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- 검색키워드
- 저자 : Kim Sung-Hyen (검색결과 355 건)
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Hyen Chung Chun,Ki Yuol Jung,Young Dae Choi,Sanghun Lee,Sung-Up Kim,Eunyoung Oh 한국토양비료학회 2017 한국토양비료학회지 Vol.50 No.5
Accurate and optimal water supply to cereal crop is critical in growing stalks and producing maximum yields. Recently, upland crops are cultivated in paddy field soils to reduce overproduced rice in Korea. In order to increase productivity of cereal crops in paddy fields which have poor percolation and drainage properties, it is necessary to fully understand crop response to excessive soil water condition and management of soil drainage system in paddy field. The objectives of this study were to investigate effects of excessive soil water to sesame growth and to quantify stress response using groundwater levels. Two cultivars of sesame were selected to investigate; Gunbak and Areum. These sesames were planted in paddy fields located in Miryang, Gyeongnam with different soil drainage levels and drainage systems. The experiment site was divided into two plots by drainage class; very poorly and somewhat poorly drained. Two different drainage systems were applied to alleviate excessive soil water in each plot: open ditch and pipe drainage system. Soil water contents and groundwater levels were measured every hour during growing season. Pipe drainage system was significantly effective to alleviate wet injury for sesame in paddy fields. Pipe drainage system decreased average soil moisture content and groundwater level during sesame cultivation. This resulted in greater yield and lignan contetns in sesame seeds than ones from open ditch system. Comparison between two cultivars, Gunbak had greater decrease in growth and yield by excessive soil water and high groundwater level than Areum. Seed components (lignan) showed decrease in seeds as soil water increased. When soil moisture content was greater than 40%, lignan content tended to decrease than ones from less soil moisture content. Based on these results, pipe drainage system would be more effective to reduce wet injury to sesame and increase lignan component in paddy field cultivation.
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Kim, Won Kyung,Byun, Woong Sub,Chung, Hwa-Jin,Oh, Jedo,Park, Hyen Joo,Choi, Jae Sue,Lee, Sang Kook Elsevier 2018 Biochemical pharmacology Vol.152 No.-
<P><B>Abstract</B></P> <P>Colorectal cancer (CRC) is the most common malignant disease worldwide due to its metastasis via the epithelial-mesenchymal transition (EMT) process. E-cadherin and Wnt signaling are emerging as potential targets for suppressing the EMT. In this context, Axin2 has been recognized as a negative regulator that inhibits glycogen synthase kinase 3β (GSK3β)-mediated degradation of Snail1, a transcriptional repressor of E-cadherin. However, Axin2 can also impede Wnt signaling via β-catenin degradation. Therefore, Axin2 may serve as either a promoter or suppressor of tumors, and the effects of its inhibition on the cell proliferation and metastasis of CRC require further elucidation. Here, esculetin (ES), a coumarin, was found to have the most potential effects on both β-catenin-responsive transcriptional and <I>E-cadherin</I> promoter activities. ES also showed anti-proliferative and anti-invasive activities in CRC cells. Mechanistically, Axin2 suppression by ES contributed to E-cadherin-mediated Wnt signaling inhibition. Moreover, the ability of ES to inhibit tumor growth and metastasis via Axin2 suppression was further supported in an HCT116-implanted orthotopic mouse model. Collectively, these findings suggest that targeting the Axin2/E-cadherin axis by ES may be an attractive therapeutic strategy for the treatment of metastatic CRC.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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( Sung Bum Cho ),( Jong Sun Rew ),( Sung Young Park ),( Hyeng Chen Park ),( Kyeong Won Yoon ),( Seok Cho ),( Wan Sik Lee ),( Chang Hwan Park ),( Hyen Soo Kim ),( Sung Kyu Choi ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background Aims: Rectal carcinoid has been increasingly detected due to the recent wide use of colonoscopy for routine health examination. Although endoscopic resection should be considered as the treatment for rectal carcinoid, the scar formation after colonoscopic biopsy can lead to unpredicted difficulty in this procedure. This study evaluates the per-procedure findings and treatment results in an attempt to elucidate the effect of scar formation after colonoscopic biopsy in endoscopic resection for rectal carcinoid. Methods: Twelve cases of rectal careinoid with scar formation were compared with 18 non-scar cases, which were treated using the endoscopic resection from January 2002 to August 2007, in terms of the endoscopic findings, resection methods and treatment results. Results: The differences in the clinical findings and tumor size between the scar group and the non-scar group were nonspecific. The average waiting-time between biopsy and resection was shorter (13±16 vs 42±26 ds; p=0.11) in the scar group. During endoscopic resection, small active ulcer was found in 4 scar cases with lesser than 7 days of waiting-time. The risk of limited elevation after submucosal injection was higher (83% vs 44%, p=0.03) in the scar group. In resection methods, ESD was frequently adopted in the scar group (4 cases vs 1 case). The difference in the result of pathologic complete resection between two group were nonspecific. Four patients in the scar group should be admitted (vs 1 case in the non-scar group). Conclusions: ESD technique should be considered in selected cases, because of the postbiopsic scar can block the submucosal elevation in endoscopic resection for rectal carcinoid.
