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Katsumi Kobayashi,K. Sadasivan Pillai,Mathews Michael,K.M. Cherian,Mariko Ohnishi 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.2
In repeated-dose 28-day oral toxicity study design, the low dose is fixed as the no observed effect level (NOEL). But, in practice the low dose usually shows significant difference in few measurable items in most of the studies. We investigated 109 of repeated-dose 28-day oral toxicity studies in rats conducted according to the Chemical Substance Control Law, Japan and examined the measurable items (functional observational battery, urinalysis, hematology, blood chemistry and absolute and relative organ weights) of the low dose group which showed a statistical significant difference (P<0.05) compared to the respective control groups. The investigation revealed that, 205/12,167 (1.6%) measurable items showed a significant difference in the low dose groups. The significant difference shown by urinalysis was high (3.3%), followed by clinical chemistry parameters, hematology, relative organ weights and absolute organ weights (1.8-1.1%). We conclude from the investigation that the low dose may be considered as NOEL, if the significant difference of measurable items of it is about 2% (maximum <5%), compared to the control. However, due consideration may be given to the clinical relevance of the items that showed a significant difference.
범가자미, Verasper variegatus의 생식소 발달단계에 따른 혈중 난황단백전구체 (vitellogenin)와 성 스테로이드 호르몬 변화
한창희,會田勝美,김윤,백혜자,小林牧人 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1
Annual plasma levels of vitellogenin and sex steroids were investigated in relation to the gonadal development for understanding the endocrine control of reproduction in spotted flounder, Verasper variegatus. The plasma vitellogenin level was highest, 6.36㎎/㎖, in November when vitellogenesis was most active. The level, thereafter, decreased to 3.81㎎/㎖ in December with the initiation of spawning. On the other hand, estradiol-17 β was highest, 2.7ng/㎖, in December, and rapidly decreased in January when spawning occurred. The decreased level of estradiol-17 β, around 0.2ng/㎖, remained unchanged until May. The profiles of plasma testosterone were similar to those of estradiol-17 β in the fish. The Plasma 17 α-hydroxyprogesterone level was relatively low throughout the spawning period, but increased slightly with the initiation of ovarian development. In males, the plasma testosterone and 11- ketotestosterone were highest in December when spermiation actively proceeded, but rapidly decreased during the spawning period (January).
범가자미, Verasper variegatus의 생식소 발달단계에 따른 혈중 난황단백전구체 (vitellogenin)와 성 스테로이드 호르몬 변화
김윤,백혜자,한창희,회전승미,소촌목인,KIM Yoon,BAEK Hea-Ja,HAN Chang-Hee,AIDA Katsumi,KOBAYASHI Makito 한국수산과학회 1999 한국수산과학회지 Vol.32 No.5
범가자미의 인위적인 번식제어를 목적으로 생식소 활성에 따른 혈중 vitellogenin (난황단백전구체)과 성 스테로이드 호르몬의 계절적 농도 변화를 조사하였다. 암컷에 있어서 혈중 vitellogenin의 농도는 난황축적이 활발한 11 월에 연중 최고치를 나타내다가 산란이 시작되는 12월에 감소하기 시작하면서 estradiol의 농도는 이 시기에 연중 최고치를 나타내었다(2.7ng/ml). 산란이 활발히 진행중인 1월에 혈중 estradiol 농도는 급격히 감소하여 5월까지 연중 매우 낮은 농도(0.2ng/ml)로 유지되었다. Testosterone도 estradiol과 유사한 경향을 보였다. 17$\alpha$-hydroxyprogesterone은 난소가 활성화되어 성장되는 시기를 제외하고는 뚜렷한 경향을 보이지 않았다. 수컷의 경우 testosterone과 11-ketotestosterone의 혈중농도는 12월에 최고치를 나타내었으며, 이 시기에 정자변태가 가장 활발하게 이루어지고 있음을 관찰하였다. 이후 완숙 및 방정기 (1월)에 이르러 이들의 농도는 급격히 감소하였다. Annual plasma levels of vitellogenin and sex steroids were investigated in relation to the gonadal development for understanding the endocrine control of reproduction in spotted flounder, Verasper variegatus. The plasma vitellogenin level was highest, 6.36 mg/ml, in November when vitellogenesis was most active. The level, thereafter, decreased to 3.81 mg/ml in December with the initiation of spawning. On the other hand, estradiol-17 $\beta$ was highest, 2.7 ng/ml, in December, and rapidly decreased in January when spawning occurred. The decreased level of estradiol-17$\beta$, around 0.2 ng/ml, remained unchanged until May. The profiles of plasma testosterone were similar to those of estradiol-17$\beta$ in the fish, The plasma 17 $\alpha$-hydroxyprogesterone level was relatively low throughout the spawning period, but increased slightly with the initiation of ovarian development, In males, the plasma testosterone and 11-ketotestosterone were highest in December when spermiation actively proceeded, but rapidly decreased during the spawning period (January).