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Potential molecular mechanisms underlying the effect of arsenic on angiogenesis
Juan Zhang,Yue Zhang,Weiyan Wang,Zhiyi Zhang 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.11
Arsenic is a potent chemotherapeutic drug thatis applied as a treatment for cancer; it exerts its functionsthrough multiple pathways, including angiogenesis inhibition. As angiogenesis is a critical component of the progressionof many diseases, arsenic is a feasible treatmentoption for patients with other angiogenic diseases, includingrheumatoid arthritis and psoriasis, among others. However,arsenic is also a well-known carcinogen, demonstrating apro-angiogenesis effect. This review will focus on the dualeffects of arsenic on neovascularization and the relevantmechanisms underlying these effects, aiming to provide arational understanding of arsenic treatment. In particular, weexpect to provide a comprehensive overview of the currentknowledge of the mechanisms by which arsenic influencesangiogenesis.
Juan Zhang,Yanqiu Cai,Guocheng Du,Jian Chen,Miao Wang,Zhen Kang 한국미생물학회 2017 The journal of microbiology Vol.55 No.7
Cutinase as a promising biocatalyst has been intensively studied and applied in processes targeted for industrial scale. In this work, the cutinase gene tfu from Thermobifida fusca was artificially synthesized according to codon usage bias of Saccharomyces cerevisiae and investigated in Saccharomyces cerevisiae. Using the α-factor signal peptide, the T. fusca cutinase was successfully overexpressed and secreted with the GAL1 expression system. To increase the cutinase level and overcome some of the drawbacks of induction, four different strong promoters (ADH1, HXT1, TEF1, and TDH3) were comparatively evaluated for cutinase production. By comparison, promoter TEF1 exhibited an outstanding property and significantly increased the expression level. By fed-batch fermentation with a constant feeding approach, the activity of cutinase was increased to 29.7 U/ml. The result will contribute to apply constitutive promoter TEF1 as a tool for targeted cutinase production in S. cerevisiae cell factory.
Synthesis and biological evaluation of glucagon-like peptide-1 receptor agonists
Zhang, Yu-Juan,Shen, Liu-Lan,Cheon, Hyae-Gyeong,Xu, Yong-Nan,Jeong, Jin-Hyun 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.5
In this study, a series of fused-heterocyclic derivatives were systematically designed and synthesized using an efficient route, and evaluated in terms of GLP-1R agonist activity. We employed short synthetic steps and reactions that are tolerant of the presence of various functional groups and suitable for parallel operations to enable the rapid generation of libraries of diverse and structurally complex small molecules. Of the compounds synthesized, 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a] pyridin-2-yl)phenyl methanesulfonate (8e) was the most potent agonist with an $EC_{50}$ of $7.89{\mu}M$, and thus is the compound with the greatest potential for application. These findings represent a valuable starting point for the design and discovery of small-molecule GLP-1R agonists that can be administered orally.
Zhang Juan 한국식물학회 2021 Journal of Plant Biology Vol.64 No.4
Auxin is well recognized for its involvement in several developmental processes like floral and leaf development and shoot elongation. The transcriptional regulation of auxin-responsive genes is mediated via auxin response factors (ARF). In this study, we identified 46 ARF genes in Nicotiana tabacum, performed phylogenetic analysis and investigated their structure, conserved domains, and motifs. Our results demonstrate that some of NtARF genes are regulated by mi-RNAs and expression in multiple tobacco tissues. Additionally, the leaf NtARFs display a diverse expression pattern in vein and shoot apical meristem in response to exogenous auxin stimulus. Transgenic NtARF10-overexpressing Arabidopsis plants exhibit larger leave areas, cell area, and more numerous cell numbers compared to wild-type plants and include several upregulated genes involved in cell division and expansion, including AtCYCD3, AtTCP1, AtTCP20, AtXTH33, and AtARGOS. This suggests NtARF10 might play a role in the regulation of leaf size. Our study contributes to a better understanding of the characteristics of the ARF family in tobacco and provides a basis for further functional research into NtARFs.
Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
Juan Liu,Yangrong Xu,Jingjing Yang,Wenzhi Wang,Jianqiang Zhang,Renmei Zhang,Qingguo Meng 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.3
Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.
RPSA Gene Mutants Associated with Risk of Colorectal Cancer among the Chinese Population
Zhang, Shan-Chun,Jin, Wen,Liu, Hui,Jin, Ming-Juan,Chen, Ze-Xin,Ding, Zhe-Yuan,Zheng, Shuang-Shuang,Wang, Li-Juan,Yu, Yun-Xian,Chen, Kun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
The primary aim of this study was to evaluate the relationship of single nucleotide polymorphisms (SNPs) in ribosomal protein SA (RPSA) gene with colorectal cancer (CRC). A case-control study including 388 controls and 387 patients with CRC was conducted in a Chinese population. Information about socio-demography and living behavior factors was collected by a structured questionnaire. Three SNPs (rs2133579, rs2269349, rs7641291) in RPSA gene were genotyped by Illumina SnapShot method. Multiple logistic regression models were used for assessing the joint effects between tea consumption and SNPs on CRC. The subjects with rs2269349 CC genotype had a decreased risk for CRC (OR=0.60; 95%CI = 0.37-0.99), compared with TT/CT genotype after adjustment for covariates. A similar association of rs2269349 with rectal cancer was observed (OR=0.49; 95%CI=0.24-1.00). Further analyses indicated that this SNP could modify the protective effect of tea drinking on CRC. Among the subjects with rs2269349 TT/CT or rs2133579 AA/GA, there was a marginal significantly lower risk of CRC (OR and 95%CI: 0.63 and 0.39-1.01 for rs2269349; 0.64 and 0.40-1.02 for rs2133579) in tea-drinking subjects in comparison to non-tea-drinking subjects. Mutants in the RPSA gene might be associated with genetic susceptibility to CRC and influence the protective effect of tea consumption in the Chinese population.
Zhang Yingchao,He Juan,Zhang Yuxia,Li Yue,Yu Yang,Jiang Xingfu,Pan Weidong 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.2
Growth-blocking peptide (GBP) is a 25 amino acid insect cytokine found in lepidopteran insects that has diverse biological activities such as larval growth regulation, paralysis induction, cell proliferation and stimulation of immune cells. Density-dependent phase polyphenism is a phenomenon of phenotypic plasticity in which the expression of a variety of traits can be affected by local population density. In the present study, the armyworm Mythimna separata larvae with four rearing densities (1 larva/vial, 2 larvae/vial, 4 larvae/vial and 6 larvae/vial) were tested for cuticular melanization and body weight throughout the third-fifth instar, and the functional role of GBP in regulating the changes was investigated. The results indicated that when reared at high densities, the larvae exhibited less body weight and more degree of cuticular melanization than larvae reared at low densities. The gene expression of GBP in armyworm larvae showed an initial rise and then decline trend with increased rearing densities in the third to fifth instar. Compared with control, more degree of cuticular melanization was observed in GBP-injected larvae (500 ng/larva in volume 50 μL) than that in Ringer’s solution-injected counterparts. Furthermore, the gene expression level of dopa decarboxylase and prophenoloxidase increased significantly in GBP-injected fifth instar larvae from 6 h to 12 h after injection, suggesting the role of GBP in modulating density-dependent phase trait of armyworm cuticular melanization.