Pyknodysostosis: report of a rare case with review of literature

Kiran Kumar Kotagudda Ramaiah,Giju Baby George,Sheeba Padiyath,Rupak Sethuraman,Babu Cherian 대한영상치의학회 2011 Imaging Science in Dentistry Vol.41 No.4

Pyknodysostosis is a rare autosomal recessive disorder characterized by the post natal onset of short limbs, short stature, and generalized hyperostosis along with acro-osteolysis with sclerosis of the terminal phalanges, a feature that is considered essentially pathognomonic. Other features include persistence of fontanelles, delayed closure of sutures, wormian bones, absence of frontal sinuses, and obtuse mandibular gonial angle with relative mandibular prognathism. We report a case of 17-year-old girl who presented with a chief complaint of retention of deciduous teeth. General physical examination demonstrated short stature, frontal and parietal bossing, depressed nasal bridge,beaked nose, hypoplastic midface, wrinkled skin over the finger tips, and nail abnormalities. Radiographs showed multiple impacted permanent and supernumerary teeth, hypoplastic paranasal sinuses with acro-osteolysis of terminal phalanges, and open fontanelles, and sutures along with wormian bones in the lambdoidal region.

Multiple myeloma presenting with a maxillary lesion as the first sign

Kiran Kumar Kotagudda Ramaiah,Vajendra Joshi,Shilpa Ravishankar Thayi,Pathalapate Sathyanarayana,Prashant Patil,Zaheer Ahmed 대한영상치의학회 2015 Imaging Science in Dentistry Vol.45 No.1

Multiple myeloma is a clonal neoplastic proliferation of terminally differentiated B-lymphocytes involving the skeletal system in a multifocal fashion. Its oral manifestations are less common in the maxilla than in the mandible due to the lower amount of hemopoietic bone marrow in the maxilla. We report the case of a 50-year-old man who presented with a mass in the left maxillary alveolar region with tooth mobility. The mass had become enlarged after the teeth were extracted 15 days previously. Radiographs demonstrated multiple punched-out radiolucent lesions in the skull and pelvic region. Computed tomography images showed a soft tissue density mass in the left maxilla, eroding the floor and walls of the maxillary sinus. Although several analytical techniques were used to characterize the lesion, it was finally confirmed as multiple myeloma through immunohistochemistry.

Biocompatability of carbon nanotubes with stem cells to treat CNS injuries

Kiran Kumar Bokara,Jong Youl Kim,Young Il Lee,Kyungeun Yun,Tom J Webster,Jong Eun Lee 대한해부학회 2013 Anatomy & Cell Biology Vol.46 No.2

Cases reporting traumatic injuries to the brain and spinal cord are extended range of disorders that affect a large percentage of the world's population. But, there are only few effective treatments available for central nervous system (CNS) injuries because the CNS is refractory to axonal regeneration and relatively inaccessible to many pharmacological treatments. The use of stem cell therapy in regenerative medicine has been extensively examined to replace lost cells during CNS injuries. But, given the complexity of CNS injuries oxidative stress, toxic byproducts, which prevails in the microenvironment during the diseased condition, may limit the survival of the transplanted stem cells affecting tissue regeneration and even longevity. Carbon nanotubes (CNT) are a new class of nanomaterials, which have been shown to be promising in different areas of nanomedicine for the prevention, diagnosis and therapy of certain diseases, including CNS diseases. In particular, the use of CNTs as substrates/scaffolds for supporting the stem cell differentiation has been an area of active research. Single-walled and multi-walled CNT's have been increasingly used as scaffolds for neuronal growth and more recently for neural stem cell growth and differentiation. This review summarizes recent research on the application of CNT-based materials to direct the differentiation of progenitor and stem cells toward specific neurons and to enhance axon regeneration and synaptogenesis for the effective treatment of CNS injuries. Nonetheless, accumulating data support the use of CNTs as a biocompatible and permissive substrate/scaffold for neural cells and such application holds great potential in neurological research.

