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Tu, T H,Kim, C-S,Kang, J-H,Nam-Goong, I S,Nam, C W,Kim, E S,Kim, Y I,Choi, J I,Kawada, T,Goto, T,Park, T,Yoon Park, J H,Choi, M-S,Yu, R Macmillan Publishers Limited 2014 International journal of obesity Vol.38 No.8
Background:4-1BB, a member of the TNF receptor superfamily, has a role in various inflammatory pathologies through its interaction with 4-1BB ligand. We previously demonstrated that it participates in initiating and promoting obesity-induced adipose inflammation in a rodent model.Objective:In this study, we examined whether 4-1BB is related to obesity-induced adipose inflammation and metabolic parameters in humans.Methods:A total of 50 subjects, 25 obese (body mass index (BMI)⩾25 kg m<SUP>−2</SUP>) and 25 lean (BMI<23 kg m<SUP>−2</SUP>) participated in the study. The levels of 4-1BB transcripts and soluble 4-1BB protein (s4-1BB) in subcutaneous adipose tissue were measured by quantitative real-time PCR and enzyme-linked immunosorbent assay, respectively. Inflammatory and metabolic parameters were measured by enzymatic analysis and immunoassay.Results:Obese subjects had higher levels of both 4-1BB transcripts and s4-1BB protein in subcutaneous adipose tissue than lean controls, and the levels were correlated with BMI and the expression of inflammatory markers, as well as with serum metabolic parameters. Moreover, s4-1BB was released from human adipocytes, and elicited chemotactic responses from human monocytes/T cells as well as enhancing their inflammatory activity, indicating that it may promote human adipose inflammation.Discussion:Our data demonstrate that elevated levels of 4-1BB transcripts and s4-1BB in adipose tissue are closely associated with obesity-induced inflammation and metabolic dysregulation. They suggest that both 4-1BB transcripts and s4-1BB could serve as novel biomarkers and/or therapeutic targets for obesity-induced inflammation and metabolic syndrome in humans.
DETECTION OF THE COSMIC FAR-INFRARED BACKGROUND IN AKARI DEEP FIELD SOUTH
Matsuura, S.,Shirahata, M.,Kawada, M.,Takeuchi, T. T.,Burgarella, D.,Clements, D. L.,Jeong, W.-S.,Hanami, H.,Khan, S. A.,Matsuhara, H.,Nakagawa, T.,Oyabu, S.,Pearson, C. P.,Pollo, A.,Serjeant, S.,Taka IOP Publishing 2011 The Astrophysical journal Vol.737 No.1
<P>We report new limits on the absolute brightness and spatial fluctuations of the cosmic infrared background (CIB) via the AKARI satellite. We carried out observations at 65, 90, 140, and 160 mu m as a cosmological survey in AKARI Deep Field South, which is one of the lowest cirrus regions with a contiguous area of the sky. After removing bright galaxies and subtracting zodiacal and Galactic foregrounds from the measured sky brightness, we successfully measured the CIB brightness and its fluctuations across a wide range of angular scales, from arcminutes to degrees. The measured CIB brightness is consistent with previous results reported from COBE data, but significantly higher than the lower limits at 70 and 160 mu m obtained via Spitzer from the stacking analysis of selected 24 mu m sources. The discrepancy with the Spitzer result is possibly due to a new galaxy population at high redshift obscured by hot dust or unknown diffuse emission. From a power spectrum analysis at 90 mu m, two components were identified: the CIB fluctuations with shot noise due to individual galaxies in a small angular scale from the beam size up to 10 arcminutes, and Galactic cirrus emission dominating at the largest angular scales of a few degrees. The overall shape of the power spectrum at 90 mu m is very similar to that at longer wavelengths, as observed by Spitzer and the Balloon-borne Large-Aperture Submillimeter Telescope (BLAST). Our power spectrum, with an intermediate angular scale of 10-30 arcminutes, gives a firm upper limit for galaxy clustering, which was found by Spitzer and BLAST. Moreover, the color of the CIB fluctuations, which is obtained by combining our data with the previous results, is as red as ultra-luminous infrared galaxies at high redshift. These galaxies are not likely to provide the majority of the CIB emission at 90 mu m, but are responsible for the fluctuations. Our results provide new constraints on the evolution and clustering properties of distant infrared galaxies and any diffuse emission from the early universe.</P>
