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      • LPS로 유도된 Human Dental Pulp Cells에서 Schisandrin C 의 항염증 효과

        Jyoti Shrestha Takanche,Sang Won Lee,Yae Jin Kim,Young Hee Lee,Jeong Seok Kim,Ji Eun Kim,Ho Keun Yi,Sin Hee Han 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.10

        Background : Tooth vitality is reflected by the health of dental pulp. Schisandrin C is a natural compound extracted from the fruit of Schisandra chinensis which has anti-inflammatory and anti-oxidant properties. The role of Schisandrin C on human dental pulp cells (HDPCs) has not been studied yet. This study examined the properties of Schisandrin C as an anti-inflammatory and anti-oxidant compound, and whether its characteristics promote mitochondrial biogenesis in HDPCs. Methods and Results : HDPCs were extracted from fresh third molars and cultured. Reactive oxidative stress (ROS) and nitric oxide (NO) formation were analyzed by a Muse cell analyzer. Western blotting and gelatin zymography were used to identify the presence of anti-oxidants, as well as inflammatory and mitochondrial biogenesis. Confocal microscopy was used for the detection of mitochondrial activity. Schisandrin C inhibited lipopolysaccharide (LPS)-stimulated inflammatory molecules; intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), matrix metalloproteinase-2 and -9 (MMP-2/9), NO production, ROS formation and the mitogen-activated protein (MAPK) pathway through minimizing the nuclear factor kappa B (NF-kB) translocation. Schisandrin C increased the expression of superoxide dismutase (SOD) enzymes as well as heme oxygenase-1 (HO-1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a) through the phosphorylated-protein kinase B (p-AKT) and nuclear factor erythroid 2-related factor-2 (Nrf-2) pathways. The anti-inflammatory and anti-oxidant properties of Schisandrin C promoted mitochondrial biogenesis. Conclusions : These results suggest that Schisandrin C may be used as an anti-inflammatory compound to reduce oral inflammation such as pulpitis.

      • KCI등재
      • KCI등재

        Numerical Simulation of Micro Hot Embossing of Polymer Substrate

        Jyoti Shankar Jha,Suhas Sitaram Joshi 한국정밀공학회 2012 International Journal of Precision Engineering and Vol. No.

        Micro hot embossing, one of the important steps in the LIGA process is aimed at increasing the scale of production. The process involves: molding- in which metallic mold is pressed into the polymer, cooling- in which mold and the polymer are held together and demolding - where in the mold is separated from the polymer. In the past, these steps in a micro hot embossing process are modelled independently. As the parameters in each of these stages influence the final product quality, the simulations were performed using DEFORM 3D and by transferring the strain history from one stage to another. The final product quality thus is a function of the preceding quality in each stage. The parametric analysis shows that, at lower level of molding speed (0.01 mm/min - 0.1 mm/min)and lower level of molding temperature (105℃-115℃), complete mold filling was evident. In the cooling stage, the difference between the molding and demolding temperature governs contact stresses and thermal shrinkage. At the same time, in the demolding stage,lower rate of demolding ensures lower residual stresses in the micro components formed. Experimental validation of the results shows that the predicted results agree fairly with the simulated values.

      • KCI등재

        FIXED POINT THEOREMS FOR (ξ,β)-EXPANSIVE MAPPING IN G-METRIC SPACE USING CONTROL FUNCTION

        Jyoti Yadav,Manoj Kumar,Reena,Mohammad Imdad,Sahil Arora 경남대학교 수학교육과 2021 Nonlinear Functional Analysis and Applications Vol.26 No.5

        In this paper, some fixed point theorems for new type of (ξ,β)-expansive mappings of type (S) and type (T) using control function and β-admissible function in G-metric spaces are proved. Further, we prove certain fixed point results by relaxing the continuity condition.

      • SCISCIESCOPUS

        Hypergolicity and ignition delay study of gelled ethanolamine fuel

        Jyoti, Botchu Vara Siva,Naseem, Muhammad S.,Baek, Seung Wook,Lee, Hyung Ju,Cho, Sung June Elsevier Science Inc 2017 Combustion and Flame Vol.183 No.-

