP initiates cancer and Cre can delete genes in specific stromal cell populations to dissect the role of endothelial cells, neutrophils, and other cell types in tumor response to radiation therapy. More recently, we have adapted CRISPR/Cas9 technology to initiate cancer. CRISPR technology can initiate tumors in wild type mice thereby decreasing the cost and time required to study cancer in animal models. We have applied CRISPR/Cas9 to study metastasis and the response of cancer to radiation and immunotherapy.
Review of alternative gate stack technology research during the last decade
Byoung Hun Lee1,Paul Kirsch,Husam Alshareef,Prashant Majhi,Rino Choi,Seungchul Song,Hsing Huang Tseng,Raj Jammy 한국세라믹학회 2006 세라미스트 Vol.9 No.4
Scaling of the gate stack has been one of the major contributors to the performance enhancement of CMOSFET devices in past technology generations The scalability of gate stack has diminished in recent years and alternative gate stack technology such as metal electrode and high-k dielectrics has been intensively studied during almost matches that of conventional SiO2-based gate dielectrics. However, many technical challenges remain to be resolved before alternative gate stacks can be introduced into mainstream technology. This paper reviews the reasearch in alternative gate stack technologies to provide insights for future reasearch.
Midterm outcomes of suture anchor fixation for displaced olecranon fractures
Michael J. Gutman,Jacob M. Kirsch,Jonathan Koa,Mohamad Y. Fares,Joseph A. Abboud 대한견주관절학회 2024 대한견주관절의학회지 Vol.27 No.1
Background: Displaced olecranon fractures constitute a challenging problem for elbow surgeons. The purpose of this study is to evaluate the role of suture anchor fixation for treating patients with displaced olecranon fractures. Methods: A retrospective review was performed for all consecutive patients with displaced olecranon fractures treated with suture anchor fixation with at least 2 years of clinical follow-up. Surgical repair was performed acutely in all cases with nonmetallic suture anchors in a double-row configuration utilizing suture augmentation via the triceps tendon. Osseous union and perioperative complications were uniformly assessed. Results: Suture anchor fixation was performed on 17 patients with displaced olecranon fractures. Functional outcome scores were collected from 12 patients (70.6%). The mean age at the time of surgery was 65.6 years, and the mean follow-up was 5.6 years. Sixteen of 17 patients (94%) achieved osseous union in an acceptable position. No hardware-related complications or fixation failure occurred. Mean postoperative shortened disabilities of the arm, shoulder, and hand (QuickDASH) score was 3.8±6.9, and mean Oxford Elbow Score was 47.5±1.0, with nine patients (75%) achieving a perfect score. Conclusions: Suture anchor fixation of displaced olecranon fractures resulted in excellent midterm functional outcomes. Additionally, this technique resulted in high rates of osseous union without any hardware-related complications or fixation failures. Level of evidence: IV.
Sustainability in Ultra precision and Micro machining: A Review
Frank Schneider,Jayanti Das,Benjamin Kirsch,Barbara Linke,Jan C. Aurich 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.6 No.3
Ultra precision and micro machining processes become more and more important. This can be led back to the development of functionalized surfaces and parts and the mass production of smaller products e.g. lenses for personal devices. With increasing application and distribution, the importance of sustainability in these processes also increases. In this paper, an overview of ultra precision and micro machining in a system approach is given and the most decisive input parameters are elaborated. Included are general findings and current issues of process design with regard to the economic, environmental and social dimension of sustainability. Finally, it is discussed how the sustainability of ultra precision and micro machining can be increased and for which class of products certain strategies are recommended.
( Alexander Swidsinski ),( Vera Loening Baucke ),( Monika Kruger ),( Steffen Kirsch ) 대한장연구학회 2012 Intestinal Research Vol.10 No.4
Background/Aims: Stroke is accompanied by septic complications due to quickly changing polymicrobials of unclear origin. This study was aimed to find the source of stroke-associated-infections. Methods: We investigated the biostructure of the colonic microbiota in patients hospitalized in two stroke units using fluorescence in situ hybridization in order to find the source of stroke-associated-infections. Non-stroke subjects and animals were used as controls. Results: Typical for stroke was a leukocyte migration into the mucus between day 1-3, in numbers that are otherwise characteristic for active ulcerative colitis (CAI ≥6); subsequent abrupt “decontamination” of the main fermentative Roseburia, Bacteroides and Faecalibacterium prausnitzii groups and disappearance of leukocytes in the stool; arrest of bacterial fermentation between day 3 to 7 in extents exceeding the effects of any presently know antibiotics. Then resetting in which Enterobacteriaceae, Bifidobacteriaceae and Clostridium difficile temporarily outnumber Bacteroides, Roseburia and Faecalibacterium prausnitzii, and after that decline with normalization of these bacteria to initial values. Conclusions: The colon is a bioreactor containing many potential pathogens. The mucus barrier shields the host from bacteria. The events following stroke stress the pivotal role of the brain in maintaining this shield and indicate an existence of emergency brakes that temporary terminate the biofermentation. (Intest Res 2012;10:332-342)