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Pregnancy, childbirth, and puerperium outcomes in female firefighters in Korea
Juha Park,Yeon-Soon Ahn,Min-Gi Kim 대한직업환경의학회 2020 대한직업환경의학회지 Vol.32 No.-
Background: Female firefighters are exposed to hazardous environmental (chemical and physical) and working (shift work, psychological, and ergonomic factors) conditions that have reported or are suspected of adverse effects on reproductive health. However, no previous studies have reported on pregnancy, childbirth, and puerperium outcomes (PCPOs) in female firefighters. Methods: The present study compared hospital admissions for PCPOs, based on 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10) codes, among Korean female firefighters with those of the general Korean population. Standardized admission ratios (SARs) and their 95% confidence intervals (CIs) were calculated. Results: The study population included 1,766 female firefighters. Total follow-up duration was 9,659 person-years. Compared to the general female population, the female firefighters" SARs were higher in all admissions for PCPOs (SAR, 1.92; 95% CI: 1.79–2.05); pregnancy and abortive outcomes (SAR, 1.56; 95% CI: 1.12–2.12); other maternal disorders predominantly related to pregnancy (SAR, 2.65; 95% CI: 1.99–3.46); maternal care related to the fetus, amniotic cavity, and possible delivery problems (SAR, 2.13; 95% CI: 1.74–2.57); labor and delivery complications (SAR, 1.55; 95% CI: 1.15–2.06); delivery (SAR, 1.94; 95% CI: 1.80–2.08); and complications predominantly related to puerperium (SAR, 4.68; 95% CI: 2.02–9.23). Conclusion: The results of this study showed high SARs in all and specific subcategories of PCPOs in female firefighters.
( Juha Park ),( Hee-jin Yoo ),( Ah-ran Yu ),( Hye Ok Kim ),( Sang Cheol Park ),( Young Pyo Jang ),( Chayul Lee ),( Wonchae Choe ),( Sung Soo Kim ),( Insug Kang ),( Kyung-sik Yoon ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.4
The Wnt/β-catenin signaling pathway is involved in breast cancer and Myxococcus fulvus KYC4048 is a myxobacterial strain that can produce a variety of bioactive secondary metabolites. Although a previous study revealed that KYC4048 metabolites exhibit anti-proliferative effects on breast cancer, the biochemical mechanism involved in their effects remains unclear. In the present study, KYC4048 metabolites were separated into polar and non-polar (ethyl acetate and n-hexane) fractions via liquid-liquid extraction. The effects of these polar and non-polar KYC4048 metabolites on the viability of breast cancer cells were then determined by MTT assay. Expression levels of Wnt/ β-catenin pathway proteins were determined by Western blot analysis. Cell cycle and apoptosis were measured via fluorescence-activated cell sorting (FACS). The results revealed that non-polar KYC4048 metabolites induced cell death of breast cancer cells and decreased expression levels of WNT2B, β-catenin, and Wnt target genes (c-Myc and cyclin D1). Moreover, the n-hexane fraction of non-polar KYC4048 metabolites was found most effective in inducing apoptosis, necrosis, and cell cycle arrest, leading us to conclude that it can induce apoptosis of breast cancer cells through the Wnt/β-catenin pathway. These findings provide evidence that the n-hexane fraction of non-polar KYC4048 metabolites can be developed as a potential therapeutic agent for breast cancer via inhibition of the Wnt/β-catenin pathway.
Effect of night shift work on the control of hypertension and diabetes in workers taking medication
Juha Park,Sang-Yeop Shin,Yangwon Kang,Jeongbae Rhie 대한직업환경의학회 2019 대한직업환경의학회지 Vol.31 No.-
Background: Night shift work induces physiological and psychological stress by altering sleep and biological rhythms and is associated with hypertension, diabetes, obesity, and cardiovascular diseases. Few studies have been conducted on the control of hypertension and diabetes. This study aimed to examine the effect of night shift work on the control rate of hypertension and diabetes. Methods: Subjects comprised workers aged 20–65 years who underwent specific health examination at a single facility in seven different affiliated examination centers from 1 January to 31 December 2016. Workers were categorised into day workers and night shift workers. Demographic and medical history were taken, and physical examination was done. Blood pressure (BP) and fasting glucose were measured. The control rate of each disease was evaluated based on treatment goals presented in the treatment guidelines of the Korean Society of Hypertension and the Korean Diabetes Association (systolic BP < 140 mmHg and diastolic BP < 90 mmHg; fasting glucose ≤ 130 mg/dL). Results: Among 631,418 subjects, 11.2% (70,450) were night shift workers. Of whom 6.1% (4,319) were taking antihypertensive medication and 2.5% (1,775) were taking diabetes medication. Among patients taking antihypertensive medications, the proportion of those whose BP was controlled to suit treatment goals was 81.7% (26,635) of day workers and 77.4% (3,343) of night shift workers, which was significantly different (p < 0.001). Among patients taking diabetes medications, the proportion of those whose blood glucose was controlled to suit treatment goals was 37.4% (4,489) of day workers and 36.5% (647) of night shift workers, but the difference was not significant. The control rates for patients taking antihypertensive medications (odds ratio [OR]: 0.74, 95% confidence interval [CI]: 0.68–0.80) were lower among night shift workers than day workers with adjustment for age, sex, smoking history, alcohol consumption, exercise, and obesity. However, there were no differences in control rates for patients taking diabetes medications (OR: 0.99, 95% CI: 0.87–1.10) between day workers and night shift workers. Conclusions: Night shift work can have an effect on the uncontrolled BP in workers taking antihypertensive medications. Therefore, additional efforts for disease control are necessary for night shift workers with hypertension.
3D 모델링 소프트웨어를 활용한 생명과학Ⅰ 수업 프로그램 개발 및 적용 - 신경계와 염색체의 구조를 중심으로 -
박주하 ( Juha Park ),정은영 ( Eunyoung Jeong ) 한국생물교육학회 2021 생물교육 Vol.49 No.4
The purpose of this study was to develop the Life Science I instruction programs using 3D modeling software to improve the students’ mental model and to investigate the effect of these programs. In order to develop the programs, the topics and 3D modeling software were selected, and lesson plan and worksheets were designed. The lessons were applied to 68 11th grade students, the mental model test was administrated before and after lessons, and the survey on students’ perception about these lessons was carried out after lessons. As a result, the Life Science I instruction programs using 3D modeling software have 4 topics; ‘structure of brain’, ‘structure of spinal cord and spinal nerve’, ‘structure of chromosomes’, and ‘mitosis’. ‘TinkerCAD’ was selected as 3D modeling software. And class activities were composed of the steps of ‘model generation’, ‘model evaluation’, and ‘model modification’ based on the GEM cycle, and the step of ‘expression of the result of observation and description of the change of mental model’. In the result of mental model test, the posttest score was higher than the pretest score(p<.001), and the students expressed the structure of brain, spinal cord, spinal nerve, and chromosome more elaborately. Most students replied to survey that they were interested and participated actively in these classes, willing to participate these classes continuously and got some help to study these topics. Based on these results, the Life ScienceⅠ instruction programs using 3D modeling software are effective in improving high school students’ mental model, and the students had positive thoughts about these programs. It is necessary to conduct research on how to use 3D modeling software on various topics of Life ScienceⅠ.