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Choi, Yoori,Kim, Hye-Sun,Shin, Ki Young,Kim, Eun-Mee,Kim, Minji,Kim, Hyun-Soo,Park, Cheol Hyoung,Jeong, Yun Ha,Yoo, Jongman,Lee, Jean-Pyo,Chang, Keun-A,Kim, Seonghan,Suh, Yoo-Hun American College of Neuropsychopharmacology 2007 Neuropsychopharmacology Vol.32 No.11
Minocycline is a semi-synthetic tetracycline antibiotic that effectively crosses the blood–brain barrier. Minocycline has been reported to have significant neuroprotective effects in models of cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, and Huntington's and Parkinson's diseases. In this study, we demonstrate that minocycline has neuroprotective effects in in vitro and in vivo Alzheimer's disease models. Minocycline was found to attenuate the increases in the phosphorylation of double-stranded RNA-dependent serine/threonine protein kinase, eukaryotic translation initiation factor-2 α and caspase 12 activation induced by amyloid β peptide<SUB>1–42</SUB> treatment in NGF-differentiated PC 12 cells. In addition, increases in the phosphorylation of eukaryotic translation initiation factor-2 α were attenuated by administration of minocycline in Tg2576 mice, which harbor mutated human APP695 gene including the Swedish double mutation and amyloid β peptide<SUB>1–42</SUB>-infused rats. We found that minocycline administration attenuated deficits in learning and memory in amyloid β peptide<SUB>1–42</SUB>-infused rats. Increased phosphorylated state of eukaryotic translation initiation factor-2 α is observed in Alzheimer's disease patients' brains and may result in impairment of cognitive functions in Alzheimer's disease patients by decreasing the efficacy of de novo protein synthesis required for synaptic plasticity. On the basis of these results, minocycline may prove to be a good candidate as an effective therapeutic agent for Alzheimer's disease.Neuropsychopharmacology (2007) 32, 2393–2404; doi:10.1038/sj.npp.1301377; published online 4 April 2007
Neutravidin coated surfaces for single DNA molecule analysis
Kim, Yoori,Jo, Kyubong Royal Society of Chemistry 2011 Chemical communications Vol.47 No.22
<P>We present a novel approach for single DNA molecule analysis using neutravidin coated surfaces. DNA molecules are elongated and reversibly immobilized on neutravidin coated surfaces with pH and salt controls. We demonstrate restriction enzyme reactions for optical mapping and ligation for tethered DNA molecules.</P> <P>Graphic Abstract</P><P>Microfluidic flow dynamically elongates 110 μm DNA biotin-tethered on neutravidin coated surfaces. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc05396a'> </P>
Shaping of the 3D genome by the ATPase machine cohesin
Kim Yoori,Yu Hongtao 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
The spatial organization of the genome is critical for fundamental biological processes, including transcription, genome replication, and segregation. Chromatin is compacted and organized with defined patterns and proper dynamics during the cell cycle. Aided by direct visualization and indirect genome reconstruction tools, recent discoveries have advanced our understanding of how interphase chromatin is dynamically folded at the molecular level. Here, we review the current understanding of interphase genome organization with a focus on the major regulator of genome structure, the cohesin complex. We further discuss how cohesin harnesses the energy of ATP hydrolysis to shape the genome by extruding chromatin loops.
Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies
Choi, Yoori,Ha, Seunggyun,Lee, Yun-Sang,Kim, Yun Kyung,Lee, Dong Soo,Kim, Dong Jin The Korea Society of Nuclear Medicine 2018 핵의학 분자영상 Vol.52 No.1
The pathological features of Alzheimer's disease are senile plaques which are aggregates of ${\beta}$-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are aggregates of hyperphosphorylated tau proteins, and these induce various other neurodegenerative diseases, such as progressive supranuclear palsy, corticobasal degeneration, frontotemporal lobar degeneration, frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and chronic traumatic encephalopathy. In the case of Alzheimer's disease, the measurement of neurofibrillary tangles associated with cognitive decline is suitable for differential diagnosis, disease progression assessment, and to monitor the effects of therapeutic treatment. This review discusses considerations for the development of tau ligands for imaging and summarizes the results of the first-in-human and preclinical studies of the tau tracers that have been developed thus far. The development of tau ligands for imaging studies will be helpful for differential diagnosis and for the development of therapeutic treatments for tauopathies including Alzheimer's disease.
Choi, Yoori,Hwang, Do won,Kim, Mee Young,Kim, Joo Yeon,Sun, Woong,Lee, Dong Soo Frontiers Media S.A. 2016 Frontiers in molecular neuroscience Vol.9 No.-
<P>MicroRNAs (miRNAs) fine-tune target protein synthesis by suppressing gene expression, temporally changing along development and possibly in pathological conditions. A method to monitor the action of miRNAs <I>in vivo</I> shall help understand their dynamic behavior during development. In this study, we established a transgenic mouse harboring miR-124 responsive element in their luciferase-eGFP reporter transgenes which enabled monitoring the action of miR-124 in the brain and other organs <I>in vivo</I> by the bioluminescence imaging. The mouse model was produced and verified by imaging <I>ex vivo</I> so that luminescence by luciferase shone and then reduced during development with miR-124 expression. Bioluminescence dramatically decreased in the brain between embryonic day 13 and 16 as endogenous miR-124 expression increased, which sustained into adulthood. The inverse relationship of miR-124 expression was observed with luciferase bioluminescence and activity <I>ex vivo</I> as well as <I>in vivo</I>. Taken together, one can use this microRNA-transgenic mouse to investigate the temporal changes of microRNA action <I>in vivo</I> in the brain as well as in other organs.</P>