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Nguyen Thu Hien,Nguyen Duc Quan,Kim Lien Nguyen Thi,Thi Thanh Ngan Nguyen,Nguyen Thi Phuong Mai,Tran Ngoc Dung,Nguyen Huy Hoang 한국유전학회 2023 Genes & Genomics Vol.45 No.4
Background Androgens and androgen receptor (AR) are critical regulators of the masculinization process in male sexual development. The absence of a functioning AR results in the development of the androgen insensitivity syndrome (AIS), a rare disorder of sexual development (DSD) characterized by the external genitalia feminization, gynecomastia, and impaired spermatogenesis. Objective To determine the AR gene mutations associated with male DSD in four unrelated Vietnamese patients. Methods To detect the disease-causing mutations, whole exome sequencing (WES) was performed on four patients diagnosed with AIS. Sanger sequencing was then used for validation of the identified mutations. Finally, 12 web-based tools, three-dimensional protein modeling software, and the guidelines issued by the American College of Medical Genetics and Genomics were used to assess the potential pathogenicity of these mutations. Results Four distinct novel mutations, namely c.1834T > A (p.Cys612Ser), c.2122 C > G (p.Leu708Val), c.2630T > G (p.Phe877Cys), and c.2641 C > A (p.Leu881Met) in the AR gene, were identified in four AIS patients using WES. The in silico analysis results revealed that the Cys612, Leu708, Phe877, and Leu881 sites are important for an appropriate response to androgens of the AR, and mutation at these sites can have adverse effects on the AR functions, androgen–AR interaction, and AR signaling pathway. Conclusions WES and in silico analyses strongly suggested that four novel AR mutations are pathogenic and have led to the development of AIS in the four Vietnamese patients under consideration.
Fintech and Banking: Evidence from Vietnam
LIEN, Nguyen Thi Kim,DOAN, Thu-Trang Thi,BUI, Toan Ngoc Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9
The paper focuses on understanding fintech and the application of fintech in the banking sector in Vietnam. To solve this research objective, the authors analyze fintech development trends, especially the fintech application in the banking sector in Vietnam. To improve the quality of fintech services at banks, the authors conducted consideration of factors affecting customers' intention to use fintech services. To accomplish this, the authors collected data through a survey of 620 customers of the banks located in Ho Chi Minh City - the largest economic center in Vietnam. For the analytical method, the authors used multivariate regression to estimate the research model. Research results show that fintech service is very important for the banking sector in Vietnam. Moreover, this paper has achieved great success by identifying the factors that influence customers' intention to use fintech services. Accordingly, the intention to use fintech (INT) services is positively affected by the perception of usefulness (PU), social impact (SI), customer trust (TRU), and perceived ease of use (PEU). Based on the results of this study, bank managers will have a basis to improve the quality of fintech services. Not only that, the results of this study are also valuable for policymakers and researchers.
The Effect of Trade Openness on Foreign Direct Investment in Vietnam
LIEN, Nguyen Thi Kim Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.3
The purpose of this paper is to study the impact of trade openness on foreign direct investment (FDI) inflows into Vietnam, an emerging country with relatively high trade openness in recent years. The study used the vector autoregression (VAR) model to examine the impact of trade openness on FDI in Vietnam, in the period from 2005 to 2019. The research data are time-series data, with quarterly frequency, from 2005:Q4 to 2019:Q3. The FDI data were collected by International Financial Statistics. The data of trade openness were calculated based on Vietnam's export, import, and GDP data collected by the General Statistics Office of Vietnam. The estimated result shows that the trade openness has a positive effect on FDI. The current FDI is heavily influenced by FDI in the past with an average explanation of 74%. The main findings indicate that trade openness has a positive effect on FDI inflows into Vietnam. The findings also show that FDI in Vietnam is significantly affected by the shocks of the FDI itself in the past. The findings of the study suggest the Vietnamese Government improves the quality of trade openness and FDI, continues and maintains economic relations with other countries to increase trade openness.
