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아이스플랜트(Mesembryanthemum crystallinum L.) 발효추출물의 항산화, 항당뇨 및 간 보호효과
남상해(Sanghae Nam),강승미(Seungmi Kang),김선정(Seonjeong Kim),고건희(Keunhee Ko) 한국생명과학회 2017 생명과학회지 Vol.27 No.8
본 연구는 아이스플랜트의 생리활성을 향상시키고, 식생활에서의 활용가능성을 높이기 위하여 물김치 형태로 발효시켰으며, 아이스플랜트의 성분 및 몇 가지 생리활성을 발효 전과 비교하였다. 물김치 침지액의 pH는 발효 6일째까지 계속해서 낮아졌으며, lactic acid의 생성량은 발효 4일째에 가장 많았다. 아이스플랜트 물김치 건더기 중의 D-pinitol은 발효 전 4.196±0.096 mg/g에서 6일째에는 3.843±0.116 mg/g으로 감소하였다. 그러나 myo-inositol과 D-chiro-inositol은 각각 발효 전 0.453±0.022와 2.815±0.008 mg/g에서 6일째에 0.630±0.029와 4.117±0.096 mg/g으로 증가하였다. 아이스플랜트 추출물의 DPPH, ABTS radical 소거활성 및 FRAP 활성은 대체로 발효 후에 높게 나타나 유사한 경향이었으며, 1 mg/ml의 농도로 처리하였을 때 각각 발효 5일째(79.09±0.69%), 4일째 (87.55±1.21%) 및 6일째(78.72±0.99%)에 가장 높았다. Lipid/MA assay에 의한 항산화 활성도 대체로 발효 후에 높게 나타나 유사한 경향이었으며, 추출물을 500 μg/ml 처리하였을 때, 발효 4일째에 가장 높은 활성(64.65±1.63%)을 나타났으며, 발효 5, 6일째에는 낮아지는 경향이었다. 아이스플랜트 추출물의 t-BHP, H2O2 및 ethanol에 의하여 손상된 BNL CL.2 세포의 생존율은 각각 14.19±0.98, 13.80±2.25 및 25.89±2.90%이었으나, 추출물을 200 μg/ml의 농도로 처리하였을 경우, 각각 발효 6일째에 50.07±4.85%, 2일째에 57.06% 및 4일째에 66.06±1.36%의 세포생존율을 나타내어 간세포가 회복되고 있음을 알 수 있었다. 그러나 발효 후에 간세포 보호효과가 뚜렷이 증가하지는 않았다. α-Glucosidase 저해활성은 모든 실험군에서 83.52±2.69~92.79±2.16%로 상당히 높게 나타났으며, 발효기간이 경과함에 따라 조금씩 증가하였다. 한편 α-Amylase 저해활성은 전체적으로 52.64±3.26~57.56±1.21%로 나타났으며 발효 전후에 뚜렷한 차이가 없었다. 이와 같은 결과로 볼 때, 아이스플랜트의 물김치 발효기간은 4~5일이 적정할 것으로 생각되었다. 한편 발효에 의한 기능성은 항산화효과를 제외한 간세포보호 및 α-Glucosidase, α-Amylase 저해활성은 전체적으로 소폭 향상에 그쳤다. 따라서 이러한 결과를 바탕으로 발효 등 다양한 가공방법이 개발되어, 향후 아이스플랜트의 소비촉진의 계기가 되기를 기대한다. Ice plant (Mesembryanthemum crystallinum L.) was fermented in brine in the form of mulkimchi (IPMB), and its contents of organic acid and cyclitols and biological activities were compared with those before fermentation. The pH of the IPMB continuously decreased until the sixth day of fermentation. The lactic acid yield was greatest on the fourth day. D-pinitol in ice plant mulkimchi solids (IPMS) decreased during fermentation. However, myo-inositol and D-chiro-inositol increased. The radical scavenging activities of ABTS and DPPH, in addition to the activity of FRAP, of the IPMS extract were generally higher after fermentation, with the activities highest on the fifth (79.09±0.69%), fourth (87.55±1.21%), and sixth (78.72±0.99%) days of fermentation, respectively, when treated with 1 mg/ml of the extract. As shown by a lipid/MA assay, antioxidant activity was generally higher after fermentation. The viability of BNL CL.2 cells damaged by t-BHP, H2O2, and ethanol was 14.19±0.98, 13.80±2.25, and 25.89±2.90%, respectively. When treated with 200 μg/ml of IPMS extract, the cell viability was 57.06±4.52% on the first day, and 66.06±1.36% on the fourth day, and 50.07±04.85% on the sixth day of fermentation. Hepatocyte protective effects did not increase significantly after fermentation. α-glucosidase inhibitory activity was quite high, with a range of 83.52±2.69 to 92.79±2.16%, and the activity increased gradually in all the groups over the fermentation period. There was no clear correlation between α-amylase inhibitory activity and fermentation.
