<i>ASXL1</i> is a molecular predictor in idiopathic cytopenia of undetermined significance

Shin, Dong-Yeop,Park, Jin-Kyun,Kim, Sung-Min,Im, Kyongok,Kim, Jung-Ah,Kim, Sun Young,Hwang, Sang Mee,Yoon, Sung-Soo,Lee, Dong-Soon Informa UK (TaylorFrancis) 2019 Leukemia & lymphoma Vol.60 No.3

Immediate Effects of Low-Dye Taping on the Ankle Motion and Ground Reaction Forces in the Pronated Rear-Foot During Gait

Sung-shin Kim,Jae-yeop Chung 한국전문물리치료학회 2016 한국전문물리치료학회지 Vol.23 No.1

Background: Increased foot pronation causes biomedchanical changes at the lower limbs, which may result in musculoskeletal injuries at the proximal joints. Pronation rear-foot leads to plantar fasciitis, Achilles tendonitis, and posterior tibial tendonitis pathologically. According to the recent meta-analysis, They showed that therapeutic adhesive taping is more effective than foot orthoses and motion control footwear, low-Dye (LD) taping has become the most popular method used by physiotherapists. Objects: The purpose of this study was to determine the immediate effects of LD taping results in different ankle motion and ground reaction force (GRF) as before and after applied LD taping on pronated rear-foot during gait. Methods: Twenty-four participants were recruited for this study. The gait data were recorded using an 8-camera motion capture system and two force platforms. At first, the experiments were carried out that participants walked barefoot without LD taping. And then they walked both feet was applied LD taping. Results: The ankle inversion minimum was significantly greater after LD taping than before LD taping (p=.04); however, in the GRF, there were no significant differences in the inversion maximum or total motion of the stance phase (p=.33, p=.07), or in the vertical (p=.33), posterior (p=.22), and lateral (p=.14) peak forces. Conclusion: The application of taping to pronation rear-foot assists in increased ankle inversion.

Interference Analysis of KPS Signals on the L-band GNSS Signals

Shin, Jang Hwan,Lim, Deok-Won,Joo, Jung-Min,Lee, Sang Jeong,Song, Hong-Yeop,Won, Jong-Hoon,Ahn, Jae Min 항법시스템학회 2020 Journal of Positioning, Navigation, and Timing Vol.9 No.4

In order to propose new satellite navigation signals, it is essential to analyze the increased level of interference effect that the existing signals suffer. In this paper, a method for estimating the power density of the interference signals on GPS signals is proposed before and after the additional transmission of the KPS signals in the L1, L2 and L5 bands. For estimation, we assume the number of visible satellites observed over the Korean peninsular and the minimum received power of the satellite navigation signals. The comparison of the estimated values shows that the power density of the interfering signal increases by up to 1.37 dB due to the introduction of KPS, but this leads to an increase in interference plus noise power density below 0.47 dB.

The Availability of Radiological Measurement of Tibial Torsion: Th ree-Dimensional Computed Tomography Reconstruction

Sang-yeop Shin,신희석,윤철호,이은신,오민균,A Ram Kim,Jong Moon Park,Jun-Hwa Shin 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.5

Objective To assess the intra-rater and inter-rater reliability for measuring tibial torsion measurements by a radiographic method using three-dimensional computed tomography reconstruction (3D-CT) and to compare the physical measures to those of 3D-CT. Method The study included 33 children who presented with intoeing gait. Tibial torsion was measured by 3D-CT. Distal reference point was the bimalleolar axis. Proximal reference points were the transtibial axis and posterior condylar axis. Physical measurements included thigh-foot angle (TFA) and bimalleolar angle (BMA). 3D-CT measurement and physical measurement were performed twice at both lower extremities by each rater. The intra-rater and inter-rater reliability were calculated by intraclass correlation coeffi ciency (ICC). Th e relationship between radiological and physical examination was calculated by Spearman correlation coefficient. Results The 3D-CT measures for tibial torsion were reliable within individual raters and between different raters. However, physical measures for tibial torsion were reliable within an individual rater but not reliable between raters. The 3D-CT measures by any proximal reference axis were more reliable within a rater and between raters than physical measurements. There was no signifi cant impact introduced by the selection of the proximal reference axis. The correlation coeffi ciency between 3D-CT and physical measurement methods was low. Conclusion Because the 3D-CT measurements for tibial torsion are more reliable than physical measurements, we recommend that accurate diagnosis of internal tibial torsion should be detected by using 3D-CT measurements. Also, considering the disadvantages of radiological measurements, physical measurement may be used for short term follow-up by same raters, as intra-rater reliability is relatively good.