DIFFUSE [CII] 158 MICRON LINE EMISSION FROM THE INTERSTELLAR MATTER AT HIGH GALACTIC LATITUDE
MATSUHARA H.,TANAKA M.,KAWADA M.,MAKIUTI S.,MATSUMOTO T.,NAKAGAWA T.,OKUDA H.,SHIBAI H.,HIROMOTO N.,OKUMURA K.,LANGE A. E.,BOCK J. J. The Korean Astronomical Society 1996 Journal of The Korean Astronomical Society Vol.29 No.suppl1
We present the results of an rocket-borne observation of far-infrared [CII] line at 157.7 ${\mu}m$ from the diffuse inter-stellar medium in the Ursa Major. We also introduce a part of results on the [CII] emission recently obtained by the IRTS, a liquid-helium cooled 15cm telescope onboard the Space Flyer Unit. From the rocket-borne observation we obtained the cooling rate of the diffuse HI gas due to the [CII] line emission, which is $1.3{\pm}0.2 {\times} 10^{-26}$ $ergss^{-1} H^{-1}_{atom}$. We also observed appreciable [CII] emission from the molecular clouds, with average CII/CO intensity ratio of 420. The IRTS observation provided the [CII] line emission distribution over large area of the sky along great circles crossing the Galactic plane at I = $50^{\circ}$ and I = $230^{\circ}$. We found two components in their intensity distributions, one concentrates on the Galactic plane and the another extends over at least $20^{\circ}$ in Galactic latitude. We ascribe one component to the emission from the Galactic disk, and the another one to the emission from the local interstellar gas. The [CII] cooling rate of the latter component is $5.6 {\pm} 2.2 {\times}10$.
Measurement of Unbound Excited States of ^(24)O
추경호,사토,T. Nakamura,N. Aoi,방형찬,S. CHOI,S. Deguchi,F. Delaunay,J. Gibelin,T. Honda,M. Ishihara,Y. Kawada,Y. Kondo,T. Kobayashi,N. Kobayashi,F. M. Marques,M. Matsushita,Y. Miyashita,T. Motobayashi,Y. Nak 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The unbound excited states of the most neutron-rich oxygen isotope, ^(24)O (Z = 8, N = 16), have been investigated using the ^(24)O(p,p') ^(24)O^* → ^(23)O+n reaction at RIKEN, where a 63 MeV/neuclon secondary beam of ^(24)O was produced in a Be production target by the projectile-like fragmentation of a 95 MeV/u ^(40)Ar primary beam. The first excited 2^* state was observed in the invariant mass spectrum. This experiment will give us a deeper understanding of the new magic number at N=16 in the neutron-rich oxygen isotopes.
Measurement of Unbound Excited States of 24O
Tshoo, K.,Satou, Y.,Nakamura, T.,Aoi, N.,Bhang, H. C.,Choi, S.,Deguchi, S.,Delaunay, F.,Gibelin, J.,Honda, T.,Ishihara, M.,Kawada, Y.,Kondo, Y.,Kobayashi, T.,Kobayashi, N.,Marques, F. M.,Matsushita, M Korean Physical Society 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.2
Kim, H.J.,Kim, H.M.,Kim, C.S.,Jeong, C.S.,Choi, H.S.,Kawada, T.,Kim, B.S.,Yu, R. North-Holland Pub ; Elsevier Science Ltd 2011 FEBS letters Vol.585 No.14
HVEM is a member of the TNF receptor superfamily that plays a role in the development of various inflammatory diseases. In this study, we show that HVEM deficiency attenuates adipose tissue inflammatory responses and glucose intolerance in diet-induced obesity. Feeding a high-fat diet (HFD) to HVEM-deficient mice elicited a reduction in the number of macrophages and T cells infiltrated into adipose tissue. Proinflammatory cytokine levels in the adipose tissue decreased in HFD-fed HVEM-deficient mice, while levels of the anti-inflammatory cytokine IL-10 increased. Moreover, glucose intolerance and insulin sensitivity were markedly improved in the HFD-fed HVEM-deficient mice. These findings indicate that HVEM may be a useful target for combating obesity-induced inflammatory responses and insulin resistance.