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Kim, Kook Hwan,Jeong, Yeon Taek,Oh, Hyunhee,Kim, Seong Hun,Cho, Jae Min,Kim, Yo-Na,Kim, Su Sung,Kim, Do Hoon,Hur, Kyu Yeon,Kim, Hyoung Kyu,Ko, TaeHee,Han, Jin,Kim, Hong Lim,Kim, Jin,Back, Sung Hoon,Ko Nature Publishing Group, a division of Macmillan P 2013 Nature medicine Vol.19 No.1
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding autophagy-related 7). Unexpectedly, these mice showed decreased fat mass and were protected from diet-induced obesity and insulin resistance; this phenotype was accompanied by increased fatty acid oxidation and browning of white adipose tissue (WAT) owing to induction of fibroblast growth factor 21 (Fgf21). Mitochondrial dysfunction induced by autophagy deficiency increased Fgf21 expression through induction of Atf4, a master regulator of the integrated stress response. Mitochondrial respiratory chain inhibitors also induced Fgf21 in an Atf4-dependent manner. We also observed induction of Fgf21, resistance to diet-induced obesity and amelioration of insulin resistance in mice with autophagy deficiency in the liver, another insulin target tissue. These findings suggest that autophagy deficiency and subsequent mitochondrial dysfunction promote Fgf21 expression, a hormone we consequently term a 'mitokine', and together these processes promote protection from diet-induced obesity and insulin resistance.
Corn Silk Extract Prevents Carrageenan-Induced Inflammatory Edema
Kim Yonghwan,Han Na Choi,Kim Taehee,Kim Su Jin,Kim Yuna,Kim Jin Soo,Lee Sang-Hoon,Goo Young-Tae,Kim Dong Woon,Do Lee Sang 건강기능식품미래포럼 2022 건강기능식품미래포럼 학술지 Vol.2 No.1
Corn silk extract (CSE) has been used as a traditional medicine for edema, cystitis, gout, kidney stones, nephritis, and prostatitis. Although CSE has been shown to be effective against oxidative stress and diabetes, the effects of CSE on peripheral edema are unclear. Therefore, in this study, the effects of CSE on carrageenan-induced peripheral edema in the hind paw of mice were examined. CSE administered orally for a week suppressed the formation of edema and inhibited the swelling of epidermis and the infiltration of inflammatory cells into the dermis. To explore the mechanism of the anti-inflammatory action, CSE was tested on the adhesion between monocytes and endothelial cells using THP-1 cells (a monocyte cell line) and human umbilical vein endothelial cells (HUVECs). CSE inhibited the adhesion only when THP-1 cells were treated with CSE but not HUVECs. This finding suggests that CSE possibly influences the expressions of the membrane proteins of the monocyte involved in the adhesion with endothelial cells. Thus, CSE was treated for 24 hours and the expressions of CD11a, CD11b, CD18, CD49d and CD162 using its respective antibody and flowcytometry. Of these proteins, CD162, also known as P-selectin glycoprotein ligand-1 (PSGL-1), was shown to be reduced in its expression. PSGL-1 is known to be required for the binding of inflammatory cells to intercellular adhesion molecules of endothelial cells. In conclusion, CSE may suppress inflammatory edema by inhibiting the binding of inflammatory cells to the vascular endothelium.
Kim Taehee,Choi Hayoung,Kim Sang Hyuk,Yang Bumhee,Han Kyungdo,Jung Jin-Hyung,Kim Bo-Guen,Park Dong Won,Moon Ji Yong,Kim Sang-Heon,Kim Tae-Hyung,Yoon Ho Joo,Shin Dong Wook,Lee Hyun 대한의학회 2024 Journal of Korean medical science Vol.39 No.11
Background: Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls. Methods: We conducted a population-based cohort study of TB survivors and 1:1 age- and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017. We compared the risk of COPD development and COPD-related hospitalization between TB survivors and controls. Results: Of the subjects, 9.6% developed COPD, and 2.8% experienced COPD-related hospitalization. TB survivors had significantly higher COPD incidence rates (36.7/1,000 vs. 18.8/1,000 person-years, P < 0.001) and COPD-related hospitalization (10.7/1,000 vs. 4.3/1,000 person-years, P < 0.001) than controls. Multivariable Cox regression analyses revealed higher risks of COPD development (adjusted hazard ratio [aHR], 1.63; 95% confidence interval [CI], 1.54–1.73) and COPD-related hospitalization (aHR, 2.03; 95% CI, 1.81–2.27) in TB survivors. Among those who developed COPD, the hospitalization rate was higher in individuals with post-TB COPD compared to those with non-TB COPD (10.7/1,000 vs. 4.9/1,000 person-years, P < 0.001), showing an increased risk of COPD-related hospitalization (aHR, 1.84; 95% CI, 1.17–2.92). Conclusion: TB survivors had higher risks of incident COPD and COPD-related hospitalization compared to controls. These results suggest that previous TB is an important COPD etiology associated with COPD-related hospitalization.
