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Ken Sasaki,Michio Hongo,Naohisa Miyakoshi,Toshiki Matsunaga,Shin Yamada,Hiroaki Kijima,Yoichi Shimada 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.4
Study Design: In vivo biomechanical study using a three-dimensional (3D) musculoskeletal model for elderly individuals with or without pelvic retroversion. Purpose: To evaluate the effect of pelvic retroversion on the sagittal alignment of the spine, pelvis, and lower limb in elderly females while standing and walking. Overview of Literature: Patients with hip–spine syndrome have concurrent hip-joint and spine diseases. However, the dynamic sagittal alignment between the hip joint and spine has rarely been investigated. We used a 3D musculoskeletal model to evaluate global spinopelvic parameters, including spinal inclination and pelvic tilt (PT). Methods: A total of 32 ambulant females (mean age=78 years) without assistance were enrolled in the study. On the basis of the radiographic measurement for PT, participants were divided into the pelvic retroversion group (R-group; PT≥20°) and the normal group (N-group; PT<20°). A 3D musculoskeletal motion analysis system was used to analyze the calculated value for the alignment of spine, pelvis, and lower limb, including calculated (C)-PT, sagittal vertical axis (C-SVA), pelvic incidence, lumbar lordosis, T1 pelvic angle (CTPA), as well as knee and hip flexion angles while standing and walking. Results: While standing, C-PT and C-TPA in the R-group were significantly larger than those in the N-group. Hip angle was significantly smaller in the R-group than in the N-group, unlike knee angle, which did not show difference. While walking, C-SVA and C-TPA were significantly increased, whereas C-PT decreased compared with those while standing. The maximum hip-flexion angle was significantly smaller in the R-group than in the N-group. There was a significant correlation between the radiographic and calculated parameters. Conclusions: The 3D musculoskeletal model was useful in evaluating the sagittal alignment of the spine, pelvis, and leg. Spinopelvic sagittal alignment showed deterioration while walking. C-PT was significantly decreased while walking in the R-group, indicating possible compensatory mechanisms attempting to increase coverage of the femoral head. The reduction in the hip flexion angle in the R-group was also considered as a compensatory mechanism.
Original Article : Role of UCP2 Expression after Hepatic Warm Ischemia-Reperfusion in the Rat
( Mizuki Ninomiya ),( Ken Shirabe ),( Mitsuo Shimada ),( Takahiro Terashi ),( Yoshihiko Maehara ) 대한간학회 2011 Gut and Liver Vol.5 No.4
Background/Aims: The role of uncoupling protein-2 (UCP2) in the liver is currently unclear. Emerging evidence suggests a relationship between UCP2 and oxidative stress. In the present study, we tested the hypothesis that UCP2 expression in the liver might change during warm ischemia-reperfusion (I/R) according to oxidative stress. Methods: Wistar rats were subjected to 40 (short ischemia) or 90 (long ischemia) minutes of partial lobar ischemia followed by 4 hours of reperfusion. UCP2 expression in the ischemic and nonischemic lobes was assessed using reverse transcription-polymerase chain reaction and immunohistochemistry. Malondialdehyde concentrations in the liver tissue were also compared. Results: Malondialdehyde concentrations in the ischemic lobes were significantly higher in the long ischemia group. In the ischemic lobes of the short ischemia group, UCP2 protein expression was induced in hepatocytes, which did not express the protein prior to treatment, and the expression levels were higher than in the long ischemia group. The intralobular distribution of UCP2 seemed to correlate inversely with that of the necrotic area. UCP2 expression was observed, even in nonischemic lobes with similar intralobular heterogeneity. Conclusions: UCP2 was induced in hepatocytes after warm I/R. Although the primitive role of UCP2 expression may be cytoprotective in nature, its actual protective effect in hepatic I/R may be minimal. (Gut Liver 2011;5:486-492)
Kataoka Masahiro,Gomi Kuniyuki,Ichioka Ken,Iguchi Takuya,Shirota Tomoki,Makino Arano,Shimada Ko,Maruyama Kiyotomi,Mihara Motohiro,Kajikawa Shoji 대한대장항문학회 2023 Annals of Coloproctolgy Vol.39 No.4
Purpose: C-reactive protein to albumin ratio (CAR) has been utilized as a prognostic factor in various carcinomas. We investigated the relationship between preoperative, postoperative day (POD) 1, and POD 7 CARs and the prognosis of patients with colorectal cancer (CRC). Methods: Three hundred twenty patients with CRC who underwent laparoscopic radical resection between May 2011 and December 2016 were enrolled. Patients were selected into 2 groups, high CAR and low CAR (72 patients per group), based on preoperative, POD 1, and POD 7 CARs. The relapse-free survival (RFS) and overall survival (OS) were compared between groups using propensity score matching. Results: The high CAR group had a significantly worse RFS (P<0.001) and OS (P=0.002) at POD 7 than those in the low CAR group. However, in preoperative and POD 1 analysis, no differences were observed. Conclusion: In patients with CRC, CAR of POD 7 was a significant prognostic factor.
