Tradeoff between the Output Voltage Deviation and Recovery Time of Boost Converters

Junjie Ge,Liqiang Yuan,Zhengming Zhao,Ting Lu,Fanbo He,Gaohui Feng 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.2

The time-optimal control for boost converters can achieve the minimum recovery time. However, their output voltage deviation is quite large. Since the minimum output voltage deviation and minimum recovery time cannot be obtained at the same time, a novel energy control is proposed to achieve a superior tradeoff between them in this paper. The peak value of the inductor current can be decreased as well. Its control parameter is easy to choose. When compared with the conventional control methods, the proposed control shows a better dynamic performance. Experimental results, which are in agreement with the theoretical analysis, are provided to verify the proposed control method.

Fluorogenic probes for disease-relevant enzymes

Zhang, Junji,Chai, Xianzhi,He, Xiao-Peng,Kim, Hae-Jo,Yoon, Juyoung,Tian, He The Royal Society of Chemistry 2019 Chemical Society reviews Vol.48 No.2

<P>Traditional biochemical methods for enzyme detection are mainly based on antibody-based immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in particular, the <I>in situ</I> activity of enzymes in live cells and <I>in vivo</I>. In this review, we comprehensively summarize recent progress that has been made in the development of small-molecule as well as material-based fluorogenic probes for sensitive detection of the activities of enzymes that are related to a number of human diseases. The principles utilized to design these probes as well as their applications are reviewed. Specific attention is given to fluorogenic probes that have been developed for analysis of the activities of enzymes including oxidases and reductases, those that act on biomacromolecules including DNAs, proteins/peptides/amino acids, carbohydrates and lipids, and those that are responsible for translational modifications. We envision that this review will serve as an ideal reference for practitioners as well as beginners in relevant research fields.</P>

Diphoton signal of the light Higgs boson in natural NMSSM

Cao, Junjie,Guo, Xiaofei,He, Yangle,Wu, Peiwen,Zhang, Yang American Physical Society 2017 Physical review. D Vol.95 No.11

<P>The natural Next-to-Minimal Supersymmetric Standard Model (nNMSSM) is featured by predicting one CP-even Higgs boson satisfying m(h1) less than or similar to 120 GeV and Higgsinos lighter than about 300 GeV, and consequently, the cross section for dark matter (DM)-nucleon scattering in this scenario is usually quite large. We study the diphoton signal of the light Higgs boson in nNMSSM by considering the tight constraints from the latest LUX and PandaX-II experiments, and we conclude that the optimal value of the signal rate at 8 TeV LHC is greatly reduced in comparison with earlier predictions. For example, previous studies indicated that the rate may exceed 120 fb for m(h1) similar or equal to 80 GeV, while it is at most 25 fb if the lightest neutralino in the scenario is fully responsible for the measured DM relic density. We also investigate the case of m(h1) similar or equal to 98 GeV, which is hinted by the excesses of the large electron proton collider analysis on Z (b) over bar b signal and the compact muon solenoid analysis on the diphoton signal. We conclude that nNMSSM can simultaneously explain the excesses at the 1 sigma level without violating any known constraints.</P>

Tradeoff between the Output Voltage Deviation and Recovery Time of Boost Converters

Ge, Junjie,Yuan, Liqiang,Zhao, Zhengming,Lu, Ting,He, Fanbo,Feng, Gaohui The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.2

The time-optimal control for boost converters can achieve the minimum recovery time. However, their output voltage deviation is quite large. Since the minimum output voltage deviation and minimum recovery time cannot be obtained at the same time, a novel energy control is proposed to achieve a superior tradeoff between them in this paper. The peak value of the inductor current can be decreased as well. Its control parameter is easy to choose. When compared with the conventional control methods, the proposed control shows a better dynamic performance. Experimental results, which are in agreement with the theoretical analysis, are provided to verify the proposed control method.

Improving the Machining Quality of Micro Structures by Using Electrophoresis-Assisted Ultrasonic Micromilling Machining

Junfeng He,Zhongning Guo,Haishan Lian,Junjie Wang,Xiaolei Chen,Jiangwen Liu 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.7 No.1

Traditional micromilling leaves burrs and has a high surface roughness in the workpiece, which compromises the microstructural machining quality. Electrophoresis-assisted ultrasonic micromilling machining (EUMM) is proposed to solve this problem. An electrophoresis assisted electric field is applied to attract abrasive particles into the machining gap. Combined with the ultrasonic vibrations of the workpiece, the impact and grinding effect of these abrasive particles in the machining gap removes burrs that are generated during machining and reduces the surface roughness of the microstructure. Micro channels were generated for this study to verify the proposed method. The experimental results show that the EUMM significantly reduces burr formation during microchannel milling. The EUMM also decreases the surface roughness (Ra); the bottom roughness using the EUMM (0.33 µm) is lower than that with either the ultrasonic micromilling (UMM) or traditional micromilling. The EUMM also improves the sidewall roughness since the grinding and particle impacts significantly smooth the sidewalls. The particles during EUMM ensure a low surface roughness of 0.34 µm for the vertical sidewalls. Furthermore, the EUMM has a lesser effect on the width of the micro channels; as the spindle speed increases, the microchannel width only increases from 486 to 498 µm.

