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( Han Ah Lee ),( Hyun Woong Lee ),( Jihwan Lim ),( Young-sun Lee ),( Young Kul Jung ),( Ji Hoon Kim ),( Jung Il Lee ),( Young Kul Jung ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ),( Kwan S 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: We investigated the clinical impact of Hepatitis B core-related antigen (HBcrAg) level in defining different phases of patients with chronic hepatitis B (CHB). Methods: Stored residual serum samples from longitudinal cohorts of CHB patients in Korea University College of Medicine were studied. Patients were divided into four phases of CHB based on the histology result: hepatitis B e antigen (HBeAg)-positive chronic infection (EPI), HBeAg-positive chronic hepatitis (EPH), HBeAg-negative chronic hepatitis (ENH), HBeAg-negative chronic infection (ENI). Results: In total, 425 patients followed up for 83.1 months were included. The number of patients in each phase are as follows: 26 in EPI, 243 in EPH, 137 in ENH, and 19 in EHI. To evaluate the clinical impact of HBCrAg in differentiating EPI and EPH, patients older than 60 years old, patients with clinically or ultrasonographically evident liver cirrhosis or fibrosis-4 index (> 3.25), and HBV-DNA ≤ 20,000 IU/mL were excluded. In 145 selected patients, 26 patients were in EPI and 119 patients were in EPH. HBCrAg level was significantly higher in EPI than in EPH (8.22 log U/mL vs. 7.57 log U/mL, P=0.003). On multivariate analysis, only higher HBCrAg level (HR 0.447, P=0.013) was significantly associated with an increased probability of EPI. To evaluate the clinical impact of HBCrAg in differentiating ENH and ENI, patients with clinically or ultrasonographically evident liver cirrhosis or fibrosis-4 index (> 3.25), and HBV-DNA > 20,000 IU/mL were excluded. In 33 selected patients, 21 patients were in ENH and 12 patients were ENI. HBCrAg level was significantly higher in ENH patients than in ENI patients (5.24 log U/mL vs. 3.98 log U/mL, P<0.001). Only elevated ALT according to the KASL criteria (HR 4.875, P=0.049) was significantly associated with increased probability of ENH. Conclusions: HBcrAg level is a useful marker in differentiating EPI and EPH in patients with CHB.
( Jung Wan Choe ),( Hyung Joon Yim ),( Seung Hwa Lee ),( Hwan Hoon Chung ),( Sang Jun Suh ),( Seung Young Kim ),( Jong Jin Hyun ),( Sung Woo Jung ),( Young Kul Jung ),( Ja Seol Koo ),( Ji Hoon Kim ),( 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: No single effective method has yet been established for the prophylactic treatment of gastric varices. So, we aimed to compare two prophylactic treatment methods, including EVO and BRTO for gastric varices. Methods: We retrospectively analyzed patients with gastric varices, who had undergone either EVO or BRTO as a prophylactic treatment. The end points were eradication rate of gastric varices and gastric variceal bleeding rate during the follow-up period. Results: Total 84 patients were consisted of 55 patients in EVO group and 29 patients in BRTO group. No difference was observed in the clinical profiles of patients, including age, gender, Child-Pugh score, etiology of liver cirrhosis, and presence of hepatocellular carcinoma, between the EVO and BRTO groups. There was also no difference with respect to endoscopic features of gastric varices including F-component and location. As primary end points, the gastric varices were disappeared partially or completely in 50 patients in EVO group, and 27 patients in BRTO group. (90.9% vs 93.1%, p= 0.542). At the complete eradication rate, there was also no difference between two groups. (49.1% vs 65.5%, p=-0.150) However, 12 patients in EVO group bled from gastric varices after treatment during the median follow-up of 28 months, compared to only one case in BRTO group. (21.8% vs 3.4%, p=0.027) In addition, there were no differences in worsening in the endoscopic classification of esophageal varices or amounts of ascites. All-cause mortalities were similar in both. Conclusions: EVO and BRTO are equally effective for eradication of gastric varices with similar frequencies of complications and mortalities. However, BRTO proved more effective in preventing bleeding from gastric varices in the long run.
SINGLET OXYGEN-MEDIATED PHOTOOXIDATION OF METHYL 11-HYDRO-13-(METHYLOXY)CARBONYLARTEMISINATE
Lee, Jung-Kul,Han, Jae-Hong,Kim, Jeong-Han,Lim, Yoong-Ho,Kim, Soo-Un Korean Society of Photoscience 1994 Journal of Photosciences Vol.1 No.2
Singlet oxygen-mediated photooxidation and subsequent triplet oxygen insertion of 11-hydro-13-(methyloxy)carbonylartemisinate (4) yielded a diketo compound 5 as the major product instead of the expected 11-hydro-13-(methyloxy)carbonylartemisinin (6). The formation of the unexpected product was in part consistent with the mechanism proposed by Acton and Roth and is the first isolation of the diketo compound from the photooxidation of artemisinate.