Preparation, characterization and application of magnetic halloysite nanotubes for dye removal
Nguyen, Thi Kim Lien,Cao, Xuan Thang,Park, Chan,Lim, Kwon Taek Informa UK (TaylorFrancis) 2017 Molecular Crystals and Liquid Crystals Vol.644 No.1
<P>Magnetic functionalized halloysite nanotubes (MNPs/HNTs) was prepared and their effective adsorption for methylene blue (MB) was illustrated. Initially, poly(glycidyl methacrylate) grafted magnetic nanoparticles (MNPs-g-PGMA) were prepared by the reversible addition fragmentation chain transfer (RAFT) polymerization of glycidyl methacrylate. The fabrication of MNPs-g-PGMA and amino-modified halloysite nanotubes (HNTs-NH2) was carried out by the reaction of epoxy rings and amino functional groups to afford MNPs/HNTs. The composite was characterized by using FT-IR, XRD, TGA, SEM, and TEM analyses. The adsorption performance of MNPs/HNTs was evaluated by the adsorption experiment of MB in aqueous solution.</P>
( Nguyen Thai Son ),( Vu Thi Thu Huong ),( Vu Thi Kim Lien ),( Do Thi Quynh Nga ),( Tran Thi Hai Au ),( Tang Thi Nga ),( Le Nguyen Minh Hoa ),( Tran Quang Binh ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.9
The extensive distribution of multidrug-resistant (MDR) methicillin-resistant Staphylococcus aureus (MRSA) poses a threat to healthcare worldwide. This study aimed to investigate the MDR and molecular patterns of MRSA isolates in children admitted to the two biggest tertiary care pediatric hospitals in northern and southern Vietnam. A total of 168 MRSA strains were collected to determine antibiotic susceptibility by minimum inhibitory concentration tests. Antibiotic-resistant genes, pulsed-field gel electrophoresis, staphylococcal cassette chromosome mec (SCCmec) typing, and multilocus sequence typing were used for the molecular characterization of MRSA. Among the total strains, the MDR rate (51.8%) was significantly higher in the northern hospital than in the southern hospital (73% vs. 39%, p < 0.0001). The MDR-MRSA with the highest rates were “ciprofloxacin-erythromycin-gentamicin-tetracyclines” (35.6%), followed by “erythromycin-tetracycline-chloramphenicol” (24.1%), and “ciprofloxacin-erythromycin-gentamicin” (19.5%), showing an accumulative total of 79.3%. The most susceptible antibiotics were rifampicin (100%) and vancomycin (100%), followed by doxycycline (94.0%), meropenem (78.0%), and cefotaxime (75.0%). The SCCmecII strains showed greater resistance to gentamicin, ciprofloxacin, tetracycline, meropenem and cephalosporins compared with the other strains. The SCCmecII strains exhibited the highest rate in the tested genes (aacA/aphD: 55.2%, ermA/B/C: 89.7%, and tetK/M: 82.8%). ST5-SCCmecII was the predominant clone in the northern hospital, whereas SCCmecIVa was more pronounced in the southern hospital. In conclusion, our results raised concerns about the predominant MDR-MRSA strains in the pediatric hospitals in Vietnam. The north-south difference in the antibiotic resistance patterns and genetic structure of MRSA suggests different MRSA origins and various uses of antimicrobial agents between the two regions.
