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C3H 생쥐에서 자외선 B의 집중조사와 분할조사가 표피내 랑게르한스 세포의 회복에 미치는 영향
구상완,한승경,박윤기,조무연 ( Sang Wahn Koo,Seung Kyung Hann,Yoon Kee Park,Moo Yon Cho ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.4
N/A The Effect on the Recovery of Epidermal Langerhans Cells in C3H Mice after Single and Fractionated Exposure of Ultraviolet B Irradiation Sang-Wahn Koo, M.D., Seung Kyung Hann, M.D., Yoon-Kee Park, M.D., Moo Yon Cho, M.D. Department of Dermatology, Yonsei University College of Medicine Seoul, Korea The study was undertaken to see the recovery in epidermal Langerhans cells in relation to time after UVB irradiation through different amounts and ways of exposure in C3H mice. We irradiated the ears of C3H mice with UVB 200mJ/㎤ and 400mJ/㎤ in a single dose at one time and 5 fractionated doses for 5 days and 10 fractionated doses for 10 days and performed biopsies on the ears of the control and experimental groups after, 2, 7, 14, 21 days of irradiation and stained them by the immunoperoxidase method. The results are summarized as follows. 1. A more significant decrease in the number of Ia-positive epidermal Langerhans cells was observed in single-dose-exposed group than fractionated-dose-exposed groups on the second day of irradiation. 2. On the seventh day of exposure, the number of the Ia-positive epidermal cells in single-dose-exposed group returned to normal, but in fractionated-dose-exposed groups the number of Langerhans cells decreased most remarkably. 3. In fractionated-dose-exposed groups, the number of Langerhans cells returned to normal on the 14th or 21st day of expposure. (Kor J Dermatol 29(4) : 459-465, 1991)
( Kee Wook Jung ),( Dong Hoon Yang ),( In Ja Yoon ),( So Young Seo ),( Hyun Sook Koo ),( Hyo Jeong Lee ),( Ho Su Lee ),( Ji Beom Kim ),( Jong Wook Kim ),( Soo Kyung Park ),( Sang Hyoung Park ),( Kyung 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.3
Background/Aims Biofeedback therapy (BFT) can be unsuccessful in constipated patients, even those with pelvic floor dysfunction. Electrical stimulation therapy (EST) has been introduced as a novel therapeutic modality in patients with chronic constipation, especially those who have rectal hyposensitivity. We evaluated the efficacy of EST based on five years` clinical experience. Methods From January 2002 to February 2007, 159 patients underwent EST. After exclusion of 12 drop-outs, 147 (M:F = 61:86, 49 ± 17 years) finished all treatment sessions. Among them, 88 (M:F = 29:59, 49 ± 17 years) were refractory to BFT without rectal hyposensitivity (RH), and 59 (M:F = 32:27, 54 ± 17 years) were those with RH. Results The overall response to EST was 59.2% (87/147) by per-protocol analysis. In the EST-responsive group, overall satisfaction im - proved significantly (from 7.3 ± 3.0 to 4.3 ± 2.5, P< 0.05). Subgroup analysis showed that the response rate was 64.8% (57/88) in patients refractory to BFT without RH, and 50.8 % (30/59) in those with RH. Conclusions EST may have additional therapeutic efficacy in patients who are refractory to BFT. EST may also be effective in patients with RH, including restoration of rectal sensation. Therefore, EST could be considered as an alternative choice in patients refractory to BFT and with or without RH. (J Neurogastroenterol Motil 2013; 19:366-373)
( Kee Wook Jung ),( Min Woo Jo ),( Seon Ha Kim ),( Woo Seung Son ),( Hyo Jeong Lee ),( Dong Hoon Yang ),( In Ja Yoon ),( So Young Seo ),( Hyun Sook Koo ),( Ji Beon Kim ),( Sang Hyoung Park ),( Kyung J 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Previous studies using Short Form-36 (SF-36) and Patient Assessment of Constipation Quality of Life (PAC-QOL) have shown a reduced quality of life (QOL) in patients with chronic constipation. However, these questionnaires were composed of more than 26 items, and these surveys taken at outpatient clinics were time-consuming. European Quality of Life-5 Dimensions (EQ-5D) is composed of 5 dimensions with 3 levels measuring people`s utility. However, the psychometric properties of EQ- 5D in chronic constipation have not been evaluated. We aimed to investigate the validity and reliability of EQ-5D and compare them with those of PAC-QOL and SF-36 in women with chronic constipation. Methods: Constipated 150 women (54 ± 16 years) who visited a constipation clinic were prospectively enrolled. They were asked to fi ll in bowel- and QOL-related questionnaires. Construct validity was examined by determining the difference betweenthe EQ-5D indexes among the questionnaires. In addition, differences in the EQ-5D index on the PAC-QOL score were analyzed. Results: The mean duration of constipation and the use of laxatives were 15.1 ± 13.6 years and 6.7 ±8.3 years, respectively. The EQ-5D index showed signifi cant differences in age, education, and comorbidities (all P< 3 times of bowel movement/week) than those with a higher frequency of defecation (= 3 times of bowel movement/week) (P Conclusions: The EQ-5D appears to be effective in measuring QOL in patients with chronic constipation. EQ-5D can be complementary to the previously used PAC-QOL and SF-36 in outpatient clinic settings.
P059 : CyPPA inhibits melanogenesis through activation of the ERK signaling pathway
( Sang Hyung Lee ),( Tai Kyung Noh ),( Sung Eun Chang ),( Mi Woo Lee ),( Jee Ho Choi ),( Kee Chan Moon ),( Hong Il Cho ),( Seung Hyun Bang ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: CyPPA is known as a positive modulator of SK2 and 3, which is found in HTS (high throughput screening for melanogenesis inhibitors). However, the effects of CyPPA on melanogenesis are not well known. Objectives: we evaluated CyPPA and impact on melanogenesis-related ERK signaling pathways. Methods: Mel-ab mouse melanocyte cells and human melanocytes were used to examine the effects of CyPPA on melanogenesis. To ascertain the CyPPA effect, microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase related protein (TRP) 1 and TRP 2 were examined by Western blotting and RT-PCR. We also investigated the phosphorylation of ERK, which is related to melanin regulation. Results: These results showed that melanin content and tyrosinase activity were significantly reduced in both cells without cytotoxicity. However, as it does not affect the activity of mushroom tyrosinase, CyPPA does not seem to be a direct inhibitor of tyrosinase. The level of MITF, Tyrosinase, TRP1 and TRP 2 expression were decreased. CyPPA induced phosphorylation of ERK and specific ERK phosphorylation inhibitor, PD98059, partially recovered the CyPPA-mediated inhibition of proteins associated with melanin synthesis such as MITF, TRP1, and TRP2. Conclusion: These results suggest that CyPPA inhibits melanogenesis through activation of the ERK signaling pathway.