Expression of Transthyretin during bovine myogenic satellite cell differentiation.

Pokharel, Smritee,Kamli, Majid Rasool,Mir, Bilal Ahmad,Malik, Adeel,Lee, Eun Ju,Choi, Inho Springer 2014 In vitro cellular & developmental biology Animal Vol.50 No.8

<P>Adult myogenesis responsible for the maintenance and repair of muscle tissue is mainly under the control of myogenic regulatory factors (MRFs) and a few other genes. Transthyretin gene (TTR), codes for a carrier protein for thyroxin (T4) and retinol binding protein bound with retinol in blood plasma, plays a critical role during the early stages of myogenesis. Herein, we investigated the relationship of TTR with other muscle-specific genes and report their expression in muscle satellite cells (MSCs), and increased messenger RNA (mRNA) and protein expression of TTR during MSCs differentiation. Silencing of TTR resulted in decreased myotube formation and decreased expression of myosin light chain (MYL2), myosin heavy chain 3 (MYH3), matrix gla protein (MGP), and voltage-dependent L type calcium channel (Cav1.1) genes. Increased mRNA expression observed in TTR and other myogenic genes with the addition of T4 decreased significantly following TTR knockdown, indicating the critical role of TTR in T4 transportation. Similarly, decreased expression of MGP and Cav1.1 following TTR knockdown signifies the dual role of TTR in controlling muscle myogenesis via regulation of T4 and calcium channel. Our computational and experimental evidences indicate that TTR has a relationship with MRFs and may act on calcium channel and related genes.</P>

Effect of porcine placenta steroid extract on myogenic satellite cell proliferation, transdifferentiation, and lipid accumulation

Lee, E. J.,Kamli, M. R.,Bhat, A. R.,Pokharel, S.,Lee, D. M.,Kim, S. H.,Kim, T. I.,Hong, S.,Choi, I. Springer Science + Business Media 2012 In vitro cellular & developmental biology. Animal Vol.48 No.5

Depot-specific gene expression profiles during differentiation and transdifferentiation of bovine muscle satellite cells, and differentiation of preadipocytes

Lee, E.J.,Lee, H.J.,Kamli, M.R.,Pokharel, S.,Bhat, A.R.,Lee, Y.H.,Choi, B.H.,Chun, T.,Kang, S.W.,Lee, Y.S.,Kim, J.W.,Schnabel, R.D.,Taylor, J.F.,Choi, I. Academic Press 2012 Genomics Vol.100 No.3

We report a systematic study of gene expression during myogenesis and transdifferentiation in four bovine muscle tissues and of adipogenesis in three bovine fat tissues using DNA microarray analysis. One hundred hybridizations were performed and 7245 genes of known and unknown function were identified as being differentially expressed. Supervised hierarchical cluster analysis of gene expression patterns revealed the tissue specificity of genes. A close relationship in global gene expression observed for adipocyte-like cells derived from muscle and adipocytes derived from intramuscular fat suggests a common origin for these cells. The role of transthyretin in myogenesis is a novel finding. Different genes were highly induced during the transdifferentiation of myogenic satellite cells and in the adipogenesis of preadipocytes, indicating the involvement of different molecular mechanisms in these processes. Induction of CD36 and FABP4 expression in adipocyte-like cells and adipocytes may share a common pathway.

Grant Allen’s The Woman Who Did : A Critique on Eugenics and New Womanhood

( Kam¸ Kyeong Yeon ) 동국대학교 영어권문화연구소 2014 영어권문화연구 Vol.7 No.2

This paper, which makes available the forgotten pictures and previously unnoticed complexites drawn from articles, introduces aspects of the work of a neglected naturalist and evolutionist writer of the late nineteenth century in Victorian era. In particular, this paper focuses on Allen's analysis of the social construction of marriage and his concern of the future race and the concomitant issue of motherhood and social progress. On the issue of recognizing and validating women's role as mothers and entitling them public recognition as a social contributor, Allen is in line with early feminists known as eugenic feminists such as Sarah Grand and Frances Swiney. As to the mechanism of evolution, however, Allen differed from their view in that he regarded nature as a driving force whereas eugenic feminist saw human control as the key note in the evolutionary process. Such tension is witnessed in Allen's New Woman Novel, The Woman Who Did (1895) in which the protagonist Herminia seeks women's emancipation through her task of mothering premised on eugenic ideology. Ironizing Herminia's failure and her death, Allen calls into question the practicability of the discourse constituting the eugenic project. Drawing on the theories on evolution and Richardson's concept of “eugenic love”, this paper examines social implication in Herminia's maternal agenda and investigates the condition of her project which is already doomed to fail.