Nguyen, Thi Kim Lien,Nguyen, Thanh Luan,Cao, Xuan Thang,Park, Chan,Lim, Kwon Taek Informa UK (TaylorFrancis) 2016 Molecular Crystals and Liquid Crystals Vol.635 No.1
<P>The composite material based on poly(oligo(ethylene glycol) methacrylate)-grafted-layered double hydroxides/Gentamicin (LDHs-g-POEGMA-GE) was prepared by the reversible addition fragmentation chain transfer polymerization, and its antibacterial property was investigated. Initially, the surface of LDHs was modified by S-(3-trimethoxysilyl) propyl trithiocarbonate as a chain transfer agent and then grafted with POEGMA. Subsequently, GE was covalently linked to the POEGMA chains by esterification reaction producing LDHs-g-POEGMA-GE. The composites were characterized by using FT-IR, GPC, XRD, TGA, and SEM analyses. The in-vitro assay with Staphylococcus aureus bacteria indicated the high antibacterial activity of the composites, which promises potential applications in the biomaterial field.</P>
Nguyen, Thi Kim Lien,Cao, Xuan Thang,Jeong, Yeon Tae,Heo, Hoon,Gal, Yeong-Soon,Lim, Kwon Taek Taylor & Francis Inc. 2017 Molecular Crystals and Liquid Crystals Vol.654 No.1
<P>A facile route for preparation of poly(tert-butyl acrylate) covalently wrapped silica nanoparticles (SiO2/PtBA) was demonstrated by the single-electron transfer mediated living radical polymerization (SETLRP). Firstly, the surface of silica nanoparticles (SiO2 NPs) was modified with (3-aminopropyl) trimethoxysilane. Subsequently, a SET-LRP initiator was immobilized on the amine functional SiO2 NPs by the Ugi reaction of 2-bromo-2-methylpropionic acid, benzaldehyde, and 1-pentyl isocyanide. The SET-LRP of tert-butyl acrylate was carried out by using copperwire and PMDTA as a catalyst system. The grafting of PtBA on the surface of SiO2 NPs was investigated by FT-IR, XRD, TGA, and TEM analysis. Gel permeation chromatography analysis illustrated the molecular weight of PtBA increased with monomer conversion. The hydrolysis of the PtBA part yielded hydrophilic poly(acrylic acid) decorated SiO 2 NPs, which showed high colloidal stability.</P>
Phytoplankton composition in intensive shrimp ponds in Bac Lieu province, Vietnam
Nguyen Thi Kim Lien,Phan Thi Cam Tu,Vo Nam Son,Huynh Truong Giang 한국수산과학회 2023 Fisheries and Aquatic Sciences Vol.26 No.8
Algal overgrowth in shrimp culture ponds can affect the quality of the aquatic environment, thereby adversely affecting the shrimp and causing economic losses. The objective of this study was to evaluate the variation in phytoplankton composition in intensive shrimp ponds in Bac Lieu province, Vietnam. Phytoplankton samples were collected in three black tiger shrimp (Penaeus monodon) ponds and three whiteleg shrimp (Litopenaeus vannamei) ponds. The collected data were analyzed using SPSS and canonical correlation analysis softwares. In total, 75 species of phytoplankton were recorded in black tiger shrimp ponds and 64 species in whiteleg shrimp ponds. Diatoms had the highest species diversity with 29–30 species (39%–47%), followed by green algae with 9–19 species (14%–25%); species numbers of other phyla varied from 5–12 (8%–16%). The total number of phytoplankton species throughout the study varied from 34–50 species. Algal density was relatively high and ranged from 497,091–2,229,500 ind./L and 1,301,134–2,237,758 ind./L in black tiger shrimp and whiteleg shrimp ponds, respectively. The diatom density tended to increase during the final stage of the production cycle in black tiger shrimp ponds. Blue-green algae and dinoflagellates also increased in abundance at the end of the cycle, which can affect shrimp growth. Diatoms were significantly positively correlated with pH, salinity, total ammonia nitrogen, and nitrate (NO3 –) concentrations (p < 0.05). Blue-green algae and dinoflagellates were positively correlated with salinity, phosphate (PO4 3–), and NO3 –. Algal species diversity was lower in the whiteleg shrimp ponds than in the black tiger shrimp ponds. Several dominant algal genera were recorded in the shrimp ponds, including Nannochloropsis, Gyrosigma, Chaetoceros, Alexandrium, and Microcystis. The results of this study provide basic data for further investigations, and they contribute to the management of algae in brackish-water shrimp ponds.