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Application of the Bounday-Element Method to Waveguide Problems
Kim, Che Young,Yu, Sang Dae,Kwon, Wu Hyen 경북대학교 1987 論文集 Vol.43 No.-
임의 단면 도파관 해석을 위한 적분방정식을 제안하였다. 제안된 적분방정식에 경계요소법을 적용하여 여러 종류의 도파관 문제 해석을 포괄적으로 취급할 수 있게 하였다. 특히 결과해의 정확성을 확인하기 위하여 엄밀해가 알려진 원통형 도파관의 차단 파수와 벽면 전류를 계산하므로서 본 방법의 타당성 여부를 논의하였다. 리즈 도파관에 대한 도파관 모드를 산출한 후 이를 다른 방법으로 계산한 결과와 비교 검토하였다.
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( Sang-yeop Lee ),( Won-seok Yang ),( Se-won Park ),( Gun-ho Han ),( Yong-chil Seo ),( Woo-hyen Kim ),( Young-sik Yoon ),( Won-sik Lee ) 한국폐기물자원순환학회(구 한국폐기물학회) 2019 한국폐기물자원순환학회 심포지움 Vol.2019 No.1
Solid refuse fuel (SRF) manufacturing facilities, residues are buried at a rate of 30~45% of incoming amount or some are disposed of by incineration facilities. It is known that landfill can increase the pollution load and it takes about 20% of total facility operation cost due to landfill disposal cost. In the study residue waste from SRF manufacturing plant was attempted to combust, the bottom ash generated from incineration tests was utilized aggregates to fabricate bricks to assess the applicability. The variation in bottom ash properties influences the characteristics of bricks and also it could be hazardous for environment. So, before making bricks from generated bottom ash, basic characteristic of bottom ash such as ignition loss and heavy metal leaching test must be analyzed. These bricks were manufactured by substitution of stone powder and sand. These can be used as an interlocking block for the sidewalk and open space. Finally we analyzed the basic characteristics of the bottom ash and analyzed the water absorption, bending strength, compressive strength, and dimensions of the mixed bricks. Following these results, as comparing with standard interlocking block, recycling brick satisfied with the less than 10% abosrption rate and more than 5Mpa flexural strenghth. we could assess the applicability of these bricks manufactured.