Recurrent Retrohepatic Abscess Due to Spilled Appendicolith
( Yang Jae Yoo ),( Ji Hoon Kim ),( Wan Bae Kim ),( Baek Hui Kim ),( Keunhee Kang ),( Eileen L Yoon ),( Hyun Jung Lee ),( Jong Eun Yeon ),( Kwan Soo Byun ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1
Introduction: An ectopic appendicolith is a rare complication that can occur as a consequence of appendix perforation or drop of appendicolith during appendectomy, which may later form complicated abscess at para-cecal or pelvis area. However, there have been only 2 case reports on perihepatic abscess and there was no reports of recurrent perihepatic abscess complicated by ectopic appendicolith. Here, we report a case of recurrent perihepatic abscess caused by spilled appendicolith during laparoscopic appendectomy, mimicking intrahepatic abscess. Case: A 45 year old woman admitted with fever, chilling and right flank pain. In past history, she received laparoscopic appendectomy 7 month ago and experienced liver abscess after 2 weeks from surgery. Dynamic CT showed 3 cm sized, heterogeneously enhanced, low density mass at liver segment 6/7 sub-capsular area and with small calcification in the central portion. We reviewed CT imaging at pre-appendectomy and previous abscess management. We found an appendicolith in pre-appendectomy CT and the same apendicolith at central portion of liver abscess both in previous abscess management and this examination. We diagnosed as recurrent liver abscess due to spilled appendicolith. After 2 weeks of IV and 2 weeks oral antibiotic therapy, follow-up dynamic CT showed decreased abscess with sustained internal appendicolith. Considering recurrent attack of liver abscess and sustained appendicolith, which was suspected as the nidus of abscess, We decided to removal of abscess cavity including appendicolith laparascopically. Dissection of adhesion and opening of abscess revealed small appendicolith within the pocket. Resected abscess wall tissue, has been verified as inflamed granulation tissue, free of liver tissue. Apendicoliths turned out to be fecal material. She was diagnosed as recurrent retrohepatic abscess due to spilled appendicolith. Conclusion: This is first case of recurrent perihepatic abscess due to spilled appendicolith. Perihepatic abscess associated with appendicolith could mimick intrahepatic abscess should be removed surgically to prevent recurrent abscess formation.
Sim, Ji Hyun,Lee, Hyun Seung,Lee, Sunkyung,Park, Dae Eun,Oh, Keunhee,Hwang, Kyung-A,Kang, Hye-Ryun,Ye, Sang-Kyu,Kim, Hang-Rae The Korean Society of Food Science and Nutrition 2014 Journal of medicinal food Vol.17 No.5
Aster yomena is used in traditional remedies to treat cough, asthma and insect bites; however, its therapeutic mechanism is not completely understood. To elucidate the anti-asthmatic effect of A. yomena, we investigated the anti-asthmatic characteristics of an alcohol extract of A. yomena in an ovalbumin (OVA)-induced murine asthma model. In this study, we showed that A. yomena extract inhibited the overall pathophysiological features of asthma by suppressing Th2 responses and enzymes associated with the production of inflammatory mediators. This suppression resulted in decreased Th2 type cytokines and eosinophils in the bronchoalveolar lavage fluid and OVA-specific IgE in serum. Additionally, A. yomena extract significantly decreased airway hyperresponsiveness and abrogated the histopathological changes in the lungs, which reached normal levels in the OVA-challenged mice treated with A. yomena extract. These findings suggest that A. yomena could be a promising natural agent for treating bronchial asthma in humans.