Dietary L-Cysteine Inhibits D-Galactosamine-induced Acute Liver Injury in Rats
이슬기,한규호,Erina Yabuki,Yumi Nakamura,Sakura Kawakami,Ken-ichiro Shimada,Hirotake Onoue,Michihiro Fukushima 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.3
The effects of L-cysteine (1 and 2%) on the antioxidative system were examined in rats with Dgalactosamine (D-GalN)-induced injury. These rats showed increases in serum antioxidative enzyme and hepatic thiobarbituric acid reactive substances (TBARS) activities, with decreased hepatic/serum glutathione (GSH) levels and GSH-related enzyme activities. However, L-cysteine supplementation resulted in a decrease of hepatic TBARS levels, and increased catalase and serum GSH levels. The activities of serum enzymes in rats receiving 2% L-cysteine were significantly (p<0.05) lower than in D-GalN-injected group rats, and similar to levels in control group rats without acute liver injury. In addition, 2% L-cysteine increased the glutathione reductase activity and decreased the serum TBARS level in liver injury group rats. Dietary L-cysteine, especially at a 2% level, exerts a hepatoprotective effect by alteration of the GSH level and antioxidative enzyme activities.
Effect of Colored Potato Flakes Against Acetaminophen-induced Liver Damage in Rats
Kiyoshi Ohba,Shoko Watanabe,Kyu-Ho Han,Naoto Hashimoto,Takahiro Noda,Ken-ichiro Shimada,Hisashi Tanaka,Mitsuo Sekikawa,Michihiro Fukushima 한국식품과학회 2007 Food Science and Biotechnology Vol.16 No.3
We examined the hepatoprotective effects of colored potato flakes on acetaminophen(AAP)-induced liver damage in rats. F344/DuCrj (8 week-old) rats were fed a cholesterol-free diet with 54,9486 g of α-corn starch/100 g diet and were orally treated with 25% colored flakes of Kitamurasaki (KM: light purple), Northern Ruby (NR: red), and Queen (SQ: medium purple) potatoes co-administered with AAP (0.5 g/100 g diet)for 4 weeks. The hepatic thiobarbituric acid-reactive substances (TBARS) values in the KM, NR, and SQ group were significantly lower (p<0.05) than those in the control groups with and wothout AAP. Furthermore, the hepatic catalase, Mn-superoxide dismutase (SOD), and Cu/Zn-SOD mRNA levels in the KM, NR, and SQ groups were higher than those in the control groups with and without AAP. The present findings suggest that colored potato flakes are useful as a prophylactic agent against oxidative liver damage.
Lipid Metabolism in Rats Fed Acetaminophen with Coadministration of Adzuki Bean Extract
Kyu-Ho Han,Kiyoshi Ohba,Chi-Ho Lee,Ken-ichiro Shimada,Mitsuo Sekikawa,Michihiro Fukushima 한국식품과학회 2007 Food Science and Biotechnology Vol.16 No.4
The effect of water extract of adzuki beans on acetaminophen-altered lipid metabolism was examined in rats. Control group of rats was fed a basal diet, another group of rats was fed 0.5% acetaminophen (APAP group), and a third group of rats was fed 0.5% acetaminophen plus 5% adzuki bean extract (ABE group) for 4 weeks. Serum total and HDL cholesterol levels in the APAP group were significantly lower than those in the control and ABE groups. Hepatic cholesterol 7α- hydroxylase and fatty acid synthase mRNA levels in the APAP and ABE groups were significantly higher and lower than in the control group, respectively. Hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA level in the APAP group was significantly lower than in the control group, whereas that in the ABE group was significantly higher than in the APAP group. These results indicate that adzuki bean extract may improve the acetaminophen-altered serum lipid metabolism in rats.