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Kim, Sun Suk,Oh, O-Jin,Min, Hye-Young,Park, Eun-Jung,Kim, Youngleem,Park, Hyen Joo,Han, Yong Nam,Lee, Sang Kook 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Inducible cyclooxygenase (COX-2) has been implicated in the processes of inflammation and carcinogenesis. Thus, the potential COX-2 inhibitors have been considered as anti-inflammatory or cancer chemopreventive agents. In this study, the methanolic extract of the cortex of Eugenia caryophyllata Thunberg (Myrtaceae) was found to potently inhibit the prostaglandin E₂ production in lipopolysaccharide (LPS)-activated mouse macrophage RAW264.7 cells (98.3% inhibition at the test concentration of 10 ㎍/㎖). Further, hexane-soluble layer was the most active partition compared to ethyl acetate, n-butanol, and water-soluble parts. By bioassay-guided fractionation of hexane-soluble partition, eugenol was isolated and exhibited a significant inhibition of PGE₂ production (IC_(50) = 0.37 μM). In addition, eugenol suppressed the cyclooxygenase-2 (COX-2) gene expression in LPS-stimulated mouse macrophage cells. On the line of COX-2 playing an important role in colon carcinogenesis further study was designed to investigate the effect of eugenol on the growth and COX-2 expression in HT-29 human colon cancer cells. Eugenol inhibited the proliferation of HT-29 cells and the mRNA expression of COX-2, but not COX-1. This result suggests that eugenol might be a plausible lead candidate for further developing the COX-2 inhibitor as an anti-inflammatory or cancer chemopreventive agent.
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Generation of Model Diesel Particles by Spark Discharge and Hydrocarbon Condensation
Kim, Hak-Joon,Kim, Jin-Ho,Choi, Young-Joo,Oh, Hyen-Chul,Chu, Jung-Bum,Kim, Sang-Soo The Korean Society of Mechanical Engineers 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.11
This study was conducted in order to generate model particles which were similar to particles in diesel emission. Spark discharge was used for carbon agglomerates and hydrocarbon condensation for particles that consist of carbon agglomerates and hydrocarbon. The size of the carbon agglomerates, whose mean size were 30 and 70 nm, ranged between 15 and 200 nm, and the total number concentration of the particles ranged from 3 to $5{\times}10^7#/cm^3$ as the controllable variables in spark discharge generator changed. The result of the hydrocarbon condensation experiment showed that the final sizes of the particles enlarged by condensation did not depend on the initial sizes, but the maximum condensational growth of carbon agglomerates by dodecane ($C_{12}H_{26}$) condensation was 112 times the initial size of 40 nm, while the size of the agglomerates by benzene ($C_6H_6$) was 3.25 times its initial size.
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KIM, GI DAE,OH, JEDO,PARK, HYEN-JOO,BAE, KIHWAN,LEE, SANG KOOK Spandidos Publications 2013 International journal of oncology Vol.43 No.2
<P>Magnolol, a neolignan from the traditional medicinal plant Magnolia obovata, has been shown to possess neuroprotective, anti-inflammatory, anticancer and anti-angiogenic activities. However, the precise mechanism of the anti-angiogenic activity of magnolol remains to be elucidated. In the present study, the anti-angiogenic effect of magnolol was evaluated in mouse embryonic stem (mES)/embryoid body (EB)-derived endothelial-like cells. The endothelial-like cells were obtained by differentiation from mES/EB cells. Magnolol (20 ?M) significantly suppressed the transcriptional and translational expression of platelet endothelial cell adhesion molecule (PECAM), an endothelial biomarker, in mES/EB-derived endothelial-like cells. To further understand the molecular mechanism of the suppression of PECAM expression, signaling pathways were analyzed in the mES/EB-derived endothelial-like cells. Magnolol induced the generation of reactive oxygen species (ROS) by mitochondria, a process that was associated with the induction of apoptosis as determined by positive Annexin V staining and the activation of cleaved caspase-3. The involvement of ROS generation by magnolol was confirmed by treatment with an antioxidant, N-acetyl-cysteine (NAC). NAC inhibited the magnolol-mediated induction of ROS generation and suppression of PECAM expression. In addition, magnolol suppressed the activation of MAPKs (ERK, JNK and p38) and the PI3K/AKT/mTOR signaling pathway in mES/EB-derived endothelial-like cells. Taken together, these findings demonstrate for the first time that the anti-angiogenic activity of magnolol may be associated with ROS-mediated apoptosis and the suppression of the PI3K/AKT/mTOR signaling pathway in mES/EB-derived endothelial-like cells.</P>
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