Introduction: Ontology of Movement as a Framework for the Mobility Studies
Taehee Kim Academy of Mobility Humanities 2023 Mobility Humanities Vol.2 No.1
It has been almost two decades since “a whole new kinetic paradigm" or “a new paradigm defined by motion,” mentioned in the epigraph quoted above, was brought to light in the name of the "new mobilities paradigm" (Sheller and Urry 207). This inauguration of the paradigm was arguably the result of "an almost/not quite ontology which is gradually gathering momentum around the key trope of 'mobility'" (Thrift 258). Needless to say, there has been no lack of criticism and resistance to this paradigm. For instance, critics discerned that "if mobility is everything," as is often assumed to be the case in this paradigm, "then it is nothing," since the difference between mobility and immobility and among diverse types of mobility cannot be discerned and, consequently, mobility has no explanatory power (Adey 75). More radically, it was criticised that every vocabulary of this research program's name, "new mobilities paradigm," qualifying it as “new,” focussing on “mobilities,” and designating it as a “paradigm,” was problematic (Cresswell, "Towards a Politics of Mobility" 18).
Kim, Taeki,Kim, Junhyung,Choi, Jaehoon,Jo, Taehee,Shin, Hyeong Chan,Jeong, Woonhyeok Korean Cleft Palate-Craniofacial Association 2021 Archives of Craniofacial Surgery Vol.22 No.2
The use of a fibula osteocutaneous flap is currently the mainstay of segmental mandibular reconstruction. This type of flap is used to treat tumors, trauma, or osteoradionecrosis of the mandible. However, a fibula osteocutaneous flap may also be a good option for reconstructing the mandible to preserve oropharyngeal function and facial appearance in cases of pathological fracture requiring extensive segmental bone resection. Chronic osteomyelitis is one of the various causes of subsequent pathologic mandibular fractures; however, it is rare, and there have been few reports using free flaps in osteomyelitis of the mandible. We share our experience with a 76-year-old patient who presented with a pathologic fracture following osteomyelitis of the mandible that was reconstructed using a fibula osteocutaneous flap after wide segmental resection.
A Study on Symbolic and Behavioural Hybrid Approach to Robotic Agent
Kim, Taehee 영산대학교 2001 영산논총 Vol.8 No.-
본 논문은 전통적인 기호주의적 접근방식과 목표 지향적인 행동기반 접근방식을 접합하는 방식의 에이전트를 제안한다. 에이전트는 시스템의 하부에 세세한 정보를 다루는 루틴과 함께 상부의 추론과 같은 추상화된 기능들을 가질 필요가 있다. 중앙집중식의 전통적인 기호주의적 접근방식은 하부의 세세함을 다루는데 있어서 적함하지 않을 것을 본 논문에서 주장한다. 대신에, 세세한 정보를 처리하는 하부의 행동기반에 의한 반응적인 기구를 채택한 방법론을 제안한다. 상부의 기호주의적 부분은 최소한의 크기를 가지고 작업 순서와 같은 전체적인 작업계획만을 생성하도록 한다. 이러한 방식은 비교적 단순하고 편리하게 복잡한 에이전트를 디자인할 수 있도록 한다. This paper proposes an approach to agent that hybridises classical symbolic approach and the goal directed behaviour-based approach. An agent is a system that usually requires detailed low level information handling routines, at the same time high level abstract functions such as reasoning. We argue that a centralised methodology based on the classical symbolic approach is inappropriate in managing low level details. Rather, we propose a methodology that employs behaviour-based reactive low level mechanism which deals with detailed information processing. High level classical symbolic component can be kept as its minimal size and generates global job plans such as job orders. This feature would provide a relatively simple and convenient methodology in designing a complex agent.
ALGEBRAICALLY CONCORDANT SEIFERT FORMS AND KNOT CONCORDANCE
Kim, Taehee Korean Mathematical Society 2020 대한수학회논문집 Vol.35 No.3
We show that if M and V are Seifert forms such that M is metabolic and has nontrivial Alexander polynomial, then there exists a knot K having Seifert form M ⊕ V that is not concordant to any knot with Seifert form V.