Strong constraints of LUX-2016 results on the natural NMSSM

Cao, Junjie,He, Yangle,Shang, Liangliang,Su, Wei,Wu, Peiwen,Zhang, Yang Institute of Physics Pub 2016 The journal of high energy physics Vol.2016 No.10

Modulatory Potential of LncRNA Zfas1 for Inflammation and Neuronal Apoptosis in Temporal Lobe Epilepsy

Chuan He,Caixia Su,Wentong Zhang,Qin Zhou,Xu Shen,Junjie Yang,Naixian Shi 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.3

Purpose: This study aimed to elucidate whether lncRNA ZFAS1 is involved in neuronal apoptosis and inflammation in temporal lobe epilepsy (TLE). Materials and Methods: Ninety-six TLE patients were recruited, and their peripheral venous blood was gathered to determine Zfas1 expression with polymerase chain reaction. Neurons were separated from hippocampal tissue of newborn SD rats, and siZfas1 or pcDNA3.1-Zfas1 was transfected into the neurons. Inflammatory cytokines released by neurons were determined, and neuronal activities were evaluated through MTT assay, colony formation assay, and flow cytometry. Results: Serum levels of Zfas1 were higher in TLE patients than in healthy controls (p<0.05). Furthermore, Zfas1 expression in neurons was raised by pcDNA3.1-Zfas1 and declined after silencing of Zfas1 (p<0.05). Transfection of pcDNA-Zfas1 weakened the viability and proliferation of neurons and increased neuronal apoptosis (p<0.05). Meanwhile, pcDNA3.1-Zfas1 transfection promoted lipopolysaccharide-induced release of cytokines, including tumor necrosis factor-α, interleukin (IL)-1, IL-6, and intercellular adhesion molecule-1 (p<0.05), and boosted NF-κB activation by elevating the expression of NF-κB p65, pIκBα, and IKKβ in neurons (p<0.05). Conclusion: Our results indicated that lncRNA ZFAS1 exacerbates epilepsy development by promoting neuronal apoptosis and inflammation, implying ZFAS1 as a promising treatment target for epilepsy.

Rapid growth in greenhouse gas emissions from the adoption of industrial-scale aquaculture

Yuan, Junji,Xiang, Jian,Liu, Deyan,Kang, Hojeong,He, Tiehu,Kim, Sunghyun,Lin, Yongxin,Freeman, Chris,Ding, Weixin Springer Science and Business Media LLC 2019 Nature climate change Vol.9 No.4

The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy

Zhao Weichen,He Chunyuan,Jiang Junjie,Zhao Zongbiao,Yuan Hongzhong,Wang Facai,Shen Bingxiang 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6

Pyroptosis, a form of cell death associated with inflammation, is known to be involved in diabetic nephropathy (DN), and discoid domain receptor 1 (DDR1), an inflammatory regulatory protein, is reported to be associated with diabetes. However, the mechanism underlying DDR1 regulation and pyroptosis in DN remains unknown. We aimed to investigate the effect of DDR1 on renal tubular epithelial cell pyroptosis and the mechanism underlying DN. In this study, we used high glucose (HG)-treated HK-2 cells and rats with a single intraperitoneal injection of streptozotocin as DN models. Subsequently, the expression of pyroptosis-related proteins (cleaved caspase-1, GSDMD-N, Interleukin-1β [IL-1β], and interleukin-18 [IL-18]), DDR1, phosphorylated NF-κB (p-NF-κB), and NLR family pyrin domain-containing 3 (NLRP3) inflammasomes were determined through Western blotting. IL-1β and IL-18 levels were determined using ELISA. The rate of pyroptosis was assessed by propidium iodide (PI) staining. The results revealed upregulated expression of pyroptosisrelated proteins and increased concentration of IL-1β and IL-18, accompanied by DDR1, p-NF-κB, and NLRP3 upregulation in DN rat kidney tissues and HG-treated HK-2 cells. Moreover, DDR1 knockdown in the background of HG treatment resulted in inhibited expression of pyroptosis-related proteins and attenuation of IL-1β and IL-18 production and PI-positive cell frequency via the NF-κB/NLRP3 pathway in HK-2 cells. However, NLRP3 overexpression reversed the effect of DDR1 knockdown on pyroptosis. In conclusion, we demonstrated that DDR1 may be associated with pyroptosis, and DDR1 knockdown inhibited HG-induced renal tubular epithelial cell pyroptosis. The NF-κB/NLRP3 pathway is probably involved in the underlying mechanism of these findings.

Low pH stress responsive transcriptome of seedling roots in wheat (Triticum aestivum L.)

Haiyan Hu,Jie He,Junjie Zhao,Xingqi Ou,Hongmin Li,Zhengang Ru 한국유전학회 2018 Genes & Genomics Vol.40 No.11

Soil acidification is one of major problems limiting crop growth and especially becoming increasingly serious in China owing to excessive use of nitrogen fertilizer. Only the STOP1 of Arabidopsis was identified clearly sensitive to proton rhizotoxicity and the molecular mechanism for proton toxicity tolerance of plants is still poorly understood. The main objective of this study was to investigate the transcriptomic change in plants under the low pH stress. The low pH as a single factor was employed to induce the response of the wheat seedling roots. Wheat cDNA microarray was used to identify differentially expressed genes (DEGs). A total of 1057 DEGs were identified, of which 761 genes were up-regulated and 296 were downregulated. The greater percentage of up-regulated genes involved in developmental processes, immune system processes, multi-organism processes, positive regulation of biological processes and metabolic processes of the biological processes. The more proportion of down-regulation genes belong to the molecular function category including transporter activity, antioxidant activity and molecular transducer activity and to the extracellular region of the cellular components category. Moreover, most genes among 41 genes involved in ion binding, 17 WAKY transcription factor genes and 17 genes related to transport activity were up-regulated. KEGG analysis showed that the jasmonate signal transduction and flavonoid biosynthesis might play important roles in response to the low pH stress in wheat seedling roots. Based on the data, it is can be deduced that WRKY transcription factors might play a critical role in the transcriptional regulation, and the alkalifying of the rhizosphere might be the earliest response process to low pH stress in wheat seedling roots. These results provide a basis to reveal the molecular mechanism of proton toxicity tolerance in plants.