DNA Ploidy and S-phase Fraction Analysis in Paediatric B-cell Acute Lymphoblastic Leukemia Cases: a Tertiary Care Centre Experience

Kumar, Banothu Kiran,Bhatia, Prateek,Trehan, Amita,Singh, Ajit Pal,Kaul, Deepak,Bansal, Deepak Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

DNA ploidy is an important prognostic parameter in paediatric B-ALL, but the significance of the S-phase fraction is unclear. In present study, DNA ploidy was assessed in 40 pediatric B-ALL cases by flow cytometry. The DI (DNA index) and percentage of cells in S-phase were calculated using Modfit software. Aneuploidy was noted in 26/40 (65%) cases. A DI of 1.10-1.6 (hyperdiploidy B) was noted in 20/40 (50%) and 6/40 (15%) had a DI>1.60 (triploid and tetraploid range). Some 14/40 (35%) cases had a diploid DI between 0.90-1.05. None of the cases had a DI <0.90 (hypodiploid) or in the 1.06-1.09 (hyperdiploid A) range. The mean S-phase fraction was 2.6%, with 24/40 (60%) having low and 16/40 (40%) high S-phase fractions. No correlation was noted with standard ALL risk and treatment response factors with DI values or S-phase data, except for a positive correlation of low S-phase with high NCI risk category (p=0.032). Overall frequency of hyperdiploidy in our cohort of B-ALL patients was very high (65%). No correlation between hyperdiploidy B and low TLC or common B-phenotype was observed in our study as 42% cases with DI 1.10-1.6 had TLC> $50{\times}10^9$ and 57.1% CD 10 negativity. The study also highlighted that S-phase fraction analysis does not add any prognostic information and is not a useful parameter for assessment in ALL cases. However, larger studies with long term outcome analysis are needed to derive definitive conclusions.

Ternary Nanocomposite for Solar Light Photocatalyic Degradation of Methyl Orange

Kumar, Akash,Billa, Sanjeev,Chaudhary, Swati,Kiran Kumar, A.B.V.,Ramana, Ch.V.V.,Kim, D. Elsevier 2018 Inorganic Chemistry Communications Vol.97 No.-

<P><B>Abstract</B></P> <P>In the present work, we reported the preparation of ZnO/PANI/RGO ternary nanocomposite by physical blending method and its photocatalytic efficiency of degradation of methyl orange under solar light. The samples were characterized by XRD, FTIR and UV–Vis spectroscopy. Optical band gap was calculated using Tauc plot for ZnO, PANI and RGO. The photocatalytic studies were evaluated using Methyl Orange with a degradation rate of 99% in 50 min. It is observed that photocatalytic efficiency enhanced by PANI (wt%). The PANI has the ability to create more charge carriers and delay the recombination process. The kinetic studies fitted to pseudo first order reaction. The nanocomposite acts as a promising photocatalyst for the removal of organic pollutants from water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Preparation of ZnO/PANI/RGO ternary nanocomposite by physical blending method. </LI> <LI> Photocatalytic degradation of methyl orange under solar light. </LI> <LI> The kinetic studies fitted to pseudo-first order reaction. </LI> <LI> Methyl Orange degradation rate is 99% in 50 minutes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Photocatalytic Mechanism of ZnO/PANI/RGO nanocomposite.</P> <P>[DISPLAY OMISSION]</P>

Fuzzy-Membership Based Writer Identification from Handwritten Devnagari Script

Kumar, Rajiv,Ravulakollu, Kiran Kumar,Bhat, Rajesh Korea Information Processing Society 2017 Journal of information processing systems Vol.13 No.4

The handwriting based person identification systems use their designer's perceived structural properties of handwriting as features. In this paper, we present a system that uses those structural properties as features that graphologists and expert handwriting analyzers use for determining the writer's personality traits and for making other assessments. The advantage of these features is that their definition is based on sound historical knowledge (i.e., the knowledge discovered by graphologists, psychiatrists, forensic experts, and experts of other domains in analyzing the relationships between handwritten stroke characteristics and the phenomena that imbeds individuality in stroke). Hence, each stroke characteristic reflects a personality trait. We have measured the effectiveness of these features on a subset of handwritten Devnagari and Latin script datasets from the Center for Pattern Analysis and Recognition (CPAR-2012), which were written by 100 people where each person wrote three samples of the Devnagari and Latin text that we have designed for our experiments. The experiment yielded 100% correct identification on the training set. However, we observed an 88% and 89% correct identification rate when we experimented with 200 training samples and 100 test samples on handwritten Devnagari and Latin text. By introducing the majority voting based rejection criteria, the identification accuracy increased to 97% on both script sets.

