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1
Postmenopausal Spontaneous Umbilical Endometriosis: A Case Report

Jung Keom Choi,Hyun A Bae,상재홍,정수호 대한폐경학회 2020 대한폐경학회지 Vol.26 No.1
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Endometriosis is a benign gynecologic disease that highly influences women of childbearing age. It is characterized by ectopic endometrial tissue. Primary umbilical endometriosis is a rare condition. It is a benign disease with endometrial tissue in an abnormal site in the navel. It may be accompanied with pain in the navel and a discolored bump. Among all locations with the potential for endometriosis, the navel has less than 1% incidence of primary umbilical endometriosis. In the present study, we reported a rare case of umbilical endometriosis revealed via a biopsy performed for a 49-year-old menopausal woman with the complaint of pain in the navel who underwent surgical excision and a biopsy after a scan.
2
Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography

Jung, Young-Jin,Kang, Hoon-Chul,Choi, Keom-Ok,Lee, Joon Soo,Kim, Dong-Seok,Cho, Jae-Hyun,Kim, Shin-Hye,Im, Chang-Hwan,Kim, Heung Dong Elsevier 2011 SEIZURE Vol.20 No.6
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AbstractIntroductionNeuroscientists are becoming interested in the application of computational EEG analysis to the identification of ictal onset zones; however, most studies have focused on the localization of ictal onset zones in focal epilepsy. The present study aimed to estimate the ictal onset zone of Lennox-Gastaut syndrome (LGS) with bilaterally synchronous epileptiform discharges from intracranial electroencephalography (iEEG) recordings using directional connectivity analysis.MethodsWe analyzed ictal iEEG data acquired from three LGS patients who underwent epileptic surgery with favorable surgical outcomes. To identify the ictal onset zones, we estimated the functional directional connectivity network among the intracerebral electrodes using the directed transfer function (DTF) method.ResultsThe analysis results demonstrated that areas with high average outflow values corresponded well with the surgical resection areas identified using electrophysiologic data and conventional neuroimaging modalities.DiscussionsOur results suggest that the DTF analysis can be a useful auxiliary tool for determining surgical resection areas prior to epilepsy surgery in LGS patients. This is the first research article demonstrating that directional connectivity analysis of iEEG recording data can be used for delineating surgical resection areas in generalized epilepsy patients who need surgical treatment.
3
The association between endoscopically diagnosed reflux esophagitis and lung function decline in healthy screening population

( Hye-rin Kang ),( Ye Jin Lee ),( Seo Young Yoon ),( Ha Youn Lee ),( Tae Yun Park ),( Jung Kyu Lee ),( Eun Young Heo ),( Seung Ho Choi ),( Hee Soon Chung ),( Deog Keom Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
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Background: Although gastroesophageal reflux disease (GERD) associates with many respiratory disorders such as bronchial asthma, chronic cough, chronic bronchitis, and idiopathic pulmonary fibrosis, the association between GERD and lung functions is controversial and its association with lung function decline was rarely reported. This study was performed to evaluate the association of endoscopically diagnosed esophagitis (e-GERD) and lung function changes. Methods: From the Gene-environment interaction and phenotype (GENIE) cohort at Seoul national university hospital Gangnam center, patients with more than two spirometry results and two spirometry- matched endoscopy were included. E-GERD was defined when the reflux esophagitis was found persistently in two discrete endoscopic examinations. Spirometric changes of patients with e-GERD were compared with matched patients without e-GERD (ratio, 1:4). Annual FEV1 or FVC changes from baseline were estimated and compared with linear mixed regression model. Severity of e-GERD was assessed with Los Angeles (LA) classification. Results: Totally 1,050 patients (210 patients with e-GERD and their matched 840 controls) were included in final analysis. Median follow-up duration for spirometry was 6 years. In e-GERD patients, mild disease (LA, A grade) was most common (165 patients, 78.6%). The adjusted annual FEV1 change in patients with e-GERD was -51.8 ml/year while it decreased by 46.8 ml/year in controls (p=0.270). The adjusted annual FVC decline was numerically larger in GERD group than in controls without statistical significance (-55.8ml/year vs. -50.5ml/year, p=0.215). With the increase of severity in e-GERD, annual decline of FEV1 became larger in trend (-51 ml/year in LA classification A, -54.8 ml/ year in LA classification B, and -61.4 ml/year in LA classification C) without statistical significance. Also the annual decline of FVC showed similar trend. Conclusion: Comparing with controls, the annual decline of FEV1 or FVC were not statistically different in patients with e-GERD despite the more declining trend.