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A Case of Acute Pancreatitis Associated with Risperidone Treatment
Kentaro Kawabe,Shu-ichi Ueno 대한정신약물학회 2014 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.12 No.1
Acute pancreatitis with antipsychotic treatment is rare but sometimes causes a fatal adverse effect. Most cases of acute pancreatitisdue to atypical antipsychotic agents are reported to occur within six months of starting antipsychotic administration. Caused by risperidone is rare. The patient had a high fever, stomachache and vomiting. The results of the abdominal computedtomograhpy scan were negative. The results of the abdominal ultrasonography were positive for gallstones in gallbladder anddistention of the common bile duct. She had been fasting and received antibiotic intravenous injections. Amylase and lipasetiters were high. After risperidone discontinuation, both the levels of the amylase and the lipase were gradually decreased. Threemonths later, the patient still maintains a good clinical balance. Although atypical antipsychotic-induced pancreatitis has beenreported in conjunction with hyperglycemia, the pathophysiologic mechanism of these adverse events remains unclear. Thiscase got pancreatitis 6 month after risperidone treatment. Using the antipsychotic agents, it is necessary to monitor pancreasfunction.
Kentaro Ohuchi,Naohisa Miyakoshi,Yuji Kasukawa,Toyohito Segawa,Hayato Kinoshita,Chie Sato,Masashi Fujii,Yoichi Shimada 대한골다공증학회 2019 Osteoporosis and Sarcopenia Vol.5 No.4
Objectives: The purpose of this study is to evaluate the effects of teriparatide (TPTD) on bone mineral density (BMD), bone strength, and bone quality in Akita mouse models of diabetes mellitus. Methods: Twelve-week-old female Akita mice and control mice (C57/BL/6NCrSlc) were divided into 4 groups: control mice treated with vehicle (n ¼ 7) or TPTD (n ¼ 6); and Akita mice treated with vehicle (n ¼ 6) or TPTD (n ¼ 7). TPTD or vehicle was administered subcutaneously 3 times a week for 8 weeks. Blood glucose, serum sclerostin, total tibial BMD, femoral shaft bone strength, and bone quality using Fourier-transform infrared spectroscopy imaging were evaluated. Results: No significant differences in serum sclerostin levels were evident among these groups after 8 weeks of treatment. TPTD significantly increased BMD in control mice (þ12.7%, P ¼ 0.02) and Akita mice (þ29.2%, P ¼ 0.001) compared with vehicle. Maximum load and stiffness were significantly higher in Akita mice treated with TPTD than in Akita mice treated with vehicle (þ56.6%, P ¼ 0.03 and þ 90.5%, P ¼ 0.02, respectively). On Fourier-transform infrared spectroscopy imaging, the mineral/matrix ratio was significantly lower in Akita mice treated with vehicle than in control mice (12.2%, P ¼ 0.02), and TPTD treatment significantly increased the mineral/matrix ratio (P ¼ 0.003). Conclusions: TPTD thus improved BMD and bone strength in both control mice and Akita mice, with improvements in the mineral/matrix ratio among Akita mice.
ROI-based Fully Automated Liver Registration in Multi-phase CT Images
Kentaro SAITO,Huimin LU,Hyoungseop KIM,Shoji KIDO,Masahiro TANABE 제어로봇시스템학회 2018 제어로봇시스템학회 국제학술대회 논문집 Vol.2018 No.10
In this paper, we propose a registration method for fully automated liver tumor detection. Multiple phases CT is used for the detection of the liver tumor because multiple phase CT can give different characteristic features of lesions for each time phases. Registration accuracy is important when obtaining image features from multiple time phases. However, since each time phases have different image density characteristics, therefore registration of multi-phase CT is a challenging task. In this paper, we propose a robust initial alignment method independent of changing image density features in each time phase, and deformable registration method with region of interests (ROI) as liver region extracted by U-Net. Our proposed method is evaluated on 15 patient image sets. This method is applied to the early arterial phase and the equilibrium phase to registries. Experimental results show that segmentation of early arterial phase is 83% and registration is 93% accuracy.
Kentaro Atsukawa,Shuntaro Amari,Hiroshi Takiyama 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.101 No.-
From the designs of product and industrial process perspectives, the solubility of a target material is oneof the most valuable qualities. We proposed the ‘solid dispersion melt crystallization (SDMC) concept’ asa original strategy for dispersing a target material in a matrix one, in which the target material is naturallydispersed between the crevices formed by the matrix material precipitatedfirst. Furthermore, the effectsof introducing some operations, such as cooling, agitation and aeration, to the SDMC concept on thedissolution rate were investigated by a binary eutectic system. According to the experimental results, thedissolution rate was enhanced by the operations (cooling, agitation and aeration). This improvement inthe dissolution rate was attributed to the SDMC concept-based enhancement of the nucleation rate. Therefore, it was revealed that an increase in the nucleation rate due to the SDMC concept had effectivelyimproved the dissolution rate.
DT Neutronics Benchmark Experiment on Lead at JAEA-FNS
Kentaro Ochiai,Keitaro Kondo,Seiki Ohnishi,Kosuke Takakura,Satoshi Sato,Yuichi Abe,Chikara Konno,Chihiro Suzuki,Takahiro Yagi 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
Lead is one of the most important candidate materials for nuclear fusion reactor blankets. We have carried out an integral benchmark experiment on lead at the DT neutron source facility of JAEA, FNS. A cubic lead assembly on a side of 45.3 cm was set up and was irradiated with the DT neutron source. Reaction rates of the ^(27)Al(n,α)^(24)Na, ^(93)Nb(n,2n)^(92m)Nb, ^(90)Zr(n,2n)^(89)Zr, and ^(115)In(n,n')^(115m)In reactions and neutron spectra above 2 MeV were measured inside the assembly with activation foil and a small NE213 spectrometer, respectively. A Monte Carlo code, MCNP5, was adopted to calculate the reaction rates and neutron spectra. The latest nuclear data libraries, JENDL-3.3 ENDF/B-VII.0, JEFF-3.1 and FENDL-2.1, were used in the calculation. The calculation results with the three libraries except for JENDL-3.3 agreed with the measured reaction rates and neutron spectra. On the other hand, that with JENDL-3.3 underestimated the measured ones with the depth. We found out that the inappropriate evaluation of the (n,2n), elastic scattering and inelastic scattering reactions in the lead isotopes of JENDL-3.3 caused the disagreements.