Replicative senescence of hematopoietic cells in patients with idiopathic cytopenia of undetermined significance

Shin, Dong-Yeop,Park, Jin Kyun,Li, Chih Chiao,Park, Hee Sue,Moon, Soo Young,Kim, Sung-Min,Im, Kyongok,Chang, Yoon Hwan,Yoon, Sung-Soo,Lee, Dong-Soon Elsevier 2019 Leukemia research Vol.79 No.-

<P><B>Abstract</B></P> <P>We hypothesized that a subset of idiopathic cytopenia of undetermined significance (ICUS) is associated with an increased autonomous proliferation with exhaustion of hematopoiesis. The aim of this study was to investigate the cell turnover rate and replicative history of the bone marrow cells of ICUS patients. To this end, we examined telomere length (TL), proliferation, and apoptosis of the bone marrow cells of ICUS patients and healthy controls (HCs) using telomere quantitative fluorescence <I>in situ</I> hybridization and immunohistochemical staining for Ki-67 and cleaved caspase-3. We also performed targeted sequencing of 88 myeloid-associated genes. A total of 37 patients with ICUS were enrolled in this study, with a median age of 66 years (range: 31–83). TLs were significantly shorter in patients with ICUS than in the HCs (8.8, interquartile range [IQR] 6.8–12.1 vs 18.4, IQR 14.4–22.0, p < 0.0001). Proliferation (Ki-67-positive) and apoptosis (cleaved caspase-3-positive) were significantly increased in patients with ICUS compared to HCs (median = 20.0% vs 5.0%, <I>p</I> = 0.0003; 45.0% vs 22.5%, <I>p</I> = 0.0005, respectively). The shortening of TL and the increased proliferation and apoptotic activity was also prominent in patients with ICUS without mutation and dysplasia than in HCs (p < 0.0001, p < 0.0001, and p = 0.0093, respectively). TL was not associated with mutational profile and clinical characteristics as well in patients with ICUS. To our knowledge, this is the first study to show that ICUS is associated with premature replicative senescence with increased proliferation and apoptosis of bone marrow cells. Further study is needed to address the cause of replicative exhaustion in ICUS patients.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Telomere is shortened in idiopathic cytopenia of undetermined significance (ICUS). </LI> <LI> Proliferation (Ki-67) and apoptosis activity (caspase-9) are increased in ICUS. </LI> <LI> Telomere shortening and increased Ki-67/caspase-9 is consistent in non-mutated ICUS. </LI> <LI> ICUS can be associated with premature replicative senescence. </LI> </UL> </P>

Radioimmunotherapy with 131I-rituximab as consolidation therapy for patients with diffuse large B-cell lymphoma

Shin, Dong-Yeop,Byun, Byung Hyun,Kim, Kyeong Min,Kang, Joo Hyun,Lim, Ilhan,Kim, Byung Il,Lee, Seung-Sook,Choi, Chang Woon,Kang, Hye Jin,Lim, Sang Moo Springer-Verlag 2016 Cancer chemotherapy and pharmacology Vol.78 No.4