        <P><B>Abstract</B></P> <P>An experimental investigation on achieving hypergolicity with a critical catalyst concentration and measuring ignition delay of non-metalized and metalized gelled ethanolamine was performed with hydrogen peroxide as an oxidizer. The experimental results of using high speed camera were obtained by adopting the drop tests in this work. This study represented a sufficient repeatability of ignition delay for hypergolic bipropellant system. Gelled ethanolamine fuel (non-metalized and metalized with nano-sized metal particle substitution) with metal catalysts presented the results in hypergolicity with ignition delays of the order of 1–5ms in most of the cases, which was comparable to the existing liquid hypergolic bipropellant systems. However, the minimum ignition delay time was recorded for pure-CCAT case. Moreover, the calculated activation energy (E<SUB>vis</SUB>) for the gelled ethanolamine fuel for non-metalized and metalized systems was within the range of 0.03–0.06kJ/mole along with shear thinning behavior. Parameters such as apparent viscosity of the fuels, blended energetic particle, catalyst type along with its critical concentration using the drop impact plays an important role in studying the hypergolicity and ignition delay time of the gel bipropellant.</P>

      • A Third Order Sliding Modes based Output-Feedback Control for Stabilization of Container-Slosh

        Jyoti Prakash Mishra,Shailaja R. Kurode,Sanket K. Gorade 제어로봇시스템학회 2014 제어로봇시스템학회 국제학술대회 논문집 Vol.2014 No.10

        This paper describes about lateral container-slosh dynamical model, which represents an under-actuated system. The dynamics is highly coupled and non-linear, moreover it is difficult to measure the slosh states. Hence an output-feedback control is proposed, which depends only on measurable states. Third order sliding mode (TOSM) based on nested controller algorithm is applied while developing the control. The stability of the system during sliding is analyzed. Finally the proposed method is validated in simulations.

      • KCI등재

        Chemoprevention of chemical-induced skin cancer by Panax ginseng root extract

        Jyoti Sharma,Pradeep K. Goyal 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.3

        Background: Cancer has emerged as a major health problem globally as a consequence to the increased longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy for reducing cancer burden. Recently, some natural products have been identified for their chemopreventive activity to reduce the cancer incidence. Ginseng is known for its potential to treat various ailments in human beings. The present study was designed to explore the anticancer and antioxidative potential of Panax ginseng against chemical-induced skin carcinogenesis in mammals. Methods: Skin tumors were induced in Swiss albino mice by a single topical application of 7,12- dimethylbenz(a)anthracene (100 mg/100 mL acetone) and, 2 wks later, promoted by repeated applications of croton oil (thrice in a wk in 1% acetone) till the end of the experiment (i.e., 16 wk). Hydroalcoholic ginseng root extract at a dose of 25 mg/kg body weight/d was orally administered at the periinitiation, postinitiation, and periepost-initiation stages. Results: Ginseng root extract treatment caused a significant reduction in tumor incidence, cumulative number of tumors, tumor yield, and tumor burden, as compared to the 7,12-dimethylbenz(a)anthracene ecroton oil-treated control group. Further, biochemical assays revealed a significant enhancement in the levels of reduced glutathione, superoxide dismutase, catalase, vitamin C, and total proteins but a significant reduction in lipid peroxidation levels in both the liver and skin with ginseng root extract treatment, as compared to carcinogen-treated control group. Conclusion: These results suggest that P. ginseng has the potential to become a pivotal chemopreventive agent that can reduce cancer in mammals.

      • Hypergolicity and ignition delay study of pure and energized ethanol gel fuel with hydrogen peroxide

        Jyoti, B.V.S.,Naseem, Muhammad Shoaib,Baek, Seung Wook Elsevier 2017 Combustion and flame Vol.176 No.-

        <P><B>Abstract</B></P> <P>An experimental study of hypergolicity and ignition delay of pure and energized gelled ethanol with hydrogen peroxide was carried out. Experimental drop test results were obtained and discussed by using Photron high speed camera imaging. This study represented a sufficient repeatability of ignition delay for hypergolic gel bipropellant development. Gelled ethanol fuel (pure and energized with nano-Al/B/C particle substitution) mixture with metal catalysts were formulated to examine its hypergolicity with ignition delays on the order of 1–30ms in most of cases, which are comparable with the existing liquid hypergolic bipropellant systems. The minimum ignition delay time was recorded for boron case at 1.33ms. And the calculated activation energy for the gelled ethanol fuel with pure and energetic particle substitution system resided within the range of 7–13kJ/mole along with shear thinning behavior. Temperature profile also indicated an exothermic nature of the propellant system with 1000 to 1600K recorded. Parameters such as apparent viscosity of the fuel, drop height and drop volume also played an important role for the hypergolicity of the system in a drop experimentation. It was also observed that the formation of a cage encapsulating the high temperature gases in a network formed by the gelling agent could result in a longer ignition delay.</P>

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