Purification and Characterization of a Thermostable Xylanase from Fomitopsis pinicola
( Jung Kul Lee ),( Yeong Suk Kim ),( Shin Keum ),( Marimuthu Jeya ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.10
An extracellular xylanase was purified to homogeneity by sequential chromatography of Fomitopsis pinicola culture supernatants on a DEAE-Sepharose column, a gel filtration column, and then on a MonoQ column with fast protein liquid chromatography. The relative molecular mass of the F. pinicola xylanase was determined to be 58 kDa by sodium dodecyl sulfate polyacrylamide gel electrophoresis and by size-exclusion chromatography, indicating that the enzyme is a monomer. The hydrolytic activity of the xylanase had a pH optimum of 4.5 and a temperature optimum of 70oC. The enzyme showed a t1/2 value of 33 h at 70oC and catalytic efficiency (kcat=77.4 s-1, kcat/Km=22.7 mg/ml/s) for oatspelt xylan. Its internal amino acid sequences showed a significant homology with hydrolases from glycoside hydrolase (GH) family 10, indicating that the F. pinicola xylanase is a member of GH family 10.
Immunological Activities of Cationic Methylan Derivatives
Lee, Jung-Kul,Kim, In-Won,Kim, Tae-Su,Choi, Joon-Ho,Kim, Jung-Hoe,Park, Si-Hyung The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.3
Methylan polysaccharide was aminated to add dialkylaminoethyl and free amino groups at hydroxyl sites in the methylan backbone, and these derivatives were quaternized to produce pH-independent cationic polyelectrolytes. The immunological activities of the resulting methylan derivatives were investigated. Diethylaminoethyl (DEAE)-methylan derivatives inhibited the classical pathway of the complement system in a dose-dependent way. Quaternized DEAE-methylan exhibited the highest anticomplementary activities among the all derivatives. Anticomplementary activities increased significantly as the cationic charge of the methylan derivatives increased via aminoderivatization followed by quaternization, indicating that there is an electrostatic interaction between the methylan derivatives and the negatively charged functional residues on the cell.
Lee, Young-Sun,Kim, Hyun Jung,Kim, Ji Hoon,Yoo, Yang Jae,Kim, Tae Suk,Kang, Seong Hee,Suh, Sang Jun,Joo, Moon Kyung,Jung, Young Kul,Lee, Beom Jae,Seo, Yeon Seok,Yim, Hyung Joon,Yeon, Jong Eun,Kim, Jae RAVEN PRESS PUBLISHERS 2017 JOURNAL OF CLINICAL GASTROENTEROLOGY Vol.51 No.4
<P>Background and Aims: Although both corticosteroids and pentoxifylline are currently recommended drugs for the treatment of patients with severe alcoholic hepatitis, their effectiveness in reducing mortality remains unclear. In this systematic review, we aimed to evaluate the therapeutic and adverse effects of corticosteroids, pentoxifylline, and combination by using Cochrane methodology and therefore determine optimal treatment for severe alcoholic hepatitis. Methods: We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from their inauguration until October 2015. Combinations of the following keywords and controlled vocabularies were searched: alcoholic hepatitis, corticosteroid, and pentoxifylline. Results: A total of 2639 patients from 25 studies were included. The treatment groups did not differ significantly in terms of overall mortality. Analysis of 1-month mortality revealed corticosteroid monotherapy reduced mortality compared with placebo (OR= 0.58; 95% CI, 0.34-0.98; P= 0.04), but pentoxifylline monotherapy did not. The mortality with dual therapy was similar to corticosteroid monotherapy (OR=0.91; 95% CI, 0.62-1.34; P= 0.63). However, dual therapy decreased the incidences of hepatorenal syndrome or acute kidney injury (OR= 0.47; 95% CI, 0.26-0.86; P= 0.01) and the infection risk (OR= 0.63; 95% CI, 0.41-0.97; P= 0.04) significantly more than corticosteroid monotherapy did. None of the treatments conferred any medium-term or long-term survival benefits in the present study. Conclusions: Dual therapy was not inferior to corticosteroid monotherapy and could reduce the incidence of hepatorenal syndrome or acute kidney injury and risk of infection. Therefore, dual therapy might be considered in treatment of patients with severe alcoholic hepatitis.</P>