<P>Purpose The aim of this study was to assess the clinical activity and toxicity of I-131-rituximab as consolidation therapy for patients with diffuse large B-cell lymphoma (DLBCL) who were treated with R-CHOP (rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisolone). Methods Patients who had been diagnosed with advanced stage (Ann Arbor III or IV) or bulky stage II DLBCL and achieved complete or partial response after six to eight cycles of R-CHOP were enrolled. Results A total of 16 patients were enrolled and treated with a single dose of I-131-rituximab as consolidation therapy after the completion of six or eight cycles of R-CHOP between December 2005 and June 2011. This trial was terminated before the scheduled enrollment owing to low recruitment. Among the 16 patients who were treated with consolidative I-131-rituximab, 6 achieved complete response (CR) after three cycles of R-CHOP, and another 9 patients further achieved CR after the completion of six or eight cycles of R-CHOP. During the median follow-up period of 73 months, only four patients (25 %) experienced relapse. Two-year relapse-free survival was 88 %, and 5-year relapse-free survival was 81 %. Grade 3 or 4 treatment-related toxicity occurred in four patients and included neutropenia and thrombocytopenia. Conclusions I-131-rituximab showed promising efficacy as consolidation treatment for patients with DLBCL. A future randomized phase III study to confirm our results is warranted.</P>

The Impact of Discrepancy between Measured versus Stated Weight on Hemorrhagic Transformation and Clinical Outcomes after Intravenous Alteplase Thrombolysis

Shin, Dong Hoon,Kang, Min-Ju,Kim, Jin Wook,Shin, Dong-Jin,Park, Hyeon-Mi,Sung, Young Hee,Kim, Eung Yeop S. Karger AG 2017 Cerebrovascular diseases Vol.44 No.5

<P><B><I>Background:</I></B> An accurate measurement of patient weight is important in determining the dosage for intravenous alteplase thrombolysis. In most emergency rooms, however, weight is not measured. We investigated the difference between stated and measured weight and its effect on hemorrhagic transformation and clinical outcomes. <B><I>Methods:</I></B> We enrolled 128 consecutive patients who had hyperacute stroke and were treated by alteplase. Alteplase dose was calculated using the weight provided by patient or guardian/caregiver, and the actual weight was measured after administration. Patients were classified into 2 groups: overused group (stated weight >measured weight) and underused group (measured weight ≥stated weight). The prevalence of hemorrhagic transformation on follow-up, determined by gradient-recalled echo MRI or non-enhanced CT, was compared between the 2 groups. The predictors for hemorrhage with progression, defined as an increase in the National Institutes of Health Stroke Scale (NIHSS) by a value of 4 or more accompanied by hemorrhage, were determined using multivariable logistic regression analysis and included the overused or underused alteplase and baseline clinical and laboratory findings. <B><I>Results:</I></B> Sixty-six (51.6%) of 128 patients were in the underused group and 62 patients (48.4%) in the overused group. The median difference between the stated and measured weights was 1.5 (interquartile range 0.56-3.81) kg, with the largest difference being 25.6 kg. Although there were no significant difference in baseline clinical and laboratory findings between the 2 groups, the overused group showed a significantly higher prevalence of hemorrhagic transformation (<I>p</I> = 0.012) and hemorrhage with progression (<I>p</I> = 0.025). The multivariable logistic regression analysis demonstrated that overused alteplase (OR 7.26; 95% CI 1.24-42.45; <I>p</I> = 0.028), baseline glucose (>144 mg/dL; OR 5.03; 95% CI 1.00-25.26; <I>p</I> = 0.050), and initial NIHSS (OR 1.13 per 1-point NIHSS increase; 95% CI 1.00-1.27; <I>p</I> = 0.047) in model 1 that use alteplase overdose as a categorical variable and overused alteplase (OR 1.67 1-mg increase; 95% CI 1.05-2.66; <I>p</I> = 0.027) in model 2 that use an overused alteplase dose as numerical variable were significant predictors for hemorrhage with progression. <B><I>Conclusion:</I></B> More alteplase usage than actual weight led to higher hemorrhagic transformation. As one of the predictors for clinical deterioration, it is important to administrate alteplase based on an accurately measured weight.</P>