Cheong, Taek-Chin,Shin, Eon Pil,Kwon, Eun-Kyung,Choi, Ji-Hye,Wang, Kang-Kyun,Sharma, Prashant,Choi, Kyong Hoon,Lim, Jin-Muk,Kim, Hong-Gee,Oh, Keunhee,Jeon, Ju-Hong,So, Insuk,Kim, In-Gyu,Choi, Myung-Si American Chemical Society 2015 ACS CHEMICAL BIOLOGY Vol.10 No.3
<P>Reactive oxygen species (ROS) play an important role in cellular signaling as second messengers. However, studying the role of ROS in physiological redox signaling has been hampered by technical difficulties in controlling their generation within cells. Here, we utilize two inert components, a photosensitizer and light, to finely manipulate the generation of intracellular ROS and examine their specific role in activating dendritic cells (DCs). Photoswitchable generation of intracellular ROS rapidly induced cytosolic mobilization of Ca<SUP>2+</SUP>, differential activation of mitogen-activated protein kinases, and nuclear translocation of NF-κB. Moreover, a transient intracellular ROS surge could activate immature DCs to mature and potently enhance migration <I>in vitro</I> and <I>in vivo</I>. Finally, we observed that intracellular ROS-stimulated DCs enhanced antigen specific T-cell responses <I>in vitro</I> and <I>in vivo</I>, which led to delayed tumor growth and prolonged survival of tumor-bearing mice when immunized with a specific tumor antigen. Therefore, a transient intracellular ROS surge alone, if properly manipulated, can cause immature DCs to differentiate into a motile state and mature forms that are sufficient to initiate adaptive T cell responses <I>in vivo</I>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/acbcct/2015/acbcct.2015.10.issue-3/cb5009124/production/images/medium/cb-2014-009124_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cb5009124'>ACS Electronic Supporting Info</A></P>
Phantom Ischemia Mimicking ST Segment Elevation Myocardial Infarction in Fulminant Myocarditis
Kim, Seung Han,Kim, Yong-Hyun,Lee, Jong Soo,Hwang, Young Jae,Lee, Jae Min,Kang, Keunhee,Song, Woo-Hyuk,Ahn, Jeong-Cheon 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2
A 30-year-old man visited the emergency room for chest pain, dyspnea and fever. Despite increased serum cardiac enzymes, ST segment elevation and inferior wall akinesis in electrocardiography and echocardiography, no atherosclerosis was evident in the coronary angiography. However, radionuclide myocardial perfusion image at day 2 showed a persistent perfusion defect in the left ventricular (LV) inferior wall. At day 3, prominent myocardial edema and severe LV systolic dysfunction developed with signs of heart failure. In this case, fulminant myocarditis seemed to originate from the right coronary artery territory and simulated a ST segment elevation myocardial infarction without coronary artery obstruction. The pathogenesis of the localized perfusion defect was unlcear.
Tai-Soon Yong,Eun-Hee Shin,Jong-Yil Chai,Woon-Mok Sohn,Keeseon S. Eom,Dong-Min Lee,Keunhee Park,Hoo-Gn Jeoung,Eui-Hyug Hoang,Yoon-Hee Lee,Hyun-Ju Woo,Ji-Hwa Lee,Sin-Il Kang,Jae-Ku Cha,Keon-Hoon Lee,Ch 대한기생충학열대의학회 2012 The Korean Journal of Parasitology Vol.50 No.2
Opisthorchis viverrini infection was found to be highly prevalent in 3 riverside villages (Ang Svay Chek A, B, and C) of the Prey Kabas District, Takeo Province. This area is located in the southern part of Cambodia, where the recovery of adult O. viverrini worms was recently reported. From May 2006 until May 2010, fecal examinations were performed on a total of 1,799 villagers using the Kato-Katz thick smear technique. In the 3 villages, the overall positive rate for helminth eggs ranged from 51.7 to 59.0% (av. 57.4%), and the percentage positive for O. viverrini was 46.4-50.6% (47.5%). Other helminths detected included hookworms (13.2%), echinostomes (2.9%), Trichuris trichiura (1.3%), Ascaris lumbricoides (0.6%), and Taenia spp. (0.06%). The prevalence of O. viverrini eggs appeared to reflect a lower infection in younger individuals (<20 years) than in the adult population (>20 years). Men (50.4%) revealed a significantly higher (P=0.02) prevalence than women (44.3%). The Ang Svay Chek villages of the Prey Kabas District, Takeo Province, Cambodia have been confirmed to be a highly endemic area for human O. viverrini infection.