Synthesis and Antimicrobial Evaluation of Sulfides, Sulfoxides, and Sulfones

Kumar, A.B.V. Kiran,Rao, K.S.V. Krishna,Chandra, M. Subhosh,Subha, M.C.S.,Choi, Yong-Lark The Korean Society for Applied Biological Chemistr 2009 Journal of Applied Biological Chemistry (J. Appl. Vol.52 No.1

Hydrogen peroxide, with sodium metavanadate as the catalyst, was used to achieve a highly efficient and selective oxidation of sulfides into sulfoxides and sulfones at room temperature in high yields and short reaction times. All of the sulfides oxidized into sulfoxides and sulfone derivatives were assayed for their in vitro antibacterial activities against Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Pseudomonas aeruginosa, and antifungal activities against Aspergillus niger and Candida albicans. A remarkable inhibition of the growth of the bacterial and fungal strains was observed. This result suggested that the compounds are promising microbial agents.

Chemoselective Synthesis of Isomerical Pair of (E),(Z)-Mono-sulfones and Bis-sulfones

Kumar, A. B. V. Kiran,Rao, K. S. V. Krishna,Maheswara, M.,Subha, M. C. S.,Cui, Shengyun,Jin, Dongri,Lee, Yong-Ill Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.11

Highly Photoconductive CdS Thin Films Synthesized by Using Chemical Bath Deposition

Ch. Kiran Kumar,Nguyen Thi Quynh Hoa,윤순길,이지홍,Geun-Hong Kim,김의태 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.1

We report the effects of the concentration of a base (NH3) and a complexing agent (triehtylamine (TEA)) on the photoconductive characteristics and growth mechanism of CdS films synthesized by using the chemical bath deposition technique. Highly photoconductive CdS thin films were successfully grown on glass substrates at 80℃ under a sulfur-poor environment, i.e. a Cd to S molar ratio of 1/0.125. Photoluminescence studies showed that all CdS films we studied had a significant amount of sulfur vacancies and that those vacancy energy states were responsible for the high photoconductivity values. Both dark and photo sheet resistance values were lower when a higher NH3 volume or a lower TEA molarity solution was used. We report the effects of the concentration of a base (NH3) and a complexing agent (triehtylamine (TEA)) on the photoconductive characteristics and growth mechanism of CdS films synthesized by using the chemical bath deposition technique. Highly photoconductive CdS thin films were successfully grown on glass substrates at 80℃ under a sulfur-poor environment, i.e. a Cd to S molar ratio of 1/0.125. Photoluminescence studies showed that all CdS films we studied had a significant amount of sulfur vacancies and that those vacancy energy states were responsible for the high photoconductivity values. Both dark and photo sheet resistance values were lower when a higher NH3 volume or a lower TEA molarity solution was used.

Pyknodysostosis: report of a rare case with review of literature

Ramaiah, Kiran Kumar Kotagudda,George, Giju Baby,Padiyath, Sheeba,Sethuraman, Rupak,Cherian, Babu Korean Academy of Oral and Maxillofacial Radiology 2011 Imaging Science in Dentistry Vol.41 No.4

Pyknodysostosis is a rare autosomal recessive disorder characterized by the post natal onset of short limbs, short stature, and generalized hyperostosis along with acro-osteolysis with sclerosis of the terminal phalanges, a feature that is considered essentially pathognomonic. Other features include persistence of fontanelles, delayed closure of sutures, wormian bones, absence of frontal sinuses, and obtuse mandibular gonial angle with relative mandibular prognathism. We report a case of 17-year-old girl who presented with a chief complaint of retention of deciduous teeth. General physical examination demonstrated short stature, frontal and parietal bossing, depressed nasal bridge, beaked nose, hypoplastic midface, wrinkled skin over the finger tips, and nail abnormalities. Radiographs showed multiple impacted permanent and supernumerary teeth, hypoplastic paranasal sinuses with acro-osteolysis of terminal phalanges, and open fontanelles, and sutures along with wormian bones in the lambdoidal region.