Highly Durable and Efficient Anion Exchange Membrane Water Electrolyzer using a Simply Fabricated Cobalt Oxide Electrode

Shin-Woo Myeong,Jaehoon Jeong,Jae-yeop Jeong,Hoseok Lee,Song Jin,Yangdo Kim,Chiho Kim,Sung Mook Choi 한국표면공학회 2023 한국표면공학회 학술발표회 초록집 Vol.2023 No.11-1

Genomic characterization of extensively drug-resistant <i>Acinetobacter baumannii</i> strain, KAB03 belonging to ST451 from Korea

Lee, Sang-Yeop,Oh, Man Hwan,Yun, Sung Ho,Choi, Chi-Won,Park, Edmond Changkyun,Song, Hyun Seok,Lee, Hayoung,Yi, Yoon-Sun,Shin, Juhyun,Chung, Chaeuk,Moon, Jae Young,Lee, Je Chul,Kim, Gun-Hwa,Kim, Seung Elsevier 2018 INFECTION GENETICS AND EVOLUTION Vol.65 No.-

<P><B>Abstract</B></P> <P>Extensively drug-resistant (XDR) <I>Acinetobacter baumannii</I> strains have emerged rapidly worldwide. The antibiotic resistance characteristics of XDR <I>A. baumannii</I> strains show regional differences; therefore, it is necessary to analyze both genomic and proteomic characteristics of emerging XDR <I>A. baumannii</I> clinical strains isolated in Korea to elucidate their multidrug resistance. Here, we isolated new sequence type of XDR <I>A. baumannii</I> clinical strain (KAB03) from Korean hospitals and performed comprehensive genome analyses. The strain belongs to new sequence type, ST451. Single nucleotide polymorphism (SNP) analysis with other types of <I>A. baumannii</I> strains revealed that KAB03 has unique SNP pattern in the regions of <I>gyrB</I> and <I>gpi</I> of MLST profiles. <I>A. baumannii</I> KAB03 harbours three antibiotic resistance islands (AbGRI1, 2, and 3). AbGRI1 harbours two copies of Tn<I>2006</I> containing <I>bla</I> <SUB>OXA-23</SUB>, which play an important role in antibiotic resistance. AbGRI2 possesses aminoglycoside resistant gene <I>aph(3′)-Ic</I> and class A β-lactamase <I>bla</I> <SUB>TEM</SUB>. AbGIR3 has macrolide resistant genes and aminoglycoside resistant gene <I>armA</I>. <I>A. baumannii</I> KAB03 harbours mutations in <I>pmrB</I> and <I>pmrC</I>, which are believed to confer colistin resistance. In addition, proteomic and transcriptional analysis of KAB03 confirmed that β-lactamases (ADC-73 and OXA-23), Ade efflux pumps (AdeIJK), outer membrane proteins (OmpA and OmpW), and colistin resistance genes (PmrCAB) were major proteins responsible for antibiotic resistance. Our proteogenomic results provide valuable information for multi-drug resistance in emerging XDR <I>A. baumannii</I> strains belonging to ST451.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Whole genome of an XDR <I>A. baumannii</I> KAB03 belonging to ST451, isolated in South Korea, was analyzed </LI> <LI> <I>A.s baumannii</I> strains belonging to ST451 have unique SNP pattern in the regions of <I>gyrB</I> and <I>gpi</I> of MLST profiles </LI> <LI> Antibiotic resistance proteins of <I>A. baumannii</I> KAB03 were suggested by proteomic and transcriptomic analysis </LI> </UL> </P>

알파형 반수석고가 지중구조물 콘크리트의 수축에 미치는 영향

신경수(Shin, Kyoung Su),성길모(Sung, Gil Mo),우상균(Woo, Sang Kyun),추인엽(Chu, In Yeop),우진호(Woo, Jin Ho) 한국콘크리트학회 2018 한국콘크리트학회 학술대회 논문집 Vol.30 No.1