大學에 있어서의 敎職敎育의 當面課題

朴甘淳 木浦大學校 敎育硏究所 1991 교육연구 Vol.4 No.-

Some improvements to make on essential problems exisited in Teacher-Education of college are as follows : ① The purpose of the Teacher-Education is to train an educational specialist who is able to accomplish the educational ideology. To become an educational specialist, he or she should be cultivate the foundation of scholarstic characterics for the teaching profession to give full play to one's educational ability as a faithful teacher in the future. ② In the education as teaching profession, reality and present circumstance of education should be understood fundamentally in an academic point of view and training quality and ability to consider and search educational plans, contents, and methods should be given top priority. ③ Functionalized specialization, which is segregated from academic autonomy and overemphasized, causes the diminution of the educational specialization led to loss of the Teacher-Education essence. To get over this, system change, which allows schools and teachers gaurantee of educational autonomy to create educational plans and so forth for schools is necessary. ④ Teacher-Education in university is too theoretical to apply in a practice. Therefore, research and education combined practice and theory referring to advantages of practical educational in college should be necessary. ⑤ In whether a teacher training school or a college the principle of teacher training to equip teachers' quality should be pursuit through aggregated education. ⑥ To make efficient improvements on Teachers-Education, contents of Teacher-Education curriculum should be closely combined with education practices. System Improvements on contents of the Educational Methodology, Teaching Methods of subjets, Educational Psychology, and the like need to make practical studies.

한국의 범죄현황과 대책에 관한 연구

황감용 大邱大學校 社會科學硏究所 2001 社會科學硏究 Vol.9 No.1

본 연구는 범죄의 원인을 규명하고 범죄예방책을 제시하는데 목적을 두고 있다. 이를 위해 연도별 범죄 실태를 분석하고 연대별 동향을 파악하였다. 범죄이론으로는 치료 및 갱생을 통한 범죄예방, 사회학적 범죄학에 근거한 예방이론, 처벌을 통한 범죄 억제이론을 설명하였다. 본 연구에서 범죄예방 활동으로 파출소의 순찰기능 강화를 우선적으로 들었다.

GIS 기법을 도입한 재난관리 시스템 구축

金甘來,鄭海珍,任健爀 明知大學校 産業技術硏究所 2007 産業技術硏究所論文集 Vol.26 No.-

Due to an urbanization phenomenon which is caused according to a large selecting land development of a city area drained by river, the keeping gate phenomenon is changed and the flood damage is happening near city river. Recently, many research to reduce such city flood damage for the prevention have been achieved, this study proposed to analyze and arrange pattern of disaster and systems designed plan and establishment further scientific, prompt service of disaster. With GIS technique for decision-making offer the necessary preliminary data(hydrography data, satellite images, DEM, etc). In order to forecast the flooding area of research object area and offer various information which can reduce the flood damage to many users, this study constructs the disaster management system using Internet GIS.

조류성장억제에 미치는 원적외선 활성수의 효과

장갑용,박성하,임경묵 한밭대학교 에너지청정기술연구소 2002 에너지청정기술논문집 Vol.3 No.1

Laboratory experiments were conducted to investigate the effect of far infrared ray(FIR) activated water on the inhibition of algal growth. The growth of S. quadricauda and C. vulgaris was enhanced by the FIR activated water in Allen media containing high concentration of nutrients, but inhibited in natural water containing low concentration of nutrients. The growth of O. tenuis and M. aeruginosa was inhibited in both Allen media and natural water. When comparing the effects of FIR treated water 1(NC1) and 2(NC2), the growth of O. tenuis and M. aeruginosa was somewhat enhanced by NC1, whereas inhibited by NC2. Therefore, it is suggested that NC2 is more effective than NC1 in controlling the algal growth.

AE 신호를 이용한 회전형 압축기의 이상상태 감시

이감규,정지홍,김전하,강명창,김정석 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.5

The compressor has one of important roles in refrigeration cycle and it determines refrigeration efficiency and quality. This paper aims to monitor rotary compressors for room air conditioners by using Acoustic Emission(AE) technique. The reliability of rotary compressors has been evaluated through visual inspection on them after long term test. This paper describes methods for acquisition and processing AE raw signal to monitor the state of rotary compressor. A detecting method of abnormal compressor in real time is suggested and special-purpose monitoring system which can be applied to automatic manufacturing line is developed using one-chip microprocessor at low cost.

북한의 관료제에 관한 연구

황감용 大邱大學校 社會科學硏究所 2000 社會科學硏究 Vol.7 No.3

이 글은 북한관료체제의 구조와 특성을 분석하고 이를 남북한 비교를 통하여 정책적 시사점을 제공하는데 그 목적을 두고 있다. 이를 위해 우선 관료제에 대한 일반적인 논의, 북한과 남한 관료체제의 차이점과 앞으로의 변화를 조명하여 보았다. 북한 관료체제의 관료의 충원형태는 다소 폐쇄적이며, 충원기준도 합리성 보다는 당성, 혁명성, 이데올르기성에 보다 중점을 두고 있다. 북한관료체제의 정책결정은 「중앙인민위원회」 (당의 실질적 최고 지도기관)와 「당정치국 상무위원회」가 가장 큰 영향력을 미치는 두 개의 축으로 볼 수 있으며, 아직 탈중앙화 및 지역의 중앙정치 참여는 이루어지지 않고 있는 실정이다. 북한의 관료제는 이념적 및 제도적, 행정관료의 역할 면에서 차이가 있는 것으로 나타났다. 그러나 북한의 관료체계도 조심스런 개혁의 움직임이 있으며, 이른바 주체사상에 입각한 「우리식 사회주의」를 지향하고 있다는 점에서 